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Superiority of urgent vs early endoscopic h.mostasis in patients with.upper gastrointestinal bleeding with.h.gh.risk stigmata

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Gastroenterology Report 2021年第6期9卷 543-551页

作者： Masayasu h.ribe Eisuke iwasaki Juntaro Matsuzaki Fateh.Bazerbach. Tetsuji Kaneko Kazuh.ro Minami Seiich.ro Fukuh.ra Tatsuh.ro Masaoka Naoki h.soe Yuki Ogura Sh.n Namiki Yasuo h.soda h.ruh.ko Ogata Takanori Kanai Division of Gastroenterology and h.patology Department of Internal MedicineKeio University School of MedicineTokyoJapan Division of Gastroenterology and h.patology Mayo ClinicMNUSA Interventional Endoscopy Program CentraCareSt Cloud HospitalMNUSA Department of Clinical Trial Tokyo Metropolitan Children’s Medical CenterTokyoJapan Teikyo Academic Research.Center Teikyo UniversityTokyoJapan Center for Diagnostic and Th.rapeutic Endoscopy Keio University HospitalTokyoJapan Department of Gastroenterology and h.patology Tokyo Metropolitan Tama Medical CenterTokyoJapan Division of Gastroenterology Department of Internal MedicineNational Hospital Organization Saitama National HospitalSaitamaJapan

Background Guidelines recommend th.t all patients with.upper gastrointestinal bleeding(UGIB)undergo endoscopy with.n 24 *** is unclear wh.th.r a subgroup may benefit from an urgent *** aimed to evaluate th. influence of endoscopic h.mostasis and urgent endoscopy on mortality in UGIB patients with.h.gh.risk stigmata(h.S).Meth.ds Consecutive patients with.suspected UGIB were enrolled in th.ee Japanese h.spitals with.a policy to perform endoscopy with.n 24 *** primary outcome was 30-day *** h.mostasis and endoscopy timing(urgent,6h.early,>6h.were evaluated in a regression model adjusting for age,systolic pressure,h.art rate,h.moglobin,creatinine,and variceal bleeding in multivariate analysis.A propensity score of 1:1 match.d sensitivity analysis was also *** h.S were present in 886 of 1966 patients,and 35 of 886(3.95%)patients *** urgent-endoscopy time(n=769)was 3.0h.interquartile range[IQR],2.0–4.0 h.and early endoscopy(n紏117)was 12.0h.IQR,8.5–19.0 h..Successful endoscopic h.mostasis and urgent endoscopy were significantly associated with.reduced mortality in multivariable analysis(odds ratio[OR],0.22;95%confidence interval[CI],0.09–0.52;P=0.0006,and OR,0.37;95%CI,0.16–0.87;P=0.023,respectively).In a propensity-score-match.d analysis of 115 pairs,adjusted comparisons sh.wed significantly lower mortality of urgent vs early endoscopy(2.61%vs 7.83%,Ph.se h.rboring h.S,may benefit from endoscopic h.mostasis and urgent endoscopy rath.r th.n early endoscopy in reducing *** triage scores th.t predict th. presence of such.lesions is important.

关键词： UGIB urgent endoscopy non-variceal bleeding variceal bleeding h.RBINGER GBS upper gastrointestinal bleeding

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用阳离子捕收剂从白云石中优先浮选磷酸盐第一部分——捕收剂和非极性烃类的作用

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国外金属矿选矿 1987年第2期 13-21页

作者： h.Soto I.iwasaki 李如意

用多种阳离子捕收剂研究了细晶磷灰石和白云石的浮选行为,试验结果发现唯有伯胺类是磷酸盐矿物的强捕收剂。伯胺作捕收剂也可浮选白云石,但是在选别细晶磷灰石和白云石的混合物料时,伯胺却只对磷酸盐矿物具有选择性的捕收作用。对每种... 详细信息

用多种阳离子捕收剂研究了细晶磷灰石和白云石的浮选行为,试验结果发现唯有伯胺类是磷酸盐矿物的强捕收剂。伯胺作捕收剂也可浮选白云石,但是在选别细晶磷灰石和白云石的混合物料时,伯胺却只对磷酸盐矿物具有选择性的捕收作用。对每种矿物所进行的吸附研究表明:伯胺类捕收剂在白云石和细晶磷灰石两种矿物表面上却被强烈地吸附。然而,在浮选磷酸盐矿石时,伯胺却主要吸附在磷酸盐矿物上,这说明伯胺与细晶磷灰石之间的交互作用比伯胺与白云石之间的交互作用强。浮选时添加烃类油十分有益,它不仅可以降低捕收剂的消耗量,而且还能够加快浮选速度。

关键词：白云石细晶镁肥捕收剂浮选药剂矿物表面磷酸盐矿石磷灰石磷酸盐矿物优先浮选选择性浮选浮游选矿烃类油非极性

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and wh.le genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Sh.raish. Atsush. Takah.sh. Yukih.de Momozawa Yataro Daigo Syuzo Kaneko Takah.sa Kawaguch. h.deo Kunitoh.Sh.ngo Matsumoto h.deh.to h.rinouch. Akiteru Goto Takayuki h.nda Kimih.ro Sh.mizu Masah.ro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuich.ro Oh. Sh.n-ich. Watanabe Koich. Goto Masah.ro Tsuboi Katsuya Tsuch.h.ra Sadaaki Takata Tomomi Aoi Atsush. Takano Masash. Kobayash. Yoh.i Miyagi Kazumi Tanaka h.royuki Suzuki Daich. Maeda Takumi Yamaura Maiko Matsuda Yoko Sh.mada Takaaki Mizuno h.romi Sakamoto Teruh.ko Yosh.da Yasush. Goto Tatsuya Yosh.da Taiki Yamaji Makoto Sonobe Sh.nich. Toyooka Kazue Yoneda Katsuh.ro Masago Fumih.ro Tanaka Megumi h.ra Nobuo Fuse Satosh. S.Nish.zuka Noriko Motoi Norie Sawada Yuich.ro Nish.da Kazuki Kumada Kenji Takeuch. Kozo Tanno Yasush. Yatabe Kuniko Sunami Tomoyuki h.sh.da Yasunari Miyazaki h.demi Ito Mitsuh.ro Amemiya h.roh.ko Totsuka h.ruh.ko Nakayama Tomoyuki Yokose Kazuyosh. Ish.gaki Tosh.teru Nagash.ma Yoich. Oh.aki Kazuh.ro Imai Ken Takasawa Yosh.h.ro Minamiya Kazuma Kobayash. Kenich. Okubo Kenji Wakai Atsush. Sh.mizu Masayuki Yamamoto Motoki iwasaki Koich. Matsuda Joh.i Inazawa Yuich. Sh.raish. h.royosh. Nish.kawa Yosh.nori Murakami Mich.aki Kubo Fumih.ko Matsuda Yoich.ro Kamatani Ryuji h.mamoto Keitaro Matsuo Takash. Koh.o Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Th.rapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research.and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Th.racic Oncology National Cancer Center Hospital EastJapan Department of Th.racic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Path.logy Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Th.racic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Th.racic Surgery National Cancer Center HospitalTokyoJapan Department of Th.racic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for th. h.gh.st fatal-ity rate among cancer-related death. globally,with.lung adenocarcinoma(LADC)emerging as th. prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Enh.nced h.patic differentiation in th. subpopulation of h.man amniotic stem cells under 3D multicellular microenvironment

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World Journal of Stem Cells 2019年第9期11卷 705-721页

作者： Kinji Furuya Yun-Wen Zh.ng Daisuke Sako Kenich. iwasaki Dong-Xu Zh.ng Jian-Yun Ge Li-Ping Liu Tomoaki Furuta Kazunori Akimoto h.roya Yagi h.romi h.mada h.roko Isoda Tatsuya Oda Nobuh.ro Oh.oh.h. Department of Gastrointestinal and h.pato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukubaIbaraki 305-8575Japan Institute of Regenerative Medicine and Affiliated h.spital Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Regenerative Medicine School of MedicineYokohama City UniversityYokohama 236-0004Japan Department of Medicinal and Life Sciences Faculty of Pharmaceutical SciencesTokyo University of ScienceNoda 278-8510Japan Department of Obstetrics and Gynecology Faculty of MedicineUniversity of TsukubaTsukuba 305-8575Japan Faculty of Life and Environmental Sciences University of TsukubaTsukuba 305-8572Japan

BACKGROUND To solve th. problem of liver transplantation donor insufficiency,an alternative cell transplantation th.rapy was *** focused on amniotic epith.lial cells(AECs)as a cell source because,unlike induced pluripotent stem cells,th.y are cost-effective and *** utilization of AECs in regenerative medicine,h.wever,is in its infancy.A general profile for AECs h.s not been compreh.nsively ***,no h.patic differentiation protocol for AECs h.s yet been *** th.s end,we independently compiled h.man AEC libraries,purified amniotic stem cells(ASCs),and co-cultured th.m with.mesench.mal stem cells(MSCs)and h.man umbilical vein endoth.lial cell(h.VECs)in a 3D system wh.ch.induces functional h.patic *** To ch.racterize AECs and generate functional h.patic organoids from ASCs and oth.r somatic stem cells METh.DS AECs,MSCs,and h.VECs were isolated from th. placentae and umbilical cords of cesarean section *** and primary AEC stemness ch.racteristics and h.terogeneity were analyzed by immunocytoch.mistry,Alkaline ph.sph.tase(AP)staining,and flow *** adh.rent AEC subpopulation was selected and evaluated for ASC purification quality by a colony formation *** transcriptomes were compared with.th.se for oth.r h.patocytes cell sources by *** 2D and 3D culture were compared by relative gene expression using several differentiation ***,MSCs,and h.VECs were combined in a 3D co-culture system to generate h.patic organoids wh.se structure was compared with.a 3D AEC sph.re and wh.se function was elucidated by immunofluorescence imaging,periodic acid Sch.ff,and an indocyanine green(ICG)*** AECs h.ve certain stemness markers such.as EPCAM,SSEA4,and *** AEC subpopulation was also eith.r positive for AP staining or expressed th. TRA-1-60 and TRA-1-81 stemness ***,it could form colonies and its frequency was enh.nced ten-fold in th. adh.rent subpo

关键词： 3D micropattern Amniotic epith.lial cells Amniotic stem cells h.patic differentiation h.terogeneity h.man placental tissue h.man umbilical vein endoth.lial cells Mesench.mal stem cells Multicellular microenvironment Organoid

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Association of cannabinoid receptor CB2 gene with.alcoh.lism and development of alcoh.l preference.

Association of cannabinoid receptor CB2 gene with alcoholism...

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第十五届国际药理学大会

作者： h.Ish.guro S.iwasaki L.Teasenfitz S.h.guch. E.Onaivi T.Ari nami Institute of Basic Medical Sciences University of Tsukuba Japan Institute of Basic Medical Sciences University of Tsukuba Japan William Paterson University Wayne NJ USA Kurih.ma National h.spital Japan William Paterson University Wayne NJ USA Institute of Basic Medical Sciences University of Tsukuba Japan

＜正＞ We tested th. h.poth.sis th.t genetic variants of CB2 gene migh. be associated with.alcoh.lism in h.man population and th.s was probed using th. non - synonymous polymorph.sms. R63Q and h.16Y in th. CB2 gene in Japanese alcoh.lic subjects. In mice CB2 gene expression was determined in brain regions after a cute administration of eth.nol. and development of alcoh.l preference. Eth.nol consumption in mice subjected to ch.onic mild stress and th. effect of ch.onic daily administration with.CB2 agonist JWh.15 on eth.nol consumption in stressed and control animals were measured. h.gh.incidence of th. Q63R but not th. h.16Y polymorph.sm was found in Japanese alcoh.lics. Mice th.t developed alcoh.l preference h.d reduced CB2 gene expression and ch.onic treatment with.JWh.15 enh.nced alcoh.l consumption in stressed but not in control mice. CB2 cannabinoid receptors are involved with.th. effects of alcoh.l along with.epigenet ic factors, such.as stressors, and may be targeted with.CB2 ligands in alcoh.lism.

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Biomedical Engineering Approach.to Evaluate Anastomosis Meth.ds for Coronary Artery Bypass Grafting

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上海大学学报（自然科学版） 2004年第B10期10卷 25-28页

Th.re are two different meth.ds for coronary artery bypass grafting: end-to-side and side-to-side anastomosis. In vitro mock test, flow visualization and animal experiments were performed in parallel to compare th. h.modynamic effect between two meth.ds. Th.s, bioengineers can provide practical useful information to th. clinical team.

关键词：生物医学工程接合方法冠状动脉分流嫁接法面对面接合冠心病

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In Vitro h.drodynamic Test and In Vitro h.molysis Test for Development of Inexpensive Spiral Vortex Ventricular Assisting System Using IABP Console

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上海大学学报（自然科学版） 2004年第B10期10卷 32-36页

作者： Y.Oh.ish. K.iwasaki h.Mizuta T.Sudo S.Muto T.Sh.ma T.Tanaka K.Ito M.Umezu IntegrativeBioscienceandBiomedicalEngineeringGraduateSch.olofWasedaUniversity TokyoJapan Yasuh.saBiomech.nicsInc. TokyoJapan

Th. purpose of th.s research.is to develop an inexpensive pulsatile blood pump system for sh.rt-term use, as a combination of th. usage of IABP console and spiral vortex pump. In vitro h.drodynamic test and in vitro h...

关键词：水力测试血泵系统螺旋涡流泵溶血测试

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自磨和球磨对硫化矿浮选的影响

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国外金属矿选矿 1985年第4期 36-44页

作者： I.iwasaki K.J.Reid h.A.Lex K.A.Smith.吴建明

探讨自磨和常规磨矿方法对德卢斯辉长岩铜-镍硫化矿浮选性能的影响。在同样的磨矿粒度下,用自磨矿浆进行浮选,铜、镍和钻的回收率较高而尾矿中残存的硫较少。用球磨矿浆进行浮选,即使增加捕收剂加入量,尾矿中残存的硫也不会低于自磨所... 详细信息

探讨自磨和常规磨矿方法对德卢斯辉长岩铜-镍硫化矿浮选性能的影响。在同样的磨矿粒度下,用自磨矿浆进行浮选,铜、镍和钻的回收率较高而尾矿中残存的硫较少。用球磨矿浆进行浮选,即使增加捕收剂加入量,尾矿中残存的硫也不会低于自磨所达到的水平。根据精矿和尾矿矿样的矿物学研究可以队为,在这两种磨机中,磨矿介质和硫化矿物之间的电化学作用对硫化矿浮选过程的影响,大于对矿样的破碎特性的影响。

关键词：自磨回收率磨矿硫化矿球磨磨机

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Biomedical Engineering Approach.to Evaluate Anastomosis Meth.ds for Coronary Artery Bypass Grafting

Biomedical Engineering Approach to Evaluate Anastomosis Meth...

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2004年生命系统建模仿真国际会议暨第一届全国生命系统建模仿真学术会议

作者： M.Umezu J.Kawai J.Sueh.ro M.Arita Y.Sh.raish. K.iwasaki T.Tanaka h.Niinami Integrative Bioscience and Biomedical Engineering Graduate Sch.ol of Waseda University Tokyo Japan Integrative Bioscience and Biomedical Engineering Graduate Sch.ol of Waseda University Tokyo Japan Yasuhisa Biomechanics Inc. Tokyo Japan Dept. of Cardiovascular Surgery Juntendo Medical University Tokyo Japan

关键词： coronary artery bypass grafting coronary simulator side-to-side anastomosis flow visualization

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Russell body gastritis with.Dutch.r bodies evaluated using magnification endoscopy

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 417-424页

作者： Kenji Yorita Takeh.ro iwasaki Kunih.sa Uch.ta Naoto Kuroda Koji Kojima Sh.nich. Iwamura Yutaka Tsutsumi Akinobu Oh.o h.roaki Kataoka Department of Diagnostic Path.logy Japanese Red Cross Kochi Hospital Department of Internal Medicine Japanese Red Cross Kochi Hospital Department of Path.logy Fujita Health University School of Medicine Path.logy Section University of Miyazaki Hospital Section of Oncopath.logy and Regenerative Biology Department of PathologyFaculty of MedicineUniversity of Miyazaki

Russell body gastritis(RBG) is an unusual type of ch.onic gastritis ch.racterized by marked infiltration of Mott cells,wh.ch.are plasma cells filled with.sph.rical eosinoph.lic bodies referred to as Russell *** was initially th.ugh. th.t h.licobacter pylori(***) infection was a major cause of RBG and th.t th. infiltrating Mott cells were polyph.notypic;h.wever,a number of cases of RBG with.ut *** infection or with.monoclonal Mott cells h.ve been ***,diagnostic difficulty exists in distinguish.ng RBG with.monoclonal Mott cells from malignant ***,we report an unusual case of an 86-year-old-Japanese man with.***-positive *** th. examination of melena,endoscopic evaluation confirmed a 13-mm wh.tish.flat lesion in th. gastric *** endoscopy with.narrowband imaging suggested th.t th. lesion was most likely a poorly differentiated *** findings were consistent with.ch.onic gastritis with.many Mott cells with.intranuclear inclusions referred to as Dutch.r *** submucosal dissection confirmed th. diagnosis of RBG with.kappa-restricted monoclonal Mott *** lymph.ma was unlikely given th. paucity of cytological atypia and Ki-67 immunoreactivity of monoclonal Mott *** is th. first reported case of RBG with.endoscopic diagnosis of malignant tumor and th. presence of Dutch.r bodies.

关键词： Russell body gastritis Mott cell Dutch.r body Mucosa-associated lymph.id tissue lymph.ma Plasmacytoma Magnification endoscopy with.narrow-band imaging

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