Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage
Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage作者机构：Department of Ophthalmology Ruijin Hospital Affiliated Medical School Shanghai Jiaotong University Shanghai 200025 China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2011年第4卷第6期
页 面：652-657页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：Supported by National Nature Science Foundation of China (No.81070728) Shanghai "Science and Technology Innovation Action Plan" Basic Research Key Project,China (No.11JC1407700 and 11 JC1407701) Shanghai Nature Science Foundation, China (No.08ZR1413900) Shanghai Leading Academic Discipline Project, China(No.S30205)
主 题：Rho/ROCK pathway neural regeneration potential therapeutic effect optic nerve damage
摘 要：Rho-associated kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors of the small GTPase RhoA. The Rho/ROCK pathway is closely related to the pathogenesis of several central nervous system (CNS) disorders, and involved in many aspects of neuronal functions including neurite outgrowth and retraction. In the adult CNS, the damaged neuron regeneration is very difficult due to the presence of myelin-associated axon growth inhibitors such as Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (Omgp), etc. The effects of these axon growth inhibitors are reversed by blocking the Rho/ROCK pathway 47 vitro, and the inhibition of Rho/ROCK pathway can promote axon regeneration and functional recovery in the injured CNS in viva In addition, the therapeutic effects of the Rho/ROCK inhibitors have also been demonstrated in some animal models and the Rho/ROCK pathway becomes an attractive target for the development of drugs for treating CNS disorders. In this review, we summarized on the effect of the Rho and the downstream factor ROCK in neural regeneration, and the potential therapeutic effect of Rho/ROCK inhibitors in the survival and axonal regeneration of retinal ganglion cell was also discussed.
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