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Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan Dal-Fabbro Minzhi Yu Ling Mei hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory ***,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： hajime Kayano Nana Mamuro Yutaro Kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi Masaki Mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,P=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;P=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),P=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,P=0.0011),and body temperature(37.7 vs 37.5℃,P=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection Postoperative biological response

Cell surface protein engineering for high-performance whole-cell catalysts

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 46-57页

作者： hajime Nakatani Katsutoshi Hori Department of Biotechnology Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan

Cell surface protein engineering facilitated by accumulation of information on genome and protein structure involves heterologous production and modifica- tion of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts. In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a cartier protein. The target proteins are fused to the carrier proteins that transport and tether them to the cell surface, as well as to a secretion signal. This paper reviews cell surface display systems for prokaryotic and eukaryotic cells from the perspective of carrier proteins, which determine the number of displayed molecules, and the localization, size, and direction （N- or C-terminal anchoring） of the passengers. We also discuss advanced methods for displaying multiple enzymes and a new method for the immobilization of whole-cell catalysts using adhesive surface proteins.

关键词： cell surface engineering surface display,whole-cell catalysts bioprocess

EXPERIMENTAL STUDY ON THE RELATION OF BED MORPHOLOGY WITH SURFACE FLOW IN MEANDER CHANNELS

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International Journal of Sediment Research 2006年第1期21卷 1-12页

作者： hajime MIWA Faculty of Agriculture Iwate University Japan Prof.

Alternate bars have the property that they migrate downstream whenever floods occur. However, in meander channels whose bend angles are larger than a critical value, the migration of bars can be suppressed, and the positions of bank erosion and flood attack also will be steady. In this study, the bed morphology in flume channels with bends of various lengths and angles is investigated at various flow discharges, and the relation of bed morphology to surface flow is investigated in detail using fluid measuring software. An effort is made to obtain guidelines for the plane shape design of meander channels. Based on the experimental results of bed topography and measurement of surface flow direction and velocity distribution, from the viewpoint of bank erosion and the concentration and dispersion of flood flow the most suitable plane shape for meandering channels is suggested through which the migration of alternate bars is suppressed.

关键词： Meander channel Alternate bars Particle Tracking Velocimetry (PTV) Particle Image Velocimetry (PIV)

Numerical prediction of colloidal phase separation by direct computation of Navier–Stokes equation

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npj Computational Materials 2019年第1期5卷 806-814页

作者： Michio Tateno hajime Tanaka Department of Fundamental Engineering Institute of Industrial ScienceUniversity of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

Numerical prediction of out-of-equilibrium processes in soft and bio matter containing liquids is highly ***,it is quite challenging primarily because the motions of the components at different hierarchical levels(e.g.,large colloids and small solvent molecules)are spatio-temporally coupled in a complicated manner via momentum *** we critically examine the predictability of numerical simulations for colloidal phase separation as a prototype example of self-organization of soft materials containing a *** use coarse-grained hydrodynamic simulations to tackle this problem,and succeed in almost perfectly reproducing the structural and topological evolution experimentally observed by three-dimensional confocal microscopy without any adjustable ***,comparison with non-hydrodynamic simulations shows the fundamental importance of many-body hydrodynamic interactions in colloidal phase *** predictive power of our computational approach may significantly contribute to not only the basic understanding of the dynamical behavior and self-organization of soft,bio and active matter but also the computer-aided design of colloidal materials.

关键词： materials. separation hydrodynamic

Motor tract reorganization after acute central nervous system injury: a translational perspective

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Neural Regeneration Research 2021年第6期16卷 1144-1149页

作者： hajime Takase Robert W.Regenhardt Department of Neurosurgery Yokohama City University Graduate School of MedicineYokohamaJapan Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUSA

Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic *** tract injury accounts for the majority of this disability;therefore,there is impetus to understand mechanisms underlying the pathophysiology of injury and subsequent reorganization of the motor tract that may lead to *** acute central nervous system injury,there are changes in the microenvironment and structure of the motor *** example,ischemic stroke involves decreased local blood flow and tissue death from lack of oxygen and *** injury,in contrast,causes stretching and shearing injury to microstructures,including myelinated axons and their surrounding *** involve blood-brain barrier dysfunction,which is an important initial *** acute central nervous system injury,motor tract reorganization occurs in the form of cortical remapping in the gray matter and axonal regeneration and rewiring in the white *** remapping involves one cortical region taking on the role of ***-response-element binding protein is a key transcription factor that can enhance plasticity in the peri-infarct *** regeneration and rewiring depend on complex cell-cell interactions between axons,oligodendrocytes,and other *** RhoA/Rho-associated coiled-coil containing kinase signaling pathway plays a central role in axon growth/regeneration through interactions with myelin-derived axonal growth inhibitors and regulation of actin cytoskeletal *** and their precursors play a role in myelination,and neurons are involved through their voltage-gated calcium *** the pathophysiology of injury and the biology of motor tract reorganization may allow the development of therapies to enhance recovery after acute central nervous system *** include targeted rehabilitation,novel pharmacotherapies,such as growth factors and axonal growt

关键词： corticospinal tract myelin-axon interaction recovery remapping reorganization RhoA/ROCK translation

Mixed layer in the Sea of Japan:numerical simulation andlong-term data analysis

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Acta Oceanologica Sinica 2005年第1期24卷 76-85页

作者： TRUSENKOVA Olga KHRAPCHENKOV Fyodor ISHIDA hajime V.I.Il'ichev Pacific Oceanological Institute Russian Academy of Sciences Vladivostok 690041 RussiaV.I.Il'ichev Pacific Oceanological Institute Russian Academy of Sciences Vladivostok 690041 RussiaFaculty of Engineering Kanazawa University Kanazawa 920-8667 Japan

Seasonal variation and topography of the mixed layer in the Sea of Japan are studied by comparison of results from long-term observation data analysis and from numerical simulation with the MHI oceanic model (Shapiro. 1998. Marine Hydrophysical Journal, 6: 26-40). The data are retrieved from Oceanographic A tlas of the Bering Sea, Okhotsk Sea, and Japan/East Sea (Rostov, Rostov, Dmitrieva, et al. 2003. Pacific Oceanography, 1(1):70-72). The simulated and long-term patterns are compared. An impact of surface buoyancy flux, wind, and convergence/divergence of surface currents upon the mixed layer in the Sea of Japan is analyzed.

关键词： numerical modeling circuktion of the Sea of Japan mixed layer depth seasonal variation spatial patterns

Controlled synthesis of magnetic carbon nanoparticles via glycerol/ferrocene co-pyrolysis with magnetic induction

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Particuology 2018年第2期16卷 9-16页

作者： Konrat Kerdnawee Noriaki Sano hajime Tamon Tawatchai Charinpanitkul Center of Excellence in Particle Technology Department of Chemical Engineering Faculty of Engineering Chulalongkorn University Bangkok Thailand Department of Chemical Engineering Graduate School of Engineering Kyoto University Kyoto Japan

We performed a controlled synthesis of magnetic carbon nanoparticles （M-CNPs） via co-pyrolysis of glycerol and ferrocene with magnetic induction. The morphology of the synthesized M-CNPs was confirmed by transmission electron microscopy, and thermogravimetric analysis was used to analyze the carbon and Fe contents. M-CNPs that responded to magnetic stimulation were also examined with an AC-magnetic susceptibility analyzer. Our investigations on the influence of synthesis temperature in the range 700-1000℃ suggested that for an initial glycerol to ferrocene weight ratio of 3：1 and a temperature of 800 ℃ gave the highest yield of M-CNPs. Comparing the synthesis with and without magnetic induction, the controlled synthesis under the influence of magnetic induction shows promise as a method for producing high quality M-CNPs in high yields.

关键词： Carbon nanoparticle Glycerol Co-pyrolysis Magnetic induction

Soft ground tunnel lithology classification using clustering-guided light gradient boosting machine

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2857-2867页

作者： Kursat Kilic hajime Ikeda Tsuyoshi Adachi Youhei Kawamura Department of Geosciences Geotechnology and Materials Engineering for ResourcesGraduate School of International Resource SciencesAkita UniversityAkita010-8502Japan Division of Sustainable Resources Engineering Faculty of EngineeringHokkaido UniversityKita 13Nishi 8Kita-kuSapporo060-8628Japan

During tunnel boring machine(TBM)excavation,lithology identification is an important issue to understand tunnelling performance and avoid time-consuming ***,site investigation generally lacks ground samples and the information is subjective,heterogeneous,and imbalanced due to mixed ground *** this study,an unsupervised(K-means)and synthetic minority oversampling technique(SMOTE)-guided light-gradient boosting machine(LightGBM)classifier is proposed to identify the soft ground tunnel classification and determine the imbalanced issue of tunnelling *** the tunnel excavation,an earth pressure balance(EPB)TBM recorded 18 different operational parameters along with the three main tunnel *** proposed model is applied using Python low-code PyCaret ***,four decision tree-based classifiers were obtained in a short time period with automatic hyperparameter tuning to determine the best model for clustering-guided SMOTE *** addition,the Shapley additive explanation(SHAP)was implemented to avoid the model black box *** proposed model was evaluated using different metrics such as accuracy,F1 score,precision,recall,and receiver operating characteristics(ROC)curve to obtain a reasonable outcome for the minority *** shows that the proposed model can provide significant tunnel lithology identification based on the operational parameters of *** proposed method can be applied to heterogeneous tunnel formations with several TBM operational parameters to describe the tunnel lithologies for efficient tunnelling.

关键词： Earth pressure balance(EPB) Tunnel boring machine(TBM) Soft ground tunnelling Tunnel lithology Operational parameters Synthetic minority oversampling technique (SMOTE) K-means clustering