慢性酒精中毒患者的认知功能障碍与弥散性大脑白质萎缩的关系研究

作     者：Mochizuki H. Masaki T. Matsushita S. 夏峰 

作者机构：Lab. Bact. Pathogenesis and Immunol. Rockefeller University1230 York Avenue New York NY 10021 United States 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第7期

页      面：14-14页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：脑白质 酒精中毒患者 慢性酒精中毒 impairment 阿尔茨海默病 传导时间 健康受试者 cortical 病理对照 atrophy 

摘      要：Objective: Diffuse brain white matter atrophy is often seen in chronic alcohol ics, but its relation with cognitive impairment remains to be solved. In order t o address this issue, in alcoholics with cognitive impairment at different level s, we studied relations of the central sensory conduction time (CSCT)or brain ma gnetic resonance imaging (MRI) findings with the cognitive function. Methods: Su bjects were 35 alcoholics with mild cognitive impairment (mini-mental state exa mination score, MMSE,≥24; mean±SD, 27.7±1.9), 12 with moderate to severe cogn itive impairment (MMSE 24; 20.3±2.7), 15 with Alzheimer’s disease (AD) (MMSE , 18.9±4.3) (disease control)and 20 healthy volunteers (MMSE, 28.5±1.6) (norma l control). Median nerve SEPs were recorded in the all subjects,and the latencie s and amplitudes of their N9, N11, P13/14, N20 and P25 components were measured. The ventri culocranial ratio (VCR) and the width of cortical sulci were measure d on MRIs. These physiological parameters and MRI findings were compared between the 4 groups of the subject, and correlations between those all features were a lso analyzed. Results: CSCT and VCR were significantly greater in alcoholics wit h moderate to severe cognitive impairment than those in the other 3 groups. Pear son’s product-moment correlation analyses of the alcoholics disclosed that bot h the CSCT and VCR had significant negative correlations with the MMSE score. Mo reover, the CSCT and VCR were positively correlated. Conclusions: Both physiolog ical and morphological estimates of the white matter function (CSCT and VCR) had a significant correlation with the cognitive dysfunction. Significance: The dif fuse white matter atrophy may be one of the factors causing cognitive impairment in chronic alcoholics.