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国际医学放射学杂志 2014年第2期 200-200页

作者： C.M.Chen S.y.Chu M.y.hsu y.L.Liao h.y.tsai 林琳 Department of Medical Imaging & Radiological Sciences Chang Gung University 259 Wen -Hwa 1st Road Kwei -ShanTaoyuanTaiwan 333

目的评估采用迭代重建(IR)法维持CT血管成像影像质量,同时减低管电压和对比剂剂量。方法机构审查委员会批准了此项前瞻性研究,对48例病人进行CT血管成像

关键词：容积CT 对比剂主动脉瘤辐射剂量放射影像增强

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： yen-Shou Kuo Kuan-hsun Lin ying-yi Chen yuan-Ming tsai Ti-hui Wu hsu-Kai huang tsai-Wang huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARy A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

SRC-3/AIB1:transcriptional coactivator in oncogenesis

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Acta Pharmacologica Sinica 2006年第4期27卷 387-394页

作者： Sophia y tsai Ming-jer tsai Department of Molecular and Cellular Biology Department of Molecular and Cellular Biology Prostate SPOREBaylor College of MedicineOne Baylor PlazaHouston.Texas 77030USA

Steroid receptor coactivator-3(SRC-3,also known as NCoA3,AIB1,p/CIP,RAC3,ACTR,and TRAM 1),localized on a frequently amplified region,20q 12,has beenassociated with multiple cancers,including breast,gastric and prostate *** SRC-3 has been implicated as an oncogene,compelling evidence hasonly recently emerged implicating it as a causal factor in the genesis of ***,we summarize recent evidence that indicates aberrant SRC-3 ex-pression is important in hormone-sensitive and -insensitive human cancers.

关键词： SRC-3/AIB1 oncogene mouse model cancer signal transduction

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

A Statistical Study on Seismo-Ionospheric Anomalies of the Total Electron Content for the Period of 56 M≥6.0 Earthquakes Occurring in China During 1998—2012

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空间科学学报 2013年第3期33卷 258-269页

作者： Liu J y Chen C h tsai h F Le h Institute of Space Science National Central University Center for Space and Remote Sensing Research National Central University Department of Earth Science National Cheng Kung University GPS Science and Application Research Center National Central University Key Laboratory of Ionospheric Environment Institute of Geology and GeophysicsChinese Academy of Sciences

This paper reports statistical results of Seismo-Ionospheric Anomalies(SIAs) of the Total Electron Content(TEC) in the Global Ionosphere Map(GIM) associated with 56 M≥6.0 earthquakes in China during 1998—*** detect SIA,a quartile-based(***-based) process is *** anomalies for the period of earthquakes without being led by magnetic storms about 10 days are further isolated and examined to confirm the SIP *** show that SIA is the TEC significantly decrease in the afternoon period 2—9 days before the earthquakes in China,which is in a good agreement with the SIA appearing before the 12 May 2008 M 8.0 Wenchuan earthquake.

关键词：电离层异常地震发生总电子含量中国统计 SIAS TEC GIM

Nanovectors for anti-cancer drug delivery in the treatment of advanced pancreatic adenocarcinoma

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World Journal of Gastroenterology 2016年第31期22卷 7080-7090页

作者： Chung-Tzu hsueh Julie h Selim James y tsai Chung-Tsen hsueh Department of Dentistry Cathay General Hospital Division of hematology/Oncology Loma Linda University Cancer Center School of Pharmacy Loma Linda University Division of Medical Oncology and hematology Department of Internal Medicine Loma Linda University

Liposome, albumin and polymer polyethylene glycol are nanovector formulations successfully developed for anti-cancer drug delivery. There are significant differences in pharmacokinetics, efficacy and toxicity between pre- and post-nanovector modification. The alteration in clinical pharmacology is instrumental for the future development of nanovector-based anticancer therapeutics. We have reviewed the results of clinical studies and translational research in nanovectorbased anti-cancer therapeutics in advanced pancreatic adenocarcinoma, including nanoparticle albumin-bound paclitaxel and nanoliposomal irinotecan. Furthermore, we have appraised the ongoing studies incorporating novel agents with nanomedicines in the treatment of pancreatic adenocarcinoma.

关键词： Pancreatic adenocarcinoma Nanovector Nanoparticle albumin-bound paclitaxel Nanoliposomal irinotecan Biomarker

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex