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丝素蛋白对皮肤光损伤的保护作用

日用化学工业(中英文) 2024年第9期54卷 1117-1124页

作者：李生鹏李静梁超赵冉张晓洁孙丽丽三立慧评(北京)检测技术有限公司

丝素蛋白是一种从蚕丝中提取的天然高分子纤维蛋白，有很好的抗氧化和减少光损伤的作用。为了研究丝素蛋白对皮肤光损伤的保护作用，以UVB诱导人角质形成细胞（ha Ca T）损伤为模型，通过EliSA和荧光检测细胞内活性氧（ROS）和钙离子(Ca... 详细信息

丝素蛋白是一种从蚕丝中提取的天然高分子纤维蛋白，有很好的抗氧化和减少光损伤的作用。为了研究丝素蛋白对皮肤光损伤的保护作用，以UVB诱导人角质形成细胞（ha Ca T）损伤为模型，通过EliSA和荧光检测细胞内活性氧（ROS）和钙离子(Ca2+)的水平，采用免疫荧光检测瞬时受体电位阳离子通道亚家族V成员1 （TRPV1）和Claudin-1的表达。此外，还使用蛋白质印迹分析了紧密连接相关蛋白Occludin和Claudin-1的表达。结果表明，120 m j/cm2的UVB刺激显著降低细胞活力，而100μg/m L丝素蛋白的存在显著增加细胞活力。UVB刺激导致细胞内活性氧水平升高，激活TRPV1通道，诱导细胞内Ca2+水平增加。同时炎症因子白细胞介素1α （IL-1α）(Pha Ca T细胞受到UVB的影响则显著降低（P<0.05）。实验证明，UVB会破坏屏障蛋白，导致屏障蛋白Claudin-1和Occludin的表达下降。丝素蛋白的加入可以降低这种影响，保护细胞间紧密连接。因此，丝素蛋白可能具有降低氧化应激、屏障损伤和炎症发生，保护皮肤免受UVB诱导的光损伤的潜在能力。

关键词：丝素蛋白 UVB 活性氧紧密连接蛋白皮肤屏障

聚多巴胺/壳聚糖改性棉织物的茶色素染色及其抗菌和防紫外线性能

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纺织学报 2024年第3期45卷 106-113页

作者：李丽丽袁亮唐雨霞杨文菊王浩安徽农业大学材料与化学学院安徽合肥230036 马鞍山市纤维检验所安徽马鞍山243011

为提高棉织物的天然色素染色性和多功能性,利用CuSO_(4)/h_(2)O_(2)氧化体系下多巴胺(DA)在织物表面快速聚合沉积后,采用壳聚糖(CS)整理制备聚多巴胺/壳聚糖(PDA/CS)改性棉织物,再用茶色素对其进行染色处理。探究了DA快速聚合沉积过程... 详细信息

为提高棉织物的天然色素染色性和多功能性,利用CuSO_(4)/h_(2)O_(2)氧化体系下多巴胺(DA)在织物表面快速聚合沉积后,采用壳聚糖(CS)整理制备聚多巴胺/壳聚糖(PDA/CS)改性棉织物,再用茶色素对其进行染色处理。探究了DA快速聚合沉积过程中各因素对改性棉织物染色性能的影响,得到较佳工艺条件:CuSO_(4)浓度为3 mmol/L,DA质量浓度为2.0 mg/mL,h_(2)O_(2)浓度为13 mmol/L,沉积时间为2 h。在此条件下,PDA/CS改性棉织物染色后的K/S值达到6.21。研究结果表明:CuSO_(4)/h_(2)O_(2)氧化体系下DA在棉织物表面形成PDA层,可与CS产生氢键作用在织物表面均匀成膜;茶色素染色PDA/CS改性棉织物的耐摩擦色牢度、耐皂洗色牢度(沾色)和耐人造光色牢度均达到4级及以上;PDA/CS改性织物染色后的UPF值为312,对金黄色葡萄球菌与大肠杆菌的抑菌率达到90%以上,具备抗菌和防紫外线的双重功效。

关键词：棉织物聚多巴胺壳聚糖茶色素染色天然染料功能整理

黄曲霉毒素B_(1)降解菌株的分离鉴定、发酵条件的优化及活性组分分析

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中国油脂 2024年第1期49卷 120-126页

作者：陈毅保刘昆仑杨趁仙李艳李天赐贾叶萍张微漾河南工业大学粮油食品学院郑州450001

为筛选出一株高效降解黄曲霉毒素B_(1)(AFB_(1))的菌株,选取土壤为菌株来源,进行富集培养,经过以香豆素为唯一碳源的初筛和添加AFB_(1)的复筛后,对筛选得到的各菌株进行16S rDNA鉴定,比对其测序结果,选取降解AFB_(1)最高的菌株,探究发... 详细信息

为筛选出一株高效降解黄曲霉毒素B_(1)(AFB_(1))的菌株,选取土壤为菌株来源,进行富集培养,经过以香豆素为唯一碳源的初筛和添加AFB_(1)的复筛后,对筛选得到的各菌株进行16S rDNA鉴定,比对其测序结果,选取降解AFB_(1)最高的菌株,探究发酵时间、发酵温度、初始ph、接种量、培养基对菌株降解AFB_(1)的影响规律,通过正交试验优化发酵条件,并对降解方式进行初步探索。结果表明:经过初筛和复筛得到7株能够降解AFB_(1)的菌株,经鉴定均为伯克霍尔德菌属,其中Burkholderiasp.D6的AFB_(1)降解率最高;最优发酵条件为以LB培养基为发酵培养基、发酵时间84h、发酵温度37℃、初始ph 7.0、接种量10%,在此条件下Burkholderiasp.D6对AFB_(1)的降解率为(87.91±2.32)%;初步判断降解AFB_(1)的活性组分是蛋白质或者酶。综上,通过筛选得到了一种能够高效降解AFB_(1)的菌株,蛋白质或酶参与了AFB_(1)的降解。

关键词：黄曲霉毒素B_(1) 伯克霍尔德菌降解

Nomogram based on multimodal magnetic resonance combined with B7-h3mRNA for preoperative lymph node prediction in esophagus cancer

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World journal of Clinical Oncology 2024年第3期15卷 419-433页

作者： Yan-han Xu Peng Lu Ming-Cheng Gao Rui Wang Yang-Yang li Rong-Qi Guo Wei-Song Zhang jian-Xiang Song School of Clinical Sciences Graduate School of Nantong UniversityYancheng 226019Jiangsu ProvinceChina Department of Thoracic Surgery Yancheng Third People's HospitalThe Affiliated Hospital 6 of Nantong UniversityYancheng 224000Jiangsu ProvinceChina Department of Imaging Yancheng Third People's HospitalThe Affiliated Hospital 6 of Nantong UniversityYancheng 224000Jiangsu ProvinceChina

Accurate preoperative prediction of lymph node metastasis(LNM)in esophageal cancer(EC)patients is of crucial clinical significance for treatment planning and *** To develop a clinical radiomics nomogram that can predict the preoperative lymph node(LN)status in EC *** A total of 32 EC patients confirmed by clinical pathology(who underwent surgical treatment)were ***-time fluorescent quantitative reverse transcription-polymerase chain reaction was used to detect the expression of B7-h3 mRNA in EC tissue obtained during preoperative gastroscopy,and its correlation with LNM was *** features were extracted from multi-modal magnetic resonance imaging of EC using Pyradiomics in *** extraction,data dimensionality reduction,and feature selection were performed using XGBoost model and leave-one-out *** logistic regression analysis was used to establish the prediction model,which included radiomics features,LN status from computed tomography(CT)reports,and B7-h3 mRNA expression,represented by a radiomics *** operating characteristic area under the curve(AUC)and decision curve analysis(DCA)were used to evaluate the predictive performance and clinical application value of the *** The relative expression of B7-h3 mRNA in EC patients with LNM was higher than in those without metastasis,and the difference was statistically significant(Phe AUC value in the receiver operating characteristic(ROC)curve was 0.718(95%CI:0.528-0.907),with a sensitivity of 0.733 and specificity of 0.706,indicating good diagnostic *** individualized clinical prediction nomogram included radiomics features,LN status from CT reports,and B7-h3 mRNA *** ROC curve demonstrated good diagnostic value,with an AUC value of 0.765(95%CI:0.598-0.931),sensitivity of 0.800,and specificity of *** indicated the practical value of the radiomics nomogram in clinical ***

关键词： Esophageal cancer Radiomics B7-h3mRNA Multimodal magnetic resonance imaging Lymph node metastasis Nomogram

Net primary productivity and its control of the Middle jurassic peatlands: An example from the southern junggar coalfield

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Science China Earth Sciences 2018年第11期61卷 1633-1643页

作者： Yanan li Longyi ShAO Zhiming YAN haihai hOU Yue TANG David j.LARGE College of Geoscience and Surveying Engineering China University of Mining and Technology Oil and Gas Resources Survey Center China Geological Survey Administration Faculty of Engineering University of Nottingham

The jurassic is an important period of global coal formation, including the development of several large coalfields in central Asia and northern China. Individual seams within these peatlands represent sustained periods of terrestrial carbon accumulation and a key environmental indicator attributed to this record is the rate of carbon accumulation. Determining the rate of carbon accumulation requires a measure of time contained within the coal and this study aimed at determining the rate via the identification of Milankovitch orbital cycles using spectral analysis. Spectral analyses of geophysical data from two thick coal seams, No. 43(35.9 m) and No. 3(13.2 m), of the Middle jurassic of the southern junggar coalfield were conducted to identify significant signals of variations in ash content. The results showed that the variations in ash content of the coal showed spatial cycles at 0.2, 0.7 and 1.1 m^(-1), which were interpreted to represent 123 ka(eccentricity), 37.1 ka(obliquity), and 21.2 ka(precession) orbital periodicities, respectively. Using this timeframe, the depositional time of the No. 43 and No. 3 coal seams were calculated to be 876–970 and 322–357 ka, respectively. In combination with an understanding of carbon loss during coalification, the carbon accumulation rates of these Middle jurassic peatlands were calculated to be 58.6–64.9 and60.3–66.8 g C m^(-2) a^(-1) for the No. 43 and No. 3 coal seams, respectively. Given that the net primary productivity(NPP) was 4.3 times the value of the carbon accumulation in a mid-latitude region of 40°–45°N, an NPP of 251.8–279.1 and259.1–287.1 g C m^(-2) a^(-1) was calculated for the No. 43 and No. 3 coal seams, respectively. In the context of the same paleolatitude(40°–45°N) and peat type, the NPP values of the Middle jurassic strata in the study area were higher than those of the peatlands of the holocene and Permian, and were similar to the NPP values of Early Cretaceous peatlands. Considering the NPP of a peat

关键词： Peatland Middle jurassic Milankovitch cycle Net primary productivity Mid-latitude region Paleoclimate

Research on Machining Mechanics and Experiment of Ultrasonic-Magnetorheological Compound Finishing

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Research on Machining Mechanics and Experiment of Ultrasonic...

Soft pneumatic actuators by digital light processing combined with injection-assisted post-curing

The International Conference on Surface Finishing Technology and Surface Engineering

作者： F.h. Zhang h.j. Wang and D.R. Luan School of Mechatronics Engineering harbin Institute of Technology harbin 150001 China.

＜正＞In this paper, ultrasonic-magnetorheological compound finishing （UMC finishing）, which is a new kind of polishing method, is first presented for the ultraprecision machining of concave optical surface with small radius. The principle of ultrasonic-magnetorheological compound finishing is studied, and experimental set-up is developed based on the foregoing study. Experiments are carried out to verify the mechanics of ultrasonic-magnetorheological compound finishing. The results show that the surface roughness of the polished optical glass by ultrasonic-magnetorheological compound finishing is on nano-scale, which can satisfy the optical surface quality requirement. Furthermore, ultrasonic-magnetorheological compound finishing can also have higher machining efficiency than magnetorheological finishing under the same experiment conditions.

关键词： asphere magnetorheological finishing ultrasonic finishing polishing ultraprecision machining.

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Applied Mathematics and Mechanics(English Edition) 2021年第2期42卷 159-172页

作者： Qiang ZhANG Shayuan WENG Zeang ZhAO h.j.QI Daining FANG State Key Laboratory for Turbulence and Complex System College of EngineeringPeking UniversityBeijing 100871China College of Aerospace Engineering Chongqing UniversityChongqing 400044China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China The George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332U.S.A.

The soft robotics display huge advantages over their rigid counterparts when interacting with living organisms and fragile *** one of the most efficient actuators toward soft robotics,the soft pneumatic actuator(SPA)can produce large,complex responses with utilizing pressure as the only input *** this work,a new approach that combines digital light processing(DLP)and injection-assisted post-curing is proposed to create SPAs that can realize different *** enable this,we develop a new class of photo-cross linked elastomers with tunable mechanical properties,good stretchability,and rapid curing *** carefully designing the geometry of the cavities embedded in the actuators,the resulting actuators can realize contracting,expanding,flapping,and twisting *** addition,we successfully fabricate a soft self-sensing bending actuator by injecting conductive liquids into the three-dimensional(3D)printed actuator,demonstrating that the present method has the potential to be used to manufacture intelligent soft robotic systems.

关键词： soft pneumatic actuator(SPA) digital light processing(DLP) injectionassisted post-curing three-dimensional(3D)printing

不同类型油脂高脂膳食对小鼠血脂水平及肠道菌群的影响

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现代预防医学 2024年第8期51卷 1412-1419页

作者：陈睿然陈洁黄佳灵李敏丽郭福川福建医科大学公共卫生学院

目的探究不同类型油脂高脂膳食对小鼠血脂水平及肠道菌群的影响。方法 30只SPF级雄性C57BL/6j小鼠按体重随机分为三组，每组10只，普通对照组(ND)给予对照饲料，棕榈油高脂组(PhFD)和大豆油高脂组(ShFD)分别给予对应高脂饲料，喂养17... 详细信息

目的探究不同类型油脂高脂膳食对小鼠血脂水平及肠道菌群的影响。方法 30只SPF级雄性C57BL/6j小鼠按体重随机分为三组，每组10只，普通对照组(ND)给予对照饲料，棕榈油高脂组(PhFD)和大豆油高脂组(ShFD)分别给予对应高脂饲料，喂养17周后测定血清生化指标，取粪便进行16S rRNA测序。结果与ND相比，PhFD和ShFD小鼠体重显著升高(PhFD显著高于ShFD(PhFD血清总胆固醇(total cholesterol, TC)、低密度脂蛋白(low-density lipoprotein cholesterol, LDL-C)水平显著升高(PhFD血清TC、甘油三酯(triglyceride, TG)水平显著升高(PhFD血清TC、LDL-C水平显著高于ShFD(PhFD Firmicutes/Bacteroidota比值(F/B值)显著升高(PhFD(PhFD特征菌Ileibacterium、Pseudomonas和Bifidobacterium相对丰度显著升高(PhFD特征菌Mucispirillum、Allobaculum和Colidextribacter相对丰度显著升高(PhFD糖代谢相关通路功能显著上升(PhFD脂代谢相关通路功能显著下降(PhFD糖脂代谢相关菌属相对丰度增加，ShFD脂质代谢相关菌属相对丰度增加，抗氧化相关菌相对丰度降低。

关键词：高脂膳食肠道菌群棕榈油大豆油

In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite

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journal of Materials Science & Technology 2013年第6期29卷 545-550页

作者： Y.h.Wu N.li Y.Cheng Y.F.Zheng Y.han Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking University Department of Materials Science and Engineering College of EngineeringPeking University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

AZ31 magnesium alloy fibers reinforced poly（lactic-co-glycolic acid）（PLGA） composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that ph values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.

关键词： Biomaterials Corrosion Polymeric composites AZ31 magnesium fiber