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SYNTHESIS AND CHARACTERIZATION OF RANDOM OR GRADIENT BUTADIENE-p-METHYLSTYRENE COPOLYMERS VIA ANIONIC POLYMERIZATION

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Chinese Journal of Polymer Science 2013年第12期31卷 1647-1659页

作者： Feng Liu hai-ying tan 唐涛 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences Graduate School of the Chinese Academy of Sciences

Copolymers of 1,3-butadiene and p-methylstyrene （p-MS） were synthesized via anionic polymerization. A benzophenone-potassium complex was added to tune the reactivity ratio of the two monomers, leading to random and gradient composition alonglthe copolymer chain. The overall composition and microstructure could be controlled and well characterized by GPC and H-NMR. The p-MS was distributed from gradient to random with increasing the content of the benzophenone-potassium complex, and the 1,2-microstrucmre in the polybutadiene sequence increased at the same time. The hydrogenation of the copolymer of 1,3-butadiene and p-MS resulted in the corresponding saturated copolymer with well- defined structure and narrow molecular weight distribution.

关键词： Anionic polymerization Butadiene p-Methylstyrene Random copolymer Gradient copolymer.

Horizontal Connection and Horizontal Mean Curvature in Carnot Groups

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Acta Mathematica Sinica,English Series 2006年第3期22卷 701-710页

作者： Kang hai tan Xiao Ping YANG Department of Applied Mathematics Nanjing University of Science and Technology

In this paper we give a geometric interpretation of the notion of the horizontal mean curvature which is introduced by Danielli Garofalo-Nhieu and Pauls who recently introduced sub- Riemannian minimal surfaces in Carnot groups. This will be done by introducing a natural nonholonomic connection which is the restriction （projection） of the natural Riemannian connection on the horizontal bundle. For this nonholonomic connection and （intrinsic） regular hypersurfaces we introduce the notions of the horizontal second fundamental form and the horizontal shape operator. It turns out that the horizontal mean curvature is the trace of the horizontal shape operator.

关键词： Carnot groups Nonholonomic connection Horizontal mean curvature Sub-Riemannian minimal surfaces

Memory Request Priority Based Warp Scheduling for GPUs

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Chinese Journal of Electronics 2018年第5期27卷 985-994页

作者： ZHANG Jun HE Yanxiang SHEN Fanfan LI Qing'an tan hai School of Software East China University of Technology Computer School Wuhan University

High performance of GPGPU comes from its super massive multithreading, which makes it more and more widely used especially in the field of throughputoriented. Data locality is one of the important factors affecting the performance of GPGPU. Although GPGPU can exploit intra/inter-warp locality by itself in part, there is still large improvement space for that. In our work, we analyze the characteristics of different applications and propose memory request based warp scheduling to better exploit inter-warp spatial locality. This method can make some warps with good inter-warp locality run faster, which is beneficial to improve the whole performance. Our experimental results show that our proposed method can achieve24.7% and 11.9% average performance improvement over LRR and MRPB respectively.

关键词： General purpose graphics processing unit(GPGPU) Memory request priority Performance Data locality Warp scheduling

Influence of nitrogen implantation into HSS substrate on internal stress and adhesion strength of c-BN films

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 286-290页

作者： ZHANG Ping CAI Zhi-hai tan Jun XIONG Wan-quan National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China

Cubic boron nitride(c-BN) films were deposited on HSS substrate implanted with nitrogen ion by RF-magnetron sputtering. The films were analyzed by bending beam method, scratch test, XRD and AFM. The results show that the implantation of N ion can reduce the internal stress and improve the adhesion strength of the *** critical load comes to 16.92N, compared to 1.75N of c-BN film on the unimplanted HSS. AFM shows that the surface of the c-BN film on the implanted HSS is low in roughness and small in grain size. The phase structure of the nitrogen implanted layer was analyzed by XRD. The influence of nitrogen implanted layer on the internal stress and adhesion strength of c-BN films were also investigated.

关键词： cubic boron nitride film HSS ion implantation internal stress adhesion

Quantitative analysis of 3D vasculature for evaluation of angiogenesis in liver fibrosis with SR-μCT

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Nuclear Science and Techniques 2016年第5期27卷 255-263页

作者： hai tan Yi Fu Da-Dong Wang Xi Zhang Ti-Qiao Xiao Shanghai Institute of Applied Physics Chinese Academy of Sciences Jiading Campus University of Chinese Academy of Sciences Department of Radiology Cancer Hospital Fudan University Department of Oncology Shanghai Medical College Fudan University Quantitative Imaging

The micro-CT imaging of vasculature is a powerful tool for evaluation of angiogenesis,a prominent characteristic of hepatic *** segment or bifurcation density,which is usually adopted to evaluate the degree of hepatic fibrosis,does not always work and may lead to incorrect assessment,especially when the threedimensional vasculature obtained is imperfect in sample preparation or image *** this paper,we propose a new parameter to solve this *** experimental results demonstrate that the method is robust and reliable,and is practical for angiogenesis evaluation,despite of image data *** quantitative analysis method can be extended to investigate other kinds of diseases in which vasculature change is a key indicator.

关键词：血管生成肝纤维化 CT成像评价三维定量分析方法图像采集样品制备

A New Approach to Urban Rainwater Management

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Journal of China University of Mining and Technology 2007年第1期17卷 82-84页

作者： ZENG Bing tan hai-qiao WU Li-juan School of Resource and Earth Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Based on an analysis of our research results and the main problems relating to urban rainwater treatment, we propose a new approach to urban rainwater management in China. The necessity and feasibility of such a new approach are discussed. From an ecological point of view all components of the global system, including residents living in cities, have the same right to enjoy rainwater. Therefore, urban rainwater should neither be simply drained as waste water, nor be completely harvested as a kind of resource. The objective of this new approach is to maintain the natural hydrological cycle in urban areas during urbanization. When necessary, it could also be used to regulate the amount of runoff, evaporation and infiltration in a city in order to rehabilitate the hydrological cycle given the local conditions. Three basic principles should be adopted in rainwater management, i.e., separation of rainfall from sewage, limited utilization and small and decentralized facilities. Four methods can be used for urban rainwater management: rainwater harvest, rainwater infiltration, rainwater storage and rainwater pipes. The natural hydrological cycle in urban areas could be rehabilitated through rainwater management, which is of great importance for sustainable development of our cities.

关键词： urban rainwater management hydrological cycle rehabilitation

Inactivated Sendai Virus Induces ROS-dependent Apoptosis and Autophagy in Human Prostate Cancer Cells

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Biomedical and Environmental Sciences 2018年第4期31卷 280-289页

作者： QIAN Miao tan hai Ming YU Ning WANG Tao ZHANG Quan Institute of Comparative Medicine College of Veterinary Medicine Yangzhou University Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University

Objective The current study aims to investigate the effect of Hemagglutinating virus of Japan envelope（HVJ-E） on induction of apoptosis and autophagy in human prostate cancer PC3 cells, and the underlying mechanisms. Methods PC3 cells were treated with HVJ-E at various multiplicity of infection（MOI）, and the generated reactive oxygen species（ROS）, cell viability, apoptosis, and autophagy were detected, respectively. Next, the role of ROS played in the regulation of HVJ-E-induced apoptosis and autuphagy in PC3 cells were analysed. In the end, the relationship between HVJ-E-induced apoptosis and autuophagy was investigated by using rapamycin and chloroquine. Results Flow cytometry assay revealed that HVJ-E treatment induced dose-dependent apoptosis and that the JNK and p38 MAPK signaling pathways were involved in HVJ-E-induced apoptosis in PC3 cells. In addition, HVJ-E was able to induce autophagy in PC3 cells via the class III PI3 K/beclin-1 pathway. The data also implyed that HVJ-E-triggered autophagy and apoptosis were ROS dependent. When ROS was blocked with N-acetylcysteine（NAC）, HVJ-E-induced LC3-II conversion and apoptosis were reversed. Interestingly, HVJ-E-induced apoptosis was significantly increased by an inducer of autophagy, rapamycin pretreatment, both in vitro and in vivo. Conclusion HVJ-E exerts anticancer effects via autophagic cell death in prostate cancer cells.

关键词： Inactivated Sendai virus(HVJ-E) Reactive oxygen species(ROS) Apoptosis Autophagy

Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 652-657页

作者： hai-Bo tan Yi-Sheng Zhong Yu Cheng and Xi Shen Department of Ophthalmology Ruijin Hospital Affiliated Medical School Shanghai Jiaotong University Shanghai 200025 China

Rho-associated kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors of the small GTPase RhoA. The Rho/ROCK pathway is closely related to the pathogenesis of several central nervous system (CNS) disorders, and involved in many aspects of neuronal functions including neurite outgrowth and retraction. In the adult CNS, the damaged neuron regeneration is very difficult due to the presence of myelin-associated axon growth inhibitors such as Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (Omgp), etc. The effects of these axon growth inhibitors are reversed by blocking the Rho/ROCK pathway 47 vitro, and the inhibition of Rho/ROCK pathway can promote axon regeneration and functional recovery in the injured CNS in viva In addition, the therapeutic effects of the Rho/ROCK inhibitors have also been demonstrated in some animal models and the Rho/ROCK pathway becomes an attractive target for the development of drugs for treating CNS disorders. In this review, we summarized on the effect of the Rho and the downstream factor ROCK in neural regeneration, and the potential therapeutic effect of Rho/ROCK inhibitors in the survival and axonal regeneration of retinal ganglion cell was also discussed.

关键词： Rho/ROCK pathway neural regeneration potential therapeutic effect optic nerve damage

Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma

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World Journal of Gastroenterology 2005年第30期11卷 4689-4692页

作者： hai-Yan tan Jun Liu Shan-Min Wu He-Sheng Luo Department of General surgery Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China

AIM： To investigate the role of survivin expression in the pathogenesis of colorectal carcinoma. METHODS： Immunohistochemistry S-P method and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling （TUNE） were used to detect the expression of survivin and apoptotic cell in situ in colorectal cancerous tissues, para-cancerous tissues and normal tissues of 48 cases of colorectal carcinoma. RESULTS： The survivin positive unit （PU） was higher in cancerous tissues （38.76±5.14） than in para-cancerous （25.17±7.26） or normal tissues （0.57±0.03）（P〈0.05）. The apoptosis index （AI） of para-cancerous tissues was （7.51±2.63%） higher than cancerous tissues （4.65±1.76%）. The expression of survivin was associated with pathological grade, lymph node metastasis and Dukes stage of colorectal carcinoma. CONCLUSION： Survivin expression may play an important role in carcinogenesis of colorectal carcinoma and may be associated with malignant biological behaviors of colorectal carcinoma.

关键词： Survivin Colorectal carcinoma Cell apoptosis