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Diet,lipids,and antitumor.immunity

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Cellular.& Molecular.Immunology 2022年第3期19卷 432-444页

作者： hannah Pr.ndeville Lydia Lynch Tr.nity Biomedical Sciences Institute Trinity College DublinDublinIreland Br.gham and Women’s Hospital Harvard Medical SchoolBostonMAUSA

Tumour.gr.wth and dissemination is lar.ely dependent on nutr.ent *** has r.cently emer.ed that the tumour.micr.envir.nment is r.ch in a diver.e ar.ay of lipids that incr.ase in abundance with tumour.pr.gr.ssion and play a r.le in pr.moting tumour.gr.wth and ***,we descr.be the pr.-tumor.genic r.les of lipid uptake,metabolism and synthesis and detail the ther.peutic potential of tar.eting lipid metabolism in ***,we highlight new insights into the distinct immunosuppr.ssive effects of lipids in the tumour.*** thr.aten an anti-tumour.envir.nment wher.by metabolic adaptation to lipid metabolism is linked to immune ***,we descr.be the differ.ntial effects of commondietar. lipids on cancer.gr.wth which may uncover.a r.le for.specific dietar. r.gimens in association with tr.ditional cancer.*** the r.lationship between dietar. lipids,tumour.and immune cells is impor.ant in the context of obesity which may r.veal a possibility to har.ess the diet in the tr.atment of cancer..

关键词： Lipids cancer obesity β-oxidation anti-tumour.immunity

Cr.sslinking of vir.l nanopar.icles with “clickable” fluor.scent cr.sslinker. at the inter.ace

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Science China Chemistr. 2010年第6期53卷 1287-1293,1459页

作者： KAUr.Gagandeep BAr.HILL hannah Depar.ment of Chemistr. and Biochemistr. and Nanocenter University of South Carolina

Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) r.action,a typical "click" r.action,is one of the modular.synthetic appr.aches which has been br.adly used in var.ous or.anic syntheses,medicinal chemistr.,mater.als development and bioconjugation *** have for.the fir.t time synthesized two dialkyne der.vatized fluor.scent cr.sslinker. which could be applied to cr.sslink two biomolecules using CuAAC *** yellow mosaic vir.s,a plant vir.s with unique str.ctur.l and chemical pr.per.ies,was used as a pr.totypical scaffold to for. a 2D single layer.at the inter.ace of two immiscible liquids and cr.sslinked with these two linker. by the CuAAC *** cr.sslinking,the fluor.scence of both linker. diminished,likely due to the distor.ion of the polymethylene backbone,which ther.for. could be used to indicate the completion of the r.action.

关键词： picker.ng emulsion cr.sslinking nanopar.icles CuAAC r.action click chemistr. inter.acial assembly

Under.tanding the timing of br.in injur. in fetal gr.wth r.str.ction:lessons fr.m a model of spontaneous gr.wth r.str.ction in piglets

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Neur.l r.gener.tion r.sear.h 2023年第2期18卷 322-323页

作者： hannah Musco Julie A.Wixey UQ Centr. for.Clinical r.sear.h Faculty of MedicineUniversity of QueenslandQueenslandAustralia

Fetal gr.wth r.str.ction(FGr.is one of the most common contr.butor. to incr.ased r.sk of mor.ality in the fetal/neonatal per.od and long-ter. mor.idity in the infant(Malhotr. et al.,2019).FGr.can ar.se fr.m many pathophysiological pr.cesses associated with mater.al,fetal,genetic,or.placental compr.mise;however.placental insufficiency is the most common cause of *** insufficiency dur.ng pr.gnancy r.sults in chr.nic fetal hypoxia wher. a lack of oxygen and nutr.ents supply to the developing fetus impacts nor.al development of the fetus.

关键词： fetal fetus insufficiency

The CUL4A ubiquitin ligase is a potential ther.peutic tar.et in skin cancer.and other.malignancies

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Chinese Jour.al of Cancer 2013年第9期32卷 478-482页

作者： Jeffr.y hannah Peng-Bo Zhou Depar.ment of Pathology and Labor.tor. Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences Depar.ment of Pathology and Labor.tor. Medicine Weill Cornell Medical College

Cullin 4A(CUL4A)is an E3 ubiquitin ligase that dir.ctly affects DNA r.pair.and cell cycle pr.gr.ssion by tar.eting substr.tes including damage-specific DNA-binding pr.tein 2(DDB2),xer.der.a pigmentosum complementation gr.up C(XPC),chr.matin licensing and DNA r.plication factor.1(Cdt1),and *** wor. fr.m our.labor.tor. has shown that Cul4a-deficient mice have gr.atly r.duced r.tes of ultr.violet-induced skin *** a cellular.level,Cul4a-deficient cells have gr.at capacity for.DNA r.pair.and demonstr.te a slow r.te of pr.lifer.tion due pr.mar.ly to incr.ased expr.ssion of DDB2 and p21,*** suggests that CUL4A pr.motes tumor.genesis(as well as accumulation of skin damage and subsequent pr.matur. aging)by limiting DNA r.pair.activity and expediting S phase *** addition,CUL4A has been found to be up-r.gulated via gene amplification or.over.xpr.ssion in br.ast cancer.,hepatocellular.car.inomas,squamous cell car.inomas,adr.nocor.ical car.inomas,childhood medulloblastomas,and malignant pleur.l *** of its oncogenic activity in skin cancer.and up-r.gulation in other.malignancies,CUL4A has ar.sen as a potential candidate for.tar.eted ther.peutic *** this r.view,we outline the established functions of CUL4A and discuss the E3ligase’s emer.ence as a potential dr.ver.of tumor.genesis.

关键词：泛素连接酶恶性肿瘤皮肤癌治疗 DNA修复 DNA结合蛋白靶点细胞水平

HOXB13 mutations and binding par.ner. in pr.state development and cancer.Function,clinical significance, and futur. dir.ctions

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Genes & Diseases 2017年第2期4卷 75-87页

作者： hannah Br.chka r.j r.Bhanvadia Calvin VanOpstall Donald J.Vander.Gr.end The Committee on Cancer.Biology The University of ChicagoChicagoILUSA The Pr.tzker.School of Medicine The University of ChicagoChicagoILUSA Depar.ment of Sur.er. Section of UrologyThe University of ChicagoChicagoILUSA

The r.cent and exciting discover. of ger.line HOXB13 mutations in familial pr.state cancer.has br.ught HOX signaling to the for.fr.nt of pr.state cancer.*** enhanced under.tanding of HOX signaling,and the co-factor. r.gulating HOX pr.tein specificity and tr.nscr.ptional r.gulation,has the high potential to elucidate novel appr.aches to pr.vent,diagnose,stage,and tr.at pr.state *** our.under.tanding of HOX biology in pr.state development and pr.state cancer.basic r.sear.h in developmental model systems as well as other.tumor.sites pr.vides a mechanistic fr.mewor. to infor. futur. studies in pr.state *** we descr.be our.cur.ent under.tanding of HOX signaling in genitour.nar. development and cancer.cur.ent clinical data of HOXB13 mutations in multiple cancer. including pr.state cancer.and the r.le of HOX pr.tein co-factor. in development and *** data highlight numer.us gaps in our.under.tanding of HOX function in the pr.state,and pr.sent numer.us potentially impactful mechanistic and clinical oppor.unities for.futur. investigation.

关键词： Andr.gen r.ceptor HOXB13 HOXB13(G84E) MEIS1 MEIS2 PBX Pr.state TALE

Bile acid signaling and biliar. functions

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Acta Phar.aceutica Sinica B 2015年第2期5卷 123-128页

作者： hannah Jones Gianfr.nco Alpini Heather.Fr.ncis Baylor.Scott & White Digestive Disease r.sear.h Center Division r.sear.h Central Texas Veterans Health Care System Depar.ment of Medicine Texas A&M University

This r.view focuses on var.ous components of bile acid signaling in r.lation to cholangiocytes. Their.r.les as tar.ets for.potential ther.pies for.cholangiopathies ar. also explor.d. While many factor. ar. involved in these complex signaling pathways, this r.view emphasizes the r.les of tr.nsmembr.ne G pr.tein coupled r.ceptor.TGr.), far.esoid X r.ceptor.FXr., ur.odeoxycholic acid(UDCA) and the bicar.onate umbr.lla. Following a gener.l backgr.und on cholangiocytes and bile acids,we will expand the r.view and include sections that ar. most r.cently known(within 5–7 year.) r.gar.ing the field of bile acid signaling and cholangiocyte function. These findings all demonstr.te that bile acids influence biliar. functions which can, in tur., r.gulate the cholangiocyte r.sponse dur.ng pathological events.

关键词： Bile acids Cholangiocytes r.ceptor. Signaling

Speed and sur.ace steepness affect inter.al tibial loading dur.ng r.nning

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Jour.al of Spor. and Health Science 2024年第1期13卷 118-124页

作者： hannah r.ce Mar.us Kur. Patr.ck Mai Leon r.ber.z Kevin Bill Timothy r.Der.ick Steffen Willwacher Depar.ment of Physical Per.or.ance Norwegian School of Sport SciencesOslo 0806Norway Spor.s Tech r.sear.h Centr. Mid Sweden UniversityÖstersund SE-83125Sweden Depar.ment of Mechanical and Pr.cess Engineer.ng Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Or.hopaedics German Sport University CologneCologne 50933Germany Depar.ment of Kinesiology Iowa State UniversityAmesIA 50011USA

Backgr.und:Inter.al tibial loading is influenced by modifiable factor. with implications for.the r.sk of str.ss *** encounter.var.ed sur.ace steepness(gr.dients)when r.nning outdoor. and may adapt their.speed accor.ing to the *** study aimed to quantify tibial bending moments and str.ss at the anter.or.and poster.or.per.pher.es when r.nning at differ.nt speeds on sur.aces of differ.nt ***:Twenty r.cr.ational r.nner. r.n on a tr.admill at 3 differ.nt speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gr.dients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).For.e and mar.er.data wer. collected synchr.nously *** moments wer. estimated at the distal thir. centr.id of the tibia about the medial-later.l axis by ensur.ng static equilibr.um at each 1%of *** was der.ved fr.m bending moments at the anter.or.and poster.or.per.pher.es by modeling the tibia as a hollow ***-way r.peated-measur.s analysis of var.ance wer. conducted using both functional and discr.te statistical ***:Ther. wer. significant main effects for.r.nning speed and gr.dient on peak bending moments and peak anter.or.and poster.or.*** r.nning speeds r.sulted in gr.ater.tibial *** uphill at+10%and+15%r.sulted in gr.ater.tibial loading than level *** downhill at-10%and-15%r.sulted in r.duced tibial loading compar.d to level *** was no differ.nce between+5%or.5%and level ***:r.nning at faster.speeds and uphill on gr.dients≥+10%incr.ased inter.al tibial loading,wher.as slower.r.nning and downhill r.nning on gr.dients≥-10%r.duced inter.al *** r.nning speed accor.ing to the gr.dient could be a pr.tective mechanism,pr.viding r.nner. with a str.tegy to minimize the r.sk of tibial str.ss injur.es.

关键词： Bending moments Gr.dient Musculoskeletal modeling Over.se injur. Tibial str.ss Tr.ining factor.

Der.gulation of splicing factor. and br.ast cancer.development

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Jour.al of Molecular.Cell Biology 2015年第5期7卷 388-401页

作者： Mar.o Silipo hannah Gautr.y Alison Tyson-Capper Institute of Cellular.Medicine Faculty of Medical SciencesNewcastle UniversityNewcastle upon Tyne NE24HHUK

It is well known that many genes implicated in the development and pr.gr.ssion of br.ast cancer.under.o aber.ant alter.ative splicing events to pr.duce *** changes in alter.ative splicingcan ar.se fr.mmutations or.single-nucleotide polymor.hisms(SNPs)within the DNA sequences of cancer.r.lated genes,which can str.ngly affect the activity of splicing factor. and influence the splice site ***,it is impor.ant to note that absence of mutations is not sufficient to pr.vent misleading choices in splice site *** is nowincr.asing evidence to demonstr.te that the expr.ssion pr.file of ten splicing factor.(including Sr. and hnr.Ps)and eight r.A-binding pr.teins changes in br.ast cancer.cells compar.d with nor.al *** modifications str.ngly influence the alter.ative splicing patter. of many cancer.r.lated genes despite the absence of any detr.mental mutations within their.DNA ***,a compr.hensive assessment of the splicing factor.status in br.ast cancer.is impor.ant to pr.vide insights into the mechanisms that lead to br.ast cancer.development and *** most studies focus on mutations that affect alter.ative splicing in cancer.r.lated genes,this r.view focuses on splicing factor. and r.A-binding pr.teins that ar. themselves der.gulated in br.ast cancer.and implicated in cancer.r.lated alter.ative splicing events.

关键词： alter.ative splicing splicing factor. r.A-binding pr.teins br.ast cancer

SPACE AND TOPOGr.PHY IN ANCIENT EGYPT

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Jour.al of Ancient Civilizations 2023年第1期38卷 69-124,127页

作者： hannah Pethen Honor.r. Fellow University of Liverpool

Intr.duction"Space"and "topogr.phy"have ver. specific meanings in the moder. wor.d. "Space"is an exter.al void,an empty physical ar.a to be acted upon. "Topogr.phy"is the "configur.tion of the sur.ace r.lief"of the ear.h,a human body,or.another.*** wor.s ar. technical ter.s implying the existence of exter.alities or.abstr.ctions;'spaces and topogr.phy that can be measur.d,r.cor.ed,obser.ed,and acted *** this they ar. associated with the Enlightenment concept of "landscape"as exter.al,viewable,and empir.cally under.tandable thr.ugh objective scientific obser.ation and r.cor.ing,often for.imper.alist pur.oses.

关键词： SPACE r.cor.ing ear.h