Synthesis, Characterization and Antitumor Activities of Co, Ni, Cu, Zn Complexes with 1,4,7,10-tetrakis(4-nitrobenzyl)-1,4,7,10 tetraazacyclododecane Macrocyclic Ligand

作     者：KONG De\|Yuan a* \ XIE Yu\|Li a\ XIE Yu\|Yuan a\ HUANG Xiao\|Ying ba (Shanghai Institute of Materia Medica, the Chinese Academy of Sciences, Taiyuan Road 294, Shanghai, 200031, P. R. China) b (Department of Chemistry, Rugters University, New Jer 

作者机构：中科院上海药物所 上海 2 0 0 0 31 Rugters University 美国 New Jersey 08102 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学(英文版))

年 卷 期：2000年第19卷第1期

页      面：39-47页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

主　　题：synthesis macrocyclic ligand antitumor activity crystal structure 

摘      要：New tetraazamacrocyclic ligand with 1,4,7,10 tetrakis(4 nitrobenzyl) pendent groups (C 36 H 40 N 8O 8, M r =712.76) crystallized in the monoclinic system, P2 1/n space group with unit cell parameters: a=7.834(2), b=22.902(6), c=10\^147(3), β=106.53(2)°, V=1745(1) 3, Z=2, D c =1.356 g/cm 3, λ (Mo Kα )=0.71069; μ =0.92cm -1 , F(000)=752, T =296K. The final R and R w values are 0\^065 and 0.066, respectively. The Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Zn(Ⅱ) complexes with this new ligand have been synthesized and characterized by elemental analyses, IR, UV, ESI MS and molar conductance. The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with the general formula: M(L)(NO 3) 2·nH 2O (M=Co, Ni, Cu, n=2; M=Zn, n=4; L=C 36 H 40 \|N 8O 8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacological tests against P 388 and A 549 tumor cell lines showed that all these complexes had considerable activities in vitro.