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Regulation of the PI3k/Akt Pathway and Fuel Utilization During Primate torpor in the Gray Mouse Lemur, Microcebus murinus

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Genomics, Proteomics & Bioinformatics 2015年第2期13卷 91-102页

作者： Shannon n.tessier Jing Zhang kyle k.Biggar Cheng-Wei Wu Fabien Pifferi Martine Perret kenneth B.Storey Institute of Biochemistry & Department of Biology Carleton University Department of Surgery & Center for Engineering in Medicine Massachusetts General Hospital & Harvard Medical School Chemistry and Chemical Engineering Department Royal Military College of Canada Biochemistry Department Schulich School of Medicine and Dentistry Western University Department of Biology Genetics Institute University of Florida UMR 7179 Centre national de la Recherche Scientifique Muse'um National d'Histoire Naturelle

Gray mouse lemurs（Microcebus murinus） from Madagascar present an excellent model for studies of torpor regulation in a primate species. In the present study, we analyzed the response of the insulin signaling pathway as well as controls on carbohydrate sparing in six different tissues of torpid versus aroused gray mouse lemurs. We found that the relative level of phospho-insulin receptor substrate（IRS-1） was significantly increased in muscle, whereas the level of phospho-insulin receptor（IR） was decreased in white adipose tissue（WAt） of torpid animals, both suggesting an inhibition of insulin/insulin-like growth factor-1（IGF-1） signaling during torpor in these tissues. By contrast, the level of phospho-IR was increased in the liver. Interestingly, muscle,WAt, and liver occupy central roles in whole body homeostasis and each displays regulatory controls operating at the plasma membrane. Changes in other tissues included an increase in phosphoglycogen synthase kinase 3a（GSk3a） and decrease in phospho-ribosomal protein S6（RPS6） in the heart, and a decrease in phospho-mammalian target of rapamycin（m tOR） in the kidney. Pyruvate dehydrogenase（PDh） that gates carbohydrate entry into mitochondria is inhibited via phosphorylation by pyruvate dehydrogenase kinase（e.g., PDk4）. In the skeletal muscle, the protein expression of PDk4 and phosphorylated PDh at Ser 300 was increased, suggesting inhibition during torpor. In contrast, there were no changes in levels of PDh expression and phosphorylation in other tissues comparing torpid and aroused animals. Information gained from these studies highlight the molecular controls that help to regulate metabolic rate depression and balance energetics during primate torpor.

关键词： Insulin signaling pathway PI3k/Akt m tOR GSk3 Pyruvate dehydrogenase Metabolic rate depression

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Diagnosis of CAh in a Sub Saharan Country: Visible Part of Iceberg

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Open Journal of Pediatrics 2024年第2期14卷 227-233页

作者： Suzanne Sap Ritha Mbono hélène kamo Jocelyn tony Charlotte Eposse Jeannette Epée Isabelle Mekone Adele Bodieu Gaelle ntsoli Paul Olivier koki Mother and Child Center of the Chantal Biya Foundation University of Yaoundé I Yaoundé Cameroon Laquintinie hospital University of Douala Douala Cameroon Genral hospital of Garoua University of Garoua Garoua Cameroon human Reproductive Center and Research on Fertility of Yaoundé University of Yaoundé I Yaoundé Cameroon Yaounde General hospital University of Yaoundé I Yaoundé Cameroon Yaounde Central hospital Yaoundé Cameroon Laquintiinie hospital Douala Cameroon

Introduction :Congenital adrenal hyperplasia (CAh) is the most common cause of primary adrenal insufficiency. It is a rare monogenic recessive disorder. In African setting in absence of neonatal screening, the diagnosis is still late, based on a clinical approach. During this clinical enquiry, information from past history or pedigree of the patient is of a huge importance and may revealed surprises. Patients and Methods: In this observational study, we retrospectively included all patients with a diagnosis of CAh. the diagnosis of CAh was retained based on a high 17 hydroxyprogesterone level in addition to clinical and morphological findings. From patients’ files, we extracted data on family history of disease, pedigree, clinical findings and genetics when available of 39 patients from two endocrinopeadiatric centers. Results: In 13 (30%) families, we found 20 reported deaths of infant less than 12 months. In these 13 families, half of the patients followed had 21 hydroxylase deficiencies and had 11 hydroxylase deficiencies. Unsurprisingly, we suspected adrenal insufficiency in these patients at verbal autopsy even in families with a patient with 11 hydroxylase deficiency. Other non DSD malformations or genetic disorders with apparently no link with CAh were reported in 3 families. the father of a patient reported to have hypospadias. Conclusion: Each diagnosis of CAh made in our context is visible part of an iceberg. Behind a diagnosis of CAh made in our setting, is a long course of care, a dramatic past history revealing access to appropriate care disparity. neonatal screening should thus be considered as an emergency.

关键词： Congenital Adrenal hyperplasia

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Multibeam laser±plasma interaction at the Gekko Ⅻ laser facility in conditions relevant for direct-drive inertial confinement fusion

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high Power Laser Science and Engineering 2023年第2期 75-85页

作者： G.Cristoforetti P.koester S.Atzeni D.Batani S.Fujioka Y.hironaka S.hüller t.Idesaka k.katagiri k.kawasaki R.kodama D.Mancelli Ph.nicolai n.Ozaki A.Schiavi k.Shigemori R.takizawa t.tamagawa D.tanaka A.tentori Y.Umeda A.Yogo L.A.Gizzi Intense Laser Irradiation Laboratory 2. Dipartimento SBAI Università di Roma ‘La Sapienza' 3. Université BordeauxCNRS CEA CELIA Institute of Laser Engineering Osaka University Centre de Physique théorique CPht CNRS IP ParisEcole Polytechnique Graduate School of Engineering Osaka University Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research Centre Institute for Integrated Radiation and nuclear Science Kyoto University

Laser±plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion. the experiment was carried out at the Gekko XII laser facility in multibeam planar target geometry at an intensity of approximately 3 × 1015W/cm2. Experimental data suggest that high-energy electrons, with temperatures of 20-50 ke V and conversion efficiencies of η nly produced by the damping of electron plasma waves driven by two-plasmon decay(tPD). Stimulated Raman scattering(SRS) is observed in a near-threshold growth regime, producing a reflectivity of approximately 0.01%, and is well described by an analytical model accounting for the convective growth in independent speckles. the experiment reveals that both tPD and SRS are collectively driven by multiple beams, resulting in a more vigorous growth than that driven by single-beam laser intensity.

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Contribution of Ct in the Exploration of non-traumatic Pathologies of the Lumbar Spine in Adults in Bangui

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Open Journal of Radiology 2024年第3期14卷 125-134页

作者： Bangue Songrou Francky kouandongui timothée Mobima Yannick héritier Sombot Borel tambala Stéphane kouzou Judith Guiaba kette Euloge tapiade Bidan Richard Bazogo national Center of Medical Imaging of Bangui Bangui Central Africa Republic Maman Elisabeth DOMItIEn hospital Bangui Central Africa Republic Community hospital of Bangui Bangui Central Africa Republic

Background: In Central African Republic, a study carried out in 2019 highlighted the limits of conventional radiography in the diagnosis of non-traumatic lower back pain in adults. Objective: the objective of this study is to show the value of Ct scanning in the exploration of non-traumatic pathologies of the lumbar spine in adults. Patients and Method: Retrospective and descriptive cross-sectional study covering the files of patients aged at least 18 years old, sent for lumbar scanning from March 1 to December 31, 2021 at the medical imaging center. Results: In total, 593 scan examinations were performed including 159 (26.8%) examinations of the lumbar spine. the average age of the patients was 49.84 years. the majority were male (66%). 127 (79.8%) were referred mainly to the neurology and rheumatology departments. Common low back pain (n = 97, 61%) was the main reason for requesting a Ct scan. the lumbar scan was performed without contrast product in 88.7% of cases. In total, 148 (93.1%) examinations were pathological and dominated by overall disc overhang (62.2%) and somatic and interapophyseal osteoarthritis (16.9%). the other lesions were spondylodiscitis (7.4%), tumor-like lesions (3.4%) and narrow lumbar canal (1.4%).

关键词： Ct Scanning Lumbar Bangui Adults

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the Interaction of Spinach nitrite Reductase with Ferredoxin： A Site-Directed Mutation Study

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Molecular Plant 2009年第3期2卷 407-415页

作者： Masakazu hirasawa Jatindra n. tripathy Ramasamy Somasundaram Michael k. Johnson Megha Bhalla James R Allen David B. knaff Department of Chemistry and Biochemistry Texas Tech University Lubbock TX 79409-1061 USA Department of Chemistry University of Georgia Athens GA 30602 USA Department of Chemistry and Biochemistry Arizona State University Tempe AZ 85287-1604 USA Institute for Biotechnology and Genomics Texas Tech University Lubbock TX 79409-1061 USA

A series of site-directed mutants of the ferredoxin-dependent spinach nitrite reductase has been characterized and several amino acids have been identified that appear to be involved in the interaction of the enzyme with ferredoxin. In a complementary study, binding constants to nitrite reductase and steady-state kinetic parameters of site-directed mutants of ferredoxin were determined in an attempt to identify ferredoxin amino acids involved in the interaction with nitrite reductase. the results have been interpreted in terms of an in-silico docking model for the 1：1 complex of ferredoxin with nitrite reductase.

关键词： Electron transport enzymology nitrogen metabolism molecular biology.

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A high-endurance 96-kbit FeRAM Embedded in a Smart Card LSI Using Ir/IrO2/PZt(MOCVD)/Ir Ferroelectric Capacitors

A High-endurance 96-Kbit FeRAM Embedded in a Smart Card LSI ...

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2001 6～(th) International Conference on Solid-State and Integrated Circuit technology

作者： h.Mori n.tanabe A.Seike h.takeuchi J.Yamada t.Miwa h.koike Y.Maejima t.tatsumi S.kobayashi t.nakura h.Sugiyama n.kasai t.hase h.hada h.toyoshima ULSI Device Development Division Microcomputer Division System Devices and Fundamental Research

We have developed a logic-embedded 96-kbit FeRAMmacro that has low-voltage operation and high-endurancefeatures for smart card *** smart card LSIwas fabricated using a 0.35 μm-standard CMOS processwith 3-level metallization and CMVP *** operation of the chip was confirmed atvoltages from 2.7 to 5.5 V with 2.5 Mhz clock *** Ir-based top and bottom electrodes,the fatigueendurance of the FeRAM was improved,which wasconfimed in burn-in *** failed bits were observed ataccelerated conditions with 5.5 V and 150℃ after 10fatigue cycles.

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Lignite-Derived humic Acid Effect on Growth of Wheat Plants in Different Soils

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Pedosphere 2011年第1期21卷 124-131页

作者： M.M.tAhIR M.khURShID M.Z.khAn M.k.ABBASI M.h.kAZMI Department of Soil and Environmental Sciences Faculty of AgricultureUniversity of Azad Jammu and Kashmir Land Resource Research Programme National Agriculture Research Centre Department of Agronomy Faculty of AgricultureUniversity of Azad Jammu and Kashmir

humic acid （hA）, a fairly stable product of decomposed organic matter that consequently accumulates in ecological systems, enhances plant growth by chelating unavailable nutrients and buffering ph. We examined the effect of hA derived from lignite on growth and macronutrient uptake of wheat （triticum acstivum L.） grown in earthen pots under greenhouse conditions. the soils used in the pot experiment were a calcareous haplustalf and a non-calcareous haplustalf collected from Raisalpur and Guliana, respectively, in Punjab Province, Pakistan. the experiment consisted of four treatments with hA levels of 0 （control without hA）, 30, 60, and 90 mg kg^-1 soil designated as hA0, hA1, hA2, and hA3, respectively. In the treatment without hA （hA0）, nitrogen （n）, phosphorus （P）, and potassium （k） were applied at 200, 100, and 125 mg kg^-1 soil, respectively. Significant differences among hA levels were recorded for wheat growth （plant height and shoot weight） and n uptake. On an average of both soils, the largest increases in plant height and shoot fresh and dry weights were found with hA2 （60 mg kg^-1 soil）, being 10%, 25%, and 18%, respectively, as compared to the control without hA （hA0）. Both soils responded positively towards hA application. the wheat growth and n uptake in the non-calcareous soil were higher than those of the calcareous soil. the hA application significantly improved k concentration of the non-calcareous soil and P and nO3-n of the calcareous soil. the highest rate of hA （90 mg kg^-1 soil） had a negative effect on growth and nutrient uptake of wheat as well as nutrient accumulation in soil, whereas the medium dose of hA （60 mg kg^-1 soil） was more efficient in promoting wheat growth.

关键词： calcareous soil nO3-n nutrient uptake plant height soil nutrient

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三次样条与求积法则之间的联系

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数学译林 2024年第1期43卷 90-92页

作者： Mark h.holmes 陆柱家(译) 陆昱(校) 不详

我们由三次样条函数的准确积分可以得到一个复合积分法则.反过来,这个方法可以推导出样条的端点条件,以得到高阶的求积公式.

关键词：三次样条求积公式求积法积分法则端点

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Dixon MRI对健康成年人背部伸肌年龄和性别相关变异的多参数定量评估

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国际医学放射学杂志 2024年第2期 247-248页

作者： P.Z.Chen Z.Zhou L.Sun X.k.Yu k.Li J.Li 王俊

摘要目的使用Dixon MRI研究健康成人年龄相关性背伸肌退变的性别差异，并分析肌肉定量参数与背肌力的关系。方法纳入105名健康受试者行腰椎Dixon MRI检查。量

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Synthesis and Structure-Activity Relationships of novel neocryptolepine Derivatives

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Chemical Research in Chinese Universities 2017年第3期33卷 373-377页

作者： Ahmed A. EL-GOkhA nader M. BOShtA Mona k. ABO hUSSEIn Ibrahim EL-t. EL SAYED Chemistry Department Faculty of Science Menoufia University Shebin EI-Koam Menoufia Egypt Department of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences Eberhard Karls Universitat Tubingen 72076 Tubingen Germany Pharmaceutical Institute Pharmaceutical Chemistry I University of Bonn 53121 Bonn Germany

herein we reported the synthesis of a novel series of neocryptolepine（5-methyl-5h-indolo[2,3-b]quinoline） derivatives containing different substituents at Cll using methyl 1h-indole-3-carboxylate and n-methylaniline as starting material. the target 21 compounds were evaluated for their axltibacterial activity in vitro against gram-positive bacteria（B, subtilis and S. aureus） and gram-negative bacteria（E, coli and ***）. Almost all the tested compounds showed moderate to high activities against the four bacterial strains at the minimum inhibitory concentrations（MICs） of 1-10μg/mL. the obtained results suggest that part of the novel synthetic neocryptolepine derivatives exhibit significant antibacterial effect against all the tested organisms.

关键词： neocryptolepine Indoloquinolme Antibacterial

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