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Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie Dong han Xiang li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

An improved particle filter indoor fusion positioning approach based on Wi-Fi/PDR/geomagnetic field

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Defence Technology（防务技术） 2024年第2期32卷 443-458页

作者： Tianfa Wang litao han Qiaoli Kong Zeyu li Changsong li Jingwei han Qi Bai Yanfei Chen College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao266590China key Laboratory of Geomatics and Digital Technology of Shandong Province Shandong University of Science and TechnologyQingdao266590China

The existing indoor fusion positioning methods based on Pedestrian Dead Reckoning(PDR)and geomagnetic technology have the problems of large initial position error,low sensor accuracy,and geomagnetic *** this study,a novel indoor fusion positioning approach based on the improved particle filter algorithm by geomagnetic iterative matching is proposed,where Wi-Fi,PDR,and geomagnetic signals are integrated to improve indoor positioning *** important contribution is that geomagnetic iterative matching is firstly proposed based on the particle filter *** the positioning process,an iterative window and a constraint window are introduced to limit the particle generation range and the geomagnetic matching range *** position is corrected several times based on geomagnetic iterative matching in the location correction stage when the pedestrian movement is detected,which made up for the shortage of only one time of geomagnetic correction in the existing particle filter *** addition,this study also proposes a real-time step detection algorithm based on multi-threshold constraints to judge whether pedestrians are moving,which satisfies the real-time requirement of our fusion positioning *** experimental verification,the average positioning accuracy of the proposed approach reaches 1.59 m,which improves 33.2%compared with the existing particle filter fusion positioning algorithms.

关键词： Fusion positioning Particle filter Geomagnetic iterative matching Iterative window Constraint window

Innovative construction of macroporous–mesoporous structured spherical alumina and its hydrothermal stability

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Particuology 2024年第7期90卷 429-435页

作者： Yufan Mo Chunli li Huiyu li Wei han He Wen Yinghong han Chunxia Che Yongjun Feng State key Laboratory of Chemical Resource Engineering Beijing Engineering Center for Hierarchical CatalystsCollege of ChemistryBeijing University of Chemical TechnologyBeijing100029China Lanzhou Petrochemical Research Center Petrochemical Research InstitutePetroChinaLanzhou730060China

The pore structure of spherical alumina supports is closely related to the dispersion of catalytically active components and the diffusion of *** excellent pore structure under strict reaction conditions is of utmost *** this work,sphericalγ-Al_(2)O_(3)support with a bimodal pore structure,composed of macropores and mesopores,was successfully synthesized using dodecane as the pore-forming agent through the oil–ammonia column-shaping *** morphology and internal pore structure of the alumina were found to be influenced by the amount of surfactant added and ultrasound treatment ***,when concentration of surfactant was 4‰and ultrasound voltage of 20 V was applied,the resultingγ-Al_(2)O_(3)-4‰-20 displayed a highly concentrated distribution of macropores with an average pore size of 100 nm,resulting in an impressive porosity of 69.21%.In contrast,the untreated sample ofγ-Al_(2)O_(3)-0-0 only exhibited a mesoporous distribution with a porosity of 54.03%.Moreover,after being subjected to a hydrothermal treatment in a high temperature(600°C)and high humidity(water vapor)environment for 120 h,theγ-Al_(2)O_(3)-4‰-20 sample maintained a high BET specific surface area of 170.9 m^(2)g^(−1)and mercury intrusion porosimetry specific surface area of 263.3 m^(2)g^(−1).

关键词： Spherical alumina supports Pore-forming agent Oil-ammonia column shaping method Hydrothermal treatment Hydrothermal stability

A Novel Tensor Decomposition-Based Efficient Detector for Low-Altitude Aerial Objects With Knowledge Distillation Scheme

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 487-501页

作者： Nianyin Zeng Xinyu li Peishu Wu han li Xin Luo Department of Instrumental and Electrical Engineering Xiamen UniversityXiamen 361005China IEEE College of Computer and Information Science Southwest UniversityChongqing 400715China

Unmanned aerial vehicles(UAVs) have gained significant attention in practical applications, especially the low-altitude aerial(LAA) object detection imposes stringent requirements on recognition accuracy and computational resources. In this paper, the LAA images-oriented tensor decomposition and knowledge distillation-based network(TDKD-Net) is proposed,where the TT-format TD(tensor decomposition) and equalweighted response-based KD(knowledge distillation) methods are designed to minimize redundant parameters while ensuring comparable performance. Moreover, some robust network structures are developed, including the small object detection head and the dual-domain attention mechanism, which enable the model to leverage the learned knowledge from small-scale targets and selectively focus on salient features. Considering the imbalance of bounding box regression samples and the inaccuracy of regression geometric factors, the focal and efficient IoU(intersection of union) loss with optimal transport assignment(F-EIoU-OTA)mechanism is proposed to improve the detection accuracy. The proposed TDKD-Net is comprehensively evaluated through extensive experiments, and the results have demonstrated the effectiveness and superiority of the developed methods in comparison to other advanced detection algorithms, which also present high generalization and strong robustness. As a resource-efficient precise network, the complex detection of small and occluded LAA objects is also well addressed by TDKD-Net, which provides useful insights on handling imbalanced issues and realizing domain adaptation.

关键词： Attention mechanism knowledge distillation(KD) object detection tensor decomposition(TD) unmanned aerial vehicles(UAVs)

用于检测生物体系中线粒体活性氧的荧光探针（英文）

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物理化学学报 2017年第8期33卷 1573-1588页

作者：楼张蓉李鹏韩克利中国科学院大连化学物理研究所分子反应动力学国家重点实验室辽宁大连116023

线粒体不仅是细胞的能量单元,还是重要的活性氧产生场所。线粒体内的活性氧与正常的生理功能和人类疾病具有紧密的联系,包括细胞信号传导,损伤核酸蛋白质以及诱导氧化应激。然而,线粒体活性氧和细胞病态之间的复杂联系还研究得不够透彻... 详细信息

线粒体不仅是细胞的能量单元,还是重要的活性氧产生场所。线粒体内的活性氧与正常的生理功能和人类疾病具有紧密的联系,包括细胞信号传导,损伤核酸蛋白质以及诱导氧化应激。然而,线粒体活性氧和细胞病态之间的复杂联系还研究得不够透彻。有效检测线粒体内活性氧的手段有助于研究线粒体内活性氧在各种人类疾病中所起的作用。近年来,发展了许多具有高灵敏度和选择性的荧光探针用于检测线粒体内活性氧。基于这一点,我们综述了用于选择性检测线粒体内活性氧的小分子荧光探针的研究进展,并详细讨论了荧光探针的设计、合成、特点及其应用。

关键词：荧光探针线粒体活性氧小分子活细胞

Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12i^(Max)

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Science China(life Sciences) 2024年第3期67卷 555-564页

作者： Jilong Ren Tang Hai Yangcan Chen ke Sun Zhiqiang han Jing Wang Chongyang li Qingwei Wang Leyun Wang Huabing Zhu Dawei Yu Wei li Shanjiang Zhao State key Laboratory of Animal Nutrition Key Laboratory of Animal GeneticsBreeding and Reproduction of Ministry of Agriculture and Rural AffairsInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China State key Laboratoryf Stem Cell and Reproductive Biology Instituteof ZooogyChinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Beijing Farm Animal Research Center Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated gene(Cas) system is continually optimized to achieve the most efficient gene editing effect. The Cas12i^(Max), a Cas12i variant, exhibits powerful DNA editing activity and enriches the gene editing toolbox. However, the application of Cas12i^(Max)in large domestic animals has not yet been reported. To verify the efficiency and feasibility of multiple gene editing in large animals, we generated porcine fibroblasts with simultaneous knockouts of IGF2, ANPEP, CD163,and MSTN via Cas12i^(Max)in one step. Phenotypically stable pigs were created through somatic cell nuclear transfer technology. They exhibited improved growth performance and muscle quality. Furthermore, we simultaneously edited three genes in bovine fibroblasts. A knockout of MSTN and PRNP was created and the amino acid Q-G in CD18 was precisely substituted. Meanwhile, no off-target phenomenon was observed by sum-type analysis or off-target detection. These results verified the effectiveness of Cas12i^(Max)for gene editing in livestock animals and demonstrated the potential application of Cas12i^(Max)in the field of animal trait improvement for agricultural production.

关键词： Cas12i^(Max) gene editing livestock multiple trait improvement

Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system

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Nuclear Science and Techniques 2024年第2期35卷 222-233页

作者： Jing-Lei Huang Guo-Bin Jia li-Feng han Wen-Qian liu li Huang Zheng-han Yang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power *** model considers the impact of thermal properties of fluid variation on accuracy and has been validated with *** study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet ***,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also *** results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial *** simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.

关键词： Molten salt reactor Combined cycle Dynamic characteristic Control

Slip distribution inversion of seismic sub-fault dip iteration using gradient based optimizer algorithm

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Geodesy and Geodynamics 2024年第2期15卷 114-121页

作者： Leyang Wang han li Ming Pang key Laboratory of Mine Environmental Monitoring and Improving Around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

This paper considers setting different dips for different sub-faults to fit the actual rupture situation based on the fault rupture of the 2013 Lushan M_(S)7.0 ***,combined with the coseismic GNSS data of the Lushan earthquake,the source parameters and sliding distribution of the Lushan earthquake fault are ***,we use the gradient based optimizer(GBO)in nonlinear inversion to obtain the source parameters of this seismic *** inversion results indicate that the strike of the fault is 206.52°,the dip is 44.10°,the length is 21.92 km,and the depth is 12.79 *** refine the sliding distribution of the seismic fault,the seismic fault is divided into 3×3 ***,we fix the central sub-fault dip of 44.10°;the dip of other sub-faults is obtained by *** that,the model is further divided into a fault layer model composed of 23×19 sub fault slices,and using the Matlab fitting function is used to fit the dip of the 23×19 sub ***,the Lushan seismic fault plane is established as a shovel structure with steep upper and gentle lower,steep south and gentle *** slip distribution inversion results indicate that the depth of the slip peak is 13 km,the corresponding maximum slip momentum is 0.67 m,the seismic moment is 1.10×10^(19)N·m and the corresponding moment magnitude is *** results above are consistent with the research results of seismology.

关键词： Gradient basedoptimizer(GBO) Lushan earthquake Non-planefault model Slid distribution

Effects of nitrogen deposition on the carbon budget and water stress in Central Asia under climate change

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Journal of Arid Land 2024年第8期16卷 1118-1129页

作者： han Qifei XU Wei li Chaofan School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing 210044China

Atmospheric deposition of nitrogen(N)plays a significant role in shaping the structure and functioning of various terrestrial ecosystems ***,the magnitude of N deposition on grassland ecosystems in Central Asia still remains highly *** this study,a multi-data approach was adopted to analyze the distribution and amplitude of N deposition effects in Central Asia from 1979 to 2014 using a process-based denitrification decomposition(DNDC)*** showed that total vegetation carbon(C)in Central Asia was 0.35(±0.09)Pg C/a and the averaged water stress index(WSI)was 0.20(±0.02)for the whole *** N deposition led to an increase in the vegetation C of 65.56(±83.03)Tg C and slightly decreased water stress in Central *** of this study will expand both our understanding and predictive capacity of C characteristics under future increases in N deposition,and also serve as a valuable reference for decision-making regarding water resources management and climate change mitigation in arid and semi-arid areas globally.

关键词： carbon dynamics climate change grassland ecosystems nitrogen deposition water stress index