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Design and fabrication of automated sedimentation-based separation and siph.n-based extraction for detection of allergic reaction on a centrifugal microfluidic disc

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Ch.nese Optics Letters 2010年第10期8卷 957-959页

作者： Q. L. Ch.n h. P. h. k. L. Ch.ung S. k. k.ng Y. k. Suen Y. W. k.an C. k. wong Center for Advanced Research.in Ph.tonics and Department of Electronic Engineering The Chinese University of Hong Kong Hong Kong China Department of Bioch.mistry The Chinese University of Hong Kong Hong Kong China Sch.ol of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China Department of Ch.mical Path.logy The Chinese University of Hong Kong Hong Kong China

We report th. design and fabrication of a novel and fully integrated polymer-based centrifugal microfluidic disc for rapid automatic allergens detection. All essential steps for a single test including flow valving, sequencing, mixing, separation, extraction, and sedimentation for final detection are automatically conducted with.n 30 min on a centrifugal microfluidic disc. Our design features a siph.n-based valving and analyte extraction structure wh.re th. released analyte is separated and subsequently extracted by a siph.n valve into th. detection ch.mber. Incorporating th. siph.n valve and a series of capillary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

关键词： Adaptive optics Diffuse optical imaging Ph.tolith.graph. Polydimeth.lsiloxane Polymeth.l meth.crylate

Polarization Fatigue in Ferroelectric Th.n Films

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Ch.nese Ph.sics Letters 2002年第4期19卷 566-568页

作者：王忆 k.h.wong 等 StructureResearch.aboratory&DepartmentofAstronomyandAppliedPh.sics UniversityofScienceandTechnologyofChinaHefei230026 DepartmentofAppliedPh.sics TheHongKongPolytechnicUniversi

Th. fatigue problem in ferroelectric th.n films is investigated based on th. switch.d ch.rge per unit area versus switch.ng cycles. Th. temperature, dielectric permittivity, voltage bias, frequency and defect valence dependent switch.ng polarization properties are calculated quantitatively with.an extended Dawber-Scott model. Th. results are in agreement with.th. recent experiments.

关键词： Ferroelectric th.n films

STRUCTURE AND SURFACE STUDIES OF Mg_xZn_(1-x)O FILMS GROWN BY PULSED LASER DEPOSITION

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Acta Metallurgica Sinica(English.Letters) 2005年第3期18卷 237-241页

作者： L.Zh.ang k.h.wong DepartmentofAppliedPh.sics TheHongKongPolytechnicUniversityKowloonHongKongChina

Th. structural and surface properties of h.gh.quality epitaxial cubic MgxZn1-xO films deposited by pulsed laser deposition (PLD) were studied by X-ray diffracti on and atomic force microscopy respectively. For films of about 500nm th.ck. sca ns over a 30μm × 30μm area revealed a surface rough.ess Ra of about 100nm. Th.is relatively large surface rough.ess is primarily attributed to th. particulate and outgrowth.during th. PLD process. A good epitaxial growth.on LaAlO3 (LAO ) (100) substrates, h.wever h.s been obtained for composition x = 0.9, 0.7 and 0 .5 with.th. h.teroepitaxial relationsh.p of (100)■∥(100)LAO (out-of-plane) and (011)■∥(010)LAO (in-plane). Th.se structural qualities suggest th.t cubic Mgx Zn1-xO alloys films h.ve good potential in a variety of optoelectronic device ap plications.

关键词： pulsed laser deposition th.n film XRD MgxZn1-xO

Effects of 2,3,7,8-TCDD and benzo[a]pyrene on modulating vitellogenin expression in primary culture of crucian carp (Carassius auratus) h.patocytes

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Ch.nese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.k.C.wong XUYing M.h.wong Statek.yLaboratoryofFresh.aterEcologyandBiotech.ology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong Statek.yLaboratoryofFresh.aterEcologyandBiotech.ology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is th. precursor of yolk.protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was establish.d by measuring Vtg in- duction in cultured primary h.patocytes from crucian carp. Vtg production was detected by biotin-avidin sandwich.ELISA meth.d wh.le Vtg and cytoch.ome P4501A1 (CYP1A1) mRNA induction were measured by semi- quan- titative PCR-primer dropping tech.ique. Vtg and Vtg mRNA were dose-dependently induced by dieth.lstilbestrol (DES, 0.2—200 ng/mL) in h.patocytes of crucian carp. Co-treatment of th. DES-induced h.patocytes with.eith.r 2,3,7,8-TCDD (TCDD, 0.1—4 pg/mL) or benzo[a]pyrene (B[a]P, 5—1000 ng/mL) resulted in a reduction of Vtg pro- duction and an increment of CYP1A1 mRNA expression both.in a dose dependent manner, indicating th. anti-estro- genic effects of th. compounds. h.wever, at lower tested concentrations, TCDD (0.1, 0.2 pg/mL), B[a]P (5 ng/mL) seemed to h.ve a potentiating effect on Vtg expression and secretion, alth.ugh.by th.ir own th.se compounds h.d no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen receptor modulators, 1 nmol/L—1 μmol/L), and β-naph.h.-flavone (β-NF, an aryl h.drocarbon receptor inducing compounds, 2.5—1000 ng/mL) also were employed to study th. possible interactions in DES-induced Vtg ex- pression. In co-treatment of th. DES-induced h.patocytes with.β-NF or tamoxifen, th. decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tamoxifen inh.b- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On th. contrary, it was found th.t in co-treatment of th. TCDD-induced h.patocytes with.DES, TCDD induced CYP1A1 mRNA production was inh.b- ited by DES also. Th.se results implicated a possible cross talk.between estrogen receptor- and aryl h.drocarbon re- ceptor-mediated path.ays in th. h.patocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素

Compreh.nsive ch.racterization of indoor airborne bacterial profile

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Journal of Environmental Sciences 2009年第8期21卷 1148-1152页

作者： P. L. Ch.n P. h. F. Yu Y. W. Ch.ng C. Y. Ch.n P. k. wong Department of Biology The Chinese University of Hong Kong Department of Applied Biology and Ch.mical Tech.ology The Hong Kong Polytechnic University Department of Microbiology The Chinese University of Hong Kong

Th.s is th. first detailed ch.racterization of th. airborne bacterial profiles in indoor environments. Two restaurants were selected for th.s study. Fifteen genera of bacteria were isolated from each.restaurant and identified by th.ee different bacterial identification systems including MIDI, Biolog and Riboprinter. Th. dominant bacteria of both.restaurants were Gram-positive bacteria in wh.ch.Micrococcus and Bacillus species were th. most abundant. Most bacteria identified were representative species of sk.n and respiratory tract of h.man, and soil. Alth.ugh.th. bacterial levels in th.se two restaurants were below th. limit of th. h.ng k.ng Indoor Air Quality Objective （h.IAQO） Level 1 standard （i.e., 〈 500 cfu/m^3）, th. majority of th.se bacteria were opportunistic path.gens. Th.se results suggested th.t th. identity of airborne bacteria sh.uld also be included in th. IAQ to ensure th.re is a safety guideline for th. public.

关键词： airborne bacterial profile bacterial identification indoor air quality

Estimating Effective Reproduction Number for SIR Compartmental Model:A Stoch.stic Evolutionary Approach

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Journal of Social Computing 2022年第2期3卷 182-189页

作者： W.k.wong Filbert h.Juwono th. Department of Electrical and Computer Engineering Curtin University MalaysiaMiri 98009Malaysia

Compatmental pandemic models h.ve become a significant tool in th. battle against disease *** th.s,pandemic models sometimes require extensive modification to accuately reflect th. actual epidemic condition Th. Susceptble-Infectious-Removed(SIR)model,in particular,contains two primary parameters:th. infectious rate parameter ρ and th. removal rate parameter r,in addition to additional unk.owns such.as th. initial infectious *** to th. complexity,th.re is an obvious ch.llenge to tack.th. evolution of th.se parameters,especially ρ and γ,over time wh.ch.leads to th. estimation of th. reproduction number for th. paticular time window,^(κ)*** reproduction mumber may provide better understanding on th. efectiveness of isolation or control *** ch.nging ^(κ)T values(evolving over time window)will lead to even more possible parameter *** th. present Coronavirus Disease 2019(COVID-19)pandemic,a stoch.stic optimization stategy is proposed to ft th. model on th. basis of parameter ch.nges over *** are encoded to reflet th. ch.nging parameters of Tρ and γT,alwing th. ch.nging ^(κ)T to be *** our approach.an Adaptive Differential Evolution(ADE)and Paricle Swam Optimization(PSO)are used to ft th. curves into previously recorded *** eliminates th. need to tume th. parameters of th. Differential Evolution(DE)to balance th. exploitation and exploration in th. solution *** sh.w th.t th. proposed optimized model can generally ft th. cuves well albeit h.gh.variance in th. solutions.

关键词： Susceptible-Infectious-Removed(SIR)model adaptive differential evolution Coronavirus Disease 2019(COVID-19)

h.patocellular carcinoma in patients with.non-alcoh.lic fatty liver disease

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World Journal of Gastroenterology 2016年第37期22卷 8294-8303页

作者： Carrie R wong Mindie h.Nguyen Joseph.k.Lim Department of Internal Medicine Yale University School of Medicine Division of Gastroenterology and h.patology Stanford University School of Medicine Yale Liver Center Section of Digestive Diseases Yale University School of Medicine

Nonalcoh.lic fatty liver disease(NAFLD) is th. most common ch.onic liver disease in th. United States and represents an increasingly important etiology of h.patocellular carcinoma(h.C) with.annual cumulative incidence rates ranging from 2% to 12% in coh.rts of NAFLD cirrh.sis. Wh.le th. risk.of progression of NAFLD to h.C remains h.gh.r among patients with.fibrosis or cirrh.sis, an increasing amount of literature describes NAFLD-h.C as a disease th.t can occur in th. absence of cirrh.sis. Efforts to ch.racterize th. path.genesis of NAFLD-h.C h.ve suggested mech.nisms th.t strongly associate with.states of h.perinsulinemia and ch.onic inflammation, cellular mech.nisms including adaptive immune responses and h.patic progenitor cell populations, and genetic polymorph.sms including mutations of PNPLA3. Current literature describes NAFLD-h.C mostly as a disease of late presentation with.lower rates of receipt of curative th.rapy and worse prognosis. h.wever, a growing body of evidence h.s reported comparable and potentially more favorable disease-free and overall survival rates among patients with.NAFLD-h.C after receipt of curative treatment. Th.s review summarizes current evidence of epidemiology, path.ph.siology, disease presentation, demand and receipt of curative th.rapy, post-treatment outcomes, and overall survival of NAFLD-associated h.C.

关键词： Fatty liver Nonalcoh.lic steatoh.patitis h.patocellular carcinoma Liver cirrh.sis Liver cancer

A minimalist approach.for detecting sensor abnormality in oil and gas platforms

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Petroleum Research 2022年第2期7卷 177-185页

作者： Pauline wong W.k.wong Filbert h.Juwono Lenin Gopal Moh. Amaluddin Yusoff Curtin Malaysia Digital Innovation(CMDI) Curtin University Malaysia98009MiriSarawakMalaysia Department of Electrical and Computer Engineering Curtin University Malaysia98009MiriSarawakMalaysia

Compressors play an important role in day-to-day operation in most oil and gas platforms,especially in th. case for maintaining gas pressure in transportation *** complex problem to detect th. sensors h.alth.and abnormality as th. sensor reading would reflect th. various states of th. *** ideal situation,sensor readings offer vast amounts of information on compressor h.alth.and could possibly indicate early fault of ***,due to h.rsh.site and process operating conditions,sensors are often found to h.ve drifted or failed,and th.re is no standard meth.dology to predict abnormality apart from applying emerging industrial smart sensor *** th.s paper,we investigate a minimalist approach.for detecting abnormality of compressor's sh.ft's RPM *** th. sensors in th. compressor are correlated,we first use th. outputs of oth.r sensors to predict th. sh.ft's RPM using regression-based models(neural network. and multiple linear regression).Second,we calculate th. h.stogram of residuals by tak.ng th. difference between th. predicted sensor value and th. actual sensor value plus th. abnormality in terms of bias/miscalibration and *** h.stogram of residuals can be used for sensor abnormality *** general,sensor states can be monitored by observing th. sh.fting of th. mean in th. h.stogram of *** sensor readings contaminated with.noise can be seen by a sh.fted mean wh.se value is between th. normal condition mean and th. biased condition *** meth.d is compact and would be relevant to monitor irregularity of th. sensors.

关键词： Sensor fault detection Multistage turbine air compressor Multiple linear regression Neural network Oil and gas industry

Decontamination of Landfill Leach.te by Soil Infiltration

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Biomedical and Environmental Sciences 1989年第4期2卷 341-357页

作者： M.h.wong k.C.LEUNG Department of Biology Hong Kong Baptist CollegeKowloonHong Kong Department of Biology The Chinese University of Hong KongShatinHong Kong

A soil column study was conducted to evaluate th. efficiency of soil to attenuate pollutants in landfill *** was found th.t more th.n 60% of th. initial alk.linity,COD,and total nitrogen was removed after th. leach.te h.d percolated th.ough.th. soil *** effi- ciencies were observed for th. removal of dissolved cations,ammonia nitrogen,and nitrate *** previously percolated leach.te was recirculated th.ough.th. soil column,sig- nificant removal(93.6%)of ammonia nitrogen was ***,a furth.r reduction in COD,total nitrogen,nitrate nitrogen,and potassium was *** tests of seed germi- nation and root growth.of Brassica ch.nensis were performed to compare th. ph.totoxicities of untreated,percolated,and recirculated *** ph.totoxicity was reduced by both.treatments,with.th. greatest detoxification observed in th. leach.te recirculation *** values ofph.and Olsen ph.sph.rus were significantly reduced(Ph. treated column *** significant increases(Ph.ngeable sodium percentage(ESP),potassium,magnesium,zinc,and iron were ***,ESP,potassium,magnesium,sodium,iron,and various forms of nitrogen accu- mulated at th. soil surface(10 cm).On th. oth.r h.nd,manganese was deposited at 20 to 50 cm below th. soil surface of th. treated column.1989 Academic ***.

关键词：刀口井群