检索结果-南通市图书馆

Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice

引用

Molecular Plant 2023年第9期16卷 1460-1477页

作者： hideki yoshida Satoshi Okada Fanmiao Wang Shohei Shiota masaki Mori Mayuko Kawamura Xue Zhao yiqiao Wang Naho Nishigaki Asako Kobayashi Kotaro Miura Shinya yoshida Masaru Ikegami Akitoshi Ito Lin-Tzu huang yue-le Caroline hsing yoshiyuki yamagata yoichi Morinaka Masanori yamasaki Toshihisa Kotake Eiji yamamoto Jian Sun Ko hirano Makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan Bioscience and Biotechnology Center Nagoya UniversityNagoyaAichi 464-8601Japan Food Resources Education and Research Center Graduate School of Agricultural ScienceKobe UniversityUzuranoKasaiHyogo 675-2103Japan Research Center of Genetic Resources NARO2-1-1 KannondaiTsukubaIbaraki 305-8602Japan Rice Research Institute Shenyang Agricultural UniversityShenyangChina Division of Life Science Graduate School of Science and EngineeringSaitama University255 Shimo-okuboSakura-kuSaitamaJapan Fukui Agricultural Experiment Station Fukui 918-8215Japan Department of Bioscience and Biotechnology Fukui Prefectural UniversityFukui 910-1195Japan hyogo Prefectural Research Center for Agriculture Forestry and FisheriesKasaiHyogo 679-0198Japan Research Insttute for Food and Agriculture Ryukoku UniversityOotsuShiga 520-2194Japan Food Research Centre Aichi Centre for Industry and Science Technology2-1-1 Shimpukuji-choNagoyaAichi 451-0083Japan institute of Plant and Microbial Biology Academia SinicaTaipeiTaiwanChina Department of Agronomy National Taiwan UniversityTaipeiTaiwanChina lant Breeding Laboratory Facultyf gricultureKyushu University744MoookaNishikuFukukaJapan Graduate School of Agiculture Meji University1-1-1 Higashi-MitaTama-kuKawasakiKanagawa 214571Japa Crop Science Laboratory Faculty of AgricultureNigata UniversityIkarashiNishi-kuNigata 950-2181Japan

Improving grain quality is a primary objective in contemporary rice *** modern rice breeding has developed two different types of rice,eating and sake-brewing rice,with different grain characteristics,indicating the selection of variant gene alleles during the breeding *** the critical importance of promptly and efficiently identifying genes selected in past breeding for future molecular breeding,we conducted genome scans for divergence,genome-wide association studies,and map-based ***,we successfully identified two genes,OsMnS and OsWOX9D,both contributing to rice grain *** encodes a mannan synthase that increases the white core frequency in the endosperm,a desirable trait for sake brewing but decreases the grain appearance ***9D encodes a grass-specific homeobox-containing transcription factor,which enhances grain width for better sake ***,haplotype analysis revealed that their defective alleles were selected in East Asia,but not Europe,during modern *** addition,our analyses indicate that a reduction in grain mannan content during African rice domestication may also be caused a defective OsMnS allele due to breeding *** study not only reveals the delicate balance between grain appearance quality and nutrition in rice but also provides a new strategy for isolating causal genes underlying complex traits,based on the concept of“breeding-assisted genomics”in plants.

关键词： rice grain quality sake brewing mannan genomic analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combination of genetic analysis and ancient literature survey reveals the diverge nee of traditional Brassica rapa varieties from Kyoto, Japan

引用

horticulture Research 2021年第1期8卷 1877-1886页

作者： yaichi Kawakatsu Tomoaki Sakamoto hokuto Nakayama Kaori Kaminoyama Kaori Igarashi masaki yasugi hiroshi Kudoh Atsushi JNagano Kentaro yano Nakao Kubo Michitaka Notaguchi Seisuke Kimura Faculty of Life Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 603-8555Japan Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Center for Plant Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 6038555Japan Graduate School of Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan School of Agriculture Meiji University1-1-1Higashi-MitaTama-kuKawasakiKanagawa 214-8571Japan Faculty of Engineering Utsunomiya University7-1-2 YotoUtsunomiyaTochigi 321-8585Japan Center for Ecological Research Kyoto UniversityHirano 2-509-3OtsuShiga 520-2113Japan Faculty of Agriculture Ryukoku University1-5 YokotaniSeta Oe-choOtsuShiga 520-2194Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural University1-5 Hangi-choShimogamoSakyo-kuKyoto 606-8522Japan Biotechnology Research Department Kyoto Prefectural AgricultureForestry and Fisheries Technology Center74 OjiKitainayazumaSeika-choSoraku-gunKyoto 6190244Japan Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Institute of Transformative Bio-Molecules Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Since ancient times,humans have bred several plants that we rely on ***,little is known about the divergence of most of these *** the present study,we investigated the divergence of Mibuna(Brassica rapa *** ***),a traditional leafy vegetable in Kyoto(Japan),by combining genetic analysis and a survey of ancient *** is considered to have been bred 200 years ago from Mizuna,another traditional leafy vegetable in *** has simple spatulate leaves,whereas Mizuna has characteristic serrated *** quantitative trait loci(QTL)and gene expression analyses suggested that the downregulation of BrTCP15 expression contributed to the change in the leaf shape from serrated to simple ***,the SNP analysis indicated that the genomic region containing the BrTCP15 locus was transferred to Mibuna by ***,we conducted a survey of ancient literature to reveal the divergence of Mibuna and found that hybridization between Mizuna and a simple-leaved turnip might have occurred in the ***,the genomic analysis of multiple turnip cultivars showed that one of the cultivars,Murasakihime,has almost the same sequence in the BrTCP15 region as *** results suggest that the hybridization between Mizuna and turnip has resulted in the establishment of Mibuna.

关键词： cultivar survey analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dopamine cannot promote oligomerization of unoxidized <i>α</i>-synuclein

引用

Journal of Biophysical Chemistry 2013年第3期4卷 110-114页

作者： Sakurako Shimotakahara Mika Matsui Chiseko Sakuma Teruaki Takahashi Takashi Fujimoto Kazuo Furihata masaki Kojima Shohei Seino Tomoya Machinami yoichi Shibusawa Kenji Uéda Mitsuru Tashiro Department of Chemistry School of Sciences and Engineering Meisei University Tokyo Japan Division of Agriculture and Agricultural Life Sciences The University of Tokyo Tokyo Japan School of Life Science Tokyo University of Pharmacy and Life Science Tokyo Japan School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan

α-Synuclein is the major component of the filamentous Lewy bodies and Lewy neurites that define neuropathological features of Parkinson’s disease and dementia with Lewy bodies. To investigate the oligomerization process of α-synuclein in association with dopamine (DA), the structural propensities to form oligomers were studied using NMR and other biophysical techniques. The1h-15N hSQC spectra indicated that both N- and C-termini interacted with DA. Although interactions with DA were also observed in the presence of glutathione by ESI-MS, the significant suppression of oligomerization was observed in the size exclusion chromatography, suggesting that oxidations of α-synuclein are required for its oligomerization.

关键词： α-Synuclein Dopamine Glutathione Oligomerization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

慢性酒精中毒患者的认知功能障碍与弥散性大脑白质萎缩的关系研究

引用

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 14-14页

作者： Mochizuki h. masaki T. Matsushita S. 夏峰 Lab. Bact. Pathogenesis and Immunol. Rockefeller University1230 York Avenue New York NY 10021 United States

Objective: Diffuse brain white matter atrophy is often seen in chronic alcohol ics, but its relation with cognitive impairment remains to be solved. In order t o address this issue, in alcoholics with cognitive impairment at different level s, we studied relations of the central sensory conduction time (CSCT)or brain ma gnetic resonance imaging (MRI) findings with the cognitive function. Methods: Su bjects were 35 alcoholics with mild cognitive impairment (mini-mental state exa mination score, MMSE,≥24; mean±SD, 27.7±1.9), 12 with moderate to severe cogn itive impairment (MMSE h Alzheimer’s disease (AD) (MMSE , 18.9±4.3) (disease control)and 20 healthy volunteers (MMSE, 28.5±1.6) (norma l control). Median nerve SEPs were recorded in the all subjects,and the latencie s and amplitudes of their N9, N11, P13/14, N20 and P25 components were measured. The ventri culocranial ratio (VCR) and the width of cortical sulci were measure d on MRIs. These physiological parameters and MRI findings were compared between the 4 groups of the subject, and correlations between those all features were a lso analyzed. Results: CSCT and VCR were significantly greater in alcoholics wit h moderate to severe cognitive impairment than those in the other 3 groups. Pear son’s product-moment correlation analyses of the alcoholics disclosed that bot h the CSCT and VCR had significant negative correlations with the MMSE score. Mo reover, the CSCT and VCR were positively correlated. Conclusions: Both physiolog ical and morphological estimates of the white matter function (CSCT and VCR) had a significant correlation with the cognitive dysfunction. Significance: The dif fuse white matter atrophy may be one of the factors causing cognitive impairment in chronic alcoholics.

关键词：脑白质酒精中毒患者慢性酒精中毒 impairment 阿尔茨海默病传导时间健康受试者 cortical 病理对照 atrophy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低温分配固液萃取结合高效液相色谱-质谱法测定食用菌中6-苄基腺嘌呤

引用

色谱 2018年第1期36卷 12-16页

作者：侯琨渡边正树王大利韩晶李永路霍虹日立仪器(大连)有限公司辽宁大连116033 株式会社日立高新技术科学日本茨城312003 大连市儿童医院辽宁大连116012 中国科学院大连化学物理研究所辽宁大连116023

建立了低温分配固液萃取(SLE-LTP)技术结合高效液相色谱-质谱(hPLC-MS)测定食用菌中6-苄基腺嘌呤(6-BA)的方法。食用菌样品经乙腈提取和低温分配,采用hitachi LaChrom C18色谱柱(250 mm×4.6 mm,5μm)分离,以0.02 mol/L乙酸铵(含0.1%(v... 详细信息

建立了低温分配固液萃取(SLE-LTP)技术结合高效液相色谱-质谱(hPLC-MS)测定食用菌中6-苄基腺嘌呤(6-BA)的方法。食用菌样品经乙腈提取和低温分配,采用hitachi LaChrom C18色谱柱(250 mm×4.6 mm,5μm)分离,以0.02 mol/L乙酸铵(含0.1%(v/v)冰乙酸)-甲醇(6∶4,v/v)溶液为流动相,等度洗脱,在电喷雾正离子模式下检测,外标法定量。结果表明,6-苄基腺嘌呤在0.05~2.0 mg/L范围内线性关系良好,相关系数为1.000 0;方法的检出限和定量限分别为0.006 mg/kg和0.02 mg/kg。加标回收率试验显示在0.1 mg/kg和0.5mg/kg添加水平下6-苄基腺嘌呤的加标回收率为81.3%~93.7%,相对标准偏差为0.7%~2.4%。该法简单、准确、稳定,可用于食用菌中6-苄基腺嘌呤的检测。

关键词：高效液相色谱-质谱低温分配固液萃取 6-苄基腺嘌呤食用菌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis

引用

World Journal of Critical Care Medicine 2015年第3期4卷 251-257页

作者： masaki Okajima Masayuki Takamura Takumi Taniguchi Intensive Care Unit Kanazawa University Hospital Department of Disease Control and homeostasis Kanazawa University Graduate School of Medicine

AIM: To investigate whether landiolol, an ultra-shortacting β1-antagonist, can safely and effectively control heart rate in septic patients with supraventricular ***: We reviewed all patients with sepsis who admitted to our intensive care unit between January 2006 and December 2011. Sixty one septic patients suffered from supraventricular tachyarrhythmias(heart rate ≥ 120 bpm for > 1 h). Among 61 patients, 39 patients were treated with landiolol(landiolol group) and 22 patients were not treated with landiolol(control group). Arterial pressure, heart rate, cardiac rhythm, pulmonary arterial pressure and cardiac output(if a pulmonary arterial catheter was inserted) were compared between the 2 groups at 1, 8 and 24 h after the initiation of tachyarrhythmias. RESULTS: Mean age and Acute Physiology and Chronic health Evaluation II and Sequential Organ Failure Assessment scores were similar between the 2 groups. Paroxysmal atrial fibrillation/flutter(87%), paroxysmal atrial tachycardia(10%), and paroxysmal supraventricular tachycardia(3%) were observed. The initial landiolol dose administered was 6.3 ± 5.8 g/kg per minute. Rapid and substantial reduction of heart rate was observed in the landiolol group without anydeterioration of hemodynamics. Landiolol significantly reduced heart rate(from 145 ± 14 bpm to 90 ± 20 bpm) compared to the control group(from 136 ± 21 bpm to 109 ± 18 bpm, P he conversion to sinus rhythm was observed more frequently in the landiolol group than in the control group at every point(P h; P h).CONCLUSION: Landiolol safely reduced heart rate and, in part, converted to sinus rhythm in septic patients with supraventricular tachyarrhythmias.

关键词： Landiolol Supraventricular tachyarrhythmias Sepsis Rate control Conversion to sinus rhythm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非痴呆患者的记忆主诉预测未来的阿尔茨海默病的病理诊断

引用

世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 47-47页

作者： Jorm A.F. masaki K.h. Davis D.G. 姚庆和 Centre for Mental health Research Australian National University Canberra ACT 0200 Australia Dr

The validity of memory complaints as a predictor of Alzheimer disease (AD) was assessed in 237 Japanese- American men autopsied at ages 74 to 97 years. These men were free of dementia at the time memory complaints were assessed 1 to 11 years earlier. Memory complaints were found to predict the neuropathologic diagnosis of AD after adjusting for age, time to death, education, depression, and cognitive functioning.

关键词：阿尔茨海默病病理诊断认知功能病理学诊断死亡时间中评估

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastric adenocarcinoma of fundic gland type:Endoscopicand clinicopathological features

引用

World Journal of Gastrointestinal Endoscopy 2016年第4期8卷 244-251页

作者： Gen Tohda Takeshi Osawa yasuyuki Asada masaki Dochin Shintarou Terahata Department of Gastroenterology Fukui Kosei HospitalFukui 918-8537Japan Department of Surgery Fukui Kosei HospitalFukui 918-8537Japan Department of Diagnostic Pathology Tonami General HospitalTonami 939-1395Japan

Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. here, we report 4 cases of GA-FG with chief cell differentiation. Endoscopic features included a submucosal tumor shape or a flat shape, whitish discoloration and dilated vessels on the surface. The tumors were located in the upper or middle third of the stomach. All cases were preoperatively diagnosed as GA-FG by biopsy, and endoscopic submucosal dissection was performed. Resected specimens revealed well-differentiated adenocarcinomas resembling chief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ, but partially positive for h+/K+-ATPase in scattered locations around the tumor margin. Despite the presence of minimal invasion of the carcinoma into the submucosal layer, which was observed in two cases, neither lymphatic nor venous invasion was detected in any of the cases. Finally, all cases showed less aggressive clinical behavior with low grade malignancy.

关键词： Early gastric cancer Low grade malignancy Fundic gland type Chief cells Endoscopic submucosaldissection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肠溶包衣压力控制结肠定位给药胶囊的体内外评价

引用

中国医院药学杂志 2009年第22期29卷 1928-1933页

作者：崔京浩唐丽华岩田雅树高间雅志村上正裕苏州大学医学部药学院江苏苏州215123 天藤制药株式会社大阪大谷大学药学部

目的:研究肠溶衣对压力控制结肠定位释放胶囊(Ent-PCDCs)的稳定性及其体内外释放特征。方法:压制法制备含咖啡因半合成脂肪酸脂囊芯,高效包衣机进行乙基纤维素(EC)和肠溶性包衣。测定PCDCs的体外崩解压力后,进行Ent-PC-DCs稳定性、体外... 详细信息

目的:研究肠溶衣对压力控制结肠定位释放胶囊(Ent-PCDCs)的稳定性及其体内外释放特征。方法:压制法制备含咖啡因半合成脂肪酸脂囊芯,高效包衣机进行乙基纤维素(EC)和肠溶性包衣。测定PCDCs的体外崩解压力后,进行Ent-PC-DCs稳定性、体外释放及恒河猴的口服药动学研究。结果:Ent-PCDCs的稳定性明显提高,其崩解压力与EC厚度呈线性关系;Ent-PCDCs在人工胃液中2h和人工肠液6h的累计释放量低于25%。药动学试验结果,EC厚度为32μm时咖啡因的Tmax和MRT分别为(5.67±1.21)h和(16.80±1.74)h,初步表明药物主要在结肠部位释放和吸收。结论:Ent-PCDC的稳定性符合要求,EC厚度对药物结肠定位释放具有重要影响。

关键词：肠道压力结肠定位肠溶衣药物释放

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

狗枣猕猴桃叶化学成分研究(Ⅱ)

引用

高等学校化学学报 2009年第3期30卷 468-473页

作者：陆娟李绪文桂明玉刘桂英朱娜于爱民马场正树奥山徹金永日吉林大学化学学院长春130021 明治药科大学东京204-8588

从狗枣猕猴桃叶中分离出4个新的黄酮类化合物,经1D NMR,2D NMR及ESI-MS等波谱分析鉴定了其结构,分别是4′-甲氧基-槲皮素-7-O-(4″-O-乙酰基-鼠李糖基)-3-O-β-D-吡喃葡萄糖苷(1),山柰甲黄素-7-O-(3″-O-乙酰基-鼠李糖基)-3-O-芸香糖苷(... 详细信息

从狗枣猕猴桃叶中分离出4个新的黄酮类化合物,经1D NMR,2D NMR及ESI-MS等波谱分析鉴定了其结构,分别是4′-甲氧基-槲皮素-7-O-(4″-O-乙酰基-鼠李糖基)-3-O-β-D-吡喃葡萄糖苷(1),山柰甲黄素-7-O-(3″-O-乙酰基-鼠李糖基)-3-O-芸香糖苷(2),山柰酚-7-O-(4″-O-乙酰基-鼠李糖基)-3-O-芸香糖苷(3)和4′-甲氧基-槲皮素-7-O-(4″-O-乙酰基-鼠李糖基)-3-O-芸香糖苷(4).

关键词：狗枣猕猴桃猕猴桃科乙酰基黄酮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：