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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie hailin xu Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

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后踝骨折中关节内嵌入骨块的研究进展

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广西医学 2024年第3期46卷 422-427页

作者：冯硕芦浩徐海林北京大学人民医院创伤骨科国家创伤医学中心北京市100044

后踝骨折是较为复杂的踝关节骨折,约占踝关节骨折的50%。研究发现,骨折累及后踝通常对预后具有不良影响。近年来,随着CT检查的普及与生物力学研究的开展,后踝骨折中关节内嵌入骨块逐渐受到重视。关节内嵌入骨块可影响后踝骨折复位,容易... 详细信息

后踝骨折是较为复杂的踝关节骨折,约占踝关节骨折的50%。研究发现,骨折累及后踝通常对预后具有不良影响。近年来,随着CT检查的普及与生物力学研究的开展,后踝骨折中关节内嵌入骨块逐渐受到重视。关节内嵌入骨块可影响后踝骨折复位,容易导致关节面不一致和踝关节不稳,且与远期创伤性关节炎的发生有关。本文对后踝骨折中关节内嵌入骨块的形态学特征、分型与损伤机制、生物力学研究、治疗及预后等研究进行综述,以期为后踝骨折的诊治提供参考。

关键词：踝关节骨折后踝骨折关节内嵌入骨块综述

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吸入乙酰半胱氨酸溶液治疗急性鼻窦炎的疗效及对患者睡眠质量影响

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世界睡眠医学杂志 2024年第5期11卷 990-993页

作者：徐海林李志永湖北省赤壁市人民医院赤壁437300 邢台市第三医院邢台054099

目的:探讨吸入乙酰半胱氨酸溶液治疗急性鼻窦炎的临床疗效以及对患者睡眠质量的影响。方法:选取2021年4月至2023年4月赤壁市人民医院收治的急性鼻窦炎患者114例作为研究对象,按照随机数字表法分为对照组和观察组,每组57例。对照组采用... 详细信息

目的:探讨吸入乙酰半胱氨酸溶液治疗急性鼻窦炎的临床疗效以及对患者睡眠质量的影响。方法:选取2021年4月至2023年4月赤壁市人民医院收治的急性鼻窦炎患者114例作为研究对象,按照随机数字表法分为对照组和观察组,每组57例。对照组采用常规药物治疗,观察组在此基础上给予吸入乙酰半胱氨酸溶液治疗,比较2组临床疗效、鼻腔鼻窦功能、炎症介质水平及睡眠质量。结果:观察组总有效率较对照组高,差异有统计学意义(P<0.05)。观察组症状及视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05)。治疗后观察组SNOT-20、Lund-Kennedy评分及鼻气道阻力(NAR)低于对照组,差异有统计学意义(P<0.05)。治疗后2组TNF-α、CRP、IL-6、IL-8、IL-10明显降低,观察组评分低于对照组,差异有统计学意义(P<0.05)。治疗后2组PSQI、SRSS评分明显降低,观察组低于对照组,差异有统计学意义(P<0.05)。结论:急性鼻窦炎采取乙酰半胱氨酸溶液雾化吸入治疗可明显减轻鼻塞、脓涕等症状,改善鼻腔鼻窦功能,抑制炎症反应,取得良好的治疗效果,利于患者恢复良好睡眠质量,值得推广。

关键词：急性鼻窦炎乙酰半胱氨酸临床疗效炎症介质睡眠质量

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可调式外固定牵伸联合关节镜下微骨折治疗距骨软骨损伤的效果分析

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中华创伤骨科杂志 2024年第3期26卷 241-246页

作者：杨华清章耀华李强刘亮徐海林韩庆海赵殿钊杨云杨启昌首都医科大学附属北京康复医院骨科北京100144 首都医科大学附属北京潞河医院运动医学科北京101100 北京大学人民医院创伤骨科北京100044

目的探讨可调式外固定牵伸联合关节镜下微骨折治疗距骨软骨损伤(OLT)的效果。方法回顾性分析2017年5月至2022年3月期间首都医科大学附属北京康复医院骨科收治的27例OLT患者资料。男16例,女11例;年龄(32.4±7.2)岁;软骨损伤部位:内侧23例... 详细信息

目的探讨可调式外固定牵伸联合关节镜下微骨折治疗距骨软骨损伤(OLT)的效果。方法回顾性分析2017年5月至2022年3月期间首都医科大学附属北京康复医院骨科收治的27例OLT患者资料。男16例,女11例;年龄(32.4±7.2)岁;软骨损伤部位:内侧23例,外侧4例;Hepple分期:Ⅰ期7例,Ⅱ期15例,Ⅲ期5例;病程为(10.6±3.3)个月。所有患者均采用可调式外固定牵伸联合关节镜下微骨折治疗。记录患者术后6、12个月的疼痛视觉模拟评分(VAS)和美国足踝外科协会(AOFAS)踝-后足评分,术后1个月的白细胞介素-1(IL-1)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)等相关炎性因子水平,术后12个月损伤面积及并发症发生情况等。结果本组患者的随访时间为(16.2±6.7)个月。27例患者术前、术后6个月及术后12个月的AOFAS踝-后足评分分别为(61.52±6.75)、(84.15±5.56)、(95.67±4.30)分,疼痛VAS评分分别为(5.88±1.02)、(2.12±0.48)、(0.66±0.36)分,以上项目3个时间点之间两两比较差异均有统计学意义(P<0.05)。27例患者术后1个月IL-1为(32.37±6.64)pg/mL,IL-6为(34.04±7.12)pg/mL,TNF-α为(17.89±4.96)ng/L,均较术前[(96.63±14.80)pg/mL、(102.33±20.42)pg/mL、(54.48±9.33)ng/L]显著降低,差异均有统计学意义(P<0.05)。术后12个月27例患者的损伤面积为(28.66±6.52)mm2,较术前[(128.52±11.32)mm2]显著缩小,差异有统计学意义(P<0.05)。1例患者发生外固定针道感染,2例患者发生下肢深静脉血栓形成。结论可调式外固定牵伸联合关节镜下微骨折治疗OLT可以取得满意的效果,改善患者症状。

关键词：距骨软骨创伤和损伤关节镜检查外固定牵伸技术微骨折

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Study on the fast elimination of smoke particle based on electro-acoustic coupling agglomeration technology

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Particuology 2024年第5期88卷 1-10页

作者： Jie Feng Mingfeng Lu Kaige Wang Kun Luo Mingzhou Yu Guangxue Zhang Jiangrong xu Shuping Pan hailin Gu The Institute for Energy Engineering China Jiliang UniversityHangzhou310018China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Qingshanhu Energy Research Center Zhejiang UniversityHangzhou310017China Zhejiang Ecological Environment Monitoring Center Hangzhou310012China

Fire smoke,which consists large amounts of fine particles,is considered as the fatal factor in *** this study,a fast smoke particle elimination method based on electro-acoustic coupling agglomeration technology is ***,the experimental results show that the electro-acoustic coupling agglomeration has higher smoke elimination efficiency compared to *** smoke transmission is much less than 80%after 30s of single acoustic or electric field action,while the coupled field reaches 90%.Then,the effects of acoustic frequency,sound pressure level and voltage on the smoke elimination characteristics are *** is found that the optimal acoustic frequency is *** as the sound pressure level and voltage increase,the elimination efficiency first increases and then tends to stabilize,the critical values of the sound pressure level and voltage are 135 dB and *** indicates that there is an optimal combination of the three ***,through the theoretical analysis of particle movement and the micro-morphology of agglomerates,the particle agglomeration mechanism under the electro-acoustic coupling is *** study provides a new idea for the fast elimination of fire smoke particle.

关键词： Smoke particle Agglomeration Electro-acoustic coupling Smoke elimination

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Evolution and Prospects of Foundation Models: From Large Language Models to Large Multimodal Models

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Computers, Materials & Continua 2024年第8期80卷 1753-1808页

作者： Zheyi Chen Liuchang xu Hongting Zheng Luyao Chen Amr Tolba Liang Zhao Keping Yu hailin Feng College of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou311300China Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Mathematics and Computer Science Department Faculty of ScienceMenofia UniversityShebin El KomMenoufia Governorate32511Egypt School of Computer Science Shenyang Aerospace UniversityShenyang110136China Graduate School of Science and Engineering Hosei UniversityTokyo184-8584Japan

Since the 1950s,when the Turing Test was introduced,there has been notable progress in machine language *** modeling,crucial for AI development,has evolved from statistical to neural models over the last two ***,transformer-based Pre-trained Language Models(PLM)have excelled in Natural Language Processing(NLP)tasks by leveraging large-scale training *** the scale of these models enhances performance significantly,introducing abilities like context learning that smaller models *** advancement in Large Language Models,exemplified by the development of ChatGPT,has made significant impacts both academically and industrially,capturing widespread societal *** survey provides an overview of the development and prospects from Large Language Models(LLM)to Large Multimodal Models(LMM).It first discusses the contributions and technological advancements of LLMs in the field of natural language processing,especially in text generation and language ***,it turns to the discussion of LMMs,which integrates various data modalities such as text,images,and sound,demonstrating advanced capabilities in understanding and generating cross-modal content,paving new pathways for the adaptability and flexibility of AI ***,the survey highlights the prospects of LMMs in terms of technological development and application potential,while also pointing out challenges in data integration,cross-modal understanding accuracy,providing a comprehensive perspective on the latest developments in this field.

关键词： Artificial intelligence large language models large multimodal models foundation models

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Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes

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Photonics Research 2016年第6期4卷 262-266页

作者： Leiming Wu Jun Guo hailin xu Xiaoyu Dai Yuanjiang Xiang SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University College of Physics and Energy Shenzhen University

An ultrasensitive biosensor based on hybrid structure and composed of long-range surface plasmon polariton(LRSPP) and dielectric planar waveguide(PWG) modes is proposed. Both PWG and LRSPP modes have strong resonances to form strong coupling between the two modes, and the two modes can couple to enhance sensitivity of sensors. In the hybrid structure, PWG is composed of cytop–Si–cytop multilayers and the LRSPP configuration is composed of cytop–metal–sensing medium multilayer slabs. The highest imaging sensitivities of 2264 and3619 RIU-1were realized in the proposed sensors based on Au and Al-monolayer graphene, respectively, which are nearly 1.2 and 1.9 times larger than the 1910 RIU-1sensitivity of the conventional LRSPR sensor(LRSPP sensor). Moreover, it is demonstrated that the PWG-coupled LRSPP biosensor is applicable to the sensing medium,with refractive index in the vicinity of 1.34.

关键词： RIU Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes

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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China Life Sciences 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of Medicine The University of Hong Kong School of Pharmacy Southwest Medical University Education Ministry Key Laboratory of Medical Electrophysiology Sichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical University College of Food Science South China Agricultural University State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center

The spreading of cancer cells from the primary tumor site to other parts of the body, known as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC). Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70% of TNBC patients. EGFR is crucial for promoting tumor metastasis and associated with poor ***, it is vital to identify effective therapeutic strategies targeting EGFR inhibition. Ononin, an isoflavonoid found in various plants,such as clover and soybeans, has been shown to have anticancer properties in several cancers. In the present study, we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular pathways. We used various assays, including cell viability,colony formation, Transwell, wound healing, ELISA, Western blotting, and staining techniques, to achieve this objective. The results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis, as evidenced by the cell viability assay, colony formation assay, and expression of apoptosis markers, and reduced the metastatic capabilities of TNBC cells. These effects were achieved through the direct suppression of cell adhesion, invasiveness and motility. Furthermore, in TNBC xenograft lung metastatic models, ononin treatment significantly reduced tumor growth and lung metastasis. Additionally, ononin reversed the epithelial-mesenchymal transition(EMT) by downregulating the expression of EMT markers and matrix metalloproteinases, as confirmed by Western blot analysis. Furthermore, ononin treatment reduced EGFR phosphorylation and suppressed the PI3K, Akt, and m TOR signaling pathways, which was further confirmed using EGFR agonists or inhibitors. Importantly, ononin treatment did not exert any toxic effects on liver or kidney function. In conclusion, our findings suggest that ononin is a safe and potentially therapeutic treatment

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

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改良胫骨近端和远端截骨搬移治疗糖尿病足的临床研究

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中国中医骨伤科杂志 2024年第2期32卷 44-49,55页

作者：杨黎黎王庆甫王元利丁小方徐海林周海涛纪坤羽梁欢杨朋杰北京市隆福医院北京100010 北京中医药大学第三附属医院北京大学人民医院

目的:比较改良胫骨近端和远端截骨搬移与改良单纯近端截骨搬移治疗Wagner 3/4级糖尿病足的临床疗效。方法:2021年1月至2023年1月收治的40例Wagner 3/4级糖尿病足患者,应用随机数字表法随机纳入观察组(一般治疗+改良胫骨近端和远端截骨搬... 详细信息

目的:比较改良胫骨近端和远端截骨搬移与改良单纯近端截骨搬移治疗Wagner 3/4级糖尿病足的临床疗效。方法:2021年1月至2023年1月收治的40例Wagner 3/4级糖尿病足患者,应用随机数字表法随机纳入观察组(一般治疗+改良胫骨近端和远端截骨搬运)与对照组(一般治疗+改良单纯近端截骨搬移),每组各20例。观察两组患者经相应治疗后的密歇根神经病变筛查仪(MNSI)评分、疼痛视觉模拟量表(VAS)评分、踝肱指数(ABI)、经皮氧分压、足踝部皮温。观察组男12例,女8例;年龄为59~88岁,平均为(72.6±6.4)岁;体重指数(BMI)为22~35 kg/m^(2),平均为(23.4±2.1)kg/m^(2)。术前足背皮肤温度为(27.50±1.08)℃,VAS评分为(7.40±0.36)分,踝肱指数为0.27±0.47,经皮氧分压为(28.4±2.14)mmHg。对照组男11例,女9例;年龄为55~85岁,平均为(76.2±6.9)岁;体重指数为22~36 kg/m^(2),平均为(25.8±1.7)kg/m^(2)。术前足背皮肤温度为(28.10±1.02)℃,VAS评分为(6.80±0.33)分,踝肱指数为0.30±0.64,经皮氧分压为(27.90±2.01)mmHg。两组患者术前基线资料及临床数据差异无统计学意义(P>0.05)。结果:观察组MNSI评分、踝肱指数、经皮氧分压、足踝部皮温高于对照组,VAS评分低于对照组,差异有统计学意义(P<0.05)。结论:改良胫骨近端和远端截骨搬移治疗Wagner 3/4级糖尿病足临床疗效优于改良单纯近端截骨搬移,促进周围血管及周围神经恢复较改良单纯近端截骨搬移快,对于治疗Wagner 3/4级重度糖尿病足患者保肢成功率高,是治疗重度糖尿病足溃疡的理想方法之一。

关键词：胫骨近端和远端截骨搬移糖尿病足

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Metallic resurfacing hemiarthroplasty of the first metatarsophalangeal joint combined with first metatarsal osteotomy for the treatment of hallux rigidus with hallux valgus in China

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Chinese Medical Journal 2014年第11期127卷 2186-2188页

作者： Jin Kaiji Wang Yuanli Fu Zhongguo An Shuai xu hailin Jiang Baoguo Department of Orthopedics & Trauma Peking University People's Hospital Beijing 100044 China Department of Orthopedics Peking Longfu Hospital Beijing 100010 China

Hallux rigidus occurs mainly at the first metatarsophalangeal （MTP） joint,causing localized pain and degenerative arthritis.1 This condition frequently occurs together with hallux valgus and is difficult to *** hallux rigidus affecting only one joint,the treatment choices include articular debridement,resection arthroplasty,prosthetic arthroplasty,and arthrodesis,depending on the degree of arthritis.

关键词： hallux rigidus hallux valgus metallic resurfacing hemiarthroplasty metatarsophalangeal joint

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