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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei Yun-Xia Wu Yun Lu Zi-Shan Wang Thi-Huong nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

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Performance evaluation of a two-way relay network with energy harvesting^and hardware noises

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Digital Communications and Networks 2021年第1期7卷 45-54页

作者： nguyen Tien Tung Pham Minh Nam Phu tran Tin Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh CityVietnam Wireless Communcations Research Group Faculy of Electrical and Electronics EngineeringTon Duc Thang UniversityHo Chi Minh CityVietnam

In this paper,we propose a Two-Way Cognitive Relay Network(TWCRN)where the secondary users operate on an underlay mode to access the licensed *** the proposed protocols,two secondary sources transmit their data to a relay in the first time slot,and then the relay would forward the received information to both sources in the remaining ***,the relay is self-powered by harvesting energy from ambient Radio Frequency(RF)signals,using the Time Switching(TS)and the Power Switching(PS)*** paper concentrates on eval-uating the performance of the secondary networks under the impact of hardware impairments and co-channel interference from the primary *** particular,based on the secondary transmitters'constraint power,we derive the closed-form expressions of the outage probability and the throughput over Rayleigh fading channels in two cases:TS and *** also investigate the energy efficiency issue and the locally optimal position of the relay to maximize the system throughput,which provides much information to install the relay ***,our derivations are verified by Monte Carlo simulation.

关键词： Energy harvesting Two-way relay Energy efficiency hardware impairments Cognitive network

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Highly active brookite TiO2-assisted photocatalytic degradation of dyes under the simulated solar-UVA radiation

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Progress in Natural Science:Materials International 2019年第6期29卷 641-647页

作者： Huyen tran Thi Thuong Chi tran Thi Kim Liem nguyen Quang Hendrik Kosslick Institute of Materials Science (IMS) Vietnam Academy of Science and Technology (VAST) University of Rostock Institute of Chemistry Department of Inorganic Chemistry

Brookite TiO2nanoparticles were synthesized by hydrothermal method and characterized by X-ray powder diffraction(XRD), diffuse reflectance UV–Visible spectroscopy(DRUV), and scanning electron microscopy(SEM). The obtained particles were spherical in shape with the diameter of about ～10 nm under the hydrothermal temperature of 175 °C. The photocatalytic performance of brookite was investigated in the photodegradation of dyes(rhodamine B and rose bengal) under UV-A radiation by low-power lamp. The activity of brookite and the photodegradation efficiency of dyes were estimated using a UV–Visible spectrophotometer and a total organic carbon(TOC) analyzer. Compared to anatase and rutile prepared by the similar synthesis procedure, brookite is highly active in terms of decolourization, aromatic ring opening, and mineralization.

关键词： Brookite Anatase Dye Photocatalytic degradation Decolourization Mineralization

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Free vibration analysis of functionally graded porous curved nanobeams on elastic foundation in hygro-thermo-magnetic environment

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Frontiers of Structural and Civil Engineering 2023年第4期17卷 584-605页

作者： Quoc-Hoa PhaM Parviz MALEKZADEH Van Ke tran Trung nguyen-THOI Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Department of Mechanical Engineering Persian Gulf UniversityBushehr ***Iran Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical-Electrical and Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 700000Vietnam Bualuang ASEAN Chair Professor Thammasat School of EngineeringThammasat UniversityPathumtani 12120Thailand

Herein,a two-node beam element enriched based on the Lagrange and Hermite interpolation function is proposed to solve the governing equation of a functionally graded porous(FGP)curved nanobeam on an elastic foundation in a hygro–thermo–magnetic *** material properties of curved nanobeams change continuously along the thickness via a power-law distribution,and the porosity distributions are described by an uneven porosity *** effects of magnetic fields,temperature,and moisture on the curved nanobeam are assumed to result in axial loads and not affect the mechanical properties of the *** equilibrium equations of the curved nanobeam are derived using hamilton’s principle based on various beam theories,including the classical theory,first-order shear deformation theory,and higher-order shear deformation theory,and the nonlocal elasticity *** accuracy of the proposed method is verified by comparing the results obtained with those of previous reliable ***,the effects of different parameters on the free vibration behavior of the FGP curved nanobeams are investigated comprehensively.

关键词： functionally graded porous material curved nanobeam hygro-thermo-magnetic enriched finite element method

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Photodiode-Based Chua＇s Circuit with Light Controllability

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Chinese Physics Letters 2014年第6期31卷 24-28页

作者： NAM Sang Guk nguyen Van ha SONG hanjung Department of Nanoseience and Engineering lnje University Gimhae 621-749 Korea Center for Nano Manufacturing Inje University Gimhae 621-749 Korea

We present a photodiode-based Chua＇s chaotic circuit that is controllable by light. The proposed circuit consists of an inductor, two passive capacitors, a photodiode-based variable resistor, and a positive feedback trans- conductor with negative nonlinearity. The chaotic dynamics of the circuit were verified by using the simulation program with integrated circuit emphasis analysis using the 0.35 #m complementary metal-oxide-semiconductor process parameters. The gain results （such as the time waveform~ frequency analysis, three-dimensional attractor, bifurcation and Lyapunov exponents diagrams） confirm that the chaotic behavior of the circuit could be controlled by light intensity via the photodiode-based variable resistor.

关键词： Feedback

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A voltage-controlled chaotic oscillator based on carbon nanotube field-effect transistor for low-power embedded systems

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Chinese Physics B 2014年第5期23卷 617-622页

作者： Van ha nguyen Wonkyeong Park Namtae Kim hanjung Song Department of Nano Systems Engineering Inje University Department of Electronics Engineering Inje University Center for Nano Manufacturing Inje University

This paper presents a compact and low-power-based discrete-time chaotic oscillator based on a carbon nanotube field-effect transistor implemented using Wong and Deng＇s well-known model. The chaotic circuit is composed of a nonlinear circuit that creates an adjustable chaos map, two sample and hold cells for capture and delay functions, and a voltage shifter that works as a buffer and adjusts the output voltage for feedback. The operation of the chaotic circuit is verified with the SPICE software package, which uses a supply voltage of 0.9 V at a frequency of 20 kHz. The time series, frequency spectra, transitions in phase space, sensitivity with the initial condition diagrams, and bifurcation phenomena are presented. The main advantage of this circuit is that its chaotic signal can be generated while dissipating approximately 7.8 μW of power, making it suitable for embedded systems where many chaos-signal generators are required on a single chip.

关键词： chaos generator carbon nanotube field-effect transistor bifurcation random noise generator

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Properties of poly（1-naphthylamine）/Fe3O4 composites and arsenic adsorption capacity in wastewater

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Frontiers of Materials Science 2016年第1期10卷 56-65页

作者： Minh Thi tran Thi Huyen trang nguyen Quoc Trung VU Minh Vuong nguyen Faculty of Physics Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Faculty of Chemistry Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Department of Physics Quynhon University 170 An Duong Vuong Quynhon Vietnam

The research results of poly（1-naphthylamine）lFe3O4 （PNA/Fe3O4） nanocomposites synthesized by a chemical method for As（Ⅲ） wastewater treatment are presented in this paper. XRD patterns and TEM images showed that the Fe3O4 grain size varied from 13 to 20 nm. The results of Raman spectral analysis showed that PNA participated in part of the PNA/Fe3O4 composite samples. The grain size of PNA/Fe3O4 composite samples is about 25-30 nm measured by SEM. The results of vibrating sample magnetometer measurements at room temperature showed that the saturation magnetic moment of PNA/Fe3O4 samples decreased from 63.13 to 43.43 emu/g, while the PNA concentration increased from 5% to 15%. The nitrogen adsorption-desorption isotherm of samples at 77 K at a relative pressure PIPo of about 1 was studied in order to investigate the surface and porous structure of nanoparticles by the BET method. Although the saturation magnetic moments of samples decreased with the polymer concentration increase, the arsenic adsorption capacity of the PNA/Fe3O4 sample with the PNA concentration of 5% is better than that of Fe3O4 in a solution with pH = 7. In the solution with pH 〉 14, the arsenic adsorption of magnetic nanoparticles is insignificant.

关键词： poly(1-naphthylamin)/Fe3O4 nanocomposite magnetization arsenic adsorption

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Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

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Progress in Natural Science:Materials International 2019年第6期29卷 612-616页

作者： Thi Ngoc Tram nguyen Diem-Huong nguyen-tran Long Giang Bach tran Hoang Du Truong Ngoc Thuy trang Le Dai hai nguyen Tra Vinh University Institute of Applied Materials Science Vietnam Academy of Science and Technology Graduate University of Science and Technology Vietnam Academy of Science and Technology nguyen Tat Thanh University 5. Institute of Research and Development Duy Tan University

A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin(DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the *** with transmission electron microscopy(TEM) and scanning electron microscopy(SEM), X-ray diffraction(XRD), nitrogen adsorption-desorption, thermogravimetric analysis(TGA) and Fourier transformed infrared(FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

关键词： Hollow mesoporous silica nanoparticles mPEG PEGylation Surface modification

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Locally weighted learning based hybrid intelligence models for groundwater potential mapping and modeling: A case study at Gia Lai province, Vietnam

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Geoscience Frontiers 2021年第5期12卷 54-68页

作者： Hoang Phan hai Yen Binh Thai Pham tran Van Phong Duong hai ha Romulus Costache Hiep Van Le Huu Duy nguyen Mahdis Amiri nguyen Van Tao Indra Prakash Department of Geography School of Social Sciences EducationVinh University182 Le DuanVinhNghe AnVietnam University of transport Technology Hanoi 100000Viet Nam Institute of Geological Sciences Vietnam Academy of Science and Technology(VAST)84 Chua LangDong DaHanoiViet Nam Institute for Water and Environment Hanoi 100000Viet Nam Research Institute of the University of Bucharest 90-92 Sos.Panduri5th DistrictBucharestRomania National Institute of Hydrology and Water Management București-Ploiești Road97E1st District013686 BucharestRomania Faculty of Geography VNU University of ScienceVietnam National University334 Nguyen TraiHanoi 100000Viet Nam Department of Watershed&Arid Zone Management Gorgan University of Agricultural Sciences&Natural ResourcesGorgan ***Iran DDG(R)Geological Survey of India Gandhinagar 382010India

The groundwater potential map is an important tool for a sustainable water management and land use planning,particularly for agricultural countries like *** this article,we proposed new machine learning ensemble techniques namely AdaBoost ensemble(ABLWL),Bagging ensemble(BLWL),Multi Boost ensemble(MBLWL),Rotation Forest ensemble(RFLWL)with Locally Weighted Learning(LWL)algorithm as a base classifier to build the groundwater potential map of Gia Lai province in *** this study,eleven conditioning factors(aspect,altitude,curvature,slope,Stream transport Index(STI),Topographic Wetness Index(TWI),soil,geology,river density,rainfall,land-use)and 134 wells yield data was used to create training(70%)and testing(30%)datasets for the development and validation of the *** statistical indices were used namely Positive Predictive Value(PPV),Negative Predictive Value(NPV),Sensitivity(SST),Specificity(SPF),Accuracy(ACC),Kappa,and Receiver Operating Characteristics(ROC)curve to validate and compare performance of *** show that performance of all the models is good to very good(AUC:0.75 to 0.829)but the ABLWL model with AUC=0.89 is the *** the models applied in this study can support decision-makers to streamline the management of the groundwater and to develop economy not only of specific territories but also in other regions across the world with minor changes of the input parameters.

关键词： Locally weighted learning Hybrid models Groundwater potential GIS Vietnam

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Context-specific chromatin remodeling activity of mSWI/SNF complexes depends on the epigenetic landscape

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Signal transduction and Targeted Therapy 2021年第11期6卷 3159-3160页

作者： Godwin Sokpor Huu Phuc nguyen tran Tuoc Department of Human Genetics Ruhr University of BochumBochumGermany

A recent article published in Science reveals how the mammalian SWI/SNF (mSWI/SNF) complexes utilize epigenetic cues in the chromatin landscape for differential chromatin remodeling.1 The heteromultimeric ATP-dependent SWI/SNF complexes can alter chromatin architecture leading to gene expression modulation (Fig. 1). Combinatorial and modular assembly of mSWI/SNF complex subunits2 partly underscore their heterogeneity and tissue-specific downstream effects. Given their implication in numerous diseases, including cancers3 and neurodevelopmental disorders,4 the mSWI/SNF or BAF complexes have attracted interest in elucidating their precise action to lend therapeutic ideas. The work of Mashtalir et al.1 has deepened our understanding by decoding the signals which instruct the assembly, localization, and activity of mSWI/SNF complexes. They provide experimental confirmation that the mSWI/SNF complexes depend on single and/or summative histone/nucleosome signatures and subunit modules to determine their activity (Fig. 1).

关键词： complexes utilize specific

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