Metabolic reprogramming in skeletal cell differentiation

作     者：Joshua C.Bertels Guangxu He Fanxin Long Joshua C.Bertels;Guangxu He;Fanxin Long

作者机构：Department of SurgeryTranslational Research Program in Pediatric OrthopedicsThe Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA Department of OrthopedicsThe Second Xiangya HospitalChangshaHunanChina Department of Orthopedic SurgeryUniversity of PennsylvaniaPhiladelphiaPAUSA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2024年第12卷第3期

页      面：539-554页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：partly supported by NIH grant R01DK125498 (FL) 

主　　题：functions skeleton programming 

摘      要：The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and mineral homeostasis and to perform critical mechanical and endocrine *** the beginning steps of chondrogenesis that prefigures most of the skeleton,to the rapid bone accrual during skeletal growth,followed by bone remodeling of the mature skeleton,cell differentiation is integral to skeletal health.