Macrophages in immunoregulation and therapeutics

作     者：Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu Gary Guishan Xiao Lang Rao Yanhong Duo Shanze Chen;Abdullah F.U.H.Saeed;Quan Liu;Qiong Jiang;Haizhao Xu;Gary Guishan Xiao;Lang Rao;Yanhong Duo

作者机构：Department of Respiratory Diseases and Critic Care UnitShenzhen Institute of Respiratory DiseaseShenzhen Key Laboratory of Respiratory DiseaseShenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020China Department of Cancer BiologyBeckman Research Institute of City of Hope National Medical CenterLos AngelesCA91010USA Department of Laboratory MedicineHuazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen UniversityShenzhen518052China Department of RespiratoryThe First Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China State Key Laboratory of Fine ChemicalsDepartment of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Biomedical Health Technology and EngineeringShenzhen Bay LaboratoryShenzhen518132China Department of MicrobiologyTumor and Cell Biology(MTC)Karolinska InstitutetStockholmSweden 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第6期

页      面：I0002-I0002,2821-2854页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 100217[医学-麻醉学] 

基　　金：supported by the National Natural Science Foundation of China(Nos:81803183,82272779,82003036,82273236) National Key R&D Program of China(2022YFF0710800,2022YFF0710802) Natural Science Foundation of Sichuan province,China(No.2019YFS0230) Science and Technology Innovation Commission of Shenzhen(Nos:JCYJ20220530141608020,JCYJ20220530141609021) Natural Science Foundation of Guangdong province,China(Nos:2214050008970,2019A1515012079) Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515030182) Science and Technology Innovation Commission of Shenzhen(No.JCYJ20220530141608020)BioRender was used to create the figures. 

主　　题：becoming polarization Macrophages 

摘      要：Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.Macrophages possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely regulated.Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered.In addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology.Moreover,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade immunotherapies.Herein,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic regulation.Furthermore,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions.Moreover,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis.Lastly,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.