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Increasing phosphorus fertilizer value of recycled iron phosphates by prolonged flooding and organic matter addition

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Pedosphere 2024年第3期34卷 631-640页

作者： Rochelle Joie SARACANLAO hannah van ryckel Mieke VERBEECK Maarten EVERAERT Erik SMOLDERS Division of Soil and Water Management Department of Earth and Environmental ScienceKU LeuvenKasteelpark Arenberg 20Heverlee B-3001(Belgium) Soil Service of Belgium.Willem De Croylaan 48 Leuven 3001(Belgium)

Iron(Fe)minerals are commonly used to remove phosphorus(P)from waste streams,producing P-loaded Fe(Ⅲ)oxides or Fe(Ⅱ)phosphate minerals(e.g.,vivianite).These minerals may be used as fertilizers to enhance P circularity if solubilized in ***,we tested the P fertilizer value of recycled Fe phosphates(FePs)in a pot trial and in an incubation experiment,hypothesizing that P release from FePs is possible under Fe(Ⅲ)-reducing ***,a pot trial was set up with rice(Oryza sativa)in all combinations of soil flooding or not,three P-deficient soils(acid,neutral,and calcareous),and six FePs(three Fe(Ⅲ)Ps and three Fe(Ⅱ)Ps)referenced to triple superphosphate(TSP)or zero *** P uptake responded to TSP application in all treatments but only marginally to *** redox potential did not decrease to-200 mV by flooding for a brief period(13 d)during the pot trial.A longer incubation experiment(60 d)was performed,including a treatment of glutamate addition to stimulate reductive conditions,and P availability was assessed with CaCl_(2)extraction of *** addition and/or longer incubation lowered soil redox potential to<-100 *** the longer term,Fe(Ⅲ)minerals released P,and adequate P was reached in the calcareous soil and in the neutral soil amended with Fe(Ⅲ)*** can be concluded that prolonged soil flooding and organic matter addition can enhance the P fertilizer efficiency of ***,application of FeP in powder form may enhance P availability.

关键词： agronomic efficiency circular economy P-loaded Fe(Ⅲ)oxides paddy soil vivianite redox

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Differences in Kinetics,Kinematics and Muscle Activation Strategies in Male and Female Team Sport Athletes During Unanticipated Sidestepping

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Journal of Science in Sport and Exercise 2019年第2期1卷 159-167页

作者： Gillian Weir Mirra Stillman Richard van Emmerik hannah Wyatt Carl Jewell Joseph Hamill Biomechanics Laboratory University of MassachusettsAmherstUSA Motor Control Laboratory University of MassachusettsAmherstUSA

Purpose The purpose of this study was to compare kinetics,kinematics and muscle activation strategies between male and female collegiate level athletes during unanticipated sidestepping tasks to further the understanding of sex-specific differ-ences in injury incidence and their potential influence on ACL injury *** Three-dimensional kinematics,ground reaction forces and surface electromyography of eight lower limb muscles were recorded during unanticipated sidestepping in 20 male soccer and 17 female field hockey National Collegiate Athlet-ics Association Division 1 ***,hip and knee kinematics,knee joint moments,total muscle activation(TMA:knee,gluteal,quadriceps,hamstrings and gastrocnemii)and directed co-contraction ratios(DCCR)were compared between groups with two-sample t *** No sex differences were observed for peak frontal and transverse plane knee moments(P>0.05),however males had 10%greater knee flexion moments(P=0.047).Females had lower hip flexion and abduction and greater hip internal rota-tion angles than males likely concomitant with the 30%reduction in gluteal TMA(P<0.05).Females had lower quadriceps TMA during pre-contact and weight acceptance and higher hamstrings TMA during weight acceptance(P<0.05).Group averages for DCCR were not representative of individual patterns,where the majority of males were quadriceps dominant compared with *** Female and male team sport athletes display similar frontal and transverse plane knee moments,however their ability to support/counter the load applied(i.e.,muscle activations strategies)to the knee joint differed.

关键词： Anterior cruciate ligament Injury Valgus Co-contraction

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Evaluation of quality of clinical management of neuroendocrine tumors

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Cancer Innovation 2022年第4期1卷 305-315页

作者： hannah Bloemen Kristien Kneepkens Karen Deraedt Anna Ivanova Gregory Sergeant Jeroen Mebis Kurt van der Speeten Department of Medicine Faculty of Medicine and Life Sciences(LCRC)Hasselt UniversityDiepenbeekBelgium Department of Pathology and Department Future Health Ziekenhuis Oost-LimburgGenkBelgium Department of Abdominal Surgery and Department Jessa&Science Jessa HospitalHasseltBelgium Department of Medical Oncology and Department Jessa&Science Jessa HospitalHasseltBelgium Department of Surgical Oncology and Department Future Health Ziekenhuis Oost-LimburgGenkBelgium

Background:Neuroendocrine tumors(NETs)are a group of biologically and clinically heterogeneous neoplasms predominantly found in the gastrointestinal and bronchopulmonary *** a rising incidence,implementation of evidence-based standardized care for this heterogenous group remains *** European Neuroendocrine Tumor Society regularly reviews guidelines regarding diagnostic and treatment strategies for *** aim of this study is to shed light on the care of patients with a NET in Belgian Limburg,to provide data as a basis for future studies and to check whether data and results are according to consensus guidelines and outcomes described in ***:Our study concerned a detailed observational data collection of two large Belgian hospitals(Jessa Hospital Hasselt and Hospital Oost-Limburg Genk)with special interest in patient profile,quality of pathology reports,use of diagnostic imaging,and overall *** on 188 patients were assembled between January 2010 and December 2014 with follow-up until June 2016(median follow-up:33.6 months).Results:Fifty percent of patients were *** were located mainly in the digestive tract(63.8%)and lung(20.2%).Appendiceal NETs were diagnosed at a significantly younger age than other tumors(41.3 vs.64.0 years).Overall,a mean pathology report quality score of 3.0/5 was observed with the highest scores for small bowel *** and nuclear imaging was performed in 74.5%and 29.8%of cases,***-four percent of the population survived until the end of the observation period with highest survival rates for appendiceal and small bowel ***:Overall,epidemiological results were comparable with findings in the *** NETs met most of the requirements of qualitative pathology reporting and diagnostic imaging as listed in the European Neuroendocrine Tumor Society consensus ***,consensus with regard to bronchopulmonary NETs is still scarce

关键词： neuroendocrine tumors epidemiology quality pathology report Ki67 overall survival guidelines

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Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases

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World Journal of Gastroenterology 2016年第47期22卷 10275-10286页

作者： hannah Ceuleers Hanne van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter Laboratory of Experimental Medicine and Pediatrics Division of Gastroenterology University of Antwerp Laboratory of Medical Biochemistry University of Antwerp Laboratory of Medicinal Chemistry and Antwerp Drug Discovery Network University of Antwerp

Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein.

关键词： Proteases Proteinase-activated receptors Protease inhibitors Visceral hypersensitivity Visceral pain Irritable bowel syndrome Inflammatory bowel diseases

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Regulation of intestinal permeability: The role of proteases

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World Journal of Gastroenterology 2017年第12期23卷 2106-2123页

作者： Hanne van Spaendonk hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter Laboratory of Experimental Medicine and Pediatrics Division of GastroenterologyUniversity of Antwerp Laboratory of Medicinal Chemistry and Antwerp Drug Discovery Network University of Antwerp Laboratory of Medical Biochemistry University of Antwerp

The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases.

关键词： Intestinal permeability Intestinal barrier Tight junction Paracellular permeability Proteases Proteinase-activated receptor Protease inhibitor Antiproteases

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HOXB13 mutations and binding partners in prostate development and cancer:Function,clinical significance, and future directions

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Genes & Diseases 2017年第2期4卷 75-87页

作者： hannah Brechka Raj R.Bhanvadia Calvin vanOpstall Donald J.vander Griend The Committee on Cancer Biology The University of ChicagoChicagoILUSA The Pritzker School of Medicine The University of ChicagoChicagoILUSA Department of Surgery Section of UrologyThe University of ChicagoChicagoILUSA

The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer has brought HOX signaling to the forefront of prostate cancer *** enhanced understanding of HOX signaling,and the co-factors regulating HOX protein specificity and transcriptional regulation,has the high potential to elucidate novel approaches to prevent,diagnose,stage,and treat prostate *** our understanding of HOX biology in prostate development and prostate cancer,basic research in developmental model systems as well as other tumor sites provides a mechanistic framework to inform future studies in prostate *** we describe our current understanding of HOX signaling in genitourinary development and cancer,current clinical data of HOXB13 mutations in multiple cancers including prostate cancer,and the role of HOX protein co-factors in development and *** data highlight numerous gaps in our understanding of HOX function in the prostate,and present numerous potentially impactful mechanistic and clinical opportunities for future investigation.

关键词： Androgen receptor HOXB13 HOXB13(G84E) MEIS1 MEIS2 PBX Prostate TALE

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Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity

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Cancer Drug Resistance 2023年第4期6卷 709-728页

作者： hannah Zaryouh Ines De Pauw Hasan Baysal Joran Melis Valentin van den Bossche Christophe Hermans Ho Wa Lau Hide Lambrechts Celine Merlin Cyril Corbet Marc Peeters Jan Baptist Vermorken Jorrit De Waele Filip Lardon An Wouters Center for Oncological Research(CORE) Integrated Personalized&Precision Oncology Network(IPPON)University of AntwerpCampus Drie EikenAntwerp 2610Belgium Pole of Pharmacology and Therapeutics(FATH) Institut de Recherche Experimentale et Clinique(IREC)UCLouvainBrussels B-1200Belgium institut Roi Albert Il Department of Medical OncologyCliniques Universitaires Saint-LucBrussels B-1200Belgium Department of Medical Oncology Antwerp University HospitalEdegem 2650Belgium

Aim:Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma(HNSCC).To accurately study novel combination treatments,suitable preclinical mouse models for cetuximab resistance are key yet currently *** study aimed to optimize an acquired cetuximab-resistant mouse model,with preservation of the innate immunity,ensuring intact antibody-dependent cellular cytotoxicity(ADCC)***:Cetuximab-sensitive and acquired-resistant HNSCC cell lines,generated in vitro,were subcutaneously engrafted in Rag2 knock-out(KO),BALB/c Nude and CB17 Scid mice with/without Matrigel or *** tumor growth was established,mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 *** addition,immunohistochemistry was used to evaluate the tumor and its ***:Despite several adjustments in cell number,cell lines and the addition of Matrigel,Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell *** tumor growth of resistant SC263-R cells could be induced in CB17 Scid ***,these cells had lost their resistance phenotype in *** revealed a high infiltration of macrophages in cetuximab-treated SC263-R ***-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to ***:We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines,*** models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.

关键词： HNSCC cetuximab resistance xenograft mouse model immunodeficient mice

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