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Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-hao huang Li-Wen lee Jrhau Lung Yu-Che Ou Chien-hui hung huei-Chieh Chuang Min-Chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public health Chang Gung UniversityTaoyuan 333Taiwan Division of hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(hIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/hIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/hIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/hIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(had a favorable PFS(≥1 year).Simple logistic models revealed that the patients with a completeness of cytoreduction score of 0(CC-0)or length of CRS≤6 h had a favorable PFS[odds ratio(OR)=0.141,P=0.004;and OR=0.361,P=0.027,respectively].In multiple logistic regression,achieving CC-0 was the strongest prognostic factor for a favorable PFS(OR=0.131,P=0.005).A peritoneal cancer index score>12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,Phieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/hIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery hyperthermic intraperitoneal chemotherapy Predictor Recurrence

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Temperature and Thermal Stress Distribution for Metal Mold in Squeeze Casting Process

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Journal of Materials Science & Technology 2008年第3期24卷 347-350页

作者： C.h.lee S.h.lee Institute of Technology and Science Chung-Ang University

In the squeeze casting process, loaded high pressure （over approximately 200 MPa） and high temperature influence the thermo-mechanical behavior and performance of the used metal mold. Therefore, to safely maintain the metal molds, the thermo-mechanical characteristics （temperature and thermal stress） of metal mold in the squeeze casting must be investigated. In this paper, temperature and thermal stress distribution of steel mold in squeeze casting process were investigated by using a three-dimensional non-steady heat conduction analysis and a three-dimensional thermal elastic-plastic analysis considering temperature-dependent thermophysical and mechanical properties of the steel mold.

关键词： Squeeze casting Steel mold Thermal stress Thermo-Mechanical analysis

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Review of vortex methods for rotor aerodynamics and wake dynamics

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Advances in Aerodynamics 2022年第1期4卷 413-448页

作者： h.lee B.Sengupta M.S.Araghizadeh R.S.Myong School of Mechanical and Aerospace Engineering Gyeongsang National UniversityJinjuGyeongnam52828South Korea

Electric vertical take-off and landing(eVTOL)aircraft with multiple lifting rotors or prop-rotors have received significant attention in recent years due to their great potential for next-generation urban air mobility(UAM).Numerical models have been developed and validated as predictive tools to analyze rotor aerodynamics and wake *** various numerical approaches,the vortex method is one of the most suitable because it can provide accurate solutions with an affordable computational cost and can represent vorticity fields downstream without numerical dissipation *** paper presents a brief review of the progress of vortex methods,along with their principles,advantages,and *** of the vortex methods for modeling the rotor aerodynamics and wake dynamics are also ***,the vortex methods suffer from the problem that it cannot deal with the nonlinear aerodynamic characteristics associated with the viscous effects and the flow behaviors in the post-stall *** overcome the intrinsic drawbacks of the vortex methods,recent progress in a numerical method proposed by the authors is introduced,and model validation against experimental data is discussed in *** validation works show that nonlinear vortex lattice method(NVLM)coupled with vortex particle method(VPM)can predict the unsteady aerodynamic forces and complex evolution of the rotor wake.

关键词： Vortex methods Nonlinear vortex lattice method Viscous vortex particle method Rotor aerodynamics Wake dynamics

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Technology trends,challenges,and opportunities of reduced-rare-earth PM motor for modern electric vehicles

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Green Energy and Intelligent Transportation 2022年第1期1卷 63-81页

作者： Shiyue Zheng Xiaoyong Zhu Zixuan Xiang Lei Xu Li Zhang Christopher h.T.lee School of Electrical and Information Engineering Jiangsu UniversityZhenjiangChina Nanyang Technological University Singapore

Nowadays,with increasing concerns about environmental pollution and energy crisis electric vehicles are rapidly developing owing to their significant environmental-friendly *** meet the diverse driving requirements of electric vehicles,the PM motors with high-performance rare-earth PMs have been widely employed in electric vehicle powertrains,which shows the performance merits of high power density and high ***,rare-earth PMs,as non-renewable strategic resources,usually suffer from unstable supply and fluctuation prices,which increases the potential risks of further large-scale application of rare-earth PM *** this also poses a negative factor for the long-term sustainable development of electric vehicles or other applications that rely heavily on rareearth PM *** this background,a type of less-rare-earth PM motors,which aims to effectively alleviate the dependence of high-performance PM motors on rare-earth PMs,has recently drawn increasing attention from experts and *** implies that the investigation and development of less-rare-earth PM motors without compromising performances is becoming a new and hot research direction in the motor *** paper reviews the existing main alternatives for less-rare-earth PM *** on the dominated torque component,the less-rareearth PM motors are divided into two types,which are the less-rare-earth PM-dominated motor and less-rare-earth PM-assisted *** operation principle,design considerations and restrictions of each type of less-rare-earth PM motor is sequentially ***,combined with the potential electric vehicle application,the key problems of less-rare-earth PM motor are summarized and the corresponding technological means are prospected.

关键词： Electric vehicles Permanent magnet motors Rare-earth materials Permanent magnet

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Precise control of surface oxygen vacancies in ZnO nanoparticles for extremely high acetone sensing response

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Journal of Advanced Ceramics 2022年第5期11卷 769-783页

作者： Jihyun lee Youngmoon ChOI Byoung Joon PARK Jeong Woo hAN hyun-Sook lee Jong hyeok PARK Wooyoung lee Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biological Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea

ZnO has been studied intensely for chemical sensors due to its high sensitivity and fast ***,we present a simple approach to precisely control oxygen vacancy contents to provide significantly enhanced acetone sensing performance of commercial ZnO nanopowders.A combination of h_(2)O_(2)treatment and thermal annealing produces optimal surface defects with oxygen vacancies on the ZnO nanoparticles(NPs).The highest response of~27,562 was achieved for 10 ppm acetone in 0.125 Mh_(2)O_(2)treated/annealed ZnO NPs at the optimal working temperature of 400℃,which is significantly higher than that of reported so far in various acetone sensors based on metal oxide semiconductors(MOSs).Furthermore,first-principles calculations indicate that pre-adsorbed O formed on the surface of h_(2)O_(2)treated ZnO NPs can provide favorable adsorption energy,especially for acetone detection,due to strong bidentate bonding between carbonyl C atom of acetone molecules and pre-adsorbed O on the ZnO *** study demonstrates that controlling surface oxygen vacancies by h_(2)O_(2)treatment and re-annealing at optimal temperature is an effective method to improve the sensing properties of commercial MOS materials.

关键词： gas sensors acetone metal oxide semiconductors(MOSs) ZnO nanoparticles(NPs) h_(2)O_(2)treatment

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hetero-deformation promoted strengthening and toughening in BCC rich eutectic and near eutectic high entropy alloys

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Journal of Materials Science & Technology 2023年第15期146卷 1-9页

作者： D.h.Chung J.lee Q.F.he Y.K.Kim K.R.Lim h.S.Kim Y.Yang Y.S.Na Department of Special Alloys Extreme Materials Research InstituteKorea Institute of Materials ScienceChangwonThe Republic of Korea Department of Mechanical Engineering City University of Hong KongKowloon TongKowloonHong KongChina Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohangThe Republic of Korea Center for heterogenic Metal Additive Manufacturing Pohang University of Science and TechnologyPohangThe Republic of Korea Department of Materials Science and Engineering City University of Hong KongKowloon TongKowloonHong KongChina

heterostructured eutectic high-entropy alloys(EhEAs)have attracted significant attention owing to their novel properties,such as balanced combinations of strength and fracture ***,the toughening/strengthening mechanisms of these EhEAs have not been thoroughly *** this study,we developed a series of dual-phase Al_((18–2x))Co_(30)Cr_((11+x))Fe_((11+x))Ni_(3)0(x=-1,0,1)eutectic and neareutectic hEAs containing face-centered cubic(FCC)and body-centered cubic(BCC)*** the high amount of BCC,which is referred to as the brittle phase,newly developed EhEAs exhibited superior fracture ***,we discovered that a fully eutectic hEA exhibited further improvements in both yield stress and fracture toughness,outperforming our off-eutectic and other previously reported *** combining experiments and theoretical models,we demonstrated that the synergistic increase in both strength and toughness in our fully eutectic hEA was derived from the high hetero-deformationinduced(hDI)strengthening/toughening associated with a high misorientation angle at the grain/phase boundaries.

关键词： Eutectic high entropy alloy Fracture toughness heterogeneous structure hetero deformation induced strengthening Misorientation angle

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术中麻醉方法对全膝置换术后镇痛效果和吗啡使用的影响:一项网状荟萃分析

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临床骨科杂志 2024年第1期27卷 136-136页

作者： YOO J D hUh M h lee S h 胡孔足(摘译) 不详

作者使用网状荟萃分析方法,纳入40项研究。结果发现,切口周围浸润麻醉结合隐神经阻滞麻醉对全膝置换患者术后第1、2天镇痛效果最好,对术后第1、3天吗啡需要量最少。股神经阻滞麻醉术后第3天镇痛效果最好,布比卡因神经阻滞麻醉术后第2天... 详细信息

作者使用网状荟萃分析方法,纳入40项研究。结果发现,切口周围浸润麻醉结合隐神经阻滞麻醉对全膝置换患者术后第1、2天镇痛效果最好,对术后第1、3天吗啡需要量最少。股神经阻滞麻醉术后第3天镇痛效果最好,布比卡因神经阻滞麻醉术后第2天吗啡需要量最少。

关键词：神经阻滞麻醉浸润麻醉荟萃分析镇痛效果布比卡因术中麻醉全膝置换吗啡

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Quantum dots-labeled polymeric scaffolds for in vivo tracking of degradation and tissue formation

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Bioactive Materials 2022年第10期7卷 285-292页

作者： Kun hee Sim Seyed Mohammand Mir Sophia Jelke Solaiman Tarafder Jinho Kim Chang h.lee Regenerative Engineering Laboratory Center for Dental and Craniofacial ResearchColumbia University Irving Medical Center630 West 168th StreetVC12-211New YorkNY10032USA Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030USA

The inevitable gap between in vitro and in vivo degradation rate of biomaterials has been a challenging factor in the optimal designing of scaffold’s degradation to be balanced with new tissue *** enable non-/minimum-invasive tracking of in vivo scaffold degradation,chemical modifications have been applied to label polymers with fluorescent ***,the previous approaches may have limited expandability due to complicated synthesis ***,we introduce a simple and efficient method to fluorescence labeling of polymeric scaffolds via blending with near-infrared(NIR)quantum dots(QDs),semiconductor nanocrystals with superior optical ***-labeled,3D-printed PCL scaffolds showed promising efficiency and reliability in quantitative measurement of degradation using a custom-built fiber-optic imaging ***,QDs-PCL scaffolds showed neither cytotoxicity nor secondary labeling of adjacent ***-PCL scaffolds also supported the engineering of fibrous,cartilaginous,and osteogenic tissues from mesenchymal stem/progenitor cells(MSCs).In addition,QDs-PCL enabled a distinction between newly forming tissue and the remaining mass of scaffolds through multi-channel ***,our findings suggest a simple and efficient QDs-labeling of PCL scaffolds and minimally invasive imaging modality that shows significant potential to enable in vivo tracking of scaffold degradation as well as new tissue formation.

关键词： Key terms:quantum dots Polycaprolactone Tissue engineering In vivo tracking Degradation

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Three-dimensional kagome structures in a PCL/hA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-hwan lee Kang-Gon lee Jaeyeon lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin heo Yongdoo Park Young-Sam Cho Bu-Kyu lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MEChABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(hA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing hA-based hydrogel and bulk-type hA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing hA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(h&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

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Mucosal delivery of nanovaccine strategy against COVID-19 and its variants

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药学学报:英文版 2023年第7期13卷 2897-2925页

作者： Junwoo lee Dongwoo Khang College of Medicine Gachon UniversityIncheon 21999South Korea lee Gil Ya Cancer and Diabetes Institute Gachon UniversityIncheon 21999South Korea Gachon Advanced Institute for health Science&Technology Gachon UniversityIncheon 21999South Korea Department of Physiology College of MedicineGachon UniversityIncheon 21999South Korea

Despite the global administration of approved COVID-19 vaccines(e.g.,ChAdOx1 nCoV-19?,mRNA-1273?,BNT162b2?),the number of infections and fatalities continue to rise at an alarming rate because of the new variants such as Omicron and its *** COVID-19 vaccines that are licensed for human use,most of the vaccines that are currently in clinical trials are administered via parenteral ***,it has been proven that the parenteral vaccines do not induce localized immunity in the upper respiratory mucosal surface,and administration of the currently approved vaccines does not necessarily lead to sterilizing *** further supports the necessity of a mucosal vaccine that blocks the main entrance route of COVID-19:nasal and oral mucosal *** the mechanism of immune regulation of M cells and dendritic cells and targeting them can be another promising approach for the successful stimulation of the mucosal immune *** paper reviews the basic mechanisms of the mucosal immunity elicited by mucosal vaccines and summarizes the practical aspects and challenges of nanotechnology-based vaccine platform development,as well as ligand hybrid nanoparticles as potentially effective target delivery agents for mucosal vaccines.

关键词： COVID-19 Vaccine platforms Mucosal vaccine Mucosa-associated lymphoid tissue(MALT) Microfold cell(M cell) Dendritic cell(DC) Polymeric nanoparticleLiposome

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