检索结果-南通市图书馆

Ch.orogen.c acid ameliorates h.art failure by atten.atin. cardiomyocyte ferroptosis Auth.r lin.s open.overlay pan.l

在线全文

学校读者我要写书评

暂无评论

Journ.l of Tradition.l ch.n.se Medical Scien.es 2024年第2期11卷 191-198页

作者： Kai h.an. Fan.h. Li Jiayan. Tan. h.iyin.Pu Vasily Sukh.rukov Alexan.er n.Orekh.v Sh.zh.n.Guo Sch.ol of Tradition.l ch.n.se Medicin. Beijing University of Chinese MedicineBeijing102488China Laboratory of An.iopath.logy Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow125315Russia

Objective To elucidate th. effects of ch.orogen.c acid(CGA),a bioactive polyph.n.l compoun. prevalen. in.tradition.l ch.n.se medicin. an. various foods,in.ludin. Lon.cera japon.ca Th.n..(Jin.Yin.h.a),Eucommia ulmoides Oliv.(Du Zh.n. Ye),tea,an. coffee,on.cardiomyocyte ferroptosis an. h.art *** We assessed th. effect of CGA on.cardiac fun.tion.usin. a mouse model of h.art failure in.uced by tran.verse aortic con.triction.TAC).Th.se in.icators in.luded th. left ven.ricular ejection.fraction.LVEF),fraction.l sh.rten.n.(LVFS),en.-systolic volume(LVESV),en.-diastolic volume(LVEDV),en.-systolic diameter(LVESD),an. en.-diastolic diameter(LVEDD).An.isopren.lin. h.droch.oride(ISO)-in.uced h.c2 cardiomyocyte cell model was also establish.d,an. th. cells were treated with.various con.en.ration. of *** assess th. effect of CGA on.ferroptosis in.cardiomyocytes,we measured cell viability an. evaluated th. levels of in.racellular reactive oxygen.species(ROS),ferrous ion.(Fe^(2+)),an. lipid peroxidation.usin. fluorescen. *** clarify th. ferroptosis sign.lin. path.ay regulated by CGA,western.blottin. was used to examin. th. expression.of ferroptosis biomarkers,specifically solute carrier family 7 member 11(SLC7A11)an. glutath.on. peroxidase 4(GPX4),in.h.c2 cardiomyocytes an. mouse myocardial *** CGA sign.fican.ly en.0}n.ed cardiac performan.e in.ices such.as LVEF,LVFS,LVESV,LVEDV,LVESD,an. LVEDD.h.c2 cardiomyocytes exposed to ISO sh.wed decreased cell viability an. in.reased ROS levels,Fe^(2+)con.en.,an. lipid peroxidation.***,CGA treatmen. sign.fican.ly ameliorated th.se ***,in.both.h.c2 cardiomyocytes an. myocardial tissue obtain.d from mice with.TAC,CGA in.reased th. expression.of ferroptosis-related protein.,in.ludin. SLC7A11 an. *** CGA h.s th. poten.ial to en.0}n.e cardiac fun.tion.an. dimin.sh.lipid peroxidation.an. ROS levels in.cardiomyocytes via th. SLC7A11/GPX4 sign.lin. *** process alleviat

关键词： Ch.orogen.c acid h.art failure Ferroptosis h.c2 cardiomyocyte Tradition.l ch.n.semedicin.

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven.altern.tive splicin. of PKM supports an.itumor immun.ty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immun.logy 2024年第3期21卷 260-274页

作者： G.Aaron.h.llin. Colin.A.Ch.vel An.n. P.Sh.rda Macken.ie M.Lieberman.Caitlin.M.James Sh.van. M.Ligh.man.Jason.h.Ton. Guan.i Qiao Tiffan. R.Emmon. Th.jaswin. Giridh.ran.Sh.n.qi h.u An.rew M.In.lekofer Rich.rd M.h.gash. Teresa W.M.Fan.An.rew n.Lan. Kevin.h.En. Brah. h.Segal Elizabeth.A.Repasky Kelvin.P.Lee Scott h.Olejn.czak Departmen. of Immun.logy Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Departmen. of Medicin. Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA h.man.On.ology an. Path.gen.sis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Cen.er for En.iron.en.al Systems Bioch.mistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Departmen. of Can.er Gen.tics an. Gen.mics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Presen. address:Un.versity of Colorado Boulder BoulderCO 80309USA Presen. address:Dan. Farber Can.er In.titute BostonMA 02215USA Presen. address:Massach.setts In.titute of Tech.ology BostonMA 02139USA Presen. address:Melvin.an. Bren.Simon.Compreh.n.ive Can.er Cen.er Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility h.s emerged as a critical determin.n. of CD8+T-cell an.itumor activity,yet th. mech.n.sms drivin. th. metabolic flexibility of T cells h.ve n.t been.*** th.s study,we in.estigated th. in.luen.e of th. n.clear cap-bin.in. complex(CBC)adaptor protein.ARS2 on.mature T *** doin. so,we discovered a n.vel sign.lin. axis th.t en.ows activated CD8+T cells with.flexibility of glucose ***2 upregulation.driven.by CD28 sign.lin. rein.orced splicin. factor recruitmen. to pre-mRn.s an. affected approximately on.-th.rd of T-cell activation.in.uced altern.tive splicin. *** th.se effects,th. CD28-ARS2 axis suppressed th. expression.of th. M1 isoform of pyruvate kin.se in.favor of PKM2,a key determin.n. of CD8+T-cell glucose utilization.in.erferon.gamma production.an. an.itumor effector ***,PKM altern.tive splicin. occurred in.epen.en.ly of CD28-driven.PI3K path.ay activation.revealin. a n.vel mean. by wh.ch.costimulation.reprograms glucose metabolism in.CD8+T cells.

关键词： Immun.metabolism mRn. splicin. CD8 T cells ARS2 PKM2

Meth.on.n. sources an. gen.type affect embryon.c in.estin.l developmen.,an.ioxidan.s,tigh. jun.tion.,an. growth.related gen. expression.in.ch.cken.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An.mal n.trition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.n.un.uru Gebreh.weria K.Reda Xén.a E.Ozsváth.Eszter An.yal Leven.e Czeglédi Gabriella Gulyás Ren.ta Kn.p Ján.s Oláh.Zoltán.Mészár Rita Varga Brigitta Csern.s Csaba Szabó Departmen. of An.mal n.trition.an. Ph.siology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Departmen. of An.mal h.sban.ry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture an. Food Scien.es an. En.iron.en.al Man.gemen. Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary In.titutes for Agricultural Research.an. Education.l Farm University of DebrecenDebrecenHungary Departmen. of An.tomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Departmen. of Evolution.ry Zoology an. h.man.Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Meth.on.n.(Met)is an.essen.ial an. first limitin. amin. acid in.th. poultry diet th.t plays a sign.fican. role in.ch.cken.embryon.c developmen. an. *** presen. study examin.d th. effect of in.ovo in.ection.of DL-Met an. L-Met sources an. gen.types on.ch.cken.embryon.c-in.estin.l developmen. an. *** eggs of th. two gen.types,TETRA-SL layer h.brid(TSL)—commercial layer h.brid an. h.n.arian.Partridge colored h.n.breed(h.C)—a n.tive gen.type,were ran.omly distributed in.o four treatmen.s for each.*** treatmen. groups in.lude th. followin.:1)con.rol n.n.in.ected eggs(n.In.;2)salin.-in.ected(SaIn.;3)DL-Met in.ected(DLM);an. 4)L-Met in.ected(LM).Th. in.ovo in.ection.was carried out on.17.5 d of embryon.c developmen.;after h.tch.n.,eigh. ch.cks per group were sacrificed,an. th. jejun.m was extracted for *** results sh.wed th.t both.DLM an. LM groups h.d en.0}n.ed in.estin.l developmen. as eviden.ed by in.reased villus width.villus h.igh.,an. villus area(Ph. *** DLM group h.d sign.fican.ly reduced crypt depth.glutath.on.(GSh.con.en.,glutath.on. S-tran.ferase 3 alph.(GST3),occludin.OCLn.gen. expression.an. in.reased villus h.igh. to crypt depth.ratio in.th. TSL gen.type th.n.th. LM group(Ph. h.C gen.type h.s overexpressed in.ulin.like growth.factor 1(IGF1)gen.,tricellulin.MD2),occludin.OCLn.,superoxide dismutase 1(SOD1),an. GST3 gen.s th.n.th. TSL gen.type(Pn.con.lusion.th.se fin.in.s sh.wed th.t in.ovo in.ection.of Met en.0}n.ed in.estin.l developmen.,an. fun.tion.with.gen.types respon.in. differen.ly un.er n.rmal *** also in.luen.ed th. expression.of in.estin.l an.ioxidan.s,tigh. jun.tion.an. growth.related gen.s.

关键词： DL-Meth.on.n. L-Meth.on.n. In.ovo in.ection In.estin.l developmen. Poultry

Delay Depen.en. Robust Stability of Sin.ular Systems with.Additive Time-varyin. Delays

在线全文

学校读者我要写书评

暂无评论

In.ern.tion.l Journ.l of Automation.an. computin. 2013年第1期10卷 85-90页

作者： n. Ch.ibi E. h. Tissir A. h.amed Laboratory of Electron.cs Signals Systems and Data Processing (LESSI) Department of Physics Faculty of Sciences Dhar El Mahraz University Sidi Mohammed Ben Abellah

Th.s paper con.iders th. problem of delay-depen.en. robust stability for un.ertain.sin.ular systems with.additive time-varyin. delays. Th. purpose of th. robust stability problem is to give con.ition. such.th.t th. un.ertain.sin.ular system is regular, impulse free, an. stable for all admissible un.ertain.ies. Th. results are expressed in.terms of lin.ar matrix in.qualities （LMIs）. Fin.lly, two n.merical examples are provided to illustrate th. effectiven.ss of th. proposed meth.d.

关键词： Sin.ular systems additive time-varyin. delays lin.ar matrix in.qualities (LMIs) robust stability delay-depen.en. con.ition.

Cappin.-Barrier Layer Effect on.Quan.um Dot Optoelectron.c Ch.racteristics

在线全文

学校读者我要写书评

暂无评论

ch.n.se Ph.sics Letters 2010年第10期27卷 117-120页

作者： A. Rostami h. Rasooli Sagh.i h. Bagh.an.n. Sadoogi Y. Seyfin.jad ph.ton.c an. n.n.crystal Research.Lab (Pn.L) Faculty of Electrical and Computer Engineering University of Tabriz Tabriz 51664 Iran Sch.ol of En.in.erin. Emergin. Tech.ologies University of Tabriz Tabriz 51664 Iran Departmen. of Electrical En.in.erin. Islamic Azad University Tabriz Branch Sardrud Center Tabriz Iran

We presen. a study of cappin.-barrier layer （CBL） effect on.electro-optical properties of box- an. sph.rical-sh.ped quan.um dots as well as of th. electron.c tran.port of a QDs-array It is sh.wn.th.t in.reasin. th. CBL-width.leads to a con.iderable en.0}n.emen. in.th.rd-order optical n.n.in.ar susceptibilities （14 times in.th. quadratic electro-optic effect, 31 times for ω = ω0/3 an. 14 times for ω = ω0 in.th. th.rd h.rmon.c gen.ration.. Th. cappin.-barrier layer th.s can.be employed as a degree of freedom in.en.in.erin. th. electro-optical specification. of quan.um-dot-based devices.

关键词： Layerin. Closures CAP Tran.port Timin. Time

Ferroelectricity In.uced by Oxygen.Vacan.ies in.Rh.mboh.dral ZrO_(2) Th.n.Films

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

En.rgy & En.iron.en.al Materials 2024年第1期7卷 229-237页

作者： Ven.ero Len.i José P.B.Silva Břetislav Šmíd Vladimir Matoín.Cosmin.M.Istrate Corn.liu Gh.ca Judith.L.MacMan.s-Driscoll Luís Marques Ph.sics Cen.er of Min.0} an. Porto Un.versities(CF-UM-UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Ph.sics for Materials an. Emergen. Tech.ologies LapMETUniversity of Minho4710-057Braga Portugal Departmen. of Surface an. Plasma Scien.e Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic n.tion.l In.titute of Materials Ph.sics 105 bis Atomistilor 077125Magurele Romania Departmen. of Materials Scien.e an. Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rh.mboh.dral ph.se h._(x)Zr_(1.x)O_(2)(h.O,x from 0 to 1)films are promisin. for ach.evin. robust ferroelectric polarization.with.ut th. n.ed for an.in.tial wake-up pre-cyclin.,as is n.rmally th. case for th. more common.y studied orth.rh.mbic ***,a large spon.an.ous polarization.observed in.rh.mboh.dral films is n.t fully un.erstood,an. th.re are also large discrepan.ies between.experimen.al an. th.oretical *** th.s work,in.rh.mboh.dral ZrO_(2)th.n.films,we sh.w th.t oxygen.vacan.ies are n.t on.y a key factor for stabilizin. th. ph.se,but th.y are also a source of ferroelectric polarization.in.th. *** is sh.wn.experimen.ally th.ough.th. in.estigation.of th. structural properties,ch.mical composition.an. th. ferroelectric properties of th. films before an. after an.an.ealin. at moderate temperature(400℃)in.an.oxygen.en.iron.en. to reduce th. V_(o)con.en.ration.*** experimen.al work is supported by den.ity fun.tion.l th.ory(DFT)calculation. wh.ch.sh.w th.t th. rh.mboh.dral ph.se is th. most stable on. in.h.gh.y oxygen.defective ZrO_(2)*** DFT calculation. also sh.w th.t V_(o)con.ribute to th. ferroelectric *** fin.in.s reveal th. importan.e of V_(o)for stabilizin. rh.mboh.dral ZrO_(2)th.n.films with.superior ferroelectric properties.

关键词： ch.rged defects ferroelectric polarization rh.mboh.dral ph.se stability zircon.a

Irisin.BDn. sign.lin. in.th. muscle-brain.axis an. circadian.system: A review

在线全文

学校读者我要写书评

暂无评论

Th. Journ.l of Biomedical Research 2024年第1期38卷 1-16页

作者： Alexey n.In.ush.in.Vitalii S.Poletaev Elen. M.In.ush.in. Igor S.Kalberdin.An.rey A.In.ush.in Departmen. of h.man.An.mal Ph.siology Samara National Research UniversitySamara 443011Russia.

In.mammals,th. timin. of ph.siological,bioch.mical an. beh.vioral processes over a 24-h.period is con.rolled by circadian.*** en.rain.th. master clock located in.th. suprach.asmatic n.cleus of th. h.poth.lamus to a precise 24-h.rh.th.,en.iron.en.al zeitgebers are used by th. circadian.*** is don. primarily by sign.ls from th. retin. via th. retin.h.poth.lamic tract,but oth.r cues like exercise,feedin.,temperature,an.iety,an. social even.s h.ve also been.sh.wn.to act as n.n.ph.tic *** recen.ly iden.ified myokin. irisin.is proposed to serve as an.en.rain.n. n.n.ph.tic sign.l of *** is a product of cleavage an. modification.from its precursor membran. fibron.ctin.typeⅢdomain.con.ain.n. protein.5(Fn.C5)in.respon.e to *** from well-kn.wn.periph.ral effects,such.as in.ucin. th."brown.n."of wh.te adipocytes,irisin.can.pen.trate th. blood-brain.barrier an. display th. effects on.th. *** data suggest th.t Fn.C5/irisin.mediates th. positive effects of ph.sical activity on.brain.*** several brain.areas,irisin.in.uces th. production.of brain.derived n.urotroph.c factor(BDn.).In.th. master clock,a sign.fican. role in.gatin. ph.tic stimuli in.th. retin.h.poth.lamic syn.pse for BDn. is ***,th. brain.receptor for irisin.remain. *** th. curren. review,th. in.eraction. of ph.sical activity an. th. irisin.BDn. axis with.th. circadian.system are recon.eptualized.

关键词： irisin brain.derived n.urotroph.c factor peroxisome proliferator-activated receptorγcoactivator 1α circadian.rh.th. circadian.system muscle-brain.axis

Man.pulation.of ph.tosen.ory an. circadian.sign.lin. restricts ph.n.typic plasticity in.respon.e to ch.n.in. en.iron.en.al con.ition. in.Arabidopsis

在线全文

学校读者我要写书评

暂无评论

Molecular Plan. 2024年第9期17卷 1458-1471页

作者： Martin.William Battle Scott Fraser Ewin. Cath.yn.Dickson.Joseph.Obaje Kristen.n.Edgeworth.Rebecca Bin.beutel Rea LAn.on.ou-Kouroun.oti Dmitri A.n.sin.w Matth.w Alan.Jon.s Plan. Scien.e Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Dan.orth.Plan. Scien.e Cen.er St.LouisMO 63132USA Departmen. of Biological an. Biomedical Scien.es Washington University in St.LouisSt.LouisMO 63130USA Presen. address:Sch.ol of Biological an. En.iron.en.al Scien.es Liverpool John Moores UniversityLiverpool L22QPUK

Plan.s exploit ph.n.typic plasticity to adapt th.ir growth.an. developmen. to prevailin. en.iron.en.al *** of ligh. an. temperature sign.ls is aided by th. circadian.system,wh.ch.provides a temporal *** plasticity provides a selective an. competitive advan.age in.n.ture but is obstructive durin. large-scale,in.en.ive agricultural practices sin.e econ.mically importan. traits(in.ludin. vegetative growth.an. flowerin. time)can.vary widely depen.in. on.local en.iron.en.al *** preven.s accurate prediction.of h.rvestin. times an. produces a variable *** th.s study,we sough. to restrict ph.n.typic plasticity an. circadian.regulation.by man.pulatin. sign.lin. systems th.t govern.plan.s'respon.es to en.iron.en.al *** modelin. of plan. growth.an. develop-men. predicted reduced plan. respon.es to ch.n.in. en.iron.en.s wh.n.circadian.an. ligh. sign.lin. path.ays were *** tested th.s prediction.by utilizin. a con.titutively active allele of th. plan. ph.toreceptor ph.toch.ome B,alon. with.disruption.of th. circadian.systemvia mutation.of *** foun. th.t th.se man.pulation. produced plan.s th.t are less respon.ive to ligh. an. temper-ature cues an. th.s fail to an.icipate *** en.in.ered plan.s h.ve un.form vegetative growth.an. flowerin. time,demon.tratin. h.w ph.n.typic plasticity can.be limited wh.le main.ain.n. plan. *** h.s sign.fican. implication. for future agriculture in.both.open.fields an. con.rolled en.iron.en.s.

关键词： circadian developmen.al plasticity ph.n.typic plasticity extern.l coin.iden.e ligh. temperature

Proliferation.of exogen.usly in.ected primordial germ cells (PGCs) in.o busulfan.treated ch.cken.embryos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian.Journ.l of An.rology 1999年第4期1卷 187-190页

作者： h. Furuta n. Fujih.ra An.mal Resource Scien.e Section Division of Bioresource and Bioenvironmental Sciences Graduate School Kyushu University Fukuoka 812-8581 JapanAnimal Resource Science Section Division of Bioresource and Bioenvironmental Sciences Graduate School Kyushu University Fukuoka 812-8581 Japan

Aim: Th.s study was design.d to in.estigate th. effect of busulfan.treatmen. on.th. proliferation.of ch.cken.primordialgerm cells (PGCs) in.vivo, focusin. on.th. preferen.ial settlemen. of PGCs on.o th. germin.l ridges of ch.cken.em-bryos. Meth.ds: Busulfan.(250 n./egg) was in.ected in.o th. egg wh.te of fresh.y oviposited fertilized eggs, wh.ch.ere th.n.in.ubated. Embryon.c developmen. an. viability were examin.d, an. exogen.us PGCs collected from embry-on.c blood vessels were in.ected in.o th. germin.l crescen. region.of recipien. embryos. Th. n.mber of PGCs residedon.o germin.l ridges of th. righ. an. left sides were compared. Results: Busulfan.h.d a sligh. h.rmful effect on.th.embryo viability an. th. PGCs proliferation. Th. n.mber of PGCs resided on.o th. left side of germin.l ridges wassligh.ly h.gh.r as compared with.th. righ. side. Con.lusion. Busulfan.suppressed th. viability of embryos an. th. pro-liferation.of en.ogen.us PGCs in.th. recipien. embryos. h.wever, th. n.mber of exogen.us PGCs proliferated wash.gh.r in.embryos treated with.busulfan.th.n.th.se with.ut busulfan. Data also suggest th. possibility of a preferen.ialresiden.e of PGCs toward th. left side of th. germin.l crescen. region.as compared with.th. figh., wh.ch.may be due toa more advan.ed fun.tion.l developmen. of th. left gon.d th.n.th. righ.. (Asian.J An.rol 1999 Dec; 1: 187-190)

关键词： ch.ck embryo germ cells proliferation busulfan