Effects of lead exposure on placental cellular apoptosis and endoplasmic reticulum stress in rats

作     者：Wang Yunying Hu Haiyan Li Hong Ma Haiyan Xu Fengsen Qu Baoming 

作者机构：Department of Medical Genetics Qingdao Municipal Hospital Qingdao University Medical College Qingdao Shandong 266071 China Department of Obstetrics and Gynecology Qingdao Municipal Hospital Qingdao University Medical College Qingdao Shandong 266011 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第9期

页      面：1744-1748页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by a grant from the Medical Research Foundation from Department of Health of Shandong  China 

主　　题：lead placenta apoptosis endoplasmic reticulum caspase-12 

摘      要：Background Lead exposure during pregnancy contributes to fetal abortion and/or *** reticulum （ER） apoptosis can be induced by various pathological conditions when ER function is ***,it is unclear whether ER stress and apoptosis play a role in the etiology of lead-exposed disease *** aimed to investigate whether lead induced placental apoptosis and subsequent toxicity is initiated by ER apoptosis via *** Sixty-three female Wistar rats were exposed to lead in drinking water during various gestational *** lead level was determined by atomic absorption *** cytoplasmic organelles were examined by electronic *** caspase-12 mRNA expression was evaluated by *** assay was used to determine the placental *** Lead exposure significant induced ER apoptosis compared to that of the controls （P 0.05）,accompanied with increased caspase-12 mRNA *** differences of caspase-12 mRNA expression levels were observed among the four groups （F=13.78,P 0.05）.Apoptotic index （AI） was significantly increased in experimental groups compared to that of the controls （F=96.15,P 0.05）.In lead-exposed groups,trophoblast cells underwent degeneration and fibrin deposition; Mitochondria were swollen and decreased in number; ER swelling,expansion,and vacuolization were *** Lead exposure contributes to placental apoptosis,as well as increased caspase-12 mRNA expression,which in turn promoted ER stress.