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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi chen yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Boosting the water gas shift reaction on Pt/CeO_(2)-based nanocatalysts by compositional modification: Support doping versus bimetallic alloying

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Journal of Energy Chemistry 2022年第4期31卷 241-249页

作者： Kun yuan Xiao-chen Sun hai-Jing Yin Liang Zhou hai-Chao Liu Chun-Hua Yan Ya-Wen Zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The water gas shift reaction is of vital significance for the generation and transition of energy due to the application in hydrogen production and industries such as ammonia synthesis and fuel *** influence of support doping and bimetallic alloying on the catalytic performance of Pt/Ce O_(2)-based nanocatalysts in water gas shift reaction was reported in this *** lanthanide ions and 3d transition metals were respectively introduced into the Ce O_(2)support or Pt to form Pt/Ce O_(2):Ln(Ln=La,Nd,Gd,Tb,Yb)and Pt M/Ce O_(2)(M=Fe,Co,Ni)*** sample of Pt/Ce O_(2):Tb showed the highest activity(TOF at 200℃=0.051 s^(-1))among the Pt/Ce O_(2):Ln and the undoped Pt/Ce O_(2)***,the sample of Pt Fe/Ce O_(2)exhibited the highest activity(TOF at 200℃=0.12 s^(-1))among Pt M/Ce O_(2)*** results of the multiple characterizations indicated that the catalytic activity of Pt/Ce O_(2):Ln catalysts was closely correlated with the amount of oxygen vacancies in doped ceria ***,the different activity of Pt M/Ce O_(2)bimetallic catalysts was owing to the various Pt oxidation states of the bimetals dispersed on *** study of the reaction pathway indicated that both the samples of Pt/Ce O_(2)and Pt/Ce O_(2):Tb catalyzed the reaction through the formate pathway,and the enhanced activity of the latter derived from the increased concentration of oxygen vacancies along with promoted water *** for the sample of Pt Fe/Ce O_(2),its catalytic mechanism was the carboxyl route with a higher reaction rate due to the moderate valence of Pt along with improved CO activation.

关键词： Pt/CeO_(2)catalysts Water–gas shift reaction Support doping Bimetallic alloying

Uncertainty of an automatic system for counting alpha tracks on CR-39

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Nuclear Science and Techniques 2017年第11期28卷 236-241页

作者： Dun-Huang Fan Wei-hai Zhuo Bo chen Wei-yuan Zhang Institute of Radiation Medicine Fudan UniversityShanghai 200032 China

For accurate counting of alpha tracks on the polyallyl diglycol carbonate of CR-39-type track detectors,the size distributions of both artifact tracks and alpha tracks were investigated with an automatic counting system. At the same temperature and etchant concentration, the numbers and sizes of alpha tracks changed significantly with the etching time, and the artifact track changes were smaller. At the etching time of 5 h, the sizes of alpha tracks were evidently larger than those of the artifact tracks, and the deviation of its size distribution was much smaller than those of longer etching time. Based on the size distribution of alpha tracks etched for 5 h, the overlap effect and uncertainty of overlap correction were studied by the Monte Carlo simulations for different track densities. It was found that the counting uncertainty of the system could be less than 6% in a density range of 10–160 tracks mm^(-2) after taking the overlap correction into account.

关键词： Uncertainty Track counting CR-39 Etching Overlap

ShadowEth： Private Smart Contract on Public Blockchain

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Journal of Computer Science & Technology 2018年第3期33卷 542-556页

作者： Rui yuan Yu-Bin Xia hai-Bo chen Bin-Yu Zang Jan Xie Institute of Parallel and Distributed Systems Shanghai Jiao Tong University Shanghai 200240 China Cryptape Inc. Hangzhou 310007 China

Blockchain is becoming popular as a distributed and reliable ledger which allows distrustful parties to transact safely without trusting third parties. Emerging blockchain systems like Ethereum support smart contracts where miners can run arbitrary user-defined programs. However, one of the biggest concerns about the blockchain and the smart contract is privacy, since all the transactions on the chain are exposed to the public. In this paper, we present ShadowEth, a system that leverages hardware enclave to ensure the confidentiality of smart contracts while keeping the integrity and availability based on existing public blockchains like Ethereum. ShadowEth establishes a confidential and secure platform protected by trusted execution environment （TEE） off the public blockchain for the execution and storage of private contracts. It only puts the process of verification on the blockchain. We provide a design of our system including a protocol of the cryptographic communication and verification and show the applicability and feasibility of ShadowEth by various case studies. We implement a prototype using the Intel SGX on the Ethereum network and analyze the security and availability of the system.

关键词： blockchain smart contract privacy trusted execution environment hardware-enclave

Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

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Chinese Journal of Natural Medicines 2018年第2期16卷 131-138页

作者： FU Qiang YANG Min MA Yu chen Jiang yuan hai-Mei College of Pharmacy and Biological Engineering Chengdu University

Four new triterpene saponins, mandshunosides F–I(1–4), together with five known compounds(5–9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin(3–9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%– 64.6% at 50 μmol·L^(-1), whereas monodesmosidic saponins with a free carboxyl group at C-28(1 and 2) showed potent inhibitory activities with IC_(50) values being 12.7 and 8.3 μmol·L^(-1), respectively.

关键词： Clematis mandshurica Triterpene saponins Mandshunosides F—I NO production

Osteochondral Integrated Scaffolds with Gradient Structure by 3D Printing Forming

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International Journal of Automation and computing 2015年第2期12卷 220-228页

作者： Wei-Hua chen yuan-yuan Liu Fu-Hua Zhang Yong-Ze Yu hai-Ping chen Qing-Xi Hu Rapid Manufacturing Engineering Center Shanghai University

Recently in the area of biological manufacturing and rapid prototyping manufacturing, the bone scaffolds based on the additive manufacturing in repairing bone defects have been paid more and more attention. In the process of preparation, path planning directly affects the structure, performance as well as the final bone cell culture conditions. Due to the special natural bone scaffold structural characteristic, the traditional rapid prototyping(RP) path planning is not fully suitable for the preparation of bone scaffolds. In this paper, based on the 3D printing extrusion forming technology, a method of path planning for osteochondral integrated scaffolds with gradient structure is put forward, which provides a theoretical basis for bone-scaffold modeling and practical preparation. The implementation of the path planning processing system makes it possible to process data automatically from the initial stereo lithography(STL) model of the actual bone defect part by computer X-ray tomography technique(CT) scan or modeling,to generate the path code and to generate the final machining information after post-processing. This work provides some guidelines for independent research and development of automation equipment for biological manufacturing preparation and software *** experiment and test results have verified the validity of the path planning method and the good properties of the bone scaffolds with gradient structures.

关键词： 3D printing biological bone-scaffold path planning additive manufacturing tissue engineering.

Bimetal nanoparticles hybridized with carbon nanotube boosting bifunctional oxygen electrocatalytic performance

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Rare Metals 2022年第8期41卷 2616-2623页

作者： chen Sun Yong-Jie Zhao Xuan-Yi yuan Jing-Bo Li hai-Bo Jin Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of Opto-Electronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing100872China

Developing bifunctional oxygen catalysts with high efficiency and low cost to replace platinum-group metal catalysts commonly utilized in metal-air batteries is critically *** this article,a convenient method to synthesis NiFe nanoparticles hybridized with N-doped carbon nanotube(NiFe@N-CNTs)is *** performance analysis indicates that Ni_(x)Fc_(1-x)@N-CNTs offers favorable oxygen reduction reaction(ORR)kinetics(onset potential(E_(onset))is 0.87 V and half-wave potential(E_(1/2))is0.84 V),together with excellent oxygen evolution reaction(OER)performance(an overpotential of 270 mV to drive10 mA·cm^(-2)).Contributed by the synergetic effect between NiFe alloy and N-CNTs,when being utilized as air cathode,rechargeable Zn-air batteries present superior cycling stability for over 150 *** research provides a universal strategy to synthesize the hybrids of intertwined carbon nanotube matrix loaded with alloy nanoparticles.

关键词： NiFe alloy Oxygen evolution reaction(OER) Oxygen reduction reaction(ORR) Zn-air batteries

Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design

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Virologica Sinica 2020年第4期35卷 445-454页

作者： Shuai yuan Kaiyue Fan Zhonghao chen Yao Sun hai Hou Ling Zhu CAS Key Laboratory of Infection and Immunity CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory for Space Bioscience and Space Biotechnology School of Life SciencesNorthwestern Polytechnical UniversityXi’an 710072China Beijing Forestry University No.35 Tsinghua East RoadHaidian DistrictBeijing 100083China Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072China Department of Molecular Biophysics and Biochemistry Yale UniversityNew HavenCT 06511USA

Human rhinoviruses(HRVs)are the predominant infectious agents for the common cold *** HRV-C species cause severe illnesses in children and are closely related to acute exacerbations of asthma.3C protease,a highly conserved enzyme,cleaves the viral polyprotein during replication and assists the virus in escaping the host immune *** key roles make 3C protease an important drug target.A few structures of 3Cs complexed with an irreversible inhibitor rupintrivir have been *** structures shed light on the determinants of drug *** we describe the structures of HRV-C153C in free and inhibitor-bound *** volume-decreased S1'subsite and half-closed S2 subsite,which were thought to be unique features of enterovirus A 3C proteases,appear in the HRV-C 3C *** assumes an“intermediate”conformation in the complex,which might open up additional avenues for the design of potent antiviral *** of the features of the three-dimensional structures and the amino acid sequences of 3C proteases suggest new applications for existing drugs.

关键词： Human rhinoviruses(HRVs) 3C protease Three-dimensional structures Inhibitors Rupintrivir(AG7088)

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying chen Meng Tian cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Removal of noises from electromagnetic radiation of coal or rock with EEMD-adaptive morphological filter

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Journal of Coal Science & Engineering(China) 2012年第3期18卷 330-336页

作者： chen Shi-hai WANG En-yuan School of Information and Electrical Engineering China University of Mining and TechnologyXuzhou 221008China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221008China Faculty of Safety Engineering China University of Mining and TechnologyXuzhou 221008China

The electromagnetic radiation （EMR） signal collected by monitoring system during coal or rock dynamic disaster may be interferred easily by electromagnetic noises in mines. The noises have a direct influence on the recognition and analysis of the EMR signal features during the disaster. With the aim of removing these noises, an ensemble empirical mode decomposition （EEMD） adaptive morphological filter was proposed. From the result of the simulation and the experiment, it is shown that the method can restrain the random noise and white Gaussian noise mixed with EMR signal effectively. The filter is highly useful for improving the robustness of the coal or rock dynamic disaster monitoring system.

关键词： coal or rock dynamic disaster electromagnetic radiation EEMD morphological filter denoising