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Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Hepatoma Research 2015年第1期1卷 147-154页

作者： hanaa A.Hassan hanaa m.serag Nabil m.Abdel-Hamid mahmoud m.Amr Department of Zoology Division of PhysiologyFaculty of ScienceMansoura UniversityMansoura 35516Egypt Biochemistry Department Pharmacy CollegeKafr El-Sheikh UniversityKafr El-Sheikh 33516Egypt

Aim:Hepatocellular carcinoma(HCC)is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver *** objective of this study was to elucidate the synergistic effect and the role of chicory extract[inulin(IN)]as a chemo-sensitizer for cisplatin(CIS)treatment of ***:Five groups of rats were treated for 4 *** groups consisted of the control group,a group receiving thioacetamide(TAA)(200 mg/kg b.w)in drinking water,a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)in addition to TAA for 4 months,a group receiving oral doses of IN(10 mg/kg b.w)in addition to TAA for 4 months,and a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)and IN(10 mg/kg b.w)plus TAA for 4 ***:The current data exhibited increment of serum and liver enzyme(alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,creatine kinase,and lactate dehydrogenase)activity,serum lipid profi le levels(total lipids,total cholesterol,triglycerides,low-density lipoprotein,and very low-density lipoprotein),and a signifi cant increase inα-fetoprotein and bilirubin,accompanied with reduced total serum protein and albumin levels in a HCC rat ***,numerous alterations were detected in hepatic tissues of HCC rats,such as lymphocytic cell infi ltration,damage of hepatocytes,dilated congested central vein with degenerated endothelial cells,and congested blood sinusoids in addition to masson’s trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi *** of HCC rats with CIS or IN improved such deleterious effects,where IN is more effective than CIS,and the best effect can be observed in rats that received both CIS and ***:It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model.

关键词： Chicory cisplatin hepatocellular carcinoma inulin

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magnetic,dielectric and electrical modulus of Ce^(3+) doped cobalt-magnesium ferrite nanoparticles

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Journal of Rare Earths 2024年第2期42卷 373-382,I0005页

作者： N.m.Basfer hanaa Almaghamsi Department of Physics Umm AL-Qura UniversityMakkahSaudi Arabia Physics Department College of Science and ArtKing Abdulaziz UniversityPOB344Rabigh291Saudi Arabi

In this work,the magnetic,dielectric properties and electric modulus of Ce^(3+) substituted cobaltmagnesium(Co_(0.7)mg_(0.3)Ce_(x)Fe_(2-x)O_4)(labeled as CmCF) ferrite nanoparticles were investigated in *** magnetization decreases from 50.05 to 34.87 emu/g for further substituting Ce^(3+) ***,coercivity increases from 738.22 Gs for the CmCFO sample to 912.10 Gs for the CmCF2 sample,then decreases monotonically to 762.1 Gs for the CmCF5 *** cerium content and particle size play important roles in controlling the magnetization and coercivity of the CmCF *** CmCF nanoferrites are suitable for microwave applications since their high-frequency response ranges from 7.72 to 11.07 *** CmCF nanoferrites' dielectric parameter dispersion exhibits normal *** pristine Co-mg nanoferrite only has ε' value of 28.25,but the nanoferrite mCmF2 has ε' value of365.03,with an enhancing ratio of 1192%.The conduction mechanism of the mCmF nanoferrites was determined by fitting the σ_(ac) results via the Jonscher power *** 653 K,large polaron tunnelling is thought to be responsible for this conduction process,which is followed by electron barrier hopping at higher ***-Cole diagrams at different temperatures,assuring the contributions of the grains and their boundaries at lower temperatures(653 K) and only the grains at higher *** on our results,the CmCF nanoferrites hold magnetic and semiconducting nature,which can be used in magnetic devices and dielectrics in lower-frequencies or conductors in higher-frequencies.

关键词： Nanoferrites Rare earth ions magnetic properties Dielectric parameters Impedance spectroscopy

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An Efficient Encryption and Compression of Sensed IoT medical Images Using Auto-Encoder

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Computer modeling in Engineering & Sciences 2023年第2期134卷 909-926页

作者： Passent El-kafrawy maie Aboghazalah Abdelmoty m.Ahmed hanaa Torkey Ayman El-Sayed School of Information Technology and Computer Science Nile UniversityGiza12677Egypt math and Computer Science Department Faculty of ScienceMenoufia UniversityMenoufia32511Egypt Department of Computer Engineering College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia Computer Science and Engineering Department Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

Healthcare systems nowadays depend on IoT sensors for sending data over the internet as a common *** ofmedical images is very important to secure patient *** these images consumes a lot of time onedge computing;therefore,theuse of anauto-encoder for compressionbefore encodingwill solve such a *** this paper,we use an auto-encoder to compress amedical image before encryption,and an encryption output(vector)is sent out over the *** the other hand,a decoder was used to reproduce the original image back after the vector was received and *** convolutional neural networks were conducted to evaluate our proposed approach:The first one is the auto-encoder,which is utilized to compress and encrypt the images,and the other assesses the classification accuracy of the image after decryption and *** hyperparameters of the encoder were tested,followed by the classification of the image to verify that no critical information was lost,to test the encryption and encoding *** this approach,sixteen hyperparameter permutations are utilized,but this research discusses three main cases in *** first case shows that the combination of mean Square Logarithmic Error(mSLE),ADAgrad,two layers for the auto-encoder,and ReLU had the best auto-encoder results with a mean Absolute Error(mAE)=0.221 after 50 epochs and 75%classification with the best result for the classification *** second case shows the reflection of auto-encoder results on the classification results which is a combination ofmean Square Error(mSE),RmSprop,three layers for the auto-encoder,and ReLU,which had the best classification accuracy of 65%,the auto-encoder gives mAE=0.31 after 50 *** third case is the worst,which is the combination of the hinge,RmSprop,three layers for the auto-encoder,and ReLU,providing accuracy of 20%and mAE=0.485.

关键词： Auto-encoder cloud image encryption IoT healthcare

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Wave Propagation model in a Human Long Poroelastic Bone under Effect of magnetic Field and Rotation

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Computers, materials & Continua 2021年第8期68卷 1485-1504页

作者： A.m.Abd-Alla hanaa Abu-Zinadah S.m.Abo-Dahab J.Bouslimi m.Omri Department of mathematics Sohag UniversitySohagEgypt Department of Statistics University of JeddahCollege of ScienceJeddahSaudi Arabia Department of mathematics South Valley UniversityQena83523Egypt Department of Engineering Physics and Instrumentation National Institute of Applied Sciences and TechnologyCarthage UniversityTunisia Department of Physics Taif UniversityTaifSaudi Arabia Deanship of Scientific Research King Abdulaziz UniversityJeddahSaudi Arabia

This article is aimed at describing the way rotation and magnetic field affect the propagation of waves in an infinite poroelastic cylindrical *** offers a solution with an exact closed *** authors got and examined numerically the general frequency equation for poroelastic ***,they calculated the frequencies of poroelastic bone for different values of the magnetic field and *** the results of previous studies,the authors noticed little frequency dispersion in the wet *** proposed model will be applicable to wide-range parametric projects of bone mechanical *** the vibration of surface waves in rotating cylindrical,long human bones under the magnetic field can have an *** findings of the study are offered in ***,a comparison with the results of the literature is conducted to show the effect of rotation and magnetic field on the wave propagation *** is worth noting that the results of the study highly match those of the literature.

关键词： Propagation of waves rotation magnetic field poroelastic wet bone natural frequency magnetic field

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Experimental evaluation of Odonata nymph in the biocontrol of schistosomiasis intermediate hosts

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 995-1000页

作者： Aly Younes hanaa El-Sherief Fathia Gawish marwa mahmoud Department of Entomology Faculty of ScienceCairo University Department of medical malacology Theodor Bilharz Research Institute

Objective:To evaluate the predatory potential of the Odonata nymph on freshwater snails that serve as intermediate hosts for Schistosoma species(Bulinus truncatus and Biomphalaria alexandrina).methods:Observations on the searching,attacking and devouring of the two snail types with series of laboratory-based predation experiments,whose aims were to determine daily predation rate,differential predation,prey preference considering small-,mediumand large-sized snails were ***:Laboratory evaluation revealed that,the Odonata nymph could kill and consume the two intermediate *** number of snails consumed differed according to the snail type,size and *** times taken for searching and handling times were dependent on the snail size,type and satiation of the *** predation rate varied also with respect to snail type,size and *** study also evaluated that Odonata nymphs consumed more Bulinus truncatus than Biomphalaria alexandrina per unit time,and that there may be a preference for smaller than larger ***:According to our observation,the predator,Hemianax ephippiger nymph may be a suitable biocontrol agent in connection with Schistosoma intermediate hosts.

关键词： Schistosoma Intermediate hosts Snails Biological control

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Kinetic spectrophotometric method for determination of amlodipine besylate in its pharmaceutical tablets

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Journal of Pharmaceutical Analysis 2012年第5期2卷 334-341页

作者： Ashraf m.mahmoud hanaa m.Abdel-Wadood Niveen A.mohamed Department of Pharmaceutical Analytical Chemistry Faculty of PharmacyAssiut UniversityAssiut 71526Egypt

A simple and sensitive kinetic spectrophotometric method has been developed and validated for determination of amlodipine besylate （AmL）. The method was based on the condensation reaction of AmL with 7-chloro-4-nitro-2,1,3-benzoxadiazole in an alkaline buffer （pH 8.6） producing a highly colored product. The color development was monitored spectrophometrically at the maximum absorption λmax 470 nm. The factors affecting the reaction were studied and the conditions were optimized. The stoichiometry of the reaction was determined, and the reaction pathway was postulated. moreover, both the activation energy and the specific rate constant （at 70 ℃） of the reaction were found to be 6.74 kcal mole-1 and 3.58 s -1, respectively. The initial rate and fixed time methods were utilized for constructing the calibration graphs lbr the determination of AmL concentration. Under the optimum reaction conditions, the limits of detection and quantification were 0.35 and 1.05 ug/mL, respectively. The precision of the method was satisfactory; the relative standard deviations were 0.85-1.76%. The proposed method was successfully applied to the analysis of AmL in its pure form and tablets with good accuracy; the recovery percentages ranged from 99.55 ± 1.69% to 100.65 ±1.48%. The results were compared with that of the reported method.

关键词： Amlodepine besylate 7-chloro-4-nitro-2,1,3-benzoxadiazole Kinetic analysis Spectrophotometry

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PVC nanocomposites for cable insulation with enhanced dielectric properties,partial discharge resistance and mechanical performance

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High Voltage 2020年第4期5卷 463-471页

作者： Nagat m.K.Abdel-Gawad Adel Z.El Dein Diaa-Eldin A.mansour hanaa m.Ahmed mohamed m.F.Darwish matti Lehtonen Department of Electrical Power and machines Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of High Voltage Networks Faculty of Energy EngineeringAswan UniversityAswanEgypt High Voltage and Superconductivity Laboratory Department of Electrical Power and Machines EngineeringFaculty of EngineeringTanta UniversityTantaEgypt Department of mathematics and Engineering Physics Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland

The current study aims to develop polyvinyl chloride(PVC)nanocomposites with enhanced electrical and mechanical properties by incorporating titanium oxide(TiO_(2))nanoparticles within PVC *** loading of nanoparticles and different nanoparticle surface states were *** surface states are unfunctionalised,functionalised using vinyl silane and functionalised using amino *** choice of a most suitable surface state was a critical factor that guarantees a good dispersion of nanoparticles and consequently enhances the compatibility between TiO_(2)and PVC *** process followed in the PVC/TiO_(2)nanocomposites preparation,loaded with different wt.%of TiO_(2)nanoparticles,was the solvent *** dielectric properties measured here were the relative permittivity(ɛr),dielectric loss(tanδ),breakdown strength(AC and DC under uniform field)and the internal partial discharges(PDs)within insulation *** measurements have been performed under room temperature and at frequency ranged from 20 to 1.0 ***,the mechanical properties of the samples like elongation,elasticity modulus and tensile strength were also *** silane showed better improvements in both electrical and mechanical performances compared to the amino silane,especially in cases of high weight fractions of TiO_(2).This is because of the improvement in the PVC-TiO_(2)interfacial region arise from the similarity of polarity and surface tension values of vinyl silane with that of PVC matrix and TiO_(2)nanoparticles.

关键词： dielectric insulation resistance

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Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： hanaa H Ahmed Ahmed m Salem Hazem m Atta Emad F Eskandar Abdel Razik H Farrag mohamed A Ghazy Neveen A Salem Hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University medical Biochemistry and molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIm: To explore the approaches exerted by mesenchymal stem cells (mSCs) to improve Parkinson’s disease (PD) ***: mSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived mSCs (Bm-mSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (mCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also ***: Bm-mSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P mCP-1 (89.6 ± 2.0 vs 112.1 ± 1.9, P m BDNF (3663 ± 17.8 vs 2905 ± 72.9, P mber of positive cells for survivin (293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

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Effect of oxygen plasma treatment on the nanofiltration performance of reduced graphene oxide/cellulose nanofiber composite membranes

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Green Chemical Engineering 2021年第1期2卷 122-131页

作者： Shabin mohammed hanaa mHegab Ranwen Ou Shasha Liu Hongyu ma Xiaofang Chen Tam Sridhar Huanting Wang Department of Chemical Engineering Monash UniversityVIC3800Australia College of the Environment&Ecology Xiamen UniversityXiamenFujian361005China

Graphene based nanosheets have been widely used as building blocks for fabrication of superior separation membrane for water *** particular,membranes made of reduced graphene oxide(rGO)show better stability compared with graphene oxide(GO).However,densely stacked of rGO often results in low water *** this study,cellulose nanofibers(CNFs)were incorporated into the rGO laminates by vacuum filtration of dilute GO/CNF solution and thermal reduction at 150C for 1.5 *** resulting rGO/CNF membrane was treated with oxygen plasma for 1–4 min to create nanopores on the membrane surface for the purpose of enhancing nano-filtration *** results showed that the optimum membrane performance was obtained by using the equal amount of GO(31.83 mg m^(-2))and CNFs accompanied by 3 min of plasma treatment,exhibiting a pure water permeance of 37.23.9 L m^(-2)h^(-1)bar^(-1)maintaining a rejection above 90%for Acid Fuchsin(1.2×1.1 nm),Rose Bengal(1.5×1.2 nm)and Brilliant Blue(2.2×1.7 nm).

关键词： Graphene oxide membrane Nanofiltration Cellulose nanofibers Oxygen plasma treatment

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Study of Luminous Emission from a Coaxial Plasma Discharge Device in the Presence of External Transverse magnetic Field

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Energy and Power Engineering 2011年第4期3卷 444-449页

作者： Tarek m. Allam hanaa A. El-Sayed hanaa m. Soliman 不详

The experimental investigations in this paper are focused on the study of luminous radiation emission from coaxial plasma discharge device and the effect of applied transverse magnetic field Btr on it. The experiment was done in (1.5 KJ - 10 KV) coaxial plasma discharge device. The discharge is operated in Nitrogen gas at pressures from 1 to 2.2 torr. Helmholtz magnetic coils are placed outside the coaxial electrodes with its axis at a distance = 3 cm from the coaxial electrodes muzzle, then Btr with a maximum induction ≈ 0.85 T is applied perpendicularly to the expanded plasma from the coaxial electrodes muzzle. The diagnostics used in the measurements include a Rogowsky coil and a photomultiplier tube equipped with light collimator. The experimental results showed that the maximum intensity of luminous radiation is detected at axial distance (side view) z = 8 cm and gas pressure, P = 2.2 torr. It also showed that the maximum value of axial luminous plasma zone velocity = 2.383 × 106 cm/s at z = 11 cm and P = 1.4 torr. In mode of presence of external Btr, the investigations have shown that, at P = 1.4 torr the maximum intensity of luminous radiation (detected at end-view position) is reduced by 17%, the full width at half maximum, FWHm of luminous radiation signal is increased by 40 times, while the luminous radiation signal is delayed by ta = 438 μs. In two modes of operation ta and FWHm have approximately a minimum values at P = 1.4 torr.

关键词： Coaxial Discharge Luminous Radiation Transverse magnetic Field Energy Losses

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