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Cement-inspired readily fabricated water-strengthened polymeric materials

Science China Chemistry 2024年第10期67卷 3458-3467页

作者： han zuo Luzhi Zhang Huixia Xuan Shijia Gu Xinxin Xu Rasoul Esmaeely Neisiany Qilin Wu Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional MaterialsCollege of Materials Science and EngineeringDonghua UniversityResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineShanghai 201620China Zhejiang Hexin Science and Technology Co. Ltd.Jiaxing 314033China Biotechnology Centre Silesian University of TechnologyKrzywoustego 844-100 GliwicePoland Department of Polymer Engineering Hakim Sabzevari UniversitySabzevar ***Iran

Polymeric materials have penetrated all aspects of society and play an irreplaceable ***,there is an inherent contradiction between their mechanical properties and processing ***,inspired by cement,a crucial construction material renowned for its excellent fabricating behavior and self-strengthening properties,we have developed dynamic crosslinked poly(oxime-urethane)(CPOU).The synthesized CPOU showed good self-healing ability and 3D printability owing to the dynamic dissociation and re-association of oxime-carbamate *** objects printed through the fused deposition modeling technique were able to be readily assembled into complex architectures through intrinsic ***,the self-strengthening of CPOU was successfully realized through multiple-step tandem *** dissociation of dynamic oxime-carbamate bonds produced–NCO groups,which reacted with the surrounding water to form polar urea bonds in the polymer network,leading to an increase in the tensile strength of CPOU from 11.95 to 19.37 *** work not only develops the polymers with combined self-healing,facile fabricating,and self-strengthening properties but also provides a new molecular strategy to modulate the properties of polymers,which could be potentially applied in diverse areas.

关键词： dynamic bonds 3D printing self-strengthening self-healing

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Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 410-416页

作者： Xu-han zuo Yu Huang Bo-Cen Chen Ming-Yue Zhu Cai-Cai Zhang han-Yi Jiao Li-Fang Lu Man Xiao han Wang Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Basic Medicine and Life SciencesHainan Medical UniversityHaikouHainanChina Experiment and Teaching Center for Clinical Skills Hainan Medical UniversityHaikouHainanChina

Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling ***:H9c2 cell viability was determined by CCK-8 and cardiomyocyte apoptosis was detected by TUNEL *** protein expressions of SIRT1 and p38 MAPK were measured by Western ***-qPCR was also used to determine SIRT1 mRNA *** addition,intracellular reactive oxygen species levels and antioxidant enzyme activities were ***:Thrombopoietin treatment reversed doxorubicin-induced decline in H9c2 cell *** also increased SIRT1 and decreased p-p38 MAPK protein *** addition,thrombopoietin significantly attenuated doxorubicin-induced apoptosis and oxidative stress,and enhanced antioxidant enzyme ***,silencing SIRT1 abrogated the protective effects of thrombopoietin,as evidenced by reduced cell viability and increased oxidative stress and reactive oxygen species ***:Thrombopoietin alleviates doxorubicin-induced cardiomyocyte injury by reducing oxidative stress and apoptosis via the SIRT1/p38 MAPK ***,its protective effects need to be further verified in animal tests.

关键词： Doxorubicin Thrombopoietin Oxidative stress Sirtuin 1 Cardiotoxicity

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互联网背景下远程教育中数字教材建设研究

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辽宁高职学报 2024年第1期26卷 82-85,112页

作者：韩祥祚王筱淳盘锦职业技术学院辽宁盘锦124000 东宁市道河镇中心学校黑龙江东宁157299

教材是教育的重要载体,但纸质教材不能更好地服务于远程教育,作为传统教材的进化产物,数字教材应运而生,数字教材的推广是顺应信息时代学习方式更新和教学改革的必然趋势。如何建设数字教材、正确认识数字教材与纸质教材的关系、充分发... 详细信息

教材是教育的重要载体,但纸质教材不能更好地服务于远程教育,作为传统教材的进化产物,数字教材应运而生,数字教材的推广是顺应信息时代学习方式更新和教学改革的必然趋势。如何建设数字教材、正确认识数字教材与纸质教材的关系、充分发挥数字教材的价值、支撑教学质量的提升,是数字教材的根本任务。通过梳理远程教育教学交互的现状,提出优化策略,同时挖掘数字教材的内涵与优势,提出数字教材与远程教育有机融合后在应用中存在的问题及研究对策。

关键词：远程教育数字教材教学交互共建共享

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初中数学跨学科主题学习的设计与实施

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教学与管理 2024年第4期 39-42页

作者：程晓亮左瀚文林殿吉吉林师范大学教务处吉林四平136000 首都师范大学数学科学学院北京100089 北京市和平街第一中学北京100012

当前,各学科都在探索立足于本学科课堂开展的跨学科主题学习活动。数学学科具有高度的抽象性、严谨的逻辑性、广泛的应用性,构建适合数学学科的跨学科主题学习设计与实施方式具有重要意义。立足于初中数学的跨学科主题学习可以“三会”... 详细信息

当前,各学科都在探索立足于本学科课堂开展的跨学科主题学习活动。数学学科具有高度的抽象性、严谨的逻辑性、广泛的应用性,构建适合数学学科的跨学科主题学习设计与实施方式具有重要意义。立足于初中数学的跨学科主题学习可以“三会”为宗旨、以“四基”为基石、以“问题”为核心设计学习模型,在实施过程中,教师要注意引领问题导向,推动合作探究,扩展评价交流,并以“问题与情境”“知识与技能”“思维与表达”“交流与反思”四个方面的表现为支撑进行评价反思。

关键词：跨学科主题学习初中数学数学核心素养跨学科情境

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Effect of Shouldering Angle on Distribution of Thermal Stress in Sapphire Single Crystal Growth Using Improved Kyropoulos

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Journal of Rare Earths 2006年第z1期24卷 233-236页

作者： Yao Tai han Jiecai zuo Hongbo Meng Songhe Zhang Mingfu Research Center for Composite Materials Harbin Institute of Technology Harbin 150001 China Research Center for Composite Materials Harbin Institute of Technology Harbin 150001 China Research Center for Composite Materials Harbin Institute of Technology Harbin 150001 China Research Center for Composite Materials Harbin Institute of Technology Harbin 150001 China Research Center for Composite Materials Harbin Institute of Technology Harbin 150001 China

A two-dimensional model was established in the rectangular co-ordinate to study the thermal stress in the sapphire single crystal grown by the improved Kyropoulos. In the simulation, the distribution, the maximum and minimum values of the thermal stress were calculated. In addition, the relationship between the thermal stress and the shouldering angles was obtained that for lower shouldering angles, the maximum of the thermal stress value is lower and the minimum value is higher. It indicates that the distribution of the thermal stress can be improved by decreasing the shouldering angles of the crystal during the growth process. To evaluate the model, the experiment was carried out and the results are in good agreement with the calculation.

关键词： simulation thermal stress sapphire improved Kyropoulos

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扭力梁式后悬架扭转工况下横梁疲劳特性研究

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塑性工程学报 2024年第1期31卷 231-239页

作者：王韬杨旭静李茂君秦银平左捍亭齐军湖南大学机械与运载工程学院湖南长沙410082 上海汇众汽车制造有限公司上海201814

基于有限元仿真,对扭力梁式后悬架扭转工况下横梁的疲劳特性进行了分析,提出了一种利用等效试样预测复杂结构零件疲劳寿命的新方法;建立了扭力梁式后悬架仿真模型,分析了横梁的应力分布规律;基于静力学分析结果,结合FB590高强钢疲劳寿... 详细信息

基于有限元仿真,对扭力梁式后悬架扭转工况下横梁的疲劳特性进行了分析,提出了一种利用等效试样预测复杂结构零件疲劳寿命的新方法;建立了扭力梁式后悬架仿真模型,分析了横梁的应力分布规律;基于静力学分析结果,结合FB590高强钢疲劳寿命曲线、成形后横梁表面粗糙度以及表面残余应力,根据名义应力法和Gerber平均应力修正计算了横梁的疲劳寿命,并根据危险区弯曲变形程度设计了不同弯曲半径的等效试样(AR、R20和R10)进行疲劳试验和疲劳断口分析,实现了对横梁疲劳台架试验结果的有效预测。结果表明,在扭转工况下横梁疲劳危险区与应力集中区位于过渡段转角处,横梁的工况幅值-寿命曲线有效覆盖了服役情况下的所有负载情况,并得到了实际载荷谱的应力幅值参考范围;在台架试验中,R10与AR、R20等效试样交点寿命在横梁实际断裂寿命区域内,表明设计的等效试样疲劳试验可以有效表征横梁危险区的疲劳性能。

关键词：扭力梁式后悬架等效试样疲劳特性疲劳寿命预测

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The critical role of therapeutic plasma exchange in ABO-incompatible liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 538-542页

作者： Cheng-zuo han Qiang Wei Meng-Fan Yang Li Zhuang Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China National Center for Healthcare Quality Management in Liver Transplant Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310022China

Background:The shortage of donor liver restricts liver transplantation(LT).Nowadays,donor liver with ABO blood group incompatibility between donor and recipient has become an option to expand the source of donor *** it is now possible to perform ABO-incompatible(ABO-I)LT,antibody-mediated rejection(AMR)has been recognized as the primary cause of desperate outcomes after ABO-I ***-A/B antibody is the trigger of immune response to ABO-I LT graft *** plasma ex-change(TPE)can quickly reduce the titer of plasma antibodies and effectively inhibit humoral *** sources:We searched PubMed and CNKI databases using search terms“therapeutic plasma ex-change”,“ABO-incompatible liver transplantation”,“ABO-I LT”,“liver transplantation”,“LT”,“antibody-mediated rejection”,and“AMR”.Additional publications were identified by a manual search of references from key *** relevant publications published before September 30,2020 were included in this ***:Different centers have made different attempts on whether to use TPE,when to use TPE and how often to use ***,the control standard of lectin revision level is always controversial,the target titer varies significantly from center to center,and the standard target titer has not yet been *** has several schemes to reduce antibody titers,but there is a lack of clinical trials that provide standardized ***:TPE is essential for ABO-I ***,further research and clinical trials should be conducted to determine the best regimen for TPE to remove ABO antibodies and prevent AMR.

关键词： Plasma exchange ABO blood group system Blood group incompatibility Liver transplantation Graft rejection

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Hyperbolic Tangent Function-Based Protocols for Global/Semi-Global Finite-Time Consensus of Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1381-1397页

作者： Zongyu zuo Jingchuan Tang Ruiqi Ke Qing-Long han Seventh Research Division Beihang University(BUAA)Beijing 100191China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia IEEE

This paper investigates the problem of global/semi-global finite-time consensus for integrator-type multi-agent *** hyperbolic tangent function-based protocols are pro-posed to achieve global and semi-global finite-time consensus for both single-integrator and double-integrator multi-agent systems with leaderless undirected and leader-following directed commu-nication *** new protocols not only provide an explicit upper-bound estimate for the settling time,but also have a user-prescribed bounded control *** addition,compared to some existing results based on the saturation function,the pro-posed approach considerably simplifies the protocol design and the stability *** examples and an application demonstrate the effectiveness of the proposed protocols.

关键词： Consensus protocol finite-time consensus hyper-bolic tangent function multi-agent systems.

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Accumulation and Mixing of Oils in Jinghu Sag of Subei Basin:Constraints from Thermal Maturity Parameters

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Journal of China University of Mining and Technology 2007年第1期17卷 53-57页

作者： han zuo-zhen ChanG Xiang-chun GUO Hai-hua PANG Ling-yun Department of Earth Science Nanjing University Nanjing Jiangsu 210093 China College of Geo-information Science and Engineering Shandong University of Science and Technology Qingdao Shandong 266510 China

Oils in Jinghu sag are abundant with high content of polar compounds and have a low ratio of saturate to aromatic hydrocarbons and a high ratio of resin to asphaltene. The gross composition of oils in the Jinghu sag suggests typical immature to low mature characteristics. Some compounds with low thermal stability were identified. Light hydrocarbons, a carbon preference index, an odd even index, n-alkane and hopane maturity parameters show mature features and little differences in the maturity level among oils. Sterane isomerization parameters indicate an immature to low mature status of oil. Transfer of the sedimentary center during sedimentation has led to different thermal histories among subsags and thus generated oils with different maturities. On the basis of source analyses, four migration and accumulation patterns with different maturity can be classified. Combined with available information on mergers of source, reservoir and long distance oil lateral migration, mixing conditions were present in the Jinghu sag. Experimental results indicate that maturity variations are caused by mixtures of hydrocarbons with different maturity.

关键词： mixed oil maturity oil/source correlation biomarker geochemistry

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Remaining oil distribution in (Ng_3)~3 bottom water reservoir of Lin 2-6 fault-block in Huimin depression and potential tapping in horizontal well

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Mining Science and Technology 2009年第1期19卷 102-107页

作者： han zuo-zhen YANG Ren-chao FAN Ai-ping CHEN Qing-chun SHAO Yun-tang Department of Geology Nanfing University Nanjing Jiangsu 210093 China College of Geoscience and Engineering Shandong University of Science and Technology Qingdao Shandong 266510 China Linpan Oil Recovery Yard Shengli Oilfields Linyi Shandong 251507 China

Oil reservoirs with secondary bottom water in Ng33 members (in Guantao formation, Paleogene system) of Lin2-6 fault block in Huimin depression (Bohai Bay Basin) have entered the late stage of ultra-high water-containing-exploitation. Oil exploitation from vertical wells is becoming more and more inefficient. The reservoir type, with water displacing oil and the remaining oil distribution are specifically studied in order to improve the efficiency of the recovery ratio. An integrated scheme for adjusting horizontal wells has been designed and the key technique of the scheme optimized. The study shows that: 1) the positive rhythm of fluvial depositional features is the internal cause of the flooding of oil reservoirs while water injection, injection-production patterns and accumulative petroleum production are the external causes; 2) oil-water driving patterns have transferred from edge water advancing to bottom-water-coning; distribution of the remaining oil mainly concentrates in the upper rhythm and top of the middle rhythm in Ng33 members; 3) a great deal of remaining oil is enriched in high positions of faults, in axes of tiny structures, in stagnation areas among water-injection wells and oil-wells and in tectonic saddle areas with sparse wells. Compared with vertical wells, horizontal wells have advantages such as high recovery, high off-take potential, high critical output, large controlling areas and long time of bottom-water breakthrough.

关键词： Huimin depression oil-reservoir with bottom water remaining oil horizontal well

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