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Macrophages in immunoregulation and therapeutics

Signal Transduction and Targeted Therapy 2023年第6期8卷 I0002-I0002,2821-2854页

作者： Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang haizhao xu Gary Guishan Xiao Lang Rao Yanhong Duo Department of Respiratory Diseases and Critic Care Unit Shenzhen Institute of Respiratory DiseaseShenzhen Key Laboratory of Respiratory DiseaseShenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020China Department of Cancer Biology Beckman Research Institute of City of Hope National Medical CenterLos AngelesCA91010USA Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen UniversityShenzhen518052China Department of Respiratory The First Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China State Key Laboratory of Fine Chemicals Department of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen518132China Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstitutetStockholmSweden

Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and *** possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely *** crucial questions about macrophage signaling and immune modulation are yet to be *** addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their ***,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade ***,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic ***,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage ***,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and ***,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

关键词： becoming polarization Macrophages

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紫外激光单脉冲辐照损伤金属薄膜的数值模拟研究

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光学仪器 2017年第4期39卷 77-84页

作者：徐海钊原晓峰张哲李文斌同济大学物理科学与工程学院精密光学工程技术研究所上海200092

针对不同厚度的镍膜以及金膜,利用多物理场耦合分析软件COMSOL Multiphysics研究了波长248nm、矩形脉冲宽度14ns激光辐照损伤阈值随膜厚变化的物理过程。本研究与他人的理论计算和实验测得的结果基本一致,研究表明:在高强度单脉冲激光... 详细信息

针对不同厚度的镍膜以及金膜,利用多物理场耦合分析软件COMSOL Multiphysics研究了波长248nm、矩形脉冲宽度14ns激光辐照损伤阈值随膜厚变化的物理过程。本研究与他人的理论计算和实验测得的结果基本一致,研究表明:在高强度单脉冲激光均匀辐照下,金属薄膜表面的损伤主要是由于激光能量在其材料内部的沉积而导致的热效应引起的;当金属薄膜的厚度小于其光学吸收长度时(镍膜厚度730nm,金膜厚度>1 050nm),其熔融损伤阈值随薄膜厚度的增大基本保持不变。

关键词：光学吸收长度热扩散长度金属薄膜温度场分布激光损伤阈值

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Multimodal MEMS vibration energy harvester with cascaded flexible and silicon beams for ultralow frequency response

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Microsystems & Nanoengineering 2023年第2期9卷 205-217页

作者： haizhao Feng Ling Bu Zhangshanhao Li Sixing xu Bingmeng Hu Minghao xu Siyao Jiang Xiaohong Wan School of Integrated Circuit Tsinghua University100084 BejingChina School of Information Engineering China University of Geosciences100083 BejingChina College of Semiconductors(College of Integrated circuits) Hunan University430001 ChangshaChina

Scavenged energy from ambient vibrations has become a promising energy supply for autonomous ***,restricted by device size,most MEMS vibration energy harvesters have much higher resonant frequencies than environmental vibrations,which reduces scavenged power and limits practical ***,we propose a MEMS multimodal vibration energy harvester with specifically cascaded flexible PDMS and"zigzag"silicon beams to simultaneously lower the resonant frequency to the ultralow-frequency level and broaden the bandwidth.A two-stage architecture is designed,in which the primary subsystem consists of suspended PDMS beams characterized by a low Young's modulus,and the secondary system consists of zigzag silicon *** also propose a PDMS lift-off process to fabricate the suspended flexible beams and the compatible microfabrication method shows high yield and good *** fabricated MEMS energy harvester can operate at ultralow resonant frequencies of 3 and 23 Hz,with an NPD index of 1.73μW/cm^(3)/g^(2)@3 *** factors underlying output power degradation in the low-frequency range and potential enhancement strategies are *** work offers new insights into achieving MEMS-scale energy harvesting with ultralow frequency response.

关键词： energy harvest harvesting

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正火温度对G115钢组织及650℃强度的影响

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金属热处理 2018年第2期43卷 173-177页

作者：李海昭梁军周超徐连勇天津大学材料科学与工程学院天津300072 神华国华(北京)电力研究院有限公司电站高温材料微创寿命评估中心北京100025

在1030-1120℃温度区间,对G115钢进行不同温度的正火处理随后进行780℃×3 h回火,并对其进行显微组织和650℃拉伸性能研究。拉伸结果表明：随正火温度的升高,650℃强度呈现“M”形变化特征。组织观察发现,1030℃时,晶粒重结晶未完全完成... 详细信息

在1030-1120℃温度区间,对G115钢进行不同温度的正火处理随后进行780℃×3 h回火,并对其进行显微组织和650℃拉伸性能研究。拉伸结果表明：随正火温度的升高,650℃强度呈现“M”形变化特征。组织观察发现,1030℃时,晶粒重结晶未完全完成;随正火温度由1065℃升至1095℃,G115钢原奥氏体平均晶粒尺寸由38.40μm,减小至34.45μm左右,在1075℃至1095℃出现“平台”;当温度升至1120℃时,原奥氏体平均晶粒尺寸为67.64μm,长大明显。对不同正火温度试样扫描电镜（SEM）的背散射电子（BSE）观察,均发现较多的富W和Fe元素的Laves相。Laves相的尺寸和尺寸超过1000 nm Laves相所占的比例呈现“W”形变化特征。650℃强度随正火温度的变化规律主要与大尺寸的Laves相相关。

关键词：正火处理 G115钢 Laves相原奥氏体晶粒尺寸高温强度

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基于强化学习的高超飞行器协同博弈制导方法

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航空学报 2023年第S2期44卷 55-66页

作者：倪炜霖王永海徐聪赤丰华梁海朝中山大学航空航天学院深圳518107 空间物理重点实验室北京100076

研究了多拦截场景下高超声速飞行器主动防御攻防对抗的智能协同博弈制导方法。针对高超声速飞行器与主动防御飞行器协同对抗多个拦截器攻击的博弈问题,提出了一种基于双延迟深度确定性策略梯度算法的高超声速飞行器智能协同博弈制导方法... 详细信息

研究了多拦截场景下高超声速飞行器主动防御攻防对抗的智能协同博弈制导方法。针对高超声速飞行器与主动防御飞行器协同对抗多个拦截器攻击的博弈问题,提出了一种基于双延迟深度确定性策略梯度算法的高超声速飞行器智能协同博弈制导方法,该方法能够在高超声速飞行器与主动防御飞行器机动能力和响应速度不足的情况下实现对于多拦截器的高成功率博弈。通过构建一类启发式连续奖励函数,设计了一种自适应渐进式课程学习方法,提出了一种快速稳定收敛训练方法,解决深度强化学习训练过程中的稀疏奖励问题,实现智能博弈算法的稳定快速收敛。最后通过数值仿真对所提出方法的有效性进行验证,仿真结果表明,所提出的理论方法能够提高训练收敛效率与稳定性,且相比于传统博弈制导方法具有更高的博弈成功率。

关键词：博弈理论奖励函数塑造课程学习深度强化学习高超声速飞行器

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