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Effects of lead exposure on placental cellular apoptosis and endoplasmic reticulum stress in rats

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Chinese Medical Journal 2014年第9期127卷 1744-1748页

作者： Wang Yunying Hu haiyan Li Hong ma haiyan Xu Fengsen Qu Baoming Department of Medical Genetics Qingdao Municipal Hospital Qingdao University Medical College Qingdao Shandong 266071 China Department of Obstetrics and Gynecology Qingdao Municipal Hospital Qingdao University Medical College Qingdao Shandong 266011 China

Background Lead exposure during pregnancy contributes to fetal abortion and/or *** reticulum （ER） apoptosis can be induced by various pathological conditions when ER function is ***,it is unclear whether ER stress and apoptosis play a role in the etiology of lead-exposed disease *** aimed to investigate whether lead induced placental apoptosis and subsequent toxicity is initiated by ER apoptosis via *** Sixty-three female Wistar rats were exposed to lead in drinking water during various gestational *** lead level was determined by atomic absorption *** cytoplasmic organelles were examined by electronic *** caspase-12 mRNA expression was evaluated by *** assay was used to determine the placental *** Lead exposure significant induced ER apoptosis compared to that of the controls （P ＜0.05）,accompanied with increased caspase-12 mRNA *** differences of caspase-12 mRNA expression levels were observed among the four groups （F=13.78,P ＜0.05）.Apoptotic index （AI） was significantly increased in experimental groups compared to that of the controls （F=96.15,P ＜0.05）.In lead-exposed groups,trophoblast cells underwent degeneration and fibrin deposition; Mitochondria were swollen and decreased in number; ER swelling,expansion,and vacuolization were *** Lead exposure contributes to placental apoptosis,as well as increased caspase-12 mRNA expression,which in turn promoted ER stress.

关键词： lead placenta apoptosis endoplasmic reticulum caspase-12

强制隔离戒毒人员对新型冠状病毒感染及疫苗认知调查分析

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中国药物滥用防治杂志 2024年第5期30卷 799-802页

作者：陈杰胡文兵钟泽郑敏杜首君马海燕杭州市富春强制隔离戒毒所戒毒医疗中心浙江杭州311400 杭州师范大学公共卫生学院浙江杭州311121

目的:调查强制隔离戒毒人员对新型冠状病毒感染及疫苗的知识了解程度,并探究其对新型冠状病毒疫苗的接种意愿。方法:通过自行编制的《新型冠状病毒感染知识及疫苗接种意愿调查问卷》,对某戒毒所的88名戒毒人员进行了问卷调查。问卷内容... 详细信息

目的:调查强制隔离戒毒人员对新型冠状病毒感染及疫苗的知识了解程度,并探究其对新型冠状病毒疫苗的接种意愿。方法:通过自行编制的《新型冠状病毒感染知识及疫苗接种意愿调查问卷》,对某戒毒所的88名戒毒人员进行了问卷调查。问卷内容包括个人基本信息、对新型冠状病毒感染及疫苗的认知和态度。采用卡方检验对调查结果进行统计分析。结果:在88名被调查对象中,新型冠状病毒的传播方式回答正确率为29.54%;新型冠状病毒疫苗非常想接种和比较想接种的比例分别为40.91%和39.77%。此外,研究发现高中及以上受教育程度的戒毒人员在新型冠状病毒知识及疫苗认知方面较高,而在对接种意愿做调查时发现,个体户和已婚人群更倾向于接种新型冠状病毒疫苗。结论:强制隔离戒毒人员对新型冠状病毒感染及疫苗的知识了解程度普遍较低,但其对新型冠状病毒疫苗的接种意愿较强。

关键词：戒毒人员新型冠状病毒感染疫苗认知接种意愿

miR-126-5p靶向maPK1对甲状腺癌顺铂耐药细胞增殖和侵袭的影响

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解剖学杂志 2024年第4期47卷 321-327,338页

作者：李璐孙弟波李萍李思宇马海燕张泽天北方学院附属第一医院血管腺体外科张家口075000 北方学院附属第一医院消化内科张家口075000

目的:研究miR-126-5p对甲状腺癌细胞顺铂耐药性和耐药细胞增殖侵袭的影响及机制。方法:RT-qPCR检测细胞miR-126-5p和maPK1 mRNA表达水平。将细胞分为对照组、miR-126-5p mimic组、miR-NC组、miR-126-5pmimic+pc-maPK1组和miR-126-5pmimic+pc-NC组。CCK-8法测定细胞顺铂抗性和增殖情况,Transwell测定细胞侵袭,双荧光素酶报告验证靶向关系,免疫印迹检测maPK1蛋白表达水平。结果:与正常组织和细胞相比,甲状腺癌组织和细胞中miR-126-5p水平显著下调;与甲状腺癌细胞系TPC-1相比,甲状腺癌顺铂耐药细胞系TPC-1/CDDP中miR-126-5p mRNA表达显著下调。TPC-1细胞、TPC-1/CDDP细胞中,与对照组相比,miR-126-5pmimic组细胞CDDP的IC50值、细胞增殖和每视野侵袭细胞数目均显著降低,miR-126-5p靶向下调maPK1。过表达maPK1逆转miR-126-5p过表达对细胞顺铂抗性的IC50值、细胞增殖和每视野侵袭细胞数。结论:miR-126-5p过表达通过靶向下调maPK1增强TPC-1和TPC-1/CDDP细胞顺铂敏感性,并抑制细胞增殖和侵袭。

关键词： miR-126-5p maPK1 甲状腺癌顺铂增殖侵袭

Dinuclear Zinc Complexes with Biphenyl-Based Chiral Aminophenolate Ligands: Synthesis, Structure and rac-Lactide Polymerization

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Dinuclear Zinc Complexes with Biphenyl-Based Chiral Aminophe...

2015年全国高分子学术论文报告会

作者： Wenlei Chu haiyan ma Laboratory of Organometallic Chemistry East China University of Science and Technology

Polylactide(PLA) has attracted great attention due to its biocompatibility, biodegradability and numerous environmental advantages over conventional polyolefin materials. PLA is usually prepared by the ring-opening polymerization of lactide, which requires a suitable organometallic catalyst. In this work, a series of dinuclear zinc complexes have been synthesized by the reaction of 2 equiv. of Zn[N(SiMe)] and 1 equiv. of biphenyl-based chiral aminophenolate ligands, which were obtained via the variation of the para-substituent of biphenyl moiety and the N-alkyl group of the chiral pyrrolidinyl ring. Interestingly, the X-ray diffraction study revealed that these dinuclear complexes involves two zinc centers of reversed configurations within one molecule [(R)-Zn/(S)-Zn]. All of these complexes displayed medium isoselectivity(Pm = 0.56 0.67) towards the ring-opening polymerization of rac-lactide at room temperature.

关键词： dinuclear zinc complex chiral aminophenolate ligand rac-lactide polymerization isoselective

Developing an atmospheric aging evaluation model of acrylic coatings:A semi-supervised machine learning algorithm

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International Journal of Minerals,Metallurgy and materials 2024年第7期31卷 1617-1627页

作者： Yiran Li Zhongheng Fu Xiangyang Yu Zhihui Jin haiyan Gong Lingwei ma Xiaogang Li Dawei Zhang Beijing Advanced Innovation Center for materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China National materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China BRI Southeast Asia Network for Corrosion and Protection(MOE) Shunde Innovation School of University of Science and Technology BeijingFoshan 528399China

To study the atmospheric aging of acrylic coatings,a two-year aging exposure experiment was conducted in 13 representative climatic environments in *** atmospheric aging evaluation model of acrylic coatings was developed based on aging data including11 environmental factors from 567 cities.A hybrid method of random forest and Spearman correlation analysis was used to reduce the redundancy and multicollinearity of the data set by dimensionality reduction.A semi-supervised collaborative trained regression model was developed with the environmental factors as input and the low-frequency impedance modulus values of the electrochemical impedance spectra of acrylic coatings in 3.5wt%NaCl solution as *** model improves accuracy compared to supervised learning algorithms model(support vector machines model).The model provides a new method for the rapid evaluation of the aging performance of acrylic coatings,and may also serve as a reference to evaluate the aging performance of other organic coatings.

关键词： acrylic coatings coatings aging atmospheric environment machine learning

Highly Isoselective Polymerization of rac-Lactide Using Zinc Initiators Supported by Chiral and Prochiral Aminophenolate-Oxazolinate Ligands

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Highly Isoselective Polymerization of rac-Lactide Using Zinc...

2015年全国高分子学术论文报告会

作者： Chao Kan haiyan ma Laboratory of Organometallic Chemistry East China University of Science and Technology

A series of novel zinc complexes supported by chiral and prochiral aminophenolate-oxazolinate ligands have been synthesized. Diastereoselective preparation of several chiral zinc complexes were achieved via the variation of the substituent on ortho-position of phenoxy moiety, skeleton N atom and stereogenic group of the chiral oxazoline ring. When chiral oxazoline ring was replaced by benzoxazole moiety, zinc complexes in racemic form were obtained from the corresponding prochiral ligands. The X-ray diffraction studies revealed the absolute configurations of typical enantiopure complex 3 and racemic complex 7. The enantiopure complex 4 and the racemic complex 7 both displayed excellent isoselectivity towards the ring-opening polymerization of rac-lactide with Pm up to 0.80 and 0.83 at r.t., respectively. Complex 4 is the most active zinc initiator among the isoselective zinc complexes, which could convert 500 equiv. of rac-LA to 93% monomer conversion within 23 min.

关键词： Zinc complex rac-lactide polymerization highly isoselective

Highly Isoselective Polymerization of rac-Lactide Using Zinc Initiators Supported by Chiral Aminophenolate Ligands

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Highly Isoselective Polymerization of rac-Lactide Using Zinc...

2013年全国高分子学术论文报告会

作者： Haobing Wang haiyan ma Laboratory of Organometallic Chemistry East China University of Science and Technology

Novel zinc complexes supported by aminophenolate ligands of multiple stereogenic centers have been diastereoselectively synthesized via the variation of the ortho-substituent of phenoxy moiety and the N-alkyl group of chiral pyrrolidinyl ring in the ligand framework. The X-ray diffraction studies revealed the molecular structures of two diastereoisomers of 1 and the enantiopure complex 4. The enantiopure complex 4 displayed excellent isooselectivity in the ring-opening polymerization of rac-lactide, representing the first example of highly isoselective （P m = 0.84） zinc initiating system. An enantiomorphic site control pathway was proposed based on the preliminary kinetic stydies. Complexes 1 to 4 showed interesting stereoselectivity variation from heterotactic bias to highly isotactic selectivity, likely a benefit of enhanced content of one specific diastereomer resulted from the increased steric bulkiness of the aminophenolate ligands.

关键词： Chiral zinc complex rac-lactide polymerization highly isoselective

Random Copolymerization of ε-Caprolactone and Lactides Using Titanium Initiators Supported by Tetradentate Aminophenoxide Ligands

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Random Copolymerization of ε-Caprolactone and Lactides Usin...

第十七届全国金属有机化学学术讨论会

作者： Yuan Wang haiyan ma East China University of Science and Technology

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Novel Zinc Complexes Containing BDI Ligands for Homo- and Copolymerization of Lactides with ε-Caprolactone

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Novel Zinc Complexes Containing BDI Ligands for Homo- and Co...

2013年全国高分子学术论文报告会

作者： maryam Keram haiyan ma Laboratory of Organometallic Chemistry East China University of Science and Technology

A series of β-diketiminate zinc silylamido complexes were synthesized by the treatment of the appropriate ligand with Zn[N（SiMe 3 ） 2 ] 2 . All of these zinc complexes showed satisfied catalytic activities for the ring-opening polymerization of rac-lactide at room temperature to afford heterotactic PLAs with high molecular weights and narrow molecular weight distributions. Typical zinc complex Zn8 was evaluated for the one pot copolymerization of L-lactide and ε-caprolactone, diblock copolymer with slight random microstructure was obtained, which was characterized by 1 H and 13 C NMR spectroscopy, GPC and DSC analysis.

关键词： β-Diketiminate zinc complexes rac-lactide ε-caprolactone polymerization copolymerization