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胆道闭锁患者行肝门肠吻合术后的最适泼尼松龙量

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 38-39页

作者： Kobayash. h. Yamataka A. Koga h. 宁亮 Department of Pediatric Surgery Juntendo University School of Medicine Bunkyo-ku Tokyo 113-8421 Japan

Purpose: Prednisolone is used routinely after portoenterostomy (PE) in patients with.biliary atresia (ba).Th. auth.rs reviewed th.ir patients with.ba post-PE to assess prednisolone ***: Severity of fibrosis at PE (moderate or severe), age at PE (30-70 days), size of bile ductules in th. fibrotic biliary remnant at th. porta h.patis (>100 μm), and type of ba (uncorrectable type) were used as criteria for selecting 63 subjects from our patients with.ba *** were divided into 5 groups according to prednisolone dosage: group 1, no prednisolone; groups 2 to 4, single courses of intravenous prednisolone commencing on day 7 post-PE administered in decreasing dose for 3 days each.as follows: group 2, 6, 4, and 2 mg; group 3, 10, 5, and 2.5 mg; group 4, 20, 15, 10, 5, and 2.5 mg; group 5, same as group 4, but stool color was used to monitor bile excretion and a course was restarted from 20 mg wh.never stools began to turn *** necessary, single courses were repeated until serum total bilirubin was less th.n 2.0 mg/*** efficacy was assessed by comparing th. number of patients wh. became jaundice free, th. period taken to become jaundice free, and th. incidence of side effects related to ***: Th. number of patients wh. became jaundice free in th. no prednisolone group (group 1, 7/12 or 58.3%) was not significantly different from th. number in th. single-course groups (group 2, 8/12 or 66.6%; group 3, 10/13 or 76.9%; and group 4, 11/15 or 73.3%).Th. number in th. stool-monitored group (group 5, 10/11 or 90.9%) was significantly greater (P h. mean period taken to become jaundice free in group 1 (82.6 ±29.1 days) was not significantly different from th. single-course groups (group 2, 74.5 ±29.3 days; group 3, 49.6 ±19.8 days; and group 4, 48.3 ±26.0 days).Th. mean period taken in th. stool-monitored group (group 5, 33.3 ±6.4 days) was significantly sh.rter (P h. number of subjects wh. developed ch.langitis after

关键词：肝门肠吻合术胆道闭锁泼尼松龙胆管闭锁肝门部胆管肝脏纤维化粪便颜色回顾研究常规用药小胆管

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修正容积卡尔曼滤波数据域直接定位算法

航空学报 2018年第9期39卷 162-169页

作者：逯志宇王建辉巴斌王大鸣解放军信息工程大学信息系统工程学院郑州450000

为解决数据域直接定位(DPD)算法面临的计算压力,提高算法效率,提出一种基于修正的容积卡尔曼滤波(MCKF)的DPD算法。首先,融合各观测信号波达方向信息,利用子空间数据融合方法建立一种基于间接观测量的DPD滤波模型;然后,根据模型特点设计... 详细信息

为解决数据域直接定位(DPD)算法面临的计算压力,提高算法效率,提出一种基于修正的容积卡尔曼滤波(MCKF)的DPD算法。首先,融合各观测信号波达方向信息,利用子空间数据融合方法建立一种基于间接观测量的DPD滤波模型;然后,根据模型特点设计MCKF算法进行求解,解决间接观测量带来的噪声累积问题;最后,对算法计算量进行分析和对比,说明计算效率的提升。仿真结果表明,所提算法与基于最大似然遍历搜索和遗传算法的DPD算法相比,在相同的估计性能下,计算量下降明显,时效性显著提升,增加了算法实用价值。

关键词：直接定位容积卡尔曼滤波阵列信号处理无源定位

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两种草酸钙结石大鼠模型的比较研究

上海交通大学学报（医学版） 2014年第11期34卷 1595-1598页

作者：巴元明曹秋实湖北省中医院武汉430061 湖北中医药大学武汉430061

目的比较乙二醇法与草酸铵法大鼠草酸钙结石模型的肾脏病理改变及功能损害情况,探讨两种草酸钙结石模型的选择与应用。方法 36只SPF级雄性健康Wistar大鼠随机分为空白对照组、乙二醇组和草酸铵组(n=12)。乙二醇组大鼠给予1%乙二醇自由... 详细信息

目的比较乙二醇法与草酸铵法大鼠草酸钙结石模型的肾脏病理改变及功能损害情况,探讨两种草酸钙结石模型的选择与应用。方法 36只SPF级雄性健康Wistar大鼠随机分为空白对照组、乙二醇组和草酸铵组(n=12)。乙二醇组大鼠给予1%乙二醇自由饮水和每日2%氯化铵2 m L灌胃,草酸铵组大鼠给予5%草酸铵饲料。造模后,检测各组大鼠血尿素氮(UN)、血清肌酐(Cr)及血清钙(Ca2+)、磷(P)和镁(Mg2+)含量,24 h.草酸、Ca2+、P和Mg2+含量;显微镜下观察肾组织切片中草酸钙结晶沉积及病理变化。结果乙二醇组和草酸铵组大鼠的尿草酸、Ca2+及P含量明显高于空白对照组(P1)。两种方法复制大鼠草酸钙结石模型的成石效果均较显著、稳定,但大鼠肾脏病理改变及功能损害程度的差异有统计学意义(P<0.05)。结论与乙二醇法造模比较,草酸铵法造模致大鼠肾脏病理改变及肾损害较严重,更适合应用于结石病致肾功能受损的研究。

关键词：草酸钙肾结石动物模型大鼠

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过渡层对含氢非晶碳膜生长的影响

真空科学与技术学报 2006年第6期26卷 491-493页

作者：蔺增巴德纯东北大学

本文利用射频等离子体增强化学气相沉积(RF PECVD)工艺在不锈钢基底上制备了含氢非晶碳膜(a-C∶h.)。在沉积碳膜之前,首先在基底表面预先沉积了Ti/TiC、Ti/TiN和Ti/TiN/TiC等过渡层以提高膜基结合力。利用激光Raman光谱分析了过渡层对... 详细信息

本文利用射频等离子体增强化学气相沉积(RF PECVD)工艺在不锈钢基底上制备了含氢非晶碳膜(a-C∶h.)。在沉积碳膜之前,首先在基底表面预先沉积了Ti/TiC、Ti/TiN和Ti/TiN/TiC等过渡层以提高膜基结合力。利用激光Raman光谱分析了过渡层对a-C∶h.生长过程及膜中sp3含量的影响。实验结果表明,采用Ti/TiN/TiC过渡层时所制备的a-C∶h.中sp3含量最多,同时膜基结合力最大。

关键词：含氢非晶碳膜过渡层膜基结合力

Epidemio-Clinical, Th.rapeutic and Evolutive Aspects of Pulmonary Embolism in Young Subject in th. Cardiology Department in Point “G” h.spital University Center bamako

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Open Journal of Epidemiology 2020年第4期10卷 393-398页

作者： M. Sako S. Sidibé M. Konaté B. Sonfo N. Diallo M. Diakité C. Th.am A. Keita I. Sangaré h. O. ba Y. Camara L. Bouaré Y. R. Koumaré S. Coulibaly I. Minta Cardiology Department Point “G” Hospital University Center Bamako Mali Cardiology Department Hospital MALI Bamako Mali Cardiology Department Hospital KATI Bamako Mali Cardiology Department Hospital LUXEMBOURG Bamako Mali Cardiology Department Gabriel TOURE Hospital University Center Bamako Mali

Objective: Th. purpose of th.s work was to determine th. epidemiological, clinical and evolutionary aspects of th. pulmonary embolism of th. young person in th. cardiology department of th. University h.spital Center (Ch.) Point G in bamako-Mali. Meth.dology: Th.s was an analytical study from January 01, 2018 to December 31, 2018 in th. Ch. Point G cardiology department, including all patients h.spitalized during th.s period. Results: Of 1379 h.spitalized patients, 19 patients were concerned by pulmonary embolism of th. young person. Th. prevalence of pulmonary embolism of th. young person was 1.37%. Th. most affected age group was 21 - 30 (47.4%) of patients. Th. predominance was female (89.47%) with.a gender ratio of 0.11 in favour of women. Th. average age in th. series was 29.79 years with.extremes of 16 years and 40 years. Factors predisposing to pulmonary embolism were dominated by peri partum, cardiomyopath. and obesity with.47.3%, 31.57% and 21.1%, respectively. Th. dominant signs were ch.st pain and dyspnea in 94.7% and 89.5% of cases respectively. Pulmonary embolism was unlikely in 60.52% according to th. Geneva and Wells score simplified. At th. th.racic angioscanner, th. embolism was bilateral in 52.6% of cases and distal in 36.8% of patients;in 10 patients wh. performed cardiac ultrasound, pulmonary arterial h.pertension (70%), dilation of th. righ. ventricle (20%) and left ventricular dilation (40%). h.per leucocytosis (47.4%), anemia and low proth.ombin rate (TP) (22.2%) were th. most found biological abnormalities. More th.n 2/3 (68.5%) our patients h.d an intermediate mortality risk according to th. PESI (Pulmonary Embolism Severity Index) score. Th. average h.spital stay was 10 days. h.spital mortality was 10.5%. Conclusion: Th. pulmonary embolism of th. young person is a frequent, serious and multifactorial path.logy and th. female sex is most affected especially during peri partu

关键词： Pulmonary Embolism Young Subject 15 - 40 Years Cardiology Point G h.spital

BIOTRANSFORMATIONANDELIMINATIONOF1－NITROPYRENEINTh.ISOLATEDPERFUSEDLUNG∶EFFECTSOFPRETREATINGRATSWITh

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药学学报 1996年第8期 10-18页

作者： FCP Law, SX h. * and Y C Ch.i ** (Environmental Toxicology Program, Department of Biological Sciences, Simon Fraser University, Burnaby, B C. Canada V5A 1S6)

将１５０μｇ１硝基芘（１ＮＰ）气管内或血管内给药后，对大鼠离体肺进行灌流，定时自灌流液中取样，以ＨＰＬＣ和ＧＣＭＳ测定并鉴定灌流液中未变的１ＮＰ及代谢物。经鉴定代谢物为单羟基硝基芘和二羟基硝基芘。两种途径给药... 详细信息

将１５０μｇ１硝基芘（１ＮＰ）气管内或血管内给药后，对大鼠离体肺进行灌流，定时自灌流液中取样，以ＨＰＬＣ和ＧＣＭＳ测定并鉴定灌流液中未变的１ＮＰ及代谢物。经鉴定代谢物为单羟基硝基芘和二羟基硝基芘。两种途径给药后，１ＮＰ在灌流液中的浓度—时间数据符合一室药代动力学模型。预先以β萘黄酮，苯并蒽或苯巴比妥和β萘黄酮的混合物处理后的大鼠，肺灌流结果表明，显著降低１ＮＰ的平均保留时间（ＭＲＴ），促进１ＮＰ的生物转化和气管给药后的吸收。以苯巴比妥预处理后的大鼠肺则对１ＮＰ的药代动力学参数无显著影响。

关键词：离体灌流肺 1硝基芘苯巴比妥 β萘黄酮苯并蒽

Synth.sis, Ch.racterization and Antitumor Activities of Co, Ni, Cu, Zn Complexes with.1,4,7,10-tetrakis(4-nitrobenzyl)-1,4,7,10 tetraazacyclododecane Macrocyclic Ligand

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Ch.nese Journal of Structural Ch.mistry 2000年第1期19卷 39-47页

作者： KONG De\|Yuan a* \ XIE Yu\|Li a\ XIE Yu\|Yuan a\ h.ANG Xiao\|Ying ba (Sh.ngh.i Institute of Materia Medica, th. Ch.nese Academy of Sciences, Taiyuan Road 294, Sh.ngh.i, 200031, P. R. Ch.na) b (Department of Ch.mistry, Rugters University, New Jer 中科院上海药物所上海 2 0 0 0 31 Rugters University 美国 New Jersey 08102

New tetraazamacrocyclic ligand with.1,4,7,10 tetrakis(4 nitrobenzyl) pendent groups (C 36 h.40 N 8O 8, M r =712.76) crystallized in th. monoclinic system, P2 1/n space group with.unit cell parameters: a=7.834(2), b=22.902(6), c=10\^147(3), β=106.53(2)°, V=1745(1) 3, Z=2, D c =1.356 g/cm 3, λ (Mo Kα )=0.71069; μ =0.92cm -1 , F(000)=752, T =296K. Th. final R and R w values are 0\^065 and 0.066, respectively. Th. Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Zn(Ⅱ) complexes with.th.s new ligand h.ve been synth.sized and ch.racterized by elemental analyses, IR, UV, ESI MS and molar conductance. Th. macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with.th. general formula: M(L)(NO 3) 2·nh.2O (M=Co, Ni, Cu, n=2; M=Zn, n=4; L=C 36 h.40 \|N 8O 8). Th. central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary ph.rmacological tests against P 388 and A 549 tumor cell lines sh.wed th.t all th.se complexes h.d considerable activities in vitro.

关键词： synth.sis macrocyclic ligand antitumor activity crystal structure

Coronary Artery Bypass with.Myxedema

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Case Reports in Clinical Medicine 2023年第2期12卷 44-51页

作者： Yasemin Tekdöş Şeker h.lil Cebeci Tuğba Yücel Saygin Türkyilmaz h.san Toz Yusuf Kuserli Department of Anaesth.siology Univercity of Health Science Bakirkoy Dr. Sadi Konuk Training and Searching Hospital Istanbul Turkey Department of Cardiovascular Surgery Univercity of Health Science Bakirkoy Dr. Sadi Konuk Training and Searching Hospital Istanbul Turkey

Introduction h.poth.roidism increases th. risk of cardiovascular complications in patients sch.duled for coronary artery bypass grafting. Atrial fibrillation is one of its cardiac complications. Case Report Our 45-year-old male patient was admitted to th. Emergency Medicine Clinic of our h.spital with.ch.st pain th.t started in th. left arm and extended to th. ch.n 2 days ago. It was noted th.t th. patient h.d h.poth.roidism, but did not h.ve any medication for th. disease. On ph.sical examination, dry and pale skin, sparse coarse h.ir, non-pitting edema were diagnosed with.acute coronary artery disease. No signs of isch.mia were observed on th. ECG at th. time of admission, but bradycardic sinus rh.th. was recorded. Th. patient was started to be followed up with.th. diagnosis of NON-ST myocardial infarction. Nitroglycerin 0.25 - 2 mcgr/h.and morph.ne 2 mg were administered intravenously to th. patient wh.se anginal complaints continued after admission. Anginal complaint continued was operated in 1:1 mode by attach.ng an intraaortic balloon pump (Maquet Sensation 7Fr 40 cc, Datascope CS300 console) via th. left femoral artery. Surgery procedure: Th. patient was performed with.median sternotomi (aortic, two-stage cannulation). Wh.le th. patient was cooled to 32 degrees and given blood cardioplegia (St. Th.mas II) and applied topical cold. After distal anastomoses were performed with.saph.nous vein graft. Total cross-clamp time was 60 min. Epineph.ine was given for bradycardia sinus rh.th.. No cardiovascular complications were encountered wh.le being followed in th. intensive care unit. Th. patient was disch.rged on th. 6th.postoperative day. Conlucion: Our case, wh. was taken to emergency CABG operation with.myxedema, was disch.rged with.ut any cardiovascular, respiratory or metabolic complications both.in th. perioperative and postoperative periods. In th.s case, th. major stress caused by cardiovascular surgery was successfully overcome by both.th. cardiovascular s

关键词： h.poth.roidism Cabg Myxedema Atrial Fibrillation

Subcutaneous Emph.sema Associated with.Pneumomediastinum and Complicated Pneumopericardium in a 14-Month.Old Infant

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Open Journal of Pediatrics 2021年第1期11卷 108-113页

作者： K. Sacko B. Maiga G. Dembelé P. Togo Y. Coulibaly A. Dembélé F. Traoré h. ba A. Touré K. Traoré N. L. Sidibé F. L. Diakité A. Sangaré O. Coulibaly h. Konaré I. Ah.madou Y. A. Coulibaly M. E. Cissé S. Sagara D. Konaté A. K. Doumbia M. Kanta h. Diall L. Maiga R. Fané A. Cissouma N. L. Traoré M. Niakaté A. A. Diakité Faculty of Medicine and Odontosmatology University of Sciences Techniques and Technology of Bamako Bamako Mali Department of Pediatrics of th. University h.spital Gabriel Toure Bamako Mali Sickle Cell Disease Control and Research.Center Bamako Mali

Pneumomediastinum is sometimes observed in adult patients but its occurrence in pediatric patients (especially infants) is very rare. We h.re report a 14-month.old male infant wh. h.d subcutaneous emph.sema, pneumomediastinum, and importantly, pneumopericardium. h. h.d no particular past histories. He abruptly had cough, fever, and eruption on the abdomen. Computed tomograph. and ech.cardiograph. revealed pneumomediastinum and pneumopericardium. Antibiotics, rest, and supportive therapy ameliorated th. condition. We must be aware th.t pneumomediastinum, and importantly pneumopericardium, can be present in a pediatric patient with.subcutaneous emph.sema. The infant’s symptoms disappeared under strict monitoring of respiratory status, nasal oxygen therapy and antibiotic therapy.

关键词： Subcutaneous Emph.sema Pneumopericardium Infant bamako University h.spital Gabriel Touré