Isolated anti-HBc is an independent risk factor for tumor recurrence in intrahepatic cholangiocarcinoma after curative resection

作     者：Xiao-Bo Xu Chen Hu Han-Jin Yang Shu-Sen Zheng Xiao-Bo Xu;Chen Hu;Han-Jin Yang;Shu-Sen Zheng

作者机构：Department of Hepatobiliary and Pancreatic Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Pulsed Power Translational Medicine of Zhejiang ProvinceHangzhou 310012China Department of Pathologythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Lab of Combined Multi-Organ TransplantationMinistry of Public HealthHangzhou 310003China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2022年第21卷第5期

页      面：472-478页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(82027803) Chinese Academy of Engineering Consulting Project(2019-ZD-06) Zhejiang University School of Medicine(jgzd20201006) 

主　　题：Cholangiocarcinoma Hepatitis B virus Isolated antibody to hepatitis B core antigen Occult hepatitis B infection 

摘      要：Background:Intrahepatic cholangiocarcinoma(ICC)is a poorly understood and aggressive malignancy with increasing incidence and *** B virus(HBV)infection is recognized as one of the important risk factors of *** are few reports focusing on whether isolated antibody to hepatitis B core antigen(isolated anti-HBc,IAHBc)have prognostic role in ICC,while positive hepatitis B surface antigen(HBsAg)has been reported to be associated with the prognosis of *** aim of this study was to investigate the prognostic value of IAHBc in ICC patients after curative resection,in order to identify those who have the high risk of ICC recurrence in the early ***:We divided 209 ICC patients who underwent curative resection into 4 groups:groupⅠ(n=40),HBsAg(-)/antibody to hepatitis B surface antigen(anti-HBs)(-)/anti-HBc(+);groupⅡ(n=70),HBsAg(+)/anti-HBc(-);groupⅢ(n=55),HBsAg(-)/anti-HBs(+)/anti-HBc(+);and groupⅣ(n=44),HBsAg(-)/anti-HBc(-).We compared the recurrence-free survival(RFS)and overall survival(OS)among these four ***:The median follow-up time was 16.93 months(range 1-34.6 months).The 1-and 2-year RFS and OS rates were 60%and 42%,and 78%and 63%respectively in all *** to the whole non-IAHBc patients(groupⅡ+groupⅢ+groupⅣ),IAHBc patients(groupⅠ)showed significantly lower RFS at 1 year(39.8%vs.64.4%,P=0.001)and 2 years(20.7%vs.46.7%,P=0.001).When compared to other three individual groups,IAHBc patients(groupⅠ)also had the lowest *** did not find significant difference in OS among the four *** multivariate analysis revealed that IAHBc was an independent risk factor of ***:IAHBc is an independent poor prognostic factor for tumor recurrence in ICC patients after curative resection.