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Chinese Chemical Letters 2010年第12期21卷 1482-1486页

作者： hai yan fu hai Long Wu Jin Fang Nie Yong Jie Yu Hong yan Zou Ru Qin Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China

A rapid,green and highly sensitive excitation-emission matrix（EEM） fluorescence method was proposed for analysis of irinotecan（CPT-11） in biological fluids including human plasma and urine samples of uncalibrated interferences with the aid of second-order *** to the serious spectral overlapping from biological matrices,the parallel factor analysis（PARAFAC） and the alternating normalization-weighted error（ANWE） have been recommended to perform directly calibration and overcome the problem which makes the traditional fluorospectrophotometer in *** results can be ***, performance of the proposed method was evaluated based on figures of merit and some statistical *** accuracy of both algorithms was validated by the elliptical joint confidence region（EJCR） *** precision and repeatability were also investigated by the relative standard deviations（RSDs） of intra-day and inter-day.

关键词： Irinotecan Biological fluids Excitation-emission matrix fluorescence PARAFAC ANWE

Influence of physical education on anxiety, depression, and selfesteem among college students

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World Journal of Psychiatry 2023年第12期13卷 1121-1132页

作者： hai-yan fu Jing Wang Jia-Xi Hu School of Physical Education Guangzhou Sport UniversityGuangzhou 510500Guangdong ProvinceChina

BACKGROUND Physical education is pivotal in our country’s education *** schools have notably enhanced the intensity of physical education in recent ***,the effects of physical education on students'anxiety,depression,and self-esteem levels,as well as their interrelations,remain *** with the domestic norms,SAS and SDS scores were higher,and SES scores were lower(P<0.05).Among the participants,210(43.93%)had PARS-3 scores below 20,94(19.67%)had scores of 20-42,and 174(36.40%)had scores above *** adjusting for daily sleep time,gender,being an only child,major,father’s educational background,mother’s educational background,and family residence,PARS-3 scores were independent influencing factors for anxiety,depression,and low self-esteem(P<0.05).The AUC of PARS-3 scores predicting anxiety,depression,and low self-esteem were 0.805(0.760-0.849),0.799(0.755-0.843),and 0.831(0.788-0.874),*** sensitivities were 0.799,0.801,and 0.748,and the specificities were 0.743,0.716,and 0.814,***-3 was negatively correlated with SAS and SDS scores(r=-0.566,-0.621,both P<0.001)and positively correlated with SES scores(r=-0.621,P<0.001).SES scores were negatively correlated with SAS and SDS scores(r=-0.508,r=-0.518,both P<0.001).CONCLUSION The amount of physical activity is negatively correlated with anxiety and depression degree and positively correlated with self-esteem degree.

关键词： Physical education Student Anxiety Depression Self-esteem Influence

Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions

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Chinese Chemical Letters 2011年第6期22卷 738-740页

作者： hai yang Liu Kun Wang hai yan fu Mao Lin Yuan Hua Chen Rui Xiang Li Key Lab of Green Chemistry and Technology Ministry of Education the Institute of Homogeneous Catalysis College of Chemistry Sichuan University Chengdu 610064 China

Amide,which is derived from proline and is inexpensive and air-stable,has been synthesized and characterized by ~1H NMR,^（13）C NMR,and *** was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling *** the Pd/amide catalytic system,aryl bromides can be coupled with phenylboronic acid in ethanol/water（1：2;v/v） in excellent yields even with a low Pd loading of 0.01 mol%.Moreover,the scope of the reaction is broad,and a wide variety of functional groups are tolerant.

关键词： Suzuki cross-coupling Palladium catalyst Aryl bromides Amide Water

Copper and amine free Sonogashira cross-coupling reaction catalyzed by efficient diphosphane-palladium catalyst

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Chinese Chemical Letters 2011年第10期22卷 1175-1178页

作者： Ting He Lei Lei Wu Xing Li fu hai yan fu Hua Chen Rui Xiang Li Key lab of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China Guangxi Vocational ＆ Technical Institute of Industry Nanning 530001 China

The commercially available diphosphane ligand MeO-BIPHEP was first investigated in the palladium-catalyzed Sonogashira reaction in the absence of copper and *** coupling of various aryl bromides and aryl chlorides wit... 详细信息

关键词： MeO-BIPHEP Sonogashira reaction Diphosphane ligand Palladium complex

Rapid recognition of Chinese herbal pieces of Areca catechu by different concocted processes using Fourier transform mid-infrared and near-infrared spectroscopy combined with partial least-squares discriminant analysis

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Chinese Chemical Letters 2013年第7期24卷 639-642页

作者： hai-yan fu Dong-Chen Huang Tian-Ming yang Yuan-Bin She Hao Zhang Third Class Laboratory About Ethno-medicine of State Administration of Traditional Chinese Medicine College of PharmacySouth-Central University for Nationalities Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission & Ministry of Education.College of Chemistry and Materials Science South-Central University for Nationalities Third Class Laboratory About Ethno-medicine of State Administration of Traditional Chinese Medicine College of Pharmacy.South-Central University for Nationalities

Rapid and sensitive recognition of herbal pieces according to different concocted processing is crucial to quality control and pharmaceutical effect. Near-infrared （NIR） and mid-infrared （MIR） technology combined with supervised pattern recognition based on partial least-squares discriminant analysis （PLSDA） was attempted to classify and recognize six different concocted processing pieces of 600 Areca catechu L. samples and the influence of fingerprint information preprocessing methods on recognition performance was also investigated in this work. Recognition rates of 99.24%, 100% and 99.49% for original fingerprint, multiple scatter correct （MSC） fingerprint and second derivative （2nd derivative） fingerprint of NIR spectra were achieved by PLSDA models, respectively. Meanwhile, a perfect recognition rate of 100% was obtained for the above three fingerprint models of MIR spectra. In conclusion, PLSDA can rapidly and effectively extract otherness of fingerprint information from NIR and MIR spectra to identify different concocted herbal pieces ofA. catechu.

关键词： NIR and MIR spectroscopy Partial least-squares discriminant analysis Different concocted processing herbal pieces

Different regional distribution of SLC25A13 mutations in Chinese patients with neonatal intrahepatic cholestasis

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World Journal of Gastroenterology 2013年第28期19卷 4545-4551页

作者： Rui Chen Xiao-Hong Wang hai-yan fu Shao-Ren Zhang Kuerbanjiang Abudouxikuer Takeyori Saheki Jian-She Wang Center for Pediatric Liver Diseases Children's Hospital of Fudan University Institute for Health Sciences Tokushima Bunri University Tokushima 770-8514 Japan Department of Pediatrics Jinshan Hospital Fudan University

AIM: To investigate the differences in the mutation spectra of the SLC25A13 gene mutations from specific regions of China. METHODS: Genetic analyses of SLC25A13 mutations were performed in 535 patients with neonatal intrahepatic cholestasis from our center over eight years. Unrelated infants with at least one mutant allele were enrolled to calculate the proportion of SLC25A13 mutations in different regions of China. The boundary between northern and southern China was drawn at the historical border of the yangtze ***: A total of 63 unrelated patients (about 11% of cases with intrahepatic cholestasis) from 16 provinces or municipalities in China had mutations in the SLC25A13 gene, of these 16 (25%) were homozygotes, 28 (44%) were compound heterozygotes and 19 (30%) were heterozygotes. In addition to four well described common mutations (c.851_854del, c.1638_1660dup23, c.615+5G>A and c.1750+72_17514dup17insNM_138459.3:2667 also known as IVS16ins3kb), 13 other mutation types were identified, including three novel mutations: c.985_986insT, c.287T>C and c.1349A>G. According to the geographical division criteria, 60 mutant alleles were identified in patients from the southern areas of China, 43 alleles were identified in patients from the border, and 4 alleles were identified in patients from the northern areas of China. The proportion of four common mutations was higher in south region (56/60, 93%) than that in the border region (34/43, 79%, χ 2 = 4.621, P = 0.032) and the northern region (2/4, 50%, χ 2 = 8.288, P = 0.041). CONCLUSION: The SLC25A13 mutation spectra among the three regions of China were different, providing a basis for the improvement of diagnostic strategies and interpretation of genetic diagnosis.

关键词： Citrin deficiency Mutation spectrum Intrahepatic cholestasis SLC25A13

Cloning One CIPK Gene from a Thermo-Sensitive Genic Self-Incompatible Line in Maize Expressing Under Different Temperatures

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Agricultural Sciences in China 2011年第6期10卷 813-819页

作者： LIN Xing-e JI Hong-qing NIU Jun-hai HU yan-min fu Zhong-jun LIU Zong-hua TANG Ji-hua College of Agronomy Henan Agricultural University Zhengzhou 450002 P.R.China

A calcineurin B-like protein-interacting protein kinases （CIPK） gene was cloned （EU 424058） from a thermo-sensitive genic self-incompatibility （TSGI） line, HE97, in maize, which was selected for suppression subtractive hybridization （SSH） library of the self-incompatible and self-compatible silks of the TSGI line under different temperatures. The full-length cDNA of the candidate CIPK-like gene consisted of 1 918 nucleotides and contained a 1 332-bp open reading frame in maize. Real-time PCR indicated that the candidate CIPK-like gene was highly expressed in the self-incompatible pollen of the TGSI line, and promoted elevated levels of calcium （Ca2＋）. High Ca2＋ concentrations in the pollen strongly inhibit pollen tube formation in silk of the same plant, thus inducing self-incompatibility （SI） under high temperature. These results implied that the CIPKs-like gene would play an important role in the regulation of HE97 characteristics under different temperatures, perhaps acting as a secondary messenger in the expression of SI in the TGSI line in maize.

关键词： CIPK gene cloning expression temperature maize

Prognostic scores in primary biliary cholangitis patients with advanced disease

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1774-1783页

作者： Juan Feng Jia-Min Xu hai-yan fu Nan Xie Wei-Min Bao Ying-Mei Tang Department of Gastroenterology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Yunnan Provincial First People’s HospitalKunming 650032Yunnan ProvinceChina

BACKGROUND Due to the chronic progressive disease characteristics of primary biliary cholangitis(PBC),patients with advanced PBC should not be *** prognostic score studies have focused on early stage *** To compare the prognostic value of various risk scores in advanced PBC to help PBC patients obtain more monitoring and *** This study considered patients diagnosed with PBC during hospitalization between 2015 and *** clinical stage was primarily middle and late,and patients usually took ursodeoxycholic acid(UDCA)after *** discriminatory performance of the scores was assessed with concordance statistics at baseline and after 1 year of UDCA *** follow-up was conducted to analyze the course and disease-associated *** follow-up deadline was December 31,*** compared the risk score indexes between those patients who reached a composite end point of death or liver transplantation(LT)and those who remained alive at the *** combined performance of prognostic scores in estimating the risk of death or LT after 1 year of UDCA treatment was assessed using Cox regression *** accuracy was evaluated by comparing predicted and actual survival through Kaplan-Meier *** We included 397 patients who were first diagnosed with PBC during hospitalization and received UDCA treatment;most disease stages were *** an average of 6.4±1.4 years of follow-up,82 patients had died,and 4 patients had undergone *** receiving UDCA treatment for 1 year,the score with the best discrimination performance was the Mayo,with a concordance statistic of 0.740(95%confidence interval:0.690-0.791).The albumin-bilirubin,GLOBE,and Mayo scores tended to overestimate transplant-free *** 7 years of calibration results showed that the Mayo score was the best *** The Mayo,GLOBE,UK-PBC,and ALBI scores demonstrated comparable discriminating performance for advanced stage

关键词： Primary biliary cholangitis Prognostic value Liver transplantation Cholangitis Mayo score

Biochemical characteristics of neonatal cholestasis induced by citrin deficiency

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World Journal of Gastroenterology 2012年第39期18卷 5601-5607页

作者： Jian-She Wang Xiao-Hong Wang Ying-Jie Zheng hai-yan fu Rui Chen Yi Lu Ling-Juan Fang Takeyori Saheki Keiko Kobayashi Department of Pediatrics Jinshan Hospital Fudan University Shanghai 200540 China The Center for Pediatric Liver Diseas- es Children's Hospital of Fudan University Shanghai 201102 China Department of Epidemiology School of Pub- lic Health Fudan University Shanghai 200032 China Institute of Resource Development and Anal- ysis Kumamoto University Kumamoto 860-0811 Japan Department of Molecular Metabolism and Biochemical Genetics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 890-8544 Japan

AIM:To explore differences in biochemical indices between neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and that with other etiologies. METHODS:Patients under 6 mo of age who were referred for investigation of conjugated hyperbiliru-binaemia from June 2003 to December 2010 were eligible for this study. After excluding diseases affecting the extrahepatic biliary system, all patients were screened for the two most common SLC25A13 mutations; the coding exons of the entire SLC25A13 gene was sequenced and Western blotting of citrin protein performed in selected cases. Patients in whom homo-zygous or compound heterozygous SLC25A13 mutation and/or absence of normal citrin protein was detected were defined as having NICCD. Cases in which no specific etiological factor could be ascertained after a com-prehensive conjugated hyperbilirubinaemia work-up were defined as idiopathic neonatal cholestasis (INC). Thirty-two NICCD patients, 250 INC patients, and 39 infants with cholangiography-confirmed biliary atresia (BA) were enrolled. Laboratory values at their first visit were abstracted from medical files and compared. RESULTS:Compared with BA and INC patients, the NICCD patients had significantly higher levels of total bile acid (TBA) [all measures are expressed as median (inter-quartile range):178.0 (111.2-236.4) μmol/L in NICCD vs 112.0 (84.9-153.9) μmol/L in BA and 103.0 (70.9-135.3) μmol/L in INC, P = 0.0001]. The NICCD patients had significantly lower direct bilirubin [D-Bil 59.6 (43.1-90.9) μmol/L in NICCD vs 134.0 (115.9-151.2) μmol/L in BA and 87.3 (63.0-123.6) μmol/L in INC, P = 0.0001]; alanine aminotransferase [ALT 34.0 (23.0-55.0) U/L in NICCD vs 108.0 (62.0-199.0) U/L in BA and 84.5 (46.0-166.0) U/L in INC, P = 0.0001]; aspartate aminotransferase [AST 74.0 (53.5-150.0) U/L in NICCD vs 153.0 (115.0-239.0) U/L in BA and 130.5 (81.0-223.0) U/L in INC, P = 0.0006]; albumin [34.9 (30.7-38.2) g/L in NICCD vs 38.4 (36.3-42.2) g/L in BA and 39.9 (37

关键词： Cholestasis Biliary atresia Infants Idio-pathic neonatal cholestasis SLC25A13

Highly active rhodium]phosphorus catalytic system for the hydroformylation of α-methylstyrene

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Chinese Chemical Letters 2016年第5期27卷 678-680页

作者： Xue-Li Zheng Cong-Ye Zheng Fan-Ding Zhou hai-yan fu Mao-Lin Yuan Rui-Xiang Li Bin Xu Hua Chen Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education Zigong 643000 China

Rhodium catalyzed hydroformylation of α-methylstyrene was investigated in the presence of monodentate phosphine ligands L1-L6. We found that the phosphine with good n-acceptability could efficiently improve the activity of the α-methylstyrene hydroformylation. The big steric hindrance ofα-C in α-methylstyrene enhanced the regioselectivity towards the linear aldehyde, which resulted in 3-phenylbutanal as the predominant product （〉99.0%）. When tris（N-pyrrolyl）phosphine （L1） modified Rh（acac）（CO）2 was employed as the catalyst, the TOF could reach up to 5786 h 1 in the α-methylstyrene hvdroformvlation at relatively mild conditions （110 ℃, 6 MPa）.

关键词： α-Methytstyrene Hydroformylation Rh complex Phosphine Pyrrole