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Chinese Physics B 2020年第6期29卷 532-537页

作者： f Sobhani h heidarzadeh h Bahador Department of Electrical and Computer Engineering University of Mohaghegh ArdabiliArdabilIran

The cluster-shaped plasmonic nanostructures are used to manage the incident light inside an ultra-thin silicon solar *** we simulate spherical,conical,pyramidal,and cylindrical nanoparticles in a form of a cluster at the rear side of a thin silicon cell,using the finite difference time domain(fDTD)*** calculating the optical absorption and hence the photocurrent,it is shown that the clustering of nanoparticles significantly improves *** photocurrent enhancement is the result of the plasmonic effects of clustering the *** comparison,first a cell with a single nanoparticle at the rear side is *** four smaller nanoparticles are put around it to make a *** photocurrents of 20.478 mA/cm2,23.186 mA/cm2,21.427 mA/cm2,and 21.243 mA/cm2 are obtained for the cells using clustering conical,spherical,pyramidal,cylindrical NPs at the backside,*** values are 13.987 mA/cm2,16.901 mA/cm2,16.507 mA/cm2,17.926 mA/cm2 for the cell with one conical,spherical,pyramidal,cylindrical NPs at the backside,***,clustering can significantly improve the ***,the distribution of the electric field and the generation rate for the proposed structures are calculated.

关键词： clustering nanoparticles plasmonic solar cell localized surface plasmon resonance photocurrent finite difference time domain(fDTD)method light management

Optimization of chemistry and process parameters for control of intermetallic formation in Mg sludges

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Journal of Magnesium and Alloys 2024年第4期12卷 1431-1448页

作者： Y.fu G.G.Wang A.hu Y.Li K.B.Thacker J.P.Weiler h.hu Department of Mechanical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Technology Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,holding and high pressure die casting practices is a very important ***,very often it is overlooked by academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of this study was to minimize the intermetallic formation in Mg sludge via the optimization of the chemistry and process *** Al8Mn5 intermetallic particles were identified by the microstructure analysis based on the Al and Mn *** design of experiment(DOE)technique,Taguchi method,was employed to minimize the intermetallic formation in the sludge of Mg alloys with various chemical compositions of Al,Mn,fe,and different process parameters,holding temperature and holding *** sludge yield(SY)and intermetallic size(IS)was selected as two *** optimum combination of the levels in terms of minimizing the intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)fe,690℃ for the holding temperature and holding at 30 mins for the holding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)fe,630℃ for the holding temperature and holding at 60 mins for the holding time,*** groups of sludge factors,Chemical Sludge(CSf),Physical Sludge(PSf)and Comprehensive Sludge factors(and CPSf)were established for prediction of sludge yields and intermetallic sizes in Al-containing Mg *** CPSf with five independent variables including both chemical elements and process parameters gave high accuracy in prediction,as the prediction of the PSf with only the two processing parameters of the melt holding temperature and time showed a relatively large deviation from the experimental *** Chemical Sludge factor was primarily designed for small ingot producers and die casters with a limited melting and holding capacity,of which process parameters could be fixed *** Physical Sludge factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguchi method Sludge factor Chemical composition Process parameter

氮碳包封fe_(3)C纳米颗粒作为高效富氧还原电催化剂

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Science China Materials 2024年第3期67卷 762-770页

作者：汪翠萍李智雷杰李松 Stijn f.L.Mertens 胡劲松 School of Chemical Engineering Anhui Province Key Laboratory of Specialty PolymersAnhui University of Science and TechnologyHuainan 232001China Department of Chemistry Energy Lancaster and Materials Science LancasterLancaster UniversityLancaster LA14YBUnited Kingdom Institute of Energy Hefei Comprehensive National Science CenterHefei 230031China

高活性MOf基催化剂的设计和合成为促进动力学不利的氧还原反应(ORR)过程开辟了新的途径.本研究通过在ZIf-8前驱体表面涂覆二茂铁甲酸,然后进行两步炭化工艺,设计和制备了一种具有新型结构的高效电催化剂,以提高ORR性能.两步炭化过程对... 详细信息

高活性MOf基催化剂的设计和合成为促进动力学不利的氧还原反应(ORR)过程开辟了新的途径.本研究通过在ZIf-8前驱体表面涂覆二茂铁甲酸,然后进行两步炭化工艺,设计和制备了一种具有新型结构的高效电催化剂,以提高ORR性能.两步炭化过程对于将热解fe_(3)C纳米颗粒封装到碳纳米管(CNTs)中以及将fe单原子隔离到N掺杂碳(NC)基体上至关重要.此外,fe元素的相对含量对优化催化剂的ORR性能至关重要.所制得fe_(3)C@CNTs/NC-M催化剂结构先进,在碱性溶液中表现出良好的长期稳定性和电催化ORR性能,其半波电位和极限电流分别达到0.941 V和6.31 mA cm^(-2).此外,该电催化剂在甲醇溶液中具有较强的耐受性和良好的稳定性.fe_(3)C@CNTs/NC-M锌空气电池(ZAB)具有1.525 V的开路电位,420 mA cm^(-2)时的峰值功率密度为348 mW cm^(-2),10 mA cm^(-2)时的最大容量为843 mA h g_(Zn)^(-1).因此,这种合成策略为构建具有有效和稳定的ORR性能的MOf基电催化材料提供了一条有效途径.

关键词： metal-organic frameworks carbon nanotubes N-doped carbon matrix oxygen reduction reaction Zn-air battery

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni f.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.f.Cao N.Cao S.A.Cetin J.f.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto f.Cossio J.J.Cui h.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis f.De Mori B.fang S.S.fang W.X.fang Y.fang Y.Q.fang R.farinelli L.fava f.feldbauer G.felici C.Q.feng J.h.feng Y.T.feng K.fischer M.fritsch C.D.fu J.L.fu Y.W.fu h.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.h.Duan P.Egorov Y.h.fan J.fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.han T.T.han X.Q.hao f.A.harris K.K.he K.L.he f.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou Z.L.hou B.Y.hu h.M.hu J.f.hu T.hu Y.hu G.S.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain f.h\"olzken N.h\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.h.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei h.Leithoff M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li f.Li G.Li h.Li h.B.Li h.J.Li h.N.Li hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Y.Li Y Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INfN Laboratori Nazionali di frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INfN Laboratori Nazionali di frascati INFN Sezione di PerugiaI-06100PerugiaItaly INfN Laboratori Nazionali di frascati University of PerugiaI-06100PerugiaItaly INfN Sezione di ferrara INFN Sezione di FerraraI-44122FerraraItaly INfN Sezione di ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

Clinical and Evolutive Aspects of Severe Acute Malnutrition in Children Aged 0 - 59 Months at Maroua Regional hospital in Cameroon’s far North Region

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Open Journal of Pediatrics 2024年第4期14卷 700-711页

作者： Palma haoua Abouame Selangai hélène Kamo Sime Tchouamo Arielle Annick fernando Kemta Lepka Daniel Nemsi Sadjo Salihou Aminou haman Soureya Yolande feudjo Ulrich Dama félicitée Nguefack faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon Maroua Regional hospital Maroua Cameroon Garoua General hospital Garoua Cameroon Yaounde Gynaeco-Obstetrics hospital Yaounde Cameroon faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Douala General hospital Douala Cameroon Department of health Sciences Catholic University of Central Africa Yaounde Cameroon University of Lisala Lisala Democratic Republic of the Congo faculty of Medicine and Biomedical Sciences University of Yaound I Yaounde Cameroon

Introduction: Severe acute malnutrition remains one of the most important causes of under-five mortality. In Cameroon, the northern regions have the highest prevalence, with 1.4% in the far North in 2021. These children are managed at the Internal therapeutic and Nutrional Centre, one of which is located at Maroua Regional hospital, the third level referral hospital. We therefore proposed to carry out a study on the clinical and evolutive aspects of these children. Materials and Methods: it was a descriptive, cross-sectional study from January 2020 to December 2022, at the ITNC (CNTI) of Maroua Regional hospital. The sample size was obtained from the Lorentz formula. Patient records were used for data collection. We excluded all incomplete records and patients with less than 24 hours of admission. Results: Out of the 873 patients we recruited, the prevalence of severe malnutrition was estimated at 18 %. The average age was 14 months, with a male predominance. The main reasons for consultation were fever (42%) and diarrhoea (35%). Marasmus was the predominant clinical form. The major medical complications were sepsis (32.9%) and malaria (16.8%). hIV prevalence was 2.5% and tuberculosis was 4.9%. Most patients had haemoglobin levels between 7 and 10g/dl. 79.3% were cured and 6.5% died. The main causes of death were sepsis and malaria. Conclusion: Severe acute malnutrition remains a major problem in the far North region. Several joint actions are needed to break this cycle.

关键词： Severe Acute Malnutrition Children far North Cameroon

further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli f.Galtarossa f.Recchia A.Illana S.Bakes I.Zanon S.Aydin G.de Angelis M.Siciliano R.Menegazzo S.M.Lenzi J.L.ferreira J.Rangel Serkan Akkoyun L.f.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-french Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of high Purity Germanium Materials and fetectors Shenzhen UniversityShenzhen 518060China INfN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INfN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INfN Sezione di NapoliI-80126 NapoliItaly Dipartimento di farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)Bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICf)products were re-quantified experimentally for this reaction *** results reveal that the ICf cross section is equivalent to that of complete fusion(Cf)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CDCC)method was performed for the aforementioned Cf and ICf cross sections;the result is consistent with the *** universal fusion function(Uff)was also compared with the measured Cf cross section for different barrier parameters,demonstrating that the Cf suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

Charge susceptibilities of armchair graphene nanoribbon in the presence of magnetic field

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Chinese Physics B 2016年第9期25卷 511-517页

作者： h Rezania f Azizi Department of Physics Razi University

We present the behaviors of both dynamical and static charge susceptibilities of undoped armchair graphene nanoribbon using the Green＇s function approach in the context of tight binding model ***,the effects of magnetic field on the the plasmon modes of armchair graphene nanoribbon are investigated via calculating the correlation function of charge density *** results show that the increase of magnetic field makes the high-frequency plasmon mode for both metallic and insulating cases *** also show that low-frequency plasmon mode for metallic nanoribbon appears due to increase of magnetic ***,the number of collective excitation modes increases with ribbon width at zero magnetic ***,the temperature dependence of the static charge structure factor of armchair graphene nanoribbon is *** effects of both magnetic field and ribbon width on the static charge structure factor are discussed in detail.

关键词： armchair graphene nanoribbon Green's function

Enabling Technologies for Autonomous Robotic Systems in Manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEMPESZ János CSERTEG Tamás GODÓGábor hAJÓS Mátyás hÁY Borbála hORVÁTh Dániel hORVÁTh Gergely JUNIKIÁdám KEMÉNY Zsolt KOVÁCS András NACSA János PANITI Imre PEDONE Gianfranco TAKÁCS Emma TIPARY Bence ZAhORÁN László VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of Manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs Nonprofit Ltd. BudapestHungary Eötvös Loránd University(ELTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at hUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

Elastic, thermodynamic, electronic, and optical properties of recently discovered superconducting transition metal boride NbRuB:An ab-initio investigation

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Chinese Physics B 2017年第10期26卷 339-347页

作者： f Parvin S h Naqib Department of Physics University of Rajshahi

The elastic, thermodynamic, electronic, and optical properties of recently discovered and potentially technologically important transition metal boride NbRuB, are investigated using the density functional formalism. Both generalized gradient approximation （GGA） and local density approximation （LDA） are used for optimizing the geometry and for estimating various elastic moduli and constants. The optical properties of NbRuB are studied for the first time with different photon polarizations. The frequency （energy） dependence of various optical constants complement quite well the essential features of the electronic band structure calculations. Debye temperature of NbRuB is estimated from the thermodynamical study. All these theoretical estimates are compared with published results, where available, and discussed in detail. Both electronic band structure and optical conductivity reveal robust metallic characteristics. The NbRuB possesses significant elastic anisotropy. Electronic features, on the other hand, are almost isotropic in nature. The effects of electronic band structure and Debye temperature on the emergence of superconductivity are also analyzed.

关键词： hard materials ternary borides DfT calculations electronic band structure optical properties superconductivity

The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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CURRENT UROLOGY 2024年第2期18卷 128-132页

作者： Chierigo, francesco flammia, Rocco Simone Sorce, Gabriele hoeh, Benedikt hohenhorst, Lukas Panunzio, Andrea Tian, Zhe Saad, fred Graefen, Marcus Gallucci, Michele Briganti, Alberto Montorsi, francesco Chun, felix K. h. Shariat, Shahrokh f. Antonelli, Alessandro Guano, Giovanni Mantica, Guglielmo Borghesi, Marco Suardi, Nazareno Terrone, Carlo Karakiewicz, Pierre I. Univ Genoa Dept Surg & Integrated Diagnost Sci Genoa Italy IRCCS Osped Policlin San Martino Genoa Italy Univ Montreal Hlth Ctr Div Urol Canc Prognost & Hlth Outcomes Unit Montreal PQ Canada IRCCS Policlin San Martino Dept Urol Genoa Italy Univ Genoa Policlin San Martino Hosp Dept Urol Largo Rosanna Benzi 10 I-16132 Genoa Italy Sapienza Rome Univ Policlin Umberto Hosp 1 Dept Maternal Child & Urol Sci Rome Italy Univ hosp frankfurt Dept Urol Frankfurt Germany Univ hosp hamburg Eppendorf Martini Klin Prostate Canc Ctr Hamburg Germany Univ Verona Azienda Osped Univ Integrata Verona Dept Urol Verona Italy IRCCS San Raffaele Sci Inst Urol Res Inst Div Expt Oncol Unit Urol Milan Italy Med Univ Vienna Comprehens Canc Ctr Dept Urol Vienna Austria Weill Cornell Med Coll Dept Urol New York NY USA Univ Texas Southwestern Dept Urol Dallas TX USA Charles Univ Prague Fac Med 2 Dept Urol Prague Czech Republic IM Sechenov first Moscow State Med Univ Inst Urol & Reprod Hlth Moscow Russia Univ Jordan Jordan Univ Hosp Dept Special Surg Div Urol Amman Jordan

Objectives: This study aimed to test the association between of type and number of D'Amico high-risk criteria (DhRCs) with cancer-specific mortality (CSM) in high-risk prostate cancer patients treated with radical prostatectomy. Materials and methods: In the Surveillance, Epidemiology, and End Results database (2004-2016), we identified 31,281 radical prostatectomy patients with at least 1 DhRC, namely, prostate-specific antigen (PSA) >20 ng/mL (hrPSA), biopsy Gleason Grade Group (hrGGG) score of 4 and 5, or clinical tumor stage >= T3 (hrcT). Multivariable Cox regression models and competing risks regression models (adjusting for other cause mortality) tested the association between DhRCs and 5-year CSM. Results: Of 31,281 patients, 14,394 (67%) exclusively harbored hrGGG, 3189 (15%) harbored hrPSA, and 1781 (8.2%) harbored hrcT. Only 2132 patients (6.8%) harbored a combination of the 2 DhRCs, and 138 (0.6%) had all 3 DhRCs. five-year CSM rates ranged from 0.9% to 3.0% when any individual DhRC was present (hrcT, hrPSA, and hrGGG, in that order), 1.6% to 5.9% when 2 DhRCs were present (hrPSA-hrcT, hrcT-hrGGG, and hrPSA-hrGGG, in that order), and 8.1% when all 3 DhRCs were present. Cox regression models and competing risks regression confirmed the independent predictor status of DhRCs for 5-year CSM that was observed in univariable analyses, with hazard ratios from 1.00 to 2.83 for 1 DhRC, 2.35 to 5.88 for combinations of 2 DhRCs, and 7.13 for all 3 DhRCs. Conclusions: Within individual DhRCs, hrcT and hrPSA exhibited weaker effects than hrGGG did. Moreover, a dose-response effect was identified according to the number of DhRCs. Accordingly, the type and number of DhRCs allow further risk stratification within the high-risk subgroup.

关键词： high risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER BEAM RADIATION-ThERAPY RATES