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Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9470-9477页

作者： han-jin yang Zhao-Ming Wang Department of Pathology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Burkitt-like lymphoma with 11q aberration(BLL-11q)is a rare provisional lymphoma,and the majority of cases are usually diagnosed by excisional lymph node *** we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the disease,reduce misdiagnosis,and identify treatment *** SUMMARY The patient was a 67-year-old *** complained of increased frequency of stools for more than one year,periumbilical pain and discomfort exceeding 3 mo.A computed tomography scan suggested an appendiceal malignant tumor with multiple metastases of the peritoneum,omentum,and *** biopsy of liver nodules showed that the tumor cells were of median size,the shape was consistent,a small number of tumor cells were large,the“starry sky”pattern was evident,and some tissue cells showed multiple apoptotic debris with coarse *** was positive for CD20,CD10,BCL6,and *** Ki-67 proliferation index was more than 95%.Molecular biological detection indicated a lack of MYC,BCL2 and BCL6 gene rearrangement with 11q ***,the diagnosis was BLL-11q of the *** eight courses of chemotherapy,the abdominal and pelvic peritoneal masses and liver nodules had almost *** patient recovered well after a follow-up period of more than 13 *** BLL-11q is rare,but patients treated with standard chemotherapy for Burkitt lymphoma can have a good *** the dose of chemotherapy or developing specific therapies to prevent overtreatment may be considered,but more case studies are needed.

关键词： Burkitt-like lymphoma Pathology Molecular 11q aberration Apoptotic debris Case report

Isolated anti-HBc is an independent risk factor for tumor recurrence in intrahepatic cholangiocarcinoma after curative resection

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 472-478页

作者： Xiao-Bo Xu Chen Hu han-jin yang Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province Hangzhou 310012China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhou 310003China

Background:Intrahepatic cholangiocarcinoma(ICC)is a poorly understood and aggressive malignancy with increasing incidence and *** B virus(HBV)infection is recognized as one of the important risk factors of *** are few reports focusing on whether isolated antibody to hepatitis B core antigen(isolated anti-HBc,IAHBc)have prognostic role in ICC,while positive hepatitis B surface antigen(HBsAg)has been reported to be associated with the prognosis of *** aim of this study was to investigate the prognostic value of IAHBc in ICC patients after curative resection,in order to identify those who have the high risk of ICC recurrence in the early ***:We divided 209 ICC patients who underwent curative resection into 4 groups:groupⅠ(n=40),HBsAg(-)/antibody to hepatitis B surface antigen(anti-HBs)(-)/anti-HBc(+);groupⅡ(n=70),HBsAg(+)/anti-HBc(-);groupⅢ(n=55),HBsAg(-)/anti-HBs(+)/anti-HBc(+);and groupⅣ(n=44),HBsAg(-)/anti-HBc(-).We compared the recurrence-free survival(RFS)and overall survival(OS)among these four ***:The median follow-up time was 16.93 months(range 1-34.6 months).The 1-and 2-year RFS and OS rates were 60%and 42%,and 78%and 63%respectively in all *** to the whole non-IAHBc patients(groupⅡ+groupⅢ+groupⅣ),IAHBc patients(groupⅠ)showed significantly lower RFS at 1 year(39.8%vs.64.4%,P=0.001)and 2 years(20.7%vs.46.7%,P=0.001).When compared to other three individual groups,IAHBc patients(groupⅠ)also had the lowest *** did not find significant difference in OS among the four *** multivariate analysis revealed that IAHBc was an independent risk factor of ***:IAHBc is an independent poor prognostic factor for tumor recurrence in ICC patients after curative resection.

关键词： Cholangiocarcinoma Hepatitis B virus Isolated antibody to hepatitis B core antigen Occult hepatitis B infection

Bonding Strength of Ni/Ni3Al Interface with Different Lattice Misfit

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Journal of Materials Science & Technology 2003年第z1期19卷 26-28页

作者： Ping PENG Caixing ZHENG Shaochang han Zhaohui jin Rui yang Zhuangqi HU Materials Science and Engineering College Hunan University Changsha 410082 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Materials Science and Engineering College Hunan University Changsha 410082 China Materials Science and Engineering College Hunan University Changsha 410082 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Titanium Alloy Laboratory Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China

The interfacial binding covalent bond density (CBD) and the local environmental total bond order (LTBO) of the Ni/Ni3Alinterface with different lattice misfits (δ) were calculated by using first-principles discrete variation Xα method. It was foundthat the effects of lattice misfits on the electronic structures of incoherent Ni/Ni3Al interface were very obvious. On one hand,less than -0.6% negative lattice misfit can promote the binding strength of γ/γ′ interface. On the other hand, the totalbonding strength of γ/γ′ interface decreases with increasing δ. Therefore, the magnitude and sign of lattice misfit must becarefully controlled for balancing the high temperature creep strength of Ni-base single crystal superalloy and the structuralstability of γ/γ′interface when one designs a new Ni-base single crystal superalloy.

关键词： γ/γ′ interface, lattice misfit, DV-Xα method, first-principles calculation

Three-dimensional computed tomography reconstruction diagnosed digestive tract perforation and acute peritonitis caused by Monopterus albus:A case report

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2351-2356页

作者： jin-han yang jin-Ying Lan An-Yuan Lin Wei-Biao Huang jin-Yuan Liao Department of Radiology Guiping People’s HospitalGuigang 537200Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Few reports have described living foreign bodies in the human *** current manuscript demonstrates that computed tomography(CT)is an effective tool for accurate preoperative evaluation of living foreign bodies in *** threedimensional(3D)reconstruction technology could clearly display anatomical structures,lesions and adjacent organs,improving diagnostic accuracy and guiding the surgical decision-making *** SUMMARY Herein we describe a 68-year-old man diagnosed with digestive tract perforation and acute peritonitis caused by a foreign body of Monopterus *** patient pre-sented to the emergency department with complaints of dull abdominal pain,profuse sweating and a pale complexion during work.A Monopterus albus had entered the patient’s body through the anus two hours *** hospitalization,the 3D reconstruction technology revealed a perforation of the middle rectum complicated with acute peritonitis and showed a clear and complete Monopterus albus bone morphology in the abdominal and pelvic cavities,with the Monopterus albus biting the *** examination detected a large(diameter of about 1.5 cm)perforation in the *** could be seen that a Monopterus albus had completely entered the abdominal cavity and had tightly bitten the mesentery of the small *** the operation,the dead Monopterus albus was taken *** The current manuscript demonstrates that CT is an effective tool for accurate preoperative evaluation of living foreign bodies in clinic.

关键词： Digestive tract perforation Acute peritonitis Monopterus albus Three-dimensional computed tomography reconstruction Case report

Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature

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World Journal of Clinical Cases 2019年第2期7卷 242-251页

作者： Qi Yu Ya-Lian Chen Shui-Hong Zhou Zhe Chen yang-yang Bao han-jin yang Hong-Tian Yao Ling-Xiang Ruan Department of Otolaryngology The First Affiliated Hospital College of Medicine Zhejiang University Department of Pathology The First Affiliated Hospital College of Medicine Zhejiang University Department of Radiology The First Affiliated Hospital College of MedicineZhejiang University

BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma(SCC) and neuroendocrine carcinoma(NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and *** SUMMARY A 61-year-old man presented with a 1-year history of hoarseness. Contrastenhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO_2 laser(Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was *** The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.

关键词： Collision carcinoma Neuroendocrine carcinoma Squamous cell carcinoma Head and neck Larynx Case report

Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients

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World Journal of Gastroenterology 2005年第36期11卷 5721-5724页

作者： Yong-Nian han jin-Long yang Shui-Gen Zheng Qun Tang Wei Zhu Research Unit of Liver Diseases Shanghai 8^th People's Hospital Shanghai 200235 China

AIM： To study the relationship of human leukocyte antigen （HLA）-DRB1 and -DQB1 alleles with the genetic susceptibility to HBV infection and the response to interferon （IFN） in HBV-infected patients. METHODS： Low-resolution DNA typing kit was used to determine HLA-DR-1 and -DQB1 genes in 72 patients with chronic hepatitis B （CHB） and HLA-DRB1 in 200 healthy people ready to donate their bone marrow in Shanghai. Among CHB patients, 35 were treated with IFNα-1b for 24 wk. RESULTS： The frequencies of HLA-DRBI＊06, DRBI＊08 and DRB1＊16 alleles in 72 patients were higher than in 200 healthy people （2.08% vs0%, OR = 3.837, P= 0.018; 11.11% vs5.50%, OR = 2.148, P= 0.034; and 6.94% vs 3.00%, OR = 0.625, P = 0.049, respectively）; whereas that of DRBI＊07 allele was lower （2.78% vs 7.75%, OR = 0.340, P= 0.046）. The frequency of HLA-DRBI＊ 14 allele was higher in 11 responders to IFN compared with 24 non-responders （18.18% vs2.08%, OR = 10.444, P = 0.031）, whereas that of DQBI＊07 allele was inverse （9.09% vs37.50%, OR = 0.167, P= 0.021）. CONCLUSION： The polymorphism of HLA class II may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRBI＊06, DRBI＊08, and DRB1＊16 may be associated with chronicity of HBV infection, HLA-DRBI＊07 with protection against HBV infection, and HLA-DRB1＊14 allele may be associated with a high rate of the response of CHB patients to IFN treatment. Compared with other HLA-DQB1 alleles, HLA-DQBI＊07 may be associated with low response rate to IFN. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Hepatitis B Human leukocyte antigens Geneticsusceptibility Interferon

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu yang Xiuxiu jin jingyang Liu Weiping Wang Xiaoli Zhang jinfeng han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

泌阳凹陷下二门地区南部核三上亚段层序地层特征及地层-岩性圈闭预测

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石油勘探与开发 2006年第1期33卷 26-31页

作者：陈亮王华韩晋阳甘华军中国科学院广州地球化学研究所中国地质大学(武汉) 中国海洋石油深圳分公司

综合应用测井、岩心、三维地震剖面等资料,分析南襄盆地泌阳凹陷下二门地区南部核三上亚段的层序地层特征及沉积相,在核三上亚段识别出3个三级层序界面,将核三上亚段分为3个三级层序,识别出4种主要的沉积体系:三角洲、扇三角洲、湖泊及... 详细信息

综合应用测井、岩心、三维地震剖面等资料,分析南襄盆地泌阳凹陷下二门地区南部核三上亚段的层序地层特征及沉积相,在核三上亚段识别出3个三级层序界面,将核三上亚段分为3个三级层序,识别出4种主要的沉积体系:三角洲、扇三角洲、湖泊及深水重力流沉积体系。根据沉积相的平面展布及演化特征,结合地层-岩性圈闭成藏条件分析,提出了一个有利的勘探靶区。

关键词：泌阳凹陷下二门油田地层-岩性圈闭

替罗非班对冠心病经皮冠状动脉介入术后患者的临床研究

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中国临床药理学杂志 2019年第23期35卷 2967-2970页

作者：白洁杨帮国韩谨阳云南省阜外心血管病医院心内科

目的观察替罗非班对冠心病患者经皮冠状动脉介入(PCI)术后的疗效。方法将进行PCI手术治疗的114例冠心病患者随机分为试验组57例和对照组57例。对照组术前及术后均服用阿司匹林300 mg·d^-1,阿托伐他汀钙40mg·d^-1,硫酸氢氯吡格雷片600... 详细信息

目的观察替罗非班对冠心病患者经皮冠状动脉介入(PCI)术后的疗效。方法将进行PCI手术治疗的114例冠心病患者随机分为试验组57例和对照组57例。对照组术前及术后均服用阿司匹林300 mg·d^-1,阿托伐他汀钙40mg·d^-1,硫酸氢氯吡格雷片600 mg·d^-1。试验组术中向冠状动脉内注射替罗非班10μg·kg^-1,同时静脉推注替罗非班3 min,用量也为10μg·kg^-1,随后静脉持续泵入替罗非班24 h,速度为0.15μg·kg^-1·min^-1。2组均治疗3个月。比较2组患者炎性因子、血脂、血管内皮功能和药物不良反应发生情况。结果治疗后,试验组的心肌肌钙蛋白Ⅰ、肌酸激酶同工酶、超敏C反应蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血管性假血友病因子、内皮素^-1、高密度脂蛋白胆固醇和一氧化氮分别为(0.14±0.09)μg·L^-1,(25.93±4.82)U·L^-1,(3.82±0.85)mg·L^-1,(3.62±0.42)mmol·L^-1,(1.23±0.72)mmol·L^-1,(2.41±0.24)mmol·L^-1,(102.48±22.17)%,(58.93±8.14)ng·L^-1,(1.73±0.69)mmol·L^-1,(83.05±11.31)mol·L^-1,对照组分别为(0.85±0.18)μg·L^-1,(71.31±9.17)U·L^-1,(6.11±0.46)mg·L^-1,(4.57±0.55)mmol·L^-1,(1.64±0.81)mmol·L^-1,(3.08±0.57)mmol·L^-1,(138.38±30.07)%,(81.26±15.27)ng·L^-1,(1.38±0.92)mmol·L^-1,(69.17±7.57)mol·L^-1,差异均有统计学意义(均P0.05)。结论对于进行PCI手术治疗的冠心病患者,阿托伐他汀钙联合硫酸氢氯吡格雷和替罗非班的综合用药方案具有良好的治疗效果,能够减少炎症损伤,改善血脂水平,提高血管内皮功能。

关键词：硫酸氢氯吡格雷替罗非班经皮冠状动脉介入冠心病心肌肌钙蛋白Ⅰ 主要不良心脏事件