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Is peri-transplant blood transfusion associated with worse transplant outcomes?A retrospective study

World Journal of Transplantation 2023年第4期13卷 157-168页

作者： Muhammad A Bukhari Faisal K alhomayani hala s al eid Najla K al-Malki Mutlaq eidah alotaibi Mohamed A Hussein Zainab N Habibullah Multi-organ Transplantation Center King Abdullah Medical CityMakkah 29123Saudi Arabia Department of Internal Medicine College of MedicineTaif UniversityTaif 23611Saudi Arabia Department of Pharmacy Alhada Armed Forces HospitalTaif 29123Saudi Arabia Department of Nephrology and Transplantation Alhada Armed Forces HospitalTaif 29123Saudi Arabia

BACKGROUND Blood transfusion is common during the peri-transplantation *** incidence of immunological reactions to blood transfusion after kidney transplantation and their consequences on graft outcomes have not been extensively *** To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation *** We conducted a single-center retrospective cohort study of 105 kidney recipients,among them 54 patients received leukodepleted blood transfusion at our center between January 2017 and March *** This study included 105 kidney recipients,of which 80%kidneys were from living-related donors,14%from living-unrelated donors,and 6%from deceased ***-related donors were mostly first-degree relatives(74.5%),while the rest were second-degree *** patients were divided into transfusion(n=54)and non-transfusion(n=51)*** average hemoglobin level at which blood transfusion was commenced was 7.4±0.9 mg/*** were no differences between the groups in terms of rejection rates,graft loss,or *** the study period,there was no significant difference in creatinine level progression between the two *** graft function was higher in the transfusion group;however,this finding was not statistically significant.A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the *** Leukodepleted blood transfusion was not associated with a higher risk of rejection,graft loss,or death in kidney transplant recipients.

关键词： Transplantation Transfusion Rejection Graft survival

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Tuberculosis-diabetes comorbidities: Mechanistic insights for clinical considerations and treatment challenges

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World Journal of Diabetes 2024年第5期15卷 853-866页

作者： Md Abdul alim al-Bari Nicholas Peake Nabil eid Department of Pharmacy University of RajshahiRajshahi 6205Bangladesh Biosciences and Chemistry and Biomolecular Research Centre Sheffield Hallam UniversitySheffield S11WBUnited Kingdom Department of Anatomy Division of Human BiologySchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

Tuberculosis(TB)remains a leading cause of death among infectious diseases,particularly in poor *** infections,multidrug-resistant and ex-tensively drug-resistant TB strains,as well as the coexistence of chronic illnesses such as diabetes mellitus(DM)greatly aggravate TB morbidity and ***[particularly type 2 DM(T2DM)]and TB have converged making their control even more *** contemporary global epidemics,TB-DM behaves like a syndemic,a synergistic confluence of two highly prevalent diseases.T2DM is a risk factor for developing more severe forms of multi-drug resistant-TB and TB recurrence after preventive *** a bidirectional relationship exists between TB and DM,it is necessary to concurrently treat both,and promote recommendations for the joint management of both *** are also some drug-drug interactions resulting in adverse treatment outcomes in TB-DM patients including treatment failure,and *** addition,autophagy may play a role in these ***,the TB-DM comorbidities present several health challenges,requiring a focus on multidisciplinary collaboration and integrated strategies,to effectively deal with this double *** effectively manage the comorbidity,further screening in affected countries,more suitable drugs,and better treatment strategies are required.

关键词： Diabetes mellitus Tuberculosis Coinfections Comorbidity Drug-drug interactions Autophagy Treatment challenges

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Enhancing Wireless sensor Network Efficiency through al-Biruni Earth Radius Optimization

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Computers, Materials & Continua 2024年第6期79卷 3549-3568页

作者： Reem Ibrahim alkanhel Doaa sami Khafaga Ahmed Mohamed Zaki Marwa M.eid Abdyalaziz A.al-Mooneam Abdelhameed Ibrahim s.K.Towfek Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer science and Intelligent systems Research Center BlacksburgVirginia24060USA Delta Higher Institute for Engineering and Technology Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Artificial Intelligence and Computational Intelligence Research Center MeridenConnecticut06450USA school of ICT Faculty of EngineeringDesign and Information&Communications Technology(EDICT)Bahrain PolytechnicP.O.Box 33349Isa TownBahrain

The networks of wireless sensors provide the ground for a range of applications,including environmental moni-toring and industrial *** the networks can overcome obstacles like power and communication reliability and sensor coverage is the crux of network *** infrastructure planning should be focused on increasing performance,and it should be affected by the detailed data about node *** work recommends the creation of each sensor’s specs and radius of influence based on a particular geographical location,which will contribute to better network planning and *** using the ARIMA model for time series forecasting and the al-Biruni Earth Radius algorithm for optimization,our approach bridges the gap between successive terrains while seeking the equilibrium between exploration and *** implementing adaptive protocols according to varying environments and sensor constraints,our study aspires to improve overall network *** compare the al-Biruni Earth Radius algorithm along with Gray Wolf Optimization,Particle swarm Optimization,Genetic algorithms,and Whale Optimization about performance on real-world *** the most efficient in the optimization process,Biruni displays the lowest error rate at *** two other statistical techniques,like ANOVA,are also useful in discovering the factors influencing the nature of sensor data and network-specific *** to the multi-faceted support the comprehensive approach promotes,there is a chance to understand the dynamics that affect the optimization outcomes better so decisions about network design can be *** delivering better performance and reliability for various in-situ applications,this research leads to a fusion of time series forecasters and a customized optimizer algorithm.

关键词： Wireless sensor networks optimization ARIMA model BER algorithm metaheuristic algorithms

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A new Late Miocene Hystrix(Hystricidae,Rodentia)from Turkey

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Integrative Zoology 2024年第3期19卷 548-563页

作者： Kazım halaÇLAR Ayla sEVIM EROL Tolga KÖROG˘LU Paul RUMMY Tao DENG serdar MAYDA Natural History Application and Research Centre Ege UniversityTurkey Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Department of Anthropology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Department of Biology Faculty of SciencesEge UniversityTurkey

TheÇorakyerler fossil locality in Anatolia reveals unique faunal *** study introduces Hystrix kayae ***.,a new Late Miocene porcupine initially classified as Hystrix *** et al.,*** finding expands our knowledge of Late Miocene Anatolian porcupines,bringing the total number of known species to *** *** larger than Hystrix aryanensis and exhibits greater upper cheek tooth crown *** cheek tooth morphology differs from Hystrix depereti,and it possesses distinctive U-shaped choanae unlike Hystrix ***Çorakyerler locality may predate sites with *** and *** but aligns temporally with Hystrix parvae *** study enhances our understanding of Late Miocene porcupine diversity in Anatolia,emphasizing the importance ofÇorakyerler in unraveling the evolutionary history of these fascinating mammals.

关键词： Çorakyerler Hystrix Late Miocene paleobiogeography Turkey

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Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-schwan Ronen schneider Florian Buerger steve seltzsam sherif El Desoky Jameela A.Kari Farkhanda Hafeez Maria szczepanska Loai A.eid Hazem s.Awad Muna al-saffar Neveen A.soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.schierbaum sophia schneider Abdul halawi Izzeldin Elmubarak Katharina Lemberg shirlee shril shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and al-Jalila Children’s specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

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structure-based discovery of *** phytochemicals as potential inhibitors against Monkeypox(mpox)viral protein

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Journal of Biosafety and Biosecurity 2024年第3期6卷 157-169页

作者： Ranjan K.Mohapatra Ahmed Mahal Pranab K.Mohapatra Ashish K.sarangi snehasish Mishra Meshari A.alsuwat Nada N.alshehri sozan M.Abdelkhalig Mohammed Garout Mohammed aljeldah Ahmad A.alshehri Ahmed saif Mohammed Abdulrahman alshahrani ali s.alqahtani Yahya A.almutawif Hamza M.A.eid Faisal M albaqami Mohnad Abdalla ali A.Rabaan Department of Chemistry Government College of EngineeringKeonjhar 758002OdishaIndia Department of Medical Biochemical Analysis College of Health TechnologyCihan University–ErbilErbilKurdistan RegionIraq Department of Chemistry CV Raman Global UniversityBhubaneswarOdishaIndia Department of Chemistry School of Applied SciencesCenturion University of Technology and ManagementBalangirOdishaIndia school of Biotechnology Campus-11KIIT Deemed-to-be-UniversityBhubaneswar 751024OdishaIndia Clinical Laboratory sciences Department College of Applied Medical SciencesTaif UniversityAl-Taif 21974Saudi Arabia Internal Medicine Department King Khalid University Medical CityCollege of MedicineAbha 61481Saudi Arabia Department of Basic Medical sciences College of MedicineAlMaarefa UniversityRiyadhSaudi Arabia Department of Community Medicine and Health Care for Pilgrims Faculty of MedicineUmm Al-Qura UniversityMakkah 21955Saudi Arabia Department of Clinical Laboratory sciences College of Applied Medical SciencesUniversity of Hafr Al BatinHafr Al Batin 39831Saudi Arabia Department of Clinical Laboratory sciences Faculty of Applied Medical SciencesNajran UniversityNajran 61441Saudi Arabia Department of Medical Laboratory sciences Faculty of Applied Medical SciencesKing Khalid UniversityAbha 61481Saudi Arabia mDepartment of Medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinah 41411Saudi Arabia Biology Department College of ScienceIslamic University of MadinahMadinah 42351Saudi Arabia Pediatric Research Institute Children’s Hospital Affiliated to Shandong UniversityJinanShandong 250022China Molecular Diagnostic Laboratory Johns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Public Health and Nutrition The University of HaripurHaripur 22610Pakistan

Outbreaks of Monkeypox(mpox)in over 100 non-endemic countries in 2022 represented a serious global health *** a neglected disease,mpox has become a global public health issue.A42R profilinlike protein from mpox(PDB ID:4QWO)represents a potential new lead for drug development and may interact with various synthetic and natural *** this report,the interaction of A42R profilinlike protein with six phytochemicals found in the medicinal plant Ficus religiosa(abundant in India)was *** on the predicted and compared protein–ligand binding energies,biological properties,IC_(50) values and toxicity,two compounds,kaempferol(C-1)and piperine(C-4),were *** characteristics and quantitative structure–activity relationship(QsAR)of these two compounds were determined,and molecular dynamics(MD)simulations were *** silico examination of the kaempferol(C-1)and piperine(C-4)interactions with A42R profilin-like protein gave best-pose ligandbinding energies of–6.98 and–5.57 kcal/mol,*** predicted IC_(50) of C-1 was 7.63 lM and 82 lM for *** data indicated that kaempferol and piperine are non-mutagenic,and the QsAR data revealed that piperlongumine(5.92)and piperine(5.25)had higher log P values than the other compounds *** simulations of A42R profilin-like protein in complex with C-1 and C-4 were performed to examine the stability of the ligand–protein ***/C and C-4 showed the highest affinity and activities,they may be suitable lead candidates for developing mpox therapeutic *** study should facilitate discovering and synthesizing innovative therapeutics to address other infectious diseases.

关键词： Monkeypox Mpox Phytochemical Molecular docking MD simulation ADMET QsAR

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sOME COMPLETELY MONOTONIC FUNCTIONs AssOCIATED WITH THE q-GAMMA AND THE q-POLYGAMMA FUNCTIONs

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Acta Mathematica scientia 2015年第5期35卷 1214-1224页

作者： Ahmed salEM eid s.KAMEL Department of Basic science Faculty of Information Systems & Computer ScienceOctober 6 University Department of Mathematics Faculty Science Al Jouf University

In this paper, the q-analogue of the stirling formula for the q-gamma function （Moak formula） is exploited to prove the complete monotonicity properties of some functions involving the q-gamma and the q-polygamma functions for all real number q 〉 0. The monotonicity of these functions is used to establish sharp inequalities for the q-gamma and the q-polygamma functions and the q-Harmonic number. Our results are shown to be a generalization of results which were obtained by selvi and Batir [23].

关键词： completely monotonic functions inequalities q-gamma function q-polygammafunction

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Efficient Classification of Remote sensing Images Using Two Convolution Channels and sVM

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Computers, Materials & Continua 2022年第7期72卷 739-753页

作者： Khalid A.alAfandy Hicham Omara hala s.El-sayed Mohammed Baz Mohamed Lazaar Osama s.Faragallah Mohammed al Achhab ENsA Abdelmalek Essaadi UniversityTetouan 93002Morocco Fs Abdelmalek Essaadi UniversityTetouan 93002Morocco Department of Electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom 32511Egypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia ENsIAs Mohammed V University in Rabat 10000Morocco Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

Remote sensing image processing engaged researchers’attentiveness in recent years,especially *** main problem in classification is the ratio of the correct predictions after *** extraction is the foremost important step to build high-performance image *** convolution neural networks can extract images’features that significantly improve the image classifiers’*** paper proposes two efficient approaches for remote sensing images classification that utilizes the concatenation of two convolution channels’outputs as a features extraction using two classic convolution models;these convolution models are the ResNet 50 and the DenseNet *** elicited features have been used by the fully connected neural network classifier and support vector machine classifier as input *** results of the proposed methods are compared with other antecedent approaches in the same experimental *** is based on learning curves plotted during the training of the proposed classifier that is based on a fully connected neural network and measuring the overall accuracy for the both proposed *** proposed classifiers are used with their trained weights to predict a big remote sensing scene’s classes for a developed *** results ensure that,compared with the other traditional classifiers,the proposed classifiers are further accurate.

关键词： Remote sensing images deep learning ResNet DenseNet sVM

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Modified sine Cosine Optimization with Adaptive Deep Belief Network for Movie Review Classification

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Intelligent Automation & soft Computing 2023年第7期37卷 283-300页

作者： hala J.alshahrani Abdulbaset Gaddah Ehab s.alnuzaili Mesfer al Duhayyim Heba Mohsen Ishfaq Yaseen Amgad Atta Abdelmageed Gouse Pasha Mohammed Department of Applied Linguistics College of LanguagesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer sciences College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of English College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer63311Saudi Arabia Department of Computer science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversityAl-Aflaj16828Saudi Arabia Department of Computer science Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer and self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

sentiment analysis(sA)is a growing field at the intersection of computer science and computational linguistics that endeavors to automati-cally identify the sentiment presented in *** linguistics aims to describe the fundamental methods utilized in the formation of computer methods for understanding natural *** is classified as a negative or positive assessment articulated through *** can be commonly used for the movie review classification that involves the automatic determination that a review posted online(of a movie)can be negative or positive toward the thing that has been *** learning(DL)is becoming a powerful machine learning(ML)method for dealing with the increasing demand for precise *** this motivation,this study designs a computational intelligence enabled modified sine cosine optimization with a adaptive deep belief network for movie review classification(MsCADBN-MVC)*** major intention of the MsCADBN-MVC technique is focused on the identification of sentiments that exist in the movie review ***,the MsCADBN-MVC model follows data pre-processing and the word2vec word embedding *** the classification of sentiments that exist in the movie reviews,the ADBN model is utilized in this *** last,the hyperparameter tuning of the ADBN model is carried out using the MsCA technique,which integrates the Levy flight concepts into the standard sine cosine algorithm(sCA).In order to demonstrate the significant performance of the MsCADBN-MVC model,a wide-ranging experimental analysis is performed on three different *** comprehensive study highlighted the enhancements of the MsCADBN-MVC model in the movie review classification process with maximum accuracy of 88.93%.

关键词： Computational linguistics movie review analysis sentiment analysis sentiment classification deep learning

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Vegetation diversity along the altitudinal and environmental gradients in the main wadi beds in the mountainous region of south sinai,Egypt

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Journal of Mountain science 2020年第10期17卷 2447-2458页

作者： Kamal H.sHalTOUT Yassin M.al-sODANY Ebrahem M.eid selim Z.HENeidY Mostafa A.TAHER Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Botany Department Faculty of ScienceKafrelsheikh UniversityKafr El-Sheikh33516Egypt Biology Department College of ScienceKing Khalid UniversityAbha61321Saudi Arabia Botany and Microbiology Department Faculty of ScienceMoharam BeyAlexandria UniversityAlexandria21511Egypt Botany Department Faculty of ScienceAswan UniversityAswan81528Egypt

south sinai includes Egypt’s highest mountains that resemble an ecological island surrounded by *** present study aims to analyse the vegetation physiognomy along the altitudinal and environmental gradients in the main wadi beds in south sinai mountainous *** includes determining the natural,native-weed and alien vegetation in representative stands in this region,analysing their vegetation in terms of species composition,abundance and life forms and determining the national and global distribution of the associated *** investigation also aims to describe the prevailing plant communities and assess the role of environmental conditions that affect the vegetation in this ***,thirty-two stands were chosen during March-June 2018 to reflect the prevailing altitude and environmental *** species was 316(229 genera and 61 families):186 species were perennials(58.9%),while 130 were annuals(41.1%).In addition,152 species were native weeds(48.1%of total species),31 were aliens(9.8%),along with 133 natural species(42.1%).Eight species were recorded as endemic to Egypt:Anarrhinum pubescens,Euphorbia sanctae-catharinae,Hypericum sinaicum,Origanum syriacum ***,Phlomis aurea,Primula boveana,Rosa arabica and solanum *** addition,10 species were recorded as near-endemics to Egypt and other adjacent countries:allium desertorum,Asclepias sinaica,Centaurea scoparia,Fagonia mollis ***,Hyoscyamus boveanus,Iphiona mucronata,Micromeria sinaica,Pterocephalus sanctus,salvia deserti and stachys *** the present study,33 species are threatened and categorized as follows:8 endangered,8 vulnerable and one indeterminate,while the rest were evaluated by the authors as *** rich plant diversity of this region is due to its extensive mountainous massif,which supports many *** high elevations in this region hinder the dispersal process of propagules,a situation which often tends to increase endemic and ne

关键词： Conservation Elevation gradient Multivariate analysis Plant diversity sinai Threatened species

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