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Journal of Geriatric Cardiology 2005年第2期2卷 123-128页

作者： Ahmed A. ARIFI Calvin S. h. ng Anthony P. C. YIM Division of Cardiothoracic Surgery The Chinese University of hong Kong Prince of Wales hospital Hong KongPeople's Republic of China

The aging of the population and improvements in outcomes after cardiovascular surgery have resulted in a worldwide growing demand of complex surgical intervention for elderly patients. We briefly review the up-to-date English-language literature with particular focus on cardiovascular surgery in elderly patients. With earlier referral, careful preoperative evaluation, strategic planning, and the continuing efforts in optimizing surgical techniques, operative mortality and morbidity following primary or reoperative coronary artery bypass grafting and valvular interventions are expected to fall in this high-risk patient subset. Importantly, accumulating evidence indicates that elderly patients may benefit from improved functional status and quality of life after cardiovascular surgical therapy(J Geriatr Cardiol 2005,2(2): 123-128).

关键词： cardiovascular surgery coronary artery bypass grafting elderly reoperation risk factor valve replacementIntroduction

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若干镧系络合物的空间群(英文)

物理化学学报 2000年第10期16卷 879-885页

作者： ng Seikweng 胡盛志马来亚大学研究生院厦门大学化学系厦门361005

摘要藉助模拟强度精修将九个镧系络合物晶体结构的空间群作了修正 .（ 1） NaN[Nd(DMSO)5(h2O)3]Cl3· 3h2O从 P1修正为 P；（ 2） Er(ClO4)3· 6(Ch3)2NC(O)N(Ch3)2从 P修正为 R；（ 3） Nd(O3SCF3)3· DMF· 6h2O从 P1修正为 R3m;(4)... 详细信息

摘要藉助模拟强度精修将九个镧系络合物晶体结构的空间群作了修正 .（ 1） NaN[Nd(DMSO)5(h2O)3]Cl3· 3h2O从 P1修正为 P；（ 2） Er(ClO4)3· 6(Ch3)2NC(O)N(Ch3)2从 P修正为 R；（ 3） Nd(O3SCF3)3· DMF· 6h2O从 P1修正为 R3m;(4)[NaNCCh3][Nd{S2CN(Ch2Ch3)2}4]从 P修正为 C 2/c;(5)[(Ch3)2NCS2]3La· 2DMSO从 Cc修正为 C 2/c;（ 6） Yb(C9h7)2· 2ThF从 Cc修正为 C 2/c；（ 7） [(C6h5)3Ge]2Yb· 4ThF从 P21修正为 P 2;(8)TlPr(C36h44N4)2从 Pna2,修正为 Pnma;(9)[CuLaSm(C4O4)4(h2O)16]· 2h2O从 P2修正为 P2.（ 8）、（ 9）两个络合物结构从非心修正到有心时，不仅改进了键长与键角值，而且影响到分子结构特征的描述 .

关键词：空间群修正模拟结构因子镧系络合物晶体结构

Ballistic impact properties of woven bamboo-woven E-glass-unsaturated polyester hybrid composites

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Defence Technology（防务技术） 2019年第3期15卷 282-294页

作者： Aidy Ali Rabiatun Adawiyah Kannan Rassiah Wei Kuan ng Faiz Arifin Faiz Othman Muhammad Shauqi hazin M.K. Faidzi M.F. Abdullah M.M.h. Megat Ahmad Department of Mechanical Engineering Faculty of Engineering Universiti Pertahanan Nasional Malaysia (UPNM) National Defense University of Malaysia (NDUM) Kem Sg. Besi 57000 Kuala Lumpur Malaysia Department of Mechanical Engineering Politeknik Port Dickson (PPD) KM 14 Jalan Pantai Si Rusa Negeri Sembilan Malaysia

In this study, a laminated woven bamboo/woven E glass/unsaturated polyester composite is developed to combat a ballistic impact from bullet under shooting test. The aim of this study is to understand the fundamental effects of the woven bamboo arrangement towards increasing ballistic resistance properties. The work focusses on the ballistic limit test known as NIJ V50, which qualifies materials to be registered for use in combat armor panels. The results show that the composites withstood 482.5 m/s ± 5 limit of bullet velocity, satisfying the NIJ test at level II. The findings give a strong sound basis decision to engineers whether or not green composites are qualified to replace synthetic composites in certain engineering applications.

关键词： Woven bamboo E glass hybrid composites Ballistic limit velocity Energy absorption

A technique for promoting detonation transmission from a confined tube into larger area for pulse detonation engine applications

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Propulsion and Power Research 2014年第1期3卷 9-14页

作者： Navid Mehrjoo Rocco Portaro hoi Dick ng Department of Mechanical and Industrial Engineering Concordia UniversityMontréalQCH3G 1M8Canada

A simple method of detonation transmission from a small tube to a large area is *** technique involves placing obstacles which create slight blockages at the exit of the confined tube before the planar detonation emerges into the larger space,thereby generating flow instability to promote the detonation *** this experimental study two mixtures of undiluted stoichiometric acetylene-oxygen and acetylene-nitrous oxide are *** mixtures can be characterized by a cellular detonation front that is irregular and representative of those potentially used in practical aerospace *** blockage ratio imposed by the obstacles is varied systematically to identify the optimal condition under which a significant reduction in critical pressure for transmission can be obtained.A new perturbation configuration for practical use in propulsion and power systems is also introduced and results are in good agreement with those obtained using thin needles as the blockage ratio is kept constant.

关键词： Combustion Detonation Pulse detonation engines Diffraction Perturbation Reactive flow

Cumulus-specific genes are transcriptionally silent following somatic cell nuclear transfer in a mouse model

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Journal of zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第8期8卷 533-539页

作者： TOng Guo-qing hEng Boon-chin ng Soon-chye Nuclear Reprogramming and Stem Cell Laboratory Department of Obstetrics and Gynecology Yong Loo Lin School of Medicine National University of Singapore 119074 Singapore Stem Cell and Developmental Biology Group Genome Institute of Singapore 138672 Singapore Stem Cell Laboratory Faculty of Dentistry National University of Singapore 119074 Singapore Embryonics International Pte Ltd. Gleneagles Hospital 258500 Singapore

This study investigated whether four cumulus-specific genes: follicular stimulating hormone receptor (FShr), hyaluronan synthase 2 (has2), prostaglandin synthase 2 (Ptgs2) and steroidogenic acute regulator protein (Star), were correctly reprogrammed to be transcriptionally silent following somatic cell nuclear transfer (SCNT) in a murine model. Cumulus cells of C57×CBA F1 female mouse were injected into enucleated oocytes, followed by activation in 10 μmol/L strontium chloride for 5 h and subsequent in vitro culture up to the blastocyst stage. Expression of cumulus-specific genes in SCNT-derived embryos at 2-cell, 4-cell and day 4.5 blastocyst stages was compared with corresponding in vivo fertilized embryos by real-time PCR. It was demonstrated that immediately after the first cell cycle, SCNT-derived 2-cell stage embryos did not express all four cumulus-specific genes, which continually remained silent at the 4-cell and blastocyst stages. It is therefore concluded that all four cumulus-specific genes were correctly reprogrammed to be silent following nuclear transfer with cumulus donor cells in the mouse model. This would imply that the poor preimplantation developmental competence of SCNT embryos derived from cumulus cells is due to incomplete reprogramming of other embryonic genes, rather than cumulus-specific genes.

关键词： Somatic cell nuclear transfer (SCNT) Nuclear reprogramming Embryo Development

(E)-1-[4-(2-hydroxy-5-methoxybenzylideneamino)-phenyl]ethanone and (E)-1-[4-(2-hydroxy-4-methoxybenzylideneamino) phenyl]ethanone:X-ray and DFT-calculated structures

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Chinese Journal of Structural Chemistry 2011年第1期30卷 111-119页

作者： SAhN Onur BYKGngR Orhan ALBAYRAK igdem ODABASOGLU Mustafa Department of Physics Faculty of Arts and SciencesOndokuz Mayls University Department of Science Education Sinop University Chemistry Programme Pamukkale University 20159 Denizli

The isomeric structures of（E）-1-[4-（2-hydroxy-5-methoxybenzylideneamino）-phenyl] ethanone（I） and（E）-1-[4-（2-hydroxy-4-methoxybenzylideneamino） phenyl]ethanone（Ⅱ） ,both C16h15NO3,have been determined using X-ray diffraction techniques and characterized by IR,and their molecular structures have also been optimized at the B3LYP/6-31G（d,p） level using density functional theory（DFT） . The energetic behaviors of the title compounds in solvent media have been examined using B3LYP method with the 6-31G（d,p） basis set by applying the polarizable continuum model（PCM） . The total energies of the title compounds decrease with the increasing polarity of the solvent. In addition,DFT calculations of the title compounds＇ molecular electrostatic potentials（MEP） were performed at the B3LYP/6-31G（d,p） level of theory. X-ray study shows that the title compounds both have strong intramolecular O-h…N hydrogen bonds. The molecules of Ⅰ are linked into a one-dimensional framework structure by C-h…π interactions,while in Ⅱ,intermolecular π···π interactions result in the formation of infinite chains running along the [010].

关键词： crystal structure Schiff base DFT molecular electrostatic potential

Clinical utility of non-invasive tests to predict clinical outcomes in non-alcoholic fatty liver disease

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hepatobiliary Surgery and Nutrition 2023年第6期12卷 916-918页

作者： Shi Yan Lee Darren J.h.Tan Wen hui Lim Cheng han ng Mark Muthiah Daniel Q.huang Division of Gastroenterology and hepatology Department of MedicineNational University HospitalSingaporeSingapore Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore

Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease,and the fastest-growing cause of hepatocellular carcinoma(hCC)worldwide(1,2).As the number of people with NAFLD is too great to perform surveillance in all,risk-stratification strategies are increasingly important to identify those at the highest risk of decompensation and hCC(3,4).

关键词： Non-alcoholic fatty liver disease(NAFLD) non-invasive tests fibrosis-4(FIB-4) vibration-controlled transient elastography(VCTE) clinical outcomes

Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine

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Translational Neurodegeneration 2022年第1期11卷 192-218页

作者： Ira Agrawal Yong Shan Lim Shi-Yan ng Shuo-Chien Ling Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeTahir Foundation BuildingMD116-03-H12 Science Drive 2Singapore 117549Singapore healthy Longevity Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute of Molecular and Cell Biology A*STAR Research EntitiesSingaporeSingapore Program in Neuroscience and Behavior Disorders Duke-National University of Singapore Medical SchoolSingaporeSingapore.

Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and *** not only regulate integrity and fluidity of biologi-cal membranes,but also serve as energy storage and bioactive molecules for *** mutations in SPTLC1(serine palmitoyltransferase long chain subunit 1)gene within the lipogenic pathway have been identified in amyo-trophic lateral sclerosis(ALS),a paralytic and fatal motor neuron ***,lipid dysmetabolism within the central nervous system and circulation is associated with ***,we aim to delineate the diverse roles of different lipid classes and understand how lipid dysmetabolism may contribute to ALS *** the different lipids,accumulation of ceramides,arachidonic acid,and lysophosphatidylcholine is commonly emerging as detri-mental to motor *** end with exploring the potential ALS therapeutics by reducing these toxic lipids.

关键词： Amyotrophic lateral sclerosis Sphingolipids Triglycerides Phospholipids Cholesterol esters Fatty acids Ceramides Arachidonic acid Lysophosphatidylcholine Eicosanoids

Physical activity,COVID-19,and respiratory comorbidities:The good,the bad,and the ugly

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Journal of Sport and health Science 2023年第2期12卷 216-218页

作者： Anh-Tuan Dinh-Xuan Thõng hua-huy Sven Günther Lung Function&Respiratory Physiology Units Department of Respiratory Physiology and Sleep MedicineAssistance Publique-Hôpitaux de ParisCochin&George Pompidou HospitalsUniversity Paris CitéParis 75006France

Almost 3 years after the outbreak of the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)responsible for the coronavirus disease 2019(COVID-19)that has caused more than 6 million deaths worldwide,1the pandemic persists and hampers our daily *** are at least 2 main reasons explaining why we still struggle to terminate this ***,novel variants of concern of SARS-CoV-2unceasingly emerge despite almost 12 billion doses of vaccinebeing administered to date.

关键词： respiratory doses acute