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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi yukihide Momozawa yataro Daigo Syuzo Kaneko Takahisa Kawaguchi hideo Kunitoh Shingo Matsumoto hidehito horinouchi Akiteru Goto Takayuki honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi yohei Miyagi Kazumi Tanaka hiroyuki Suzuki Daichi Maeda Takumi yamaura Maiko Matsuda yoko Shimada Takaaki Mizuno hiromi Sakamoto Teruhiko yoshida yasushi Goto Tatsuya yoshida Taiki yamaji Makoto Sonobe Shinichi Toyooka Kazue yoneda Katsuhiro Masago Fumihiro Tanaka Megumi hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno yasushi yatabe Kuniko Sunami Tomoyuki hishida yasunari Miyazaki hidemi Ito Mitsuhiro Amemiya hirohiko Totsuka haruhiko Nakayama Tomoyuki yokose Kazuyoshi Ishigaki Toshiteru Nagashima yoichi Ohtaki Kazuhiro Imai Ken Takasawa yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa yuichi Shiraishi hiroyoshi Nishikawa yoshinori Murakami Michiaki Kubo Fumihiko Matsuda yoichiro Kamatani Ryuji hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Microstructural analyses of all-solid-state Li–S batteries using LiBh4-based solid electrolyte for prolonged cycle performance

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Journal of Energy Chemistry 2020年第11期29卷 424-429页

作者： Kazuaki Kisu Sangryun Kim Ryuga yoshida hiroyuki Oguchi Naoki Toyama Shin-ichi Orimo Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan Institute for Materials Research(IMR) Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan

Complex hydride materials have been widely investigated as potential solid electrolytes because they have good compatibility with the lithium metal anodes used in all-solid-state batteries. however, the development of all-solid-state batteries utilizing complex hydrides has been difficult as these cells tend to have short cycle lives. This study investigated the capacity fading mechanism of all-solid-state lithium–sulfur(Li–S) batteries using Li4(Bh4)3I solid electrolytes by analyzing the cathode microstructure. Crosssectional scanning electron microscopy observations after 100 discharge–charge cycles revealed crack formation in the Li4(Bh4)3I electrolyte and an increased cathode thickness. Raman spectroscopy indicated that decomposition of the Li4(Bh4)3I solid electrolyte occurred at a constant rate during the cycling *** combat these effects, the cycle life of Li–S batteries was improved by increasing the amount of solid electrolyte in the cathode.

关键词： All-solid-state battery Complex hydride solid electrolyte Li metal anode Li–S battery Microstructure

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Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation

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World Journal of Gastroenterology 2009年第32期15卷 4067-4069页

作者： Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles h Scudamore Andrzej K Buczkowski Eric M yoshida Division of Gastroenterology Department of MedicineVancouver General HospitalVancouverBC V5Z 1M9Canada British Columbia Center for Disease Control VancouverBC V5Z 4R4Canada Department of Surgery Faculty of MedicineVancouver General HospitalVancouverBC V5Z 1M9Canada

Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.

关键词： Parvovirus B19 Fulminant hepatic failure Orthotopic liver transplant Fulminant hepatitis

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Optical Beam Controlin Gekko Ⅻ Glass Laser

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光电子·激光 1989年第2期 76-77页

作者： M.NAKATSUKA T.JITSUNO T.KANABE y.KATO K.MIMA K.NIShIhARA T.SASAKI h.TAKABE T.yAMANAKA K.yoshida S.NAKAI Institute of Laser engineering Osaka University Suita

After constructions of 10 to 100 KJ glass laser drivers in the world for the inertial confinement fusion, the rapid extension of the experimental researches of the high density compression up to 100 times solid density, the efficient coupling of about 5% between the laser energy to compressed fuel energy have been obtained 1). The key issues of recent developments 2). of the promissing implosion relevantto the energy driver are as follows;

关键词： Glass Laser Optical Beam Controlin Gekko

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Super-low friction of ta-C coating in presence of oleic acid

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Friction 2014年第2期2卷 156-163页

作者： Makoto KANO Jean Michel MARTIN Kentaro yoshida Maria Isabel DE BARROS BOUChET Division of Mechanical&Material Engineering Kanagawa Industrial Technology Center705-1 Shimo-ImaizumiEbinaKanagawaJapan LTDS Ecole Centrale de Lyon 69380EcullyFrance

Friction tests have been carried out on bearing steel friction pairs coated with a-C:h and ta-C under lubricated conditions with 1-hexadecene and pure oleic acid,*** results show that ta-C leads to the super-low regime with oleic acid(friction coefficient below 0.01)and that a-C:h is quite well lubricated by *** analyses by coupling X-ray photoelectron spectroscopy(XPS)and secondary ion mass spectrometry(SIMS)have been carried out in the case of oleic acid with ta-C and a-C:h *** show that tribochemical reactions have *** groups terminate the ta-C surface whereas a-C:h is covered by a thin tribofilm and is terminated by oleic acid *** superlow regime in the case of ta-C is mainly attributed to the presence of the Oh-termination.

关键词： epoxy composite short carbon fiber friction wear

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变压器绝缘材料的老化

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变压器 1989年第7期26卷 36-39页

作者： h.yoshida 贾杰红

在试验室,利用油浸绝缘系统模型做加速老化试验,研究绝缘纤维材料性能的变化,并把这些试验数据同长期运行的变压器的绝缘纸中获得的性能数据做比较。从研究中发现,绝缘油中的绝缘纸产生的气体的含量与抗拉强度、聚合度的残留率之间有着... 详细信息

在试验室,利用油浸绝缘系统模型做加速老化试验,研究绝缘纤维材料性能的变化,并把这些试验数据同长期运行的变压器的绝缘纸中获得的性能数据做比较。从研究中发现,绝缘油中的绝缘纸产生的气体的含量与抗拉强度、聚合度的残留率之间有着密切的联系。因此根据气体含量就可以了解变压器绝缘纸的老化程度。

关键词：变压器绝缘材料老化

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Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer

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World Journal of Gastroenterology 2010年第15期16卷 1854-1858页

作者： Minoru Tomizawa Fuminobu Shinozaki Takao Sugiyama Shigenori yamamoto Makoto Sueishi Takanobu yoshida Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Department of Rheu-matology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Internal Medicine National Hospital Organization Shimoshizu Hospital

AIM:To develop a molecular therapy for pancreatic cancer, the insulin-like growth factor-I (IGF-I) signaling pathway was ***: Pancreatic cancer cell lines (MIA-Paca2, NOR-P1, PANC-1, PK-45h, PK-1, PK-59 and KP-4) were cultured in media with 10 mL/L fetal bovine serum. Western blotting analysis was performed to clarify the expression of IGF-I receptor (IGF-IR). Picropodophyllin (PPP), a specific inhibitor of IGF-IR, Ly294002, a specific inhibitor of phosphatidylinositol3 kinase (PI3K), and PD98059, a specific inhibitor of mitogen-activated protein kinase, were added to the media. After 72 h, a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium inner salt (MTS) assay was performed to analyze cell proliferation. A wound assay was performed to analyze cell motility with hematoxylin and eosin (hE) staining 48 h after addition of each inhibitor. RESULTS: All cell lines clearly expressed not only IGF-IR but also phosphorylated IGF-IR. PPP significantly suppressed proliferation of MIA-Paca2, NOR-P1, PANC-1, PK-45h, PK-1, PK-59 and KP-4 cells to 36.9% ± 2.4% (mean ± SD), 30.9% ± 5.5%, 23.8% ± 3.9%, 37.1% ± 5.3%, 10.4% ± 4.5%, 52.5% ± 4.5% and 22.6% ± 0.4%, at 2 μmol/L, respectively (P y294002 significantly suppressed proliferation of MIA-Paca2, NOR-P1, PANC-1, PK-45h, PK-1, PK-59 and KP-4 cells to 44.4% ± 7.6%, 32.9% ± 8.2%, 53.9% ± 8.0%, 52.8% ± 4.0%, 32.3% ± 4.2%, 51.8% ± 4.5%, and 30.6% ± 9.4%, at 50 μmol/L, respectively (P y suppress cell proliferation. PPP at 2 μmol/L suppressed motility of MIA-Paca2, NOR-P1, PANC-1, PK-45h, PK-1, PK-59 and KP-4 cells to 3.0% ± 0.2%, 0%, 0%, 2.0% ± 0.1%, 5.0% ± 0.2%, 3.0% ± 0.1%, and 5.0% ± 0.2%, respectively (P y294002 at 50 μmol/L suppressed motility of MIA-Paca2, NOR-P1, PANC-1, PK-45h, PK-1, PK-59 and KP-4 to 3.0% ± 0.2%, 0%, 3.0% ± 0.2%, 0%, 0%, 0% and 3% ± 0.1%, respectively (P < 0.05). PD980509 at 20 μmol/L did not suppress

关键词： Insulin-like growth factor-I receptor Phosphatidylinositol 3 kinase Pancreatic neoplasms

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Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation

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hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 488-493页

作者： Calvin hy Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar haque holly Wiesenger Charles h Scudamore Urs P Steinbrecher Alan A Weiss Eric M yoshida Division of Gastroenterology General hospital University of British Columbia Department of Surgery Vancouver General hospital University of British Columbia

BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two *** study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus ***:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver *** frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and *** response of anastomotic stricture to endoscopic therapy was also ***:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary ***-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic *** comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver *** strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups.

关键词： endoscopic retrograde cholangiopancreatography liver transplantation biliary tract surgical procedures biliary tree liver failure

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Insight into relationship between composition,thickness and electrochemistry behavior of oxide film formed on TA15under different potentials in 0.5 mol·L^(-1)h_(2)SO_(4)

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Rare Metals 2023年第5期42卷 1760-1772页

作者： Fei-Fei huang yi Qin Qing-Rui Wang hiroaki yoshida Lei Wen hai Chang ying Jin National Center for Materials Service Safety University of Science and Technology BeijingBeijing100083China Innovation Group of Marine Engineering Materials and Corrosion Control Southern Marine Science and Engineering Guangdong LaboratoryZhuhai519080China Department of Physical Science Hiroshima UniversityHigashi-Hiroshima739-8526Japan

The oxide film formed on TA15 alloy in0.5 mol·L^(-1)h_(2)SO_(4)at different applied potentials is investigated by evaluating the film formation current density,film thickness,surface film composition,valence state,and the electrochemical *** relative quantitative spectral analysis revealed by X-ray photoelectron spectroscopy(XPS)and X-ray absorption spectra(XAS)shows that the increasing applied potential promotes the formation of thick and high-valence state *** contrasting with XAS of the reference titanium oxides,it is found that TiO_(2)within the oxide film changes from anatase type to rutile type with the potential increases to 2.00 *** oxide film formed at passive region has better protection performance,and with the increase of applied potential,the corrosion resistance of passive film increases,whereas the ND(donor density)values obtained from the Mott-Schottky(MS)results decrease with the increasing applied potential,indicating a better uniformity and protective effect of the oxide *** on above facts,the model of the oxide films formed on TA15 at different applied potentials in passive region and dissolve region is ***,the existence forms of all the TA15alloying elements under the most corrosion resistant condition are confirmed.

关键词： TA15 Electrochemical passivation Corrosion behavior Surface compositions and structures

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Assessing the kinetic model of hydro-distillation and chemical composition ofAquilaria malaccensis leaves essential oil

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Chinese Journal of Chemical Engineering 2017年第2期25卷 216-222页

作者： Mahtab Samadi Zurina Zainal Abidin Robiah yunus Dayang Radiah Awang Biak hiroyuki yoshida Eng hai Lok Department of Chemical and Environmental Engineering Faculty of EngineeringUniversity Putra MalaysiaserdangSelangorDaml Ehsan 43400Malaysia Aerospace Manufacturing Research Centre(AMRC) Level 7Tower BlockFaculty of EngineeringUniversity Putra Malaysia43400 5erdang SelangorMalaysia Forest Research Institute Malaysia 52109 Kepong5elangorDarul EhsanMalaysia

This study aimed to model the kinetic of hydro-distillation of Aquilaria malaccensis leaves oil in order to understand and optimize the extraction process. In addition, this study, for the first time, aimed to identify the chemical compositions of the A. rnalaccensis leave-oil. By assessing both first-order kinetic model and the model of simultaneous washing and diffusion, the result indicated that the model of simultaneous washing and diffusion better describes the hydro-distillation mechanism of the essential oil from A. rnalaccensis leaves. The optimum time, solid to liquid ratio, and the heating power for extracting the highest amount of essential oil were found to be around 3 h, 1：10 （g. ml-1）, and 300 W respectively. yellow essential oil with a strong smell and a yield of 0.05 v/w was extracted by hydro-distillation Clevenger apparatus. Chemical compounds of the essential oil were analyzed using gas chromatography-mass spectroscopy （GC/MS）, which resulted in identification of 42 compounds that constitute 93% of essential oil. Among the identified components, Pentadecanal （32.082%）, 9-Octadecenal, （Z）（15.894%）, and Tetradecanal （6.927%） were the major compounds. Considering the fact that all the identified major components possess pesticidal properties, A. malaccensis leaves can be regarded as a promising natural source for producing pesticides.

关键词： Aquilaria malaccensisEssential oilhydro-distillationOptimizationKinetic modeling

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