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Effect of Interaction Phenolic Compounds with Milk Proteins on Cell Line

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Food and Nutrition Sciences 2014年第22期5卷 2130-2146页

作者： Nayra Shaker Mehanna Zakaria Mohamed Rezk Hassan hala Mohamed Faker el-Din Ali Abd-elaziz Ali Ryszard Amarowicz Tamer Mohammed el-Messery Dairy Science &Technology Department National Research Center Dokki Egypt Food Science Department Faculty of Agriculture Ain Shams University Cairo Egypt Institute of Animal Reproduction and Food Research of Polish Academy of Sciences Division of Food Science Olsztyn Poland

Plant flavonoids are polyphenolic compounds, commonly found in vegetables, fruits and many food sources that form a significant portion of our diet. These compounds act as anticancer and anti-proliferative but after interaction with milk proteins they form complexes which become less effective than these compounds alone. Investigation has been conducted to delineate the action of some phenolic compounds of natural origin and complexes formed from interactions between phenolic compounds and milk proteins in three human tumors cell lines: Breast (MCF7), Liver (HePG2) and colon (HCT116), these interactions were studied by fourier transform infrared spectroscopy (FTIR). Phenolic compounds have positive effect on human cancer cell lines but after interaction with milk protein and forming complexes, they become less effective than phenolics and some time have negative effect and become pro-cancer;this interaction can be studied by (FTIR) to know which groups do this complex. The spectra were recorded under conditions generally applied in quantitative work. IR spectra were recorded in the region from 4000 - 250 cm–1, but the bands in the region 4000 - 1400 cm–1 were analyzed in detail, since they are characteristic of OH groups while NH groups appeared at (3000 - 4000 cm–1) of various protonic species that undergo hydrogen bonding interaction. Another region of interest was the region from 1800 - 1400 cm–1, characteristic of the bending vibrations of the same group. Since the bands in this region were wide and complex.

关键词： Phenolic Compounds Protein Interaction and Human Cell Line

Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study

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The Journal of Biomedical Research 2014年第3期28卷 240-245页

作者： Mohammed A Bawahab Walid M Abd el Maksoud Saeed A Alsareii Fahad S Al Amri hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz General Surgery Department Faculty of MedicineKing Khalid University General Surgery Department Faculty of MedicineNajran University General Surgery Department Sheikh Khalifa Medical CityAbu DhabiP.O.51900United Arab Emirates General Surgery Abha Private Hospital

Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April *** were extracted from hospital case *** data included clinical presentation,routine investigations and liver function *** data included excessive adhesions,bleeding,bile leak,and drain *** cases such as pericholecystic collections,mucocele and empyema were also *** who needed therapeutic drainage were *** data included hospital stay,volume of drained fluid,time of drain removal,and drain site *** study included 103 patients allocated into two groups;group A（n = 38） for patients with operative drain insertion and group B（n = 65） for patients without drain *** number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B（80%） than group A（36.8%）（P 〈 0.001）.Operative time was significantly longer in group *** patients who were converted from laparoscopic to open cholecystectomy were in group *** analysis revealed that hospital stay was significantly（P 〈 0.001） longer in patients with preoperative *** was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases.

关键词： acute cholecystitis routine drainage cholecystectomy subhepatic collection

T-Helper I Cell/T-Helper 2 Cell Balance with Anti Inflammatory Therapy in Partly Controlled Asthmatic Children

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Journal of Life Sciences 2012年第11期6卷 1206-1213页

作者： Gamal Abdel Naser Yamamah hala Hamdy Shaaban Emad Ezzat Salama Nevine el Helaly Solaf Kamel elham Mostafa Pediatrics Department National Research Center (NRC) Cairo 12622 Egypt Pediatrics Department Faculty of Medicine Cairo University Cairo 11562 Egypt Clinical and Chemical Pathology Department National Research Center Cairo 12622 Egypt

The authors aimed to assess Thl （T-helper cell 1）/Th2 （T-helper cell 2） balance, through evaluation of serum IFN-γ （interferon gamma） and IL-4 （interleukin 4）, during asthma exacerbation and study the effect of anti inflammatory therapy. A randomized prospective case-control study was designed. The sludy included 30 asthmatic patients, aging 8-14 years. All were diagnosed as partly controlled asthmatics. Twenty, age and sex matched, healthy children were included in the study as control group All participants were subjected to medical history, clinical examination, pulmonary function testing, eosinophilic blood counting, estimation of serum interleukine-4 and interferon gamma. Patients were treated for 6 weeks with 2 different anti inflammatory drugs. All methods were then repeated for follow up. IL-4 serum level was significantly higher in subjects with partly controlled asthma than in control subjects （P = 0.01）, and then in asthmatic patients after therapy （P = 0.0000）, while IFN-）, serum level was significantly lower in subjects with partly controlled asthma than in control subjects （P = 0.01）, and than in asthmatic patients after therapy （P = 0.0000）. Interferon gamma showed a significant negative correlation with IL-4 among the healthy control group （r = -0.559, P = 0.010）. Both LTA （leukotriene antagonist） and ICS （inhaled corticosteroids） therapy lead to significant improvement, but there were no statistically significant differences （P 〉 0.05） between them as regard the pulmonary functions and the laboratory evaluating parameters. Both serum levels of IL-4 and IFN-γ, could be used as a reliable inflammatory biomarker for the evaluation and follow up of asthmatic patients.

关键词： Thl Th2 IFN-γ IL-4 partly controlled asthma LTA ICS.

Letrozole versus Gonadotropin in Unexplained Infertile Couples Failed to Conceive with Clomiphene Citrate

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Open Journal of Obstetrics and Gynecology 2014年第10期4卷 636-641页

作者： Moustafa Abbas Ibrahaiem Sherin A. Shazly Khaled F. Helal hala Mowafy Manal M. el Behery Obstetrics and Gynecology Department Faculty of Medicine Zagazig University Ash Sharqiyah Egypt

Background:?Unexplained infertility represents about 15% - 20% of infertile couples. Usually, these cases need assistance. Clomiphene citrate is the most used drug for this problem but sometimes pregnancy failed to achieve it, so other options for assistance are gonadotrophin or letrezole. The objective of our study was to compare the pregnancy rate for letrezole and gonadotropin inunexplained infertile women’s who failed to conceive with clomiphene citrate. Methods: This prospective quasi-randomized trial was carried out in cytogenetic unite at obstetrics and gynecology department, Zagazig University Hospital. 140 infertile females were included, induction of ovulation by letrozole for half of them and by gonadotrophin for the other half. Results: There was statistically highly significant decrease in duration of stimulation, E2 levels and endometrial thickness at day of HCG in letrezole group, no significant difference between two groups as regard number of follicles and pregnancy rate per cycle, while the cumulative pregnancy rate and the cost of stimulation are significantly higher in gonadotrophin group. Conclusion: In patient with unexplained infertility who failed to conceive with clomiphene citrate, gonadotrophins have a higher pregnancy rate than letrezole. However, pregnancy rate was high enough with lower cost with letrezole to be acceptable and justified its use in this group of patients.

关键词： Letrozole Gonadotropin Infertility Clomiphene Citrate

Preparation and Properties of a New Carbon Paste Iron Selective electrodes and Their Applications

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American Journal of Analytical Chemistry 2014年第2期5卷 140-148页

作者： Refat F. Aglan Mahmoud S. Rizk Gehad G. Mohamed Ahmed H. el-Wahy hala A. Mohamed Chemistry Administration Cairo Egypt Chemistry Department Faculty of Science Cairo University Giza Egypt Hot Laboratory Center Atomic Energy Authority Cairo Egypt

The new ferrous-selective modified carbon paste electrodes (I and II) based on 5,5’-(propane-1,3-diylbis(sulfanediyl))bis(3-benzyl-4H-1,2,4-triazol-4-amine) (electrode I, A-ionophore) and 5,5’-(butane-1,4-diyl-bis(sulfane- diyl))bis(3-benzyl-4H-1,2,4-triazol-4-amine) (electrode II, B-ionophore) as ionophores are described. These electrodes exhibit Nernstian slopes of 30.2 ± 0.5 and 29.1 ± 0.5 mV·decade-1, linear range of 1.0 × 10-7 - 1.0 × 10-2 mol·L-1 Fe(II) ion and detection limit of 1.0 × 10-7 mol·L-1 Fe(II) ion for electrode (I) and electrode (II), respectively. Both electrodes (I and II) have a fast response time of about 15 sand can be used for at least 3 months. The two electrodes revealed a good selectivity for Fe(II) over a wide variety of other metal ions and could be used in the pH range of 1.8 - 3.0 without any divergence in potential. The proposed sensors were successfully applied for the determination of Fe(II) ion in different real samples.

关键词： Triazol Ionophores Ferrous Ion Determination Modified Carbon Paste electrodes

An Improved Design of a Fully Automated Multiple Output Micropotentiometer

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Energy and Power Engineering 2010年第2期2卷 103-110页

作者： hala Mohamed Abdel Mageed Ahmed Faheem Zobaa Mohamed Helmy Abdel Raouf Abla Hosni Abd el-Rahman Mohamed Mamdouh Abdel Aziz National Institute for Standards GizaEgypt University of Exeter ExeterUK Cairo University GizaEgypt

This paper describes in details a new design of a fully automated multiple output micropotentiometer (?pot). A prototype has been built at the National Institute for Standards (NIS), Egypt to establish this highly improved AC voltage source in the millivolt range. The new device offers three different outputs covering a wide frequency range from only one outlet. This valuably supports the precise sourcing ranges of low AC voltage at NIS. The design and the operation theory of this prototype have been discussed in details. An automatic calibration technique has been introduced through specially designed software using the LabVIEW program to enhance the calibration technique and to reduce the uncertainty contributions. Relative small AC-DC differences of our prototype in the three output ranges are fairly verified. The expanded uncertainties of the calibration results for the three output ranges have been faithfully estimated. However, further work is needed to achieve the optimum performance of this new device.

关键词： Multiple Output μpot AC-DC Transfer Standard Single Junction Thermal Converter Calibration Uncertainty

Temperature Effects on the electrical Performance of Large Area Multicrystalline Silicon Solar Cells Using the Current Shunt Measuring Technique

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Engineering（科研） 2010年第11期2卷 888-894页

作者： hala Mohamed Abdel Mageed Ahmed Faheem Zobaa Mohamed Helmy Abdel Raouf Abla Hosni Abd el-Rahman Mohamed Mamdouh Abdel Aziz 不详

The temperature effects on the electrical performance of a large area multicrystalline silicon solar cell with back-contact technology have been studied in a desert area under ambient conditions using the current shunt measuring technique. Therefore, most of the problems encountered with traditional measuring techniques are avoided. The temperature dependency of the current shunt from 5oC up to 50oC has been investigated. Its temperature coefficient proves to be negligible which means that the temperature dependency of the solar cell is completely independent of the current shunt. The solar module installed in a tilted position at the optimum angle of the location, has been tested in two different seasons (winter and summer). The obtained solar cell short circuit current, open circuit voltage and output power are correlated with the measured incident radiation in both seasons and all results are discussed.

关键词： Large Area Multicrystalline Silicon Solar Cell Current Shunt Measuring Technique Temperature Effects Short Circuit Current Open Circuit Voltage Accumulated Power Incident Radiation

Grave’s Eye Ophthalmopathy Developing Following Radioiodine Therapy for Toxic Adenoma

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Open Journal of Endocrine and Metabolic Diseases 2013年第6期3卷 259-262页

作者： hala Chafic Ahmadieh Ibrahim Salti American University of Beirut-Medical Center Riad El-Solh Beirut Lebanon

The development of Grave’s ophthalmopathy following radioiodine treatment for Grave’s disease is well recognized. However, development of Grave’s ophthalmopathy following radioiodine therapy given for toxic adenoma or toxic nodular goiter has been reported but very rarely. Hereby, we reported a case of a 69-year-old male patient who developed ophthalmopathy after receiving 30 mCi (1110 mBq) 131 I radioiodine treatment for a toxic nodule. In addition, a review of the current literature with regards to this topic is presented.

关键词： Grave’s Ophthalmopathy Toxic Adenoma Toxic Nodular Goiter Radioiodine Therapy

A new measuring technique in detecting of high voltage three phase induction motor for single phasing

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Journal of Measurement Science and Instrumentation 2014年第3期5卷 6-11页

作者： Ali M el-Rifaie hala M Abdel Mageed National Institute of Standards (NIS)

Open phase in three phase induction motors is a common fault that can occur as a result of a fuse blowing or a pro- tective device failing on one phase of the motor. This paper introduces a new method,which is based on the transient mea- surement and can distinguish the fault of one phase connecting ground. The method has been proved to be in correspondence with the simulation results by Matlab and LabVIEW in practice, The method has merits of simplicity, accuracy and ease of USe.

关键词： high voltage induction motor transient protection single phasing detection