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Identification of 3-ketocapnine reductase activity within the human microbiota

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mLife 2024年第2期3卷 307-316页

作者： Xiaotong Wu Lukuan Hou haili zhang Yi Ma Jufang Wang Mingwei Cai Xiaoyu Tang School of Biology and Biological Engineering South China University of TechnologyGuangzhouChina Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhenChina College of Chemistry and Pharmacy Northwest A&F UniversityYanglingChina

The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing ***,the enzymes responsible for their biosynthesis remain largely *** this study,we identified and verified the role of 3-ketocapnine reductase,the third-step enzyme,in the four-step conversion of L-phosphoserine into sulfobacin B both in vivo and in *** finding builds upon our previous research into sulfonolipid biosynthesis,which focused on the vaginal bacterium Chryseobacterium gleum DSM 16776 and the gut bacterium Alistipes finegoldii DSM *** comprehensive gene mapping,we demonstrate the widespread presence of potential sulfonolipid biosynthetic genes across diverse bacterial species inhabiting various regions of the human *** findings shed light on the prevalence of sulfonolipid-like metabolites within the human microbiota,suggesting a potential role for these lipid molecules in influencing the intricate biointeractions within the complex microbial ecosystem of the human body.

关键词： 3-ketocapnine reductase capnines human microbiota sulfonolipids

Design and technology review of the solar X-ray detector onboard the Macao Science Satellite-1B

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Science China Technological Sciences 2024年

作者： ZUO FuChang SHI YongQiang CHEN JianWu zhang XiaoPing FU WeiChun CHANG Ye GAI FangQin LIU SiYuan XIONG Yan zhang haili SUN Yan WANG Li ZHENG Ran LI LianSheng MEI ZhiWu HUANG He ZHA GangQiang zhang KeKe Space Optoelectronic Measurement and Perception Lab. Beijing Institute of Control Engineering State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology School of Astronautics Northwestern Polytechnical University Key Laboratory of Radiation Detection Materials and Devices Northwestern Polytechnical University Research and Development Institute of Northwestern Polytechnical University in Shenzhen

On May 21, 2023, the Macao Science Satellite-1B(MSS-1B), a low-inclination, low-latitude, and high-precision scientific exploration satellite for geomagnetic fields and space environments, was successfully launched. The solar X-ray detector(SXD),one of the two major scientific payloads onboard the MSS-1B, has obtained a large amount of solar X-ray radiation data, which reveals the distribution law of the magnetic field in the low Earth orbit, as well as the coupling law of the Earth's magnetic field and the solar radiation and energy particle distributions. First, the overall design of the multi-detection-unit, broad-energy-range,small-volume, and low-power SXD was implemented to achieve the scientific objectives of the mission. Second, the technical indicators of the instrument were decomposed into various components, and the key technologies, such as collimator, processing circuit, thermal, and payload dataset designs, were reviewed. Third, the backgrounds, including electronic noise, cosmic diffuse X-ray background, and high-energy background in the Earth's radiation belts in and out of the field of view, were analyzed for the instrument. Then, the ground calibrations of the energy response, detection efficiency, and temperature-dependent peak drift of the SXD flight model were conducted. Finally, the in-orbit temperature, energy spectrum data, background, and solar flare process observation of the instrument in the in-orbit test stage are presented, verifying the instrument design, analysis, and ground calibration, providing a foundation for obtaining accurate solar X-ray radiation data, and achieving the scientific objectives of the satellite.

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宜昌紫云地方铁路提升沿线物流服务能力对策探讨

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铁道经济研究 2024年第1期 47-52页

作者：张海丽中铁工程设计咨询集团有限公司线站院北京100055

为推动区域经济高质量发展,紫云铁路亟需提升物流服务能力,加快提高运营效益。在分析紫云铁路基础设施、物流服务区域、货运量完成情况等现状的基础上,剖析紫云铁路物流服务能力存在货运设施设备有待补强、运营效益有待提高等问题,通过... 详细信息

为推动区域经济高质量发展,紫云铁路亟需提升物流服务能力,加快提高运营效益。在分析紫云铁路基础设施、物流服务区域、货运量完成情况等现状的基础上,剖析紫云铁路物流服务能力存在货运设施设备有待补强、运营效益有待提高等问题,通过借鉴国内外铁路发展现代物流相关经验启示,研究提出紫云铁路提升物流服务能力对策,即:既有货运设施物流化补强改造、积极拓展铁路物流市场、做强铁水多式联运、采用HXN系列大功率内燃机车、提升紫云铁路综合效益等,促进紫云铁路更好地服务沿线工业园区及港区发展需要。

关键词：宜昌紫云铁路地方铁路工业园区物流服务能力运营效益提升对策

Combining microbial and chemical syntheses for the production of complex naturalproducts

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Chinese Journal of Natural Medicines 2022年第10期20卷 729-736页

作者： zhang haili TANG Xiaoyu Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China

Nature,a rich source of bioactive natural products,serves as a massive pool of drug candidates for the pharmaceutical ***,the supply of these structurally complex chemicals is costly as most of the natural products are scarce in nature,thus requiring de novo *** supply chain issue hinders the development of novel therapeutic agents from natural *** synthesis,based on the expression of biosynthetic genes in a suitable microbial host to produce certain chemicals,is a sustainable strategy to produce complex natural ***,this strategy requires gaining insights into the biosynthesis of target *** natural products are biosynthetically unknown or not fully elucidated;thus,the sole application of microbial synthesis strategy to produce a given molecule is *** this review,we highlight a strategy that combines microbial and chemical syntheses to tackle the supply chain issue in developing drugs from natural *** believe this strategy can revive the drug development pipeline for natural products.

关键词： Microbial Chemical syntheses Biosynthesis Brasilicardins

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基于聚酰亚胺的柔性湿度传感器制备及研究

仪表技术与传感器 2024年第4期 11-18,47页

作者：张海力谢光忠刘太君代静宁波大学信息科学与工程学院浙江纺织服装职业技术学院物联网应用技术研究院电子科技大学光电科学与工程学院

文中以聚酰胺酸(PAA)为前驱体,通过热处理工艺可得聚酰亚胺(PI)薄膜,添加氧化石墨烯(GO)合成PI/GO复合薄膜及后续电极制备得到基于聚酰亚胺的平行板电容式柔性湿度传感器。在此基础上深入研究了叉指电极式和平行板式构型、PAA旋涂转速、... 详细信息

文中以聚酰胺酸(PAA)为前驱体,通过热处理工艺可得聚酰亚胺(PI)薄膜,添加氧化石墨烯(GO)合成PI/GO复合薄膜及后续电极制备得到基于聚酰亚胺的平行板电容式柔性湿度传感器。在此基础上深入研究了叉指电极式和平行板式构型、PAA旋涂转速、PAA酰亚胺化温度、GO喷涂量对湿度传感器性能的影响,最终得到的湿度传感器具有良好重复性、快速的响应恢复时间,最大湿滞仅为3.8%RH,且具有优异的柔性性能,在可穿戴柔性电子器件领域具有广泛的应用前景。

关键词：柔性湿度传感器聚酰亚胺(PI) 氧化石墨烯(GO) PI/GO复合薄膜平行板电容结构湿敏特性

Advance in Structural Classification and Stability Study of Superamphiphobic Surfaces

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Journal of Bionic Engineering 2023年第1期20卷 366-389页

作者： haili zhang Deke Li Jinxia Huang Zhiguang Guo Weiming Liu Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science and Engineering and Hubei Key Laboratory of Polymer MaterialsHubei UniversityWuhan430062China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China School of Materials Engineering Lanzhou Institute of TechnologyLanzhou730050China

Superamphiphobic surfaces have great potential applications in flame resistance,anti-icing,self-cleaning,anti-adhesion,micro-flow control and so ***,the surface durability is poor owing to the limitation of design *** recent years,a lot of efforts have been carried out on the morphology,structure,and stability of superamphiphobic surfaces,resulting in significant improvement in their surface superwetting *** this review,we present a brief classification of the morphological types of superamphiphobic surfaces and summary of the recent progress of researches on the stability of superamphiphobic *** testing methods of mechanical and chemical stability are listed in the article,together with the characteristic results,to provide a better and more detailed understanding of the current research status on superamphiphobic surface stability,which will be of considerable importance as a reference guide for our future *** course,there are still some issues that need to be addressed for the application of superamphiphobic surfaces at large scale,and this is where our future researches will be ***,we discuss the challenges as well as the prospects in the study of superamphiphobic surfaces.

关键词： Superamphiphobicity Structure Morphology Stability

Harnessing nature's biosynthetic capacity to facilitate total synthesis

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National Science Review 2022年第11期9卷 16-18页

作者： haili zhang Ge Liao Xiaozhou Luo Xiaoyu Tang Institute of Chemical Biology Shenzhen Bay Laboratory Center for Synthetic Biochemistry Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences

Natural products (NPs) have long piqued the interests of chemists due to their structural complexity. More importantly, evolution has conferred NPs with the ability to interact with biological macromolecules (such as nucleic acids, proteins, carbohydrates and lipids), making them privileged scaffolds for drug discovery. Until now,

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基于GRU神经网络的恒温晶振频率漂移预测

电子器件 2024年第2期47卷 502-508页

作者：王彬晏学成张海利刘岳巍石家庄铁道大学电气与电子工程学院河北石家庄050043 河北远东通信系统工程有限公司河北石家庄050200

恒温晶振作为新时代5G通信系统的重要器件,其频率稳定性相当重要,准确预测恒温晶振频率漂移可以提高系统工作状态的安全性与可靠性。为进一步提高频率漂移预测精度,满足5G通信系统需求,提出了一种基于门控循环单元(GRU)神经网络的晶振... 详细信息

恒温晶振作为新时代5G通信系统的重要器件,其频率稳定性相当重要,准确预测恒温晶振频率漂移可以提高系统工作状态的安全性与可靠性。为进一步提高频率漂移预测精度,满足5G通信系统需求,提出了一种基于门控循环单元(GRU)神经网络的晶振频率预测模型。该模型同时考虑温度、老化两种因素,并利用神经网络具有出色的自适应性与非线性泛化能力,学习恒温晶振频率漂移变化规律。最后以14 d实测数据为例进行研究分析,并与循环神经网络、长短时记忆神经网络做对比实验,以均方根误差、平均绝对误差、算法运行时间作为评价指标,结果表明GRU网络具有更高的预测精度、更快的运算速度。

关键词：恒温晶振频率漂移预测温度老化 GRU神经网络

Tm-2^2 Confers Different Resistance Responses against Tobacco mosaic virus Dependent on Its Expression Level

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Molecular Plant 2013年第3期6卷 971-974页

作者： haili zhang Jinping Zhao Shanshan Liu Da-Peng zhang Yule Liu MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 PR China

Dear Editor, The innate immunity system of plants can be summarized into two clades. The former clade, where resistant processes are mediated by pattern recognition receptors, is termed pathogen-associated molecular ... 详细信息

关键词： TOBACCO mosaic virus DISEASE resistance of plants TOBACCO mosaic disease