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Decoding m^(6)A mRNA methylation by reader proteins in liver diseases

Genes & Diseases 2024年第2期11卷 711-726页

作者： Lijiao Sun Xin Chen Sai Zhu Jianan wang Shaoxi Diao jinyu liu jinjin Xu Xiaofeng Li Yingyin Sun Cheng Huang Xiaoming Meng Xiongwen Lv Jun Li Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical UniversityHefeiAnhui 230032China The Key Laboratory of Anti-inflammatory and Immune Medicines Anhui Medical UniversityMinistry of EducationHefeiAnhui 230032China Institute for Liver Diseases of Anhui Medical University ILD-AMUAnhui Medical UniversityHefeiAnhui 230032China Department of Nephropathy The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032China

N6-methyladenosine(m^(6)A)is a dynamic and reversible epigenetic *** the most prevalent internal post-transcriptional modification in eukaryotic RNA,it participates in the regulation of gene expression through various mechanisms,such as mRNA splicing,nuclear export,localization,translation efficiency,mRNA stability,and structural *** involvement of m^(6)A in the regulation of gene expression depends on the specific recognition of m^(6)A-modified RNA by reader *** the pathogenesis and treatment of liver disease,studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m^(6)A modification,in which abnormal expression of reader proteins determines the fate of these gene *** this review,we introduce m^(6)A readers,summarize the recognition and regulatory mechanisms of m^(6)A readers on mRNA,and focus on the biological functions and mechanisms of m^(6)A readers in liver cancer,viral hepatitis,non-alcoholic fatty liver disease(NAFLD),hepatic fibrosis(HF),acute liver injury(ALI),and other liver *** information is expected to be of high value to researchers deciphering the links between m^(6)A readers and human liver diseases.

关键词： IGF2BPs Liver diseases m^(6)A modification m^(6)A reader mRNA metabolism YTH domain protein

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时效温度对SiC/Al-Zn-Mg-Cu复合材料时效析出行为的影响

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金属学报 2024年第8期60卷 1043-1054页

作者：张冉朱士泽刘振宇柯于斌王东肖伯律马宗义中国科学院金属研究所师昌绪先进材料创新中心沈阳110016 中国科学技术大学材料科学与工程学院沈阳110016 散裂中子源科学中心东莞523803 中国科学院高能物理研究所北京100049

SiC/Al-Zn-Mg-Cu复合材料力学性能的提升需要充分理解SiC颗粒的添加对Al基体时效析出行为的影响。但由于受到表征手段的限制,其内在机制尚不明确。本工作结合原位小角中子散射、透射电子显微术和拉伸实验等手段,研究了时效温度(100和160... 详细信息

SiC/Al-Zn-Mg-Cu复合材料力学性能的提升需要充分理解SiC颗粒的添加对Al基体时效析出行为的影响。但由于受到表征手段的限制,其内在机制尚不明确。本工作结合原位小角中子散射、透射电子显微术和拉伸实验等手段,研究了时效温度(100和160℃)对15%SiC(体积分数)增强Al-7.5Zn-1.8Mg-1.7Cu(质量分数,%)复合材料时效析出行为与沉淀强化机制的影响,并与Al-7.5Zn-1.8Mg-1.7Cu合金进行了对比。结果表明,100℃时效时,随着时效时间由0.5 h延长至3 h,复合材料中的析出相由GPI区演变为GPI区+GPII区,且尺寸明显增加。但由于该温度下时效动力学缓慢,析出相的体积分数仅略有增加。析出相尺寸和体积分数的增加均可以增大位错切过析出相的阻力,从而提升复合材料的沉淀强化能力。160℃时效温度下时效动力学加速,复合材料中析出相的尺寸和体积分数均随时效时间的延长而增加,析出相类型也由时效0.5 h的GPII区+η'相演变为时效3 h的η'相+η相。此时的沉淀强化机制以绕过型为主,尽管析出相体积分数的增加有利于提高复合材料的强度,但其尺寸的增大以及强化能力较差的平衡相η相的出现却会削弱强化效果,因此复合材料的屈服强度随时效时间的延长仅有小幅提高。与Al-7.5Zn-1.8Mg-1.7Cu合金相比,100与160℃时效3 h后复合材料的屈服强度均降低,但相关机制并不相同。100℃时效时2种材料中析出相的类型和尺寸大致相同,但复合材料由于SiC/Al界面反应消耗Mg导致析出相的体积分数减少,从而使得沉淀强化能力减弱。160℃时效时加速的时效动力学补偿了Mg消耗引起的析出相体积分数的减少,但复合材料中较低的空位浓度导致析出相粗化且平衡相η相占比增加,这也会削弱其沉淀强化能力。

关键词： SiC/Al-Zn-Mg-Cu复合材料时效析出行为强化机制小角中子散射

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交通基础设施建设、国内市场一体化与乡村振兴——基于市场准入视角的研究

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山西财经大学学报 2024年第5期46卷 16-27页

作者：王彩艳刘修岩东南大学经济管理学院江苏南京211189 兰州理工大学经济管理学院甘肃兰州730050 东南大学国家发展与政策研究院江苏南京211189

通过构建市场可达性指标——市场准入,定量研究交通基础设施改善引致的国内市场一体化对乡村振兴的影响。研究发现,交通基础设施改善引致的国内市场一体化水平提高显著促进了乡村振兴,并且铁路比公路对乡村振兴的促进作用更大,来自省内... 详细信息

通过构建市场可达性指标——市场准入,定量研究交通基础设施改善引致的国内市场一体化对乡村振兴的影响。研究发现,交通基础设施改善引致的国内市场一体化水平提高显著促进了乡村振兴,并且铁路比公路对乡村振兴的促进作用更大,来自省内的市场一体化水平提高比来自国内其他地方的市场一体化水平提高对乡村振兴的促进作用更大。进一步研究发现,在国内市场一体化发展的初级、中级和高级阶段,交通基础设施改善分别通过促进城乡人口流动、推动产业结构升级和降低城市间行政壁垒推动了乡村振兴。

关键词：交通基础设施改善国内市场一体化乡村振兴市场准入城乡市场一体化

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中国未破裂颅内动脉瘤临床管理指南(2024版)解读

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中华医学杂志 2024年第21期104卷 1903-1906页

作者：赵兵刘清源王硕上海交通大学医学院附属仁济医院神经外科上海200127 首都医科大学附属北京天坛医院神经外科北京100070

随着脑血管影像技术的普及,未破裂颅内动脉瘤(UIA)临床检出率越来越高。UIA破裂风险低,但是一旦破裂,严重影响人类健康。UIA治疗存在较大争议,引起临床广泛关注。中华医学会神经外科学分会、中国卒中学会脑血管外科分会、国家神经系统... 详细信息

随着脑血管影像技术的普及,未破裂颅内动脉瘤(UIA)临床检出率越来越高。UIA破裂风险低,但是一旦破裂,严重影响人类健康。UIA治疗存在较大争议,引起临床广泛关注。中华医学会神经外科学分会、中国卒中学会脑血管外科分会、国家神经系统疾病医学中心与国家神经系统疾病临床研究中心联合制订《中国未破裂颅内动脉瘤临床管理指南(2024版)》,该指南采用模块化形式,突出推荐意见,并指出当前研究不足及未来研究方向,从UIA流行病学、人群筛查、临床影像诊断、破裂风险评估、治疗决策及选择,术后随访及长期管理等方面提供了全面的临床管理意见。将证据来源分为中国人群和其他人群,有助于指导国内临床实践。

关键词：颅内动脉瘤指南破裂风险治疗临床管理

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Cratonic Strike-Slip faults in the Southwest Ordos Basin(Central China)， and Their Influence on Hydrocarbon Accumulation

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Journal of Earth Science 2024年

作者： Zhao wang Lei Huang Chiyang liu faqi He Huichong Jia Fubin wang Peng yang Fei yang Xiaowei Li Sixuan Wu State Key Laboratory of Continental Dynamics， Northwest University Institute of Oil and Gas Basin， Northwest University Xi'an Sinopec North China Oil and Gas Branch Geology and Geophysics Program， Missouri University of Science and Technology Exploration and Development Research Institute， PetroChina Southwest Oil & Gasfield Company

Cratonic strike-slip fault， despite its potentially significant influence on hydrocarbon accumulation， has attracted limited attention. This study investigates the geometry and kinematics of the cratonic strike-slip faults newly identified within the southwest Ordos Basin， Central China， based on 3D seismic reflection data. We recognized three dominant sets of faults with strike-slip nature trending respectively in NW， ENE， and N–S directions in the study area. These faults exhibit a stratified style characterized by distinct trends across various strata， with ENE-trending faults in the Mesozoic strata (Area A)， N-S-trending faults in the Paleozoic strata， and vertically discontinuous structures in the Mesozoic and Paleozoic strata (NW-trending Yudu fault zone and ENE-trending Yulinzi and Zaosheng fault zones). The contrasting kinematics of strike-slip faults observed in deep and shallow layers further confirm such fault stratification， suggesting isolated fault evolution within respective layers. The quantified fault parameters obtained from seismic reflection data， including length， width and displacement， suggest that these cratonic strike-slip faults in the Ordos Basin are immature. Comparisons with strike-slip faults in other cratonic basins and active tectonic settings suggest that the strike-slip faults within the Ordos Basin are representative of cratonic strike-slip faults， characterized by low maturity and a stratified faulting style， and they have special propagation mechanism (preferentially occurring in the shallow strata of the interior of the basin). Moreover， these fault characteristics have dual impacts on petroleum accumulation in the southwest Ordos Basin. The low faulty maturity makes the fault zone a special hydrocarbon reservoir (fault-fracture volume) in tight sandstone， while the stratified faulting style vertically separates the Mesozoic and Paleozoic petroleum systems in the southwest Ordos Basin. Our findings therefore contribute significa

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Basic research and industrial development status of suancai in Northeast China: History， microflora diversity， processing technology， nutrition and safety

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Food Science and Human Wellness 2024年

作者： Qianqian wang jingbo yang Yuqi wang Meiru Xie Xiaoxi Qi Ramnarain Ramakrishna Libo liu Wenkui Guo Guofang Zhang Chun Li Key Laboratory of dairy Science， Ministry of Education， College of Food Science， Northeast Agricultural University Department of Plant Sciences， North Dakota State University Heilongjiang Institute of Green Food Science

Suancai has a lengthy history and a wide range of categories， which has some influence on the pickled diet culture around the world. Suancai production is transitioning to a large-scale， standardized production due to the growth of the market. It has a unique flavor and is rich in nutrients， and its abundance of free amino acids， vitamins and phenolics has many positive effects on the human body. This review gives the types and history of suancai， as well as its impact on the world's pickled culture. The changes in nutritional composition and flavor of suancai during fermentation are summarized. It presented the production technology and influencing factors of the northeast suancai， examined the quality and safety issues in suancai， and put forth some ideas and opinions on the standardization development of the suancai industry. It also summarized the geographic distribution and flora diversity of pickles around the world. In order to provide some knowledge and guidance for the promotion of modern industrial production in the suancai industry.

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中国石油陆上中-高成熟度页岩油勘探现状、进展与未来思考

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石油与天然气地质 2024年第2期45卷 327-340页

作者：赵喆白斌刘畅王岚周海燕刘羽汐中国石油勘探开发研究院北京100083 多资源协同陆相页岩油绿色开采全国重点实验室黑龙江大庆163712

中国石油天然气集团公司(简称中国石油)矿权区陆相页岩油地质资源丰富,“十三五”资源评价,中国石油陆上中-高熟页岩油(简称页岩油)地质资源量201×108t,占中国页岩油地质资源总量的71%。鄂尔多斯盆地延长组7段、松辽盆地青山口组和准... 详细信息

中国石油天然气集团公司(简称中国石油)矿权区陆相页岩油地质资源丰富,“十三五”资源评价,中国石油陆上中-高熟页岩油(简称页岩油)地质资源量201×108t,占中国页岩油地质资源总量的71%。鄂尔多斯盆地延长组7段、松辽盆地青山口组和准噶尔盆地芦草沟组等重点层系的产量显著增长,中国石油页岩油年产量从2010年的2.5×10^(4)t增至2023年的391.6×10^(4)t,勘探潜力巨大。研究表明:近年来由于陆相不同类型页岩油具有地质特征非均质性强、富集高产因素明显差异的特点,其效益勘探存在地质认识与勘探技术的双重挑战。特别是:(1)夹层型页岩油虽在鄂尔多斯盆地长71+2亚段(延长组7段1+2亚段)实现规模勘探,但勘探靶体钻遇率变化大,深湖区细粒沉积体系研究薄弱,靶体空间展布刻画技术的准确性仍需提升;(2)混积型页岩油地层垂向厚度大、岩性频繁变化、发育多套地质甜点,在柴达木盆地、渤海湾盆地虽然实现了勘探突破,但垂向地质甜点产量差异明显,页岩油高产主控因素不清,主力靶体评价优选技术、方法仍需完善;(3)页岩型页岩油在松辽盆地青山口组实现了古龙页岩油勘探突破,但陆相湖盆不同类型页岩生、排烃差异明显,页岩原位滞留烃特征变化大,地质-工程一体化靶体评价技术、方法仍需深化研究。总体上中国石油页岩油勘探开发仍处于快速推进阶段,未来应:(1)加强淡水湖盆深湖区多类型砂体成因机制研究,实现薄层浊积砂体等夹层型页岩油效益勘探;(2)加强咸化湖盆富碳酸盐混积型页岩油源-储组合评价,优选主体靶体实现混积型页岩油高效勘探;(3)加强淡水、咸化湖盆优质源岩生、排烃差异性评价,优选最佳靶体,实现不同湖盆页岩型页岩油地质-工程一体化精细勘探。

关键词：理论技术进展靶体甜点评价勘探现状勘探规划陆相页岩油中国石油

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Seismic anisotropy and upper mantle dynamics in Alaska:A review of shear wave splitting analyses

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Earthquake Research Advances 2024年第2期4卷 72-81页

作者： Zhaofeng jin Yuchen yang Muhammad Ishaidir Siregar Zihao Mu S.M.Ariful Islam Qichao Zhao Dan wang fan Zhang Xugang yang Liwei Song School of Earth Sciences Northeast Petroleum UniversityDaqing163318China Department of Geoscience University of IndonesiaDepok16424Indonesia School of Computer and Information Technology Northeast Petroleum UniversityDaqing163318China Center for Earthquake Research and Information University of MemphisMemphis38152USA College of Environment and Civil Engineering Chengdu University of TechnologyChengdu610059China School of Petroleum Engineering China University of PetroleumQingdao266555China School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing163318China

Shear wave splitting(SWS)is regarded as the most effective geophysical method to delineate mantle flow fields by detecting seismic azimuthal anisotropy in the earth's upper mantle,especially in tectonically active regions such as subduction *** Aleutian-Alaska subduction zone has a convergence rate of approximately 50 mm/yr,with a trench length reaching nearly 2800 *** a long subduction zone has led to intensive continental deformation and numerous strong earthquakes in southern and central Alaska,while northern Alaska is relatively *** sharp contrast makes Alaska a favorable locale to investigate the impact of subduction on mantle ***,the uniqueness of this subduction zone,including the unusual subducting type,varying slab geometry,and atypical magmatic activity and composition,has intrigued the curiosity of many *** identify different sources of seismic anisotropy beneath the Alaska region and probe the influence of a geometrically varying subducting slab on mantle dynamics,extensive SWS analyses have been conducted in the past ***,the insufficient station and azimuthal coverage,especially in early studies,not only led to some conflicting results but also strongly limited the in-depth investigation of layered anisotropy and the estimation of anisotropy *** the completion of the Transportable Array project in Alaska,recent studies have revealed more detailed mantle structures and characteristics based on the dense station coverage and newly collected massive seismic *** this study,we review significant regional-and continental-scale SWS studies in the Alaska region and conclude the mantle flow fields therein,to understand how a geometrically varying subducting slab alters the regional mantle *** summarized mantle flow mechanisms are believed to be conducive to the understanding of seismic anisotropy patterns in other subduction zones with a complicated tectonic setting.

关键词： Seismic anisotropy Shear wave splitting Mantle flow Alaska subduction zone Slab

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Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 842-859页

作者： Bo-Tao Duan Xue-Kai Zhao yang-yang Cui De-Zheng liu Lin wang Lei Zhou Xing-Yuan Zhang Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

关键词： Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis

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Hierarchical learning of gastric cancer molecular subtypes by integrating multi-modal DNA-level omics data and clinical stratification

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Quantitative Biology 2024年第2期12卷 182-196页

作者： binyu yang Siying liu Jiemin Xie Xi Tang Pan Guan Yifan Zhu Xuemei liu Yunhui Xiong Zuli yang Weiyao Li Yonghua wang Wen Chen Qingjiao Li Li C.Xia Department of Statistics and Financial Mathematics School of MathematicsSouth China University of TechnologyGuangzhouChina School of Physics and Optoelectronics South China University of TechnologyGuangzhouChina Department of Pathology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Laboratory Medicine the Eighth Affiliated HospitalSun Yat-sen UniversityShenzhenChina

Molecular subtyping of gastric cancer(GC)aims to comprehend its genetic ***,the efficacy of current subtyping methods is hampered by their mixed use of molecular features,a lack of strategy optimization,and the limited availability of public GC *** is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and *** on TCGA subtypes,we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping(HCG),which employs gene mutations,copy number aberrations,and methylation patterns as *** incorporating the closely related esophageal adenocarcinomas dataset,we expanded the TCGA GC dataset for the training and testing of HCG(n=453).The optimization of HCG was achieved through three hierarchical strategies using Lasso-Logistic regression,evaluated by their overall the area under receiver operating characteristic curve(auROC),accuracy,F1 score,the area under precision-recall curve(auPRC)and their capability for clinical stratification using multivariate survival ***-specific DNA alteration biomarkers were discerned through difference tests based on HCG defined *** HCG classifier demonstrated superior performance in terms of overall auROC(0.95),accuracy(0.88),F1 score(0.87)and auPRC(0.86),significantly improving the clinical stratification of patients(overall p-value=0.032).Difference tests identified 25 subtype-specific DNA alterations,including a high mutation rate in the SYNE1,ITGB4,and COL22A1 genes for the MSI subtype,and hypermethylation of ALS2CL,KIAA0406,and RPRD1B genes for the EBV *** is an accurate and robust classifier for DNA-based GC molecular subtyping with highly predictive clinical stratification *** training and test datasets,along with the analysis programs of HCG,are accessible on the GitHub website(***/LabxSCUT).

关键词： DNA alterations gastric cancer hierarchical classification molecular subtyping multi-omics

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