Tuberculosis-diabetes comorbidities: Mechanistic insights for clinical considerations and treatment challenges
作者机构：Department of PharmacyUniversity of RajshahiRajshahi 6205Bangladesh Biosciences and Chemistry and Biomolecular Research CentreSheffield Hallam UniversitySheffield S11WBUnited Kingdom Department of AnatomyDivision of Human BiologySchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2024年第15卷第5期
页 面：853-866页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Diabetes mellitus Tuberculosis Coinfections Comorbidity Drug-drug interactions Autophagy Treatment challenges
摘 要：Tuberculosis(TB)remains a leading cause of death among infectious diseases,particularly in poor *** infections,multidrug-resistant and ex-tensively drug-resistant TB strains,as well as the coexistence of chronic illnesses such as diabetes mellitus(DM)greatly aggravate TB morbidity and ***[particularly type 2 DM(T2DM)]and TB have converged making their control even more *** contemporary global epidemics,TB-DM behaves like a syndemic,a synergistic confluence of two highly prevalent diseases.T2DM is a risk factor for developing more severe forms of multi-drug resistant-TB and TB recurrence after preventive *** a bidirectional relationship exists between TB and DM,it is necessary to concurrently treat both,and promote recommendations for the joint management of both *** are also some drug-drug interactions resulting in adverse treatment outcomes in TB-DM patients including treatment failure,and *** addition,autophagy may play a role in these ***,the TB-DM comorbidities present several health challenges,requiring a focus on multidisciplinary collaboration and integrated strategies,to effectively deal with this double *** effectively manage the comorbidity,further screening in affected countries,more suitable drugs,and better treatment strategies are required.
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