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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

On tail behavior of nonlinear autoregressive functional conditional heteroscedastic model with heavy-tailed innovations

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Science China Mathematics 2005年第9期48卷 1169-1181页

作者： PAN Jiazhu WU guangxu LMAM and School of Mathematical Sciences Peking University Beijing 100871 China LMAM and School of Mathematical Sciences Peking University Beijing 100871 China

We study the tail probability of the stationary distribution of nonparametric nonlinear autoregressive functional conditional heteroscedastic (NARFCH) model with heavytailed innovations. Our result shows that the tail of the stationary marginal distribution of an NARFCH series is heavily dependent on its conditional variance. When the innovations are heavy-tailed, the tail of the stationary marginal distribution of the series will become heavier or thinner than that of its innovations. We give some specific formulas to show how the increment or decrement of tail heaviness depends on the assumption on the conditional variance function. Some examples are given.

关键词： tail probability, stationary distribution, nonlinear AR model, nonlinear autoregressive functional conditional heteroscedastic model, heavy-tailed distribution.

Multi-level intelligence empowering lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 535-552,I0011页

作者： guangxu Zhang Jiangong Zhu haifeng Dai Xuezhe Wei School of Materials Science and Engineering Tongji UniversityShanghai 201804China School of Automotive Studies Tongji UniversityShanghai 201804China

With the significant and widespread application of lithium-ion batteries,there is a growing demand for improved performances of lithium-ion *** intricate degradation throughout the whole lifecycle profoundly impacts the safety,durability,and reliability of lithium-ion *** ensure the long-term,safe,and efficient operation of lithium-ion batteries in various fields,there is a pressing need for enhanced battery intelligence that can withstand extreme *** work reviews the current status of intelligent battery technology from three perspectives:intelligent response,intelligent sensing,and intelligent *** intelligent response of battery materials forms the foundation for battery stability,the intelligent sensing of multi-dimensional signals is essential for battery management,and the intelligent management ensures the long-term stable operation of lithium-ion *** critical challenges encountered in the development of intelligent battery technology from each perspective are thoroughly analyzed,and potential solutions are proposed,aiming to facilitate the rapid development of intelligent battery technologies.

关键词： Battery intelligence Intelligent response Intelligent sensing Intelligent management

A comprehensive evaluation of re-circulated bio-filter as a pretreatment process for petroleum refinery wastewater

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Journal of Environmental Sciences 2016年第12期28卷 49-55页

作者： Xiaoli Dai Chunmao then guangxu Yan Yu Chen Shaohui Guo State Key Laboratory of Heavy 0il Processing Beijing Key Laboratory of Oil and Gas Pollution Control China University of Petroleum Beijing 102249China

Conventional biological treatment process is not very efficient for the treatment of petroleum refinery wastewater （PRW） that contains high-concentration of organic contaminants. Prior to biological treatment, an additional pretreatment process for PRW is required for the effluent to meet the discharge standards. While re-circulated bio-filter （RBF） has been applied as a pretreatment process in several PRW treatment plants, its effects have not been comprehen- sively evaluated. In this study, the parameters of operation, the changes in pollution indexes and contaminant composition in an engineered RBF have been investigated. We found that mainly highly active de-carbonization bacteria were present in the RBF, while no nitrification bacteria were found in the RBF. This indicated the absence of nitrification in this process. The biodegradable organic contaminants were susceptible to degradation by RBF, which decreased the Biological Oxygen Demand （BODs） by 83.64% and the Chemical Oxygen Demand （CODcr） by 54.63%. Consequently, the alkalinity and pH value of RBF effluent significantly increased, which was unfavorable for the control of operating parameters in subsequent biological treatment. Along with the decrease of CODcr, the RBF effluent exhibited a reduction in biodegradability. 834 kinds of recalcitrant polar organic contaminants remained in the effluent; most of the contaminant molecules having complex structures of aromatic, polycyclic and heterocyclic rings. The results of this study showed that RBF could efficiently treat PRW for biodegradable organic contaminants removal; however, it is difficult to treat bio-refractory organic contaminants, which was unfavorable for the subsequent biological treatment process operation. An improved process might provide overall guarantees for the PRW treatment.

关键词： Petroleum refinery wastewater Re-circulated bio-filter Pretreatment Comprehensive evaluation

Three-stage tectonic subsidence and its implications for the evolution of conjugate margins of the southwest subbasin,South China Sea

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Journal of Oceanology and Limnology 2021年第5期39卷 1854-1870页

作者： Wenlong WANG Dongdong DONG Xiujuan WANG guangxu ZHANG CAS Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center of Ocean Mega-Science Chinese Academy of SciencesQingdao266071China

To reveal the tectonic characteristics of the continental margins in the southwest subbasin(SWB)of the South China Sea,a long high-resolution seismic profile was studied using empty basin *** find that tectonic subsidence features on both margins are uniformly divided into three stages:(1)slow subsidence from Tg to 18.5 Ma(synrift stage);(2)extremely slow subsidence/uplift from18.5 to 16 Ma(spreading stage);and(3)accelerated subsidence from 16 to 0 Ma(post-spreading stage).This feature differs from the classic tectonic subsidence pattern of rifted basins,which exhibits fast subsidence during synrift stage and slow subsidence during the post-rift *** tectonic uplift occurred during the spreading stage and the magnitude increased from the continent to the ocean,which is likely related to mantle flow during seafloor *** propose that lower crustal flow played a significant role in the tectonic evolution of the continental margins of the *** lower crust of the SWB margins was warmer and therefore weaker,and more prone to flow beneath the faulting center,which compensated for the upper crustal thinning caused by brittle faulting during the synrift period and thus reduced the tectonic subsidence *** the spreading stage,faulting attenuated rapidly,and a necking zone appeared at the continentocean transition formed by lithospheric *** upwelling asthenosphere,small-scale secondary mantle convection occurred under the necking zone,which raised the continental margin isotherms and increased the ***,secondary mantle convection lifted the overriding crust,thus the overall subsidence rate decreased sharply or even reversed to *** seafloor spreading,the effect of mantle convection faded away,and sediment loading drove the lower crust to flow *** relaxation,lower crust flow,and vanish of secondary mantle convection together led to rapid subsidence in this stage.

关键词： tectonic subsidence lower crustal flow tectonic evolution southwest subbasin South China Sea

Photosensitizing metal-organic layers for photocatalysis,artificial photosynthesis and fluorescence imaging

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Science China Chemistry 2023年第12期66卷 3372-3382页

作者： An Li Yufeng Zhang Zichen Sun Zhiyang Niu guangxu Lan Beijing National Laboratory for Molecular Science State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100084China

In recent years,metal-organic layers(MOLs)with high-density and accessible open sites have emerged as a two-dimensional version of metal-organic frameworks(MOFs)with various potential ***,MOLs represent a promising platform for photocatalysis,artificial photosynthesis,and fluorescence imaging through the hierarchical assembly of photosensitizers and catalysts or other functional groups into *** review provides an overview of the structural design and synthesis strategies of MOLs with a particular emphasis on the applications of photosensitizing MOLs,illustrating the advantages of the MOLs-based *** final part discusses perspectives on the challenges encountered in this field and the emerging developments that can be expected.

关键词： metal-organic layers metal-organic frameworks photocatalysis artificial photosynthesis

Metabolic reprogramming in skeletal cell differentiation

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Bone Research 2024年第3期12卷 539-554页

作者： Joshua C.Bertels guangxu He Fanxin Long Department of Surgery Translational Research Program in Pediatric OrthopedicsThe Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA Department of Orthopedics The Second Xiangya HospitalChangshaHunanChina Department of Orthopedic Surgery University of PennsylvaniaPhiladelphiaPAUSA

The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and mineral homeostasis and to perform critical mechanical and endocrine *** the beginning steps of chondrogenesis that prefigures most of the skeleton,to the rapid bone accrual during skeletal growth,followed by bone remodeling of the mature skeleton,cell differentiation is integral to skeletal health.

关键词： functions skeleton programming

Baeyer–Villiger oxidation of cyclohexanone catalyzed by cordierite honeycomb washcoated with Mg–Sn–W composite oxides

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Chinese Journal of Chemical Engineering 2019年第3期27卷 564-574,F0004页

作者： Yang Han Shengnan Li Rong Ding Wenjin Xu guangxu Zhang School of Chemistry Chemical Engineering and Life Science Wuhan University of Technology

In this work, a series of Mg–Sn–W oxide powder catalysts with different tungsten oxide contents(0, 15 wt% and 30 wt%) were prepared and washcoated on cordierite honeycomb monoliths to produce monolithic catalysts,which were tested for the Baeyer–Villiger oxidation of cyclohexanone. The obtained monolithic catalysts,which combined the advantages of both homogeneous and heterogeneous catalysts, showed high catalytic efficiency and overcame the problems of product separation that occurred in the homogeneous catalytic *** and EDX tests showed that the catalytic coating, with a thickness of approximately 20 μm, was compact and homogeneous, and an enlarged BET surface area was indicated by N_2 adsorption–desorption compared with the bare cordierite honeycomb. The chemical properties on the catalytic surface of the powder and monolithic catalysts were characterized by XPS, which indicated the tin and tungsten on the catalysts exhibited their full oxide states and presented mainly as stannate and tungstate, as confirmed by XRD and FTIR ***, the catalytic activity test indicated that the tungsten content of the catalysts played an important role in catalytic efficiency and that monolithic catalysts were produced without obvious catalytic activity loss compared with the corresponding powders.(M)W30, which exhibited excellent mechanical stability and maintained high activity after recycling three times, was the optimal catalyst, showing a high selectivity that exceeded 86%and a conversion above 64%. Therefore, the structured Mg–Sn–W oxide catalysts have great potential for application in practical production.

关键词： Baeyer–Villiger oxidation Monolith Mg–Sn–W oxide catalysts Synthesis ε-Caprolactone

Advances in the treatment of hepatocellular carcinoma using drug-eluting beads

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Journal of Interventional Medicine 2020年第3期3卷 122-127页

作者： guangxu Wei Jijin Yang Interventional Department Changhai HospitalNaval Medical UniversityNo.168ChangHai RoadShanghai200433China

Hepatocellular carcinoma(HCC)is one of the most common types of malignant *** radical surgery and liver transplantation are possible cures for the disease,most patients are beyond the optimum stage for radical treatment at the time of *** chemoembolization(TACE)is the first choice of treatment for advanced *** to the widespread use of conventional TACE(cTACE),the problems with this treatment cannot be ***-eluting beads(DEBs),a new type of embolization material,appear to overcome the problems of cTACE,and they have other advantages such as synchronous controlled continuous drug release after chemotherapy and embolization and low blood concentrations after *** review summarizes the recent advances in the use of DEB-TACE to treat HCC.

关键词： Hepatocellular carcinoma Drug-eluting beads DEB-TACE cTACE