HOXB13 mutations and binding partners in prostate development and cancer:Function,clinical significance, and future directions
作者机构：The Committee on Cancer BiologyThe University of ChicagoChicagoILUSA The Pritzker School of MedicineThe University of ChicagoChicagoILUSA Department of SurgerySection of UrologyThe University of ChicagoChicagoILUSA
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2017年第4卷第2期
页 面：75-87页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：DOD PCRP PC130587(Vander Griend) NWU/UC/NSUHS Prostate SPORE(P50 CA180995)the University of Chicago Comprehensive Cancer Center(UCCCC) especially the Cancer Center Support Grant(P30CA014599) H.Brechka and C.Van Opstall were supported by the Cancer Biology Training Grant(T32 CA009594) R.Bhanvadia is supported by a University of Chicago Pritzker School of Medicine Fellowship
主 题：Androgen receptor HOXB13 HOXB13(G84E) MEIS1 MEIS2 PBX Prostate TALE
摘 要：The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer has brought HOX signaling to the forefront of prostate cancer *** enhanced understanding of HOX signaling,and the co-factors regulating HOX protein specificity and transcriptional regulation,has the high potential to elucidate novel approaches to prevent,diagnose,stage,and treat prostate *** our understanding of HOX biology in prostate development and prostate cancer,basic research in developmental model systems as well as other tumor sites provides a mechanistic framework to inform future studies in prostate *** we describe our current understanding of HOX signaling in genitourinary development and cancer,current clinical data of HOXB13 mutations in multiple cancers including prostate cancer,and the role of HOX protein co-factors in development and *** data highlight numerous gaps in our understanding of HOX function in the prostate,and present numerous potentially impactful mechanistic and clinical opportunities for future investigation.
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