Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine

作     者：Ira Agrawal Yong Shan Lim Shi-Yan Ng Shuo-Chien Ling 

作者机构：Department of PhysiologyYong Loo Lin School of MedicineNational University of SingaporeTahir Foundation BuildingMD116-03-H12 Science Drive 2Singapore 117549Singapore Healthy Longevity Translational Research ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute of Molecular and Cell BiologyA*STAR Research EntitiesSingaporeSingapore Program in Neuroscience and Behavior DisordersDuke-National University of Singapore Medical SchoolSingaporeSingapore. 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2022年第11卷第1期

页      面：192-218页

核心收录：

学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 1009[医学-特种医学] 10[医学] 

基　　金：National Medical Research Council(NMRC/OFIRG/0042/2017) National Research Foundation(NRF2019-NRF-ISF003-3221) Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L 

主　　题：Amyotrophic lateral sclerosis Sphingolipids Triglycerides Phospholipids Cholesterol esters Fatty acids Ceramides Arachidonic acid Lysophosphatidylcholine Eicosanoids 

摘      要：Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and *** not only regulate integrity and fluidity of biologi-cal membranes,but also serve as energy storage and bioactive molecules for *** mutations in SPTLC1(serine palmitoyltransferase long chain subunit 1)gene within the lipogenic pathway have been identified in amyo-trophic lateral sclerosis(ALS),a paralytic and fatal motor neuron ***,lipid dysmetabolism within the central nervous system and circulation is associated with ***,we aim to delineate the diverse roles of different lipid classes and understand how lipid dysmetabolism may contribute to ALS *** the different lipids,accumulation of ceramides,arachidonic acid,and lysophosphatidylcholine is commonly emerging as detri-mental to motor *** end with exploring the potential ALS therapeutics by reducing these toxic lipids.