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Recent advances of high-pressure generation in a multianvil apparatus using sintered diamond anvils

Geoscience Frontiers 2011年第1期2卷 101-106页

作者： Shuangmeng Zhai Eiji ito Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space Sciences Peking University Beijing 100871 China Institute for Study of the Earth＇s Interior Okayama University Misasa Tottori-ken 682-0193 Japan

The tried and tested multianvil apparatus has been widely used for high-pressure and hightemperature experimental studies in Earth science. As a result, many important results have been obtained for a better understanding of the components, structure and evolution of the Earth. Due to the strength limi- tation of materials, the attainable multianvil pressure is generally limited to about 30 GPa （corresponding to about 900 km of the depth in the Earth） when tungsten carbide cubes are adopted as second-stage anvils. Compared with tungsten carbide, the sintered diamond is a much harder material. The sintered diamond cubes were introduced as second-stage anvils in a 6--8 type multianvil apparatus in the 1980s, which largely enhanced the capacity of pressure generation in a large volume press. With the development of material synthesis and processing techniques, a large sintered diamond cube （14 ram） is now available. Recently, maximum attainable pressures reaching higher than 90 GPa （corresponding to about 2700 km of the depth in the Earth） have been generated at room temperature by adopting 14-mm sintered diamond anvils. Using this technique, a few researches have been carried out by the quenched method or combined with synchrotron radiation in situ observation. In this paper we review the properties of sintered diamond and the evolu- tion of pressure generation using sintered diamond anvils. As-yet unsolved problems and perspectives for uses in Earth Science are also discussed.

关键词： Pressure generation Sintered diamond anvil Multianvil apparatus

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Difference in symptom manifestation between postmenopausal and premenopausal women in acute uncomplicated cystitis:A multi-institutional pilot study

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Current Urology 2023年第3期17卷 174-178页

作者： Atsushi Wanifuchi Yuki Kyoda Takuto Ogasawara Ko Kobayashi Naoki ito Tetsuya Shindo Atsushi Takahashi Yasuharu Kunishima Naoya Masumori Department of Urology Sapporo Medical University School of MedicineSapporo060-8543Japan Department of Urology NTT East Sapporo HospitalSapporoJapan Department of Urology Hakodate Goryoukaku HospitalHakodateJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan

Objectives:We aimed to prospectively compare lower urinary tract symptoms in premenopausal and postmenopausal women with acute uncomplicated cystitis before and after antibiotic *** and methods:This study included adult women with acute uncomplicated cystitis who visited 4 institutions between 2019 and *** registration,we administered oral antibiotics and prospectively documented the changes in lower urinary tract symptoms from the first visit to a follow-up visit at 1 week using the Core Lower Urinary Tract Symptoms Score(CLSS)***:After treatment,pyuria disappeared in 60 of the 66 patients(14 premenopausal and 46 postmenopausal).The CLSS total score(range)changed from 13(3-29)to 4(0-18)with a significant improvement in all CLSS *** baseline,nocturia,urgency,and urgency incontinence were more prominent in postmenopausal women than in premenopausal *** contrast,baseline urethral pain and quality of life index were more severe in premenopausal women than in postmenopausal *** treatment,the CLSS total score was still higher in postmenopausal women,as reflected by the relatively higher scores for nocturia and urgency,irrespective of the comparable scores for urethral pain and the quality of life index in the 2 ***:Our results suggest that if storage symptoms persist,they should be carefully interpreted according to menopausal status.

关键词： Acute uncomplicated cystitis Core Lower Urinary Tract Symptoms Score Lower urinary tract symptoms Postmenopausal women

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Mitochondrial control of hematopoietic stem cell balance and hematopoiesis

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Frontiers in Biology 2015年第2期10卷 117-124页

作者： Massimo Bonora Paolo Pinton Keisuke ito Department of Morphology Surgery Experimental Medicine University of Ferrara Section of Pathology Oncologye Experimental~Bi~~~~gySa~b~rat~rY~f~r TechnologiesofAdvanced rherapies(LT.T.A) Ferrara Italy Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Departments of Cell Biology and Medicine Albert Einstein Cancer Center and Einstein-Sinai Diabetes Research Center Albert Einstein College of Medicine Bronx NY 10461 USA

hematopoietic stem cells （hSCs） are stem cells from mesodermal derivation that reside in bone marrow and provide blood cells for the whole life of an adult individual, through a process called hematopoiesis. The long lasting support of hSCs for hematopoiesis is permitted by the fine regulation of quiescence and division output. Exit from the quiescent state is to produce a committed and/or stem daughter cells, in an event defined asymmetric or symmetric division. A deregulation in the proportion between asymmetric and symmetric divisions is critical in the appearance of hematological disorders ranging from bone marrow failure to hematological malignancies. Over the past years, several studies have indicated how the metabolism of hSCs is determinant in the regulation of hSC quiescence and commitment process. A metabolism shifted to the glycolytic pathway promotes hSCs quiescence and sustainment of hematopoiesis. Boosting mitochondrial respiration promotes the stem cell commitment followed by stem pool exhaustion, and minimal mitochondrial activity is required to maintain the hSCs quiescence. In the present review are discussed the most recent advances in comprehension of the roles of mitochondria in the hematopoiesis and in the division balance.

关键词： mitochondria metabolism hematopoiesis hematopoietic stem cells division balance hypoxia inducible factor 1alpha (hif- 1α)

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State feedback stabilization of cascaded nonlinear systems with discontinuous connection

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控制理论与应用（英文版） 2008年第1期6卷 45-52页

作者： Maiko hIRANO Tielong ShEN Kazuhisa ito Katutoshi TAMURA Department of Mechanical Engineering Sophia University Tokyo 102-8554 Japan Department of Mechanical Engineering Tottori University Tottori 680-8552 Japan

In practical engineering, many phenomena are described as a discontinuous function of a state variable, and the discontinuity is usually the main reason for the degradation of the control performance. For example, in the set-point control problem of mechanical systems, the static friction （described by a sgn function of velocity of the contacting faces） causes undesired positioning error. In this paper, we will investigate the stabilization problem for a class of nonlinear systems that consist of two subsystems with cascaded connection. We will show the basic idea with a special case first, and then the result will be extended to more general cases. Some interesting numerical examples will be given to demonstrate the effectiveness of the proposed design approach.

关键词： Cascaded connection Discontinuous systems Filippov solution

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Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

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World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro ito Kenichi Takahashi Yusuke Asai Takahiro Miyazu Tomohiro higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi hamaya Satoshi Osawa Ken Sugimoto Department of Endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo Endoscopic Subscore(MES),Ulcerative Colitis Endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire *** To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical *** In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were *** diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for *** samples were collected the day before or after the colonoscopy for measurement of *** evaluations were performed using MES,UCEIS,and *** primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and *** secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal *** and UCCIS showed a significant correlation with UCEIS (r = 0.537, P haracteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P he 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the

关键词： Ulcerative colitis Mayo Endoscopic Subscore Ulcerative Colitis Endoscopic Index of Severity Ulcerative Colitis Colonoscopic Index of Severity Fecal calprotectin Relapse

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Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

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World Journal of Gastrointestinal Surgery 2022年第7期14卷 670-684页

作者： Yuzuru Sakamoto Shingo Shimada Toshiya Kamiyama Ko Sugiyama Yoh Asahi Akihisa Nagatsu Tatsuya Orimo Tatsuhiko Kakisaka hirofumi Kamachi Yoichi M ito Akinobu Taketomi Department of Gastroenterological Surgery Hokkaido University Graduate School of MedicineSapporo 060-8638HokkaidoJapan Data Science Center Promotion UnitInstitute of Health Science Innovation for Medical CareHokkaido University HospitalSapporo 060-8648HokkaidoJapan

BACKGROUND hepatocellular carcinoma(hCC)is one of the most common malignancies ***,the number of patients with chronic kidney disease(CKD)is on the rise because of the increase in lifestyle-related *** To establish a tailored management strategy for hCC patients,we evaluated the impact of comorbid renal dysfunction(RD),as stratified by using the estimated glomerular filtration rate(EGFR),and assessed the oncologic validity of hepatectomy for hCC patients with *** We enrolled 800 hCC patients who underwent hepatectomy between 1997 and 2015 at our university *** categorized patients into two(RD,EGFRhree groups(severe CKD,EGFRhe *** survival(OS)and recurrence-free survival(RFS)were compared among these groups with the log-rank test,and we also analyzed survival by using a propensity score matching(PSM)model to exclude the influence of patient *** mean postoperative observation period was 64.7±53.0 *** The RD patients were significantly older and had lower serum total bilirubin,aspartate aminotransferase,and aspartate aminotransferase levels than the non-RD patients(Phemodialysis after *** the overall postoperative complication rates were similar between the RD and non-RD patients,the proportions of postoperative bleeding and surgical site infection were significantly higher in the RD patients(5.5%vs 1.8%;Phe highest in the severe CKD group(Phe degree of comorbid RD,OS and RFS were comparable,even after PSM between the RD and non-RD groups to exclude the influence of patient characteristics,liver function,and other causes of dea

关键词： hepatocellular carcinoma hepatectomy Renal dysfunction Estimated glomerular filtration rate

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The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

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Protein & Cell 2011年第9期2卷 755-763页

作者： Kentaro ito Akinori Takahashi Masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in heLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced ChOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

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Enamel Matrix Derivative Stimulates Osteogenesis-and Chondrogenesis-related Transcription Factors in C3h10T1/2 Cells

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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 1-7页

作者： Masataka NARUKAWA Naoto SUZUKI Tadahiro TAKAYAMA Yasuhiko YAMAShITA Kichibee OTSUKA Koichi ito Department of Periodontology Nihon University School of DentistryTokyo101-8310Japan Department of Biochemistry Nihon University School of DentustryTokyo 101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Department of Biochemistry Nihon University School of DentistryTokyo101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo101-8310Japan

Our purpose was to determine how enamel matrix derivative (EMD) affects the expression ofosteogenesis- and chondrogenesis-related transcription factors in undifferentiated mesenchymal cells.C3h10T1/2 cell line,a typical pluripotential mesenchymal cell line,was cultured with or without EMD forup to 7 *** of mRNAs encoding osteogenesis-and chondrogenesis-related transcription factors(Runx2, Osterix,AJ18,Dlx5,Msx2,Sox5,Sox9 and Zfp60) was measured using real-time polymerasechain ***2 and Sox9 protein expression and the presence of bone morphogenetic protein (BMP)-6-like molecules in EMD were determined by Western *** substantially increased mRNA levels ofosteogenesis-and chondrogenesis-related transcription *** also induced Runx2 and Sox9 *** blotting analysis of EMD using anti-BMP-6 antibody revealed immunoreactive bandscorresponding to about 14 kDa and 60 *** results suggest that EMD stimulates osteogenesis- andchondrogenesis-related transcription factors,and these activities may be mediated,at least in part,by BMP-6in EMD.

关键词： enamel matrix derivative osteogenesis chondrogenesis

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Lattice Boltzmann Flow Simulation in a Combined Nanochannel

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Advances in Applied Mathematics and Mechanics 2010年第5期2卷 609-625页

作者： Kazuhiko Suga Susumu Takenaka Takahiko ito Masayuki Kaneda Department of Mechanical Engineering Osaka Prefecture UniversitySakai 599-8531Japan

The widely used micro-flow wall-boundary conditions for lattice Boltzmann method(LBM)are evaluated in a force driven combined nanochannel *** flow field consists of a two-dimensional nanochannel(mother channel)of an infinite length having flat plates of a finite length *** flat plate is set above the bottom wall of the nanochannel with a narrow *** flow,thus,develops through this narrow gap(narrower channel)and the other side of the plate(wide gap).The Knudsen number based on the mother channel height is Kn=0.14 whereas the characteristic Knudsen number in the narrower channel is *** obtain the reference data,the molecular dynamics(MD)simulation is performed with a fully diffusive wall *** LBMs are based on the lattice BGK model and with the bounce-back/specular reflection(BSBC)and the diffuse scattering(DSBC)wall boundary *** relaxation time is modified to include sensitivity to *** DSBC shows generally satisfactory results in the test flow cases including fully developed force driven Poiseuille flows,where the BSBC performs worse at Kn>0.5 with a fixed bridge coefficient of b=*** results in its overprediction of the flow rate in the narrower channel region since the characteristic Knudsen number there is *** MD simulation suggests that the flow develops gradually through the narrower channel region though all the LBM predictions show almost instant flow *** fact suggests that the relaxation time model needs to have more sensitivity to the locally defined *** discussions of the BSBC with a different set of models suggest that the regularization process is required for predicting complex nanoscale flows.

关键词： Lattice Boltzmann method Knudsen number molecular dynamics simulation nanochannel wall boundary condition slippage velocity

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Evaluation of thermal sprayed coating using ultrasonic inspection by means of bottom echo back reflection

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中国有色金属学会会刊：英文版 2009年第4期19卷 984-987页

作者： Toshifumi KUBOhORI Toru ito Wahidul lah WAhI Yasuyuki INUI Toshiro IKUTA School of Science and Engineering Kinki University

Thermal spraying technique is widely used in various mechanical parts as a surface reforming ***,as demand to maintain superior mechanical performance in harsh operating environment increases,the need for non-destructive evaluation method for thermal spray coating becomes more *** this purpose,we thinned the thickness of the thermal sprayed coating by abrasion with blasting and used ultrasonic inspection by means of bottom echo reflection for effective measurement of abrasion quantity in thermal sprayed *** results obtained are summarized as *** the thickness of thermal sprayed coating becomes thin,the echo height *** is because thermal sprayed coatings absorb ultrasonic *** energy absorbed by Al2O3 is smaller compared with Fe-13Cr *** sprayed coatings submerged in water have a lower echo height compared with *** mentioned above,the thermal sprayed coating thickness can be estimated using ultrasonic inspection by means of bottom echo back reflection.

关键词：超声波检测热喷涂层评价方法声反射底部热喷涂涂层涂层厚度能量吸收

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