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Big Data Bot with.a Special Reference to Bioinformatics

Computers, Materials & Continua 2023年第5期75卷 4155-4173页

作者： Ah.ad M.Al-Omari Sh.fa M.Tawalbeh.Yazan h.Akkam Moh.mmad Al-Tawalbeh.Sh.ma’a Younis Abdullah.A.Mustafa Jonath.n arnold Biomedical Systems and Informatics Engineering Department Yarmouk UniversityIrbid21163Jordan Department of Medicinal Ch.mistry and Ph.rmacognosy Yarmouk UniversityIrbid21163Jordan Department of Electrical Computer and Software EngineeringUniversity of Ontario Institute of TechnologyOshawaL1H7K4Canada Department of Mech.nical Engineering University of MosulMosul41001Iraq Genetics Department University of GeorgiaAthens30602GAUSA

Th.re are quintillions of data on deoxyribonucleic acid(DNA)and protein in publicly accessible data banks,and th.t number is expanding at an exponential *** scientific fields,such.as bioinformatics and drug discovery,rely on such.data;neverth.less,gath.ring and extracting data from th.se resources is a tough.*** data sh.uld go th.ough.several processes,including mining,data processing,analysis,and *** study proposes software th.t extracts data from big data repositories automatically and with.th. particular ability to repeat data extraction ph.ses as many times as needed with.ut h.man *** software simulates th. extraction of data from web-based(point-and-click)resources or graph.cal user interfaces th.t cannot be accessed using command-line *** software was evaluated by creating a novel database of 34 parameters for 1360 ph.sicoch.mical properties of antimicrobial peptides(AMP)sequences(46240 h.ts)from various MARVIN software panels,wh.ch.can be later utilized to develop novel ***,for mach.ne learning research.th. program was validated by extracting 10,000 protein tertiary structures from th. Protein Data *** a result,data collection from th. web will become faster and less expensive,with.no need for manual data *** software is critical as a first step to preparing large datasets for subsequent stages of analysis,such.as th.se using mach.ne and deep-learning applications.

关键词： Bioinformatics big data data extraction bot drug design

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Towards seamless environmental prediction-development of Pan-Eurasian EXperiment(PEEX)modelling platform

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Big Earth.Data 2024年第2期8卷 189-230页

作者： Alexander Mah.ra Alexander Baklanov Risto Makkonen Mich.el Boy Tuukka Petäjä h.nna KLappalainen Roman Nuterman Veli-Matti Kerminen Steph.n R.arnold Markus Joch.m Anatoly Sh.idenko Igor Esau Mikh.il Sofiev Andreas Stoh. Tuula Aalto Jianh.i Bai Ch.ch. Ch.n Yafang Ch.ng Oxana Drofa Mei h.ang Leena Järvi h.rri Kokkola Rostislav Kouznetsov Tingting Li Piero Malguzzi Sarah.Monks Mads Bruun Poulsen Steffen M.Noe Yuliia Palamarch.k Benjamin Foreback Petri Clusiu Till Andreas Soya Rasmussen Jun Sh. Jens h.vskov Sørensen Dominick Spracklen h.ng Su Juh. Tonttila Siwen Wang Jiandong Wang Tobias Wolf-Grosse Yongqiang Yu Qing Zh.ng Wei Zh.ng Wen Zh.ng Xunh.a Zh.ng Siqi Li Yong Li Putian Zh.u Markku Kulmala Faculty of Science Institute for Atmospheric and Earth System Research(INAR)/PhysicsUniversity of Helsinki(UHEL)HelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Boh. Institute University of CopenhagenCopenhagenDenmark Climate System Research Finnish Meteorological Institute(CSR-FMI)HelsinkiFinland Sch.ol of Engineering Sciences Lappeenranta University of TechnologyLappeenrantaFinland Institute for Climate and Atmosph.ric Science School of Earth and EnvironmentUniversity of LeedsLeedsUK Biodiversity and Natural Resources Program International Institute for Applied Systems Analysis(IIASA)LaxenburgAustria Department of Ph.sics and Tech.ology UiT-The Arctic University of NorwayTromsoNorway Nansen Environmental and Remote Sensing Center(NERSC) BergenNorway Atmosph.ric Composition Finnish Meteorological Institute(AC-FMI)HelsinkiFinland Norwegian Institute for Air Research.NILU) KjellerNorway LAGEO Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP-CAS)BeijingChina Max Planck Institute for Ch.mistry(MPI-Ch.m) MainzGermany Institute of Atmosph.ric Sciences and Climate National Research Council of Italy(CNR-15SAC)BolognaItaly Institute of Geograph.c Sciences and Natural Resources Research.IGSNRR) Chinese Academy of Sciences(CAS)BeijingChina Faculty of Science Helsinki Institute of Sustainability Science(HELSUS)University of Helsinki(UHEL)HelsinkiFinland Atmosph.ric Research.Centre of Eastern Finland Finnish Meteorological Institute(ARCEF-FMI)KuopioFinland Institute of Atmosph.ric Ph.sics Chinese Academy of Sciences(IAP-CAS)BeijingChina Department of Plant Ph.siology Estonian University of Life Sciences(EULS)Institute of Agricultural and Environmental Sciences(IAES)TartuEstonia Danish.Meteorological Institute(DMI) CopenhagenDenmark State Key Laboratory of Atmosph.ric Boundary Layer Ph.sics and Atmosph.ric Ch.mistry LAPC) Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)BeijingChina Uni

Th. Pan-Eurasian Experiment Modelling Platform(PEEX-MP)is one of th. key blocks of th. PEEX Research.*** PEEX MP h.s more th.n 30 models and is directed towards seamless envir-onmental *** main focus area is th. Arctic-boreal regions and *** models used in PEEX-MP cover several main components of th. Earth.s system,such.as th. atmosph.re,h.drosph.re,pedosph.re and biosph.re,and resolve th. ph.sicalch.micalbiological processes at different spatial and temporal scales and *** paper introduces and discusses PEEX MP multi-scale modelling concept for th. Earth.system,online integrated,forward/inverse,and socioeconomical modelling,and oth.r approach.s with.a particular focus on applications in th. PEEX geograph.cal *** employed h.gh.performance com-puting facilities,capabilities,and PEEX dataflow for modelling results are *** virtual research.platforms(PEEXView,Virtual Research.Environment,Web-based Atlas)for h.ndling PEEX modelling and observational results are *** over-all approach.allows us to understand better ph.sical-ch.micalbiological processes,Earth.s system interactions and feedbacks and to provide valuable information for assessment studies on evaluating risks,impact,consequences,*** population,envir-onment and climate in th. PEEX *** work was also one of th. last projects of *** Zilitinkevich.wh. passed away on 15 February *** th. finalization took time,th. paper was actually submitted in 2023 and we could not argue th.t th. final paper text was agreed with.h.m.

关键词： Multi-scale and-processes modelling concept seamless coupling h.gh.performance computing data infrastructure virtual research.platforms

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多用热象仪

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红外技术 1984年第4期 41-45页

作者： David h. arnold 柳圭如索恩·伊美电子有限公司

热成象技术在现代战场上的应用,使在烟雾、黑夜和能见度差的情况下执行各种任务的能力有了新的增强。在过去十年中,设计和制做了许多实验性的热成象装置,热象仪在许多方面逐渐得到应用,因而热成象技术的潜在应用得到了开发。特别是英国... 详细信息

热成象技术在现代战场上的应用,使在烟雾、黑夜和能见度差的情况下执行各种任务的能力有了新的增强。在过去十年中,设计和制做了许多实验性的热成象装置,热象仪在许多方面逐渐得到应用,因而热成象技术的潜在应用得到了开发。特别是英国军队,已完全认识到了热成象技术的潜力,并实现了在多方面的观察应用之间尽可能地引进通用性的要求,以便最大限度地降低热象仪在寿命期的费用。

关键词：热象仪多用直接观察英国车辆大不列颠及北爱尔兰联合王国热成象技术组件化转换器变换器间接观察视场

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Gastrointestinal function testing model using a new laryngoph.ryngeal ph.probe(Restech.in patients after Ivor-Lewis esoph.gectomy

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 612-624页

作者： Benjamin Babic Dolores T Müller Florian Gebauer Lars Mortimer Sch.ffmann Rabi R Datta WolfgangSch.öder Ch.istiane J bruns Jessica M Leers h.ns F Fuch. Department of General VisceralCancer and Transplant SurgeryUniversity of CologneCologne 50931Germany

BACKGROUND Th.re is no establish.d correlation between 24-h.esoph.geal ph.metry(Eso-ph.and th. new laryngoph.ryngeal ph.monitoring system(Restech.as only small case series ***-ph.was not designed to detect laryngoph.ryngeal reflux(LPR)and Restech.may detect LPR *** h.ve previously publish.d a dataset using th. two tech.iques in a large patient collective with.gastroesoph.geal reflux ***,patients after esoph.gectomy were reported to represent an ideal h.man reflux model as no reflux barrier *** To use a h.man reflux model to examine our previously publish.d correlation in th.se *** Patients after Ivor Lewis esoph.gectomy underwent our routine follow-up program with.surveillance endoscopies,computed tomograph. scans and furth.r exams following *** patients with.a complete ch.ck-up program and reflux symptoms were offered inclusion into th.s prospective study and evaluated using Restech.and simultaneous ***,th. relationsh.p between th. two tech.iques was evaluated RESULTS A total of 43 patients from May 2016-November 2018 were *** patients presented with.mainly typical reflux symptoms such.as h.artburn(74%),regurgitation(84%),ch.st pain(58%),and dysph.gia(47%).Extraesoph.geal symptoms such.as cough.h.arseness,asth.a symptoms,and globus sensation were also *** 24-h.ur ph.metry was abnormal in 88%of patients with.a mean DeMeester Score of 229.45[range 26.4-319.5].Restech.evaluation was abnormal in 61%of cases in th.s h.gh.y selective patient *** patients with.abnormal supine LPR were also abnormal for supine esoph.geal reflux measured by conventional *** Patients following esoph.gectomy and reconstruction with.gastric interposition can ideally serve as a h.man reflux ***,laryngoph.ryngeal reflux ph.ses occur mainly in th. uprigh. *** th.s h.man volume-reflux model,results of simultaneous esoph.geal and laryngoph.ryngeal(Restech.ph

关键词： Gastroesoph.geal reflux disease Laryngoph.ryngeal reflux Minimally invasive esoph.gectomy Surgical tech.ology Restech Esoph.geal ph.metry

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1-甲基环丙烯采后处理对樱桃番茄果实成熟过程的影响(英文)

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植物生理与分子生物学学报 2005年第1期31卷 27-33页

作者： arnold M.Opiyo 应铁进浙江大学食品科学与营养系杭州310029

研究了不同浓度(0、0.035、0.07和0.11 μL/L)的乙烯受体竞争性抑制剂1-甲基环丙烯(1- MCP)采后处理对绿熟期樱桃番茄的乙烯合成、果实软化、果实色素(叶绿素、茄红素、β-胡萝卜素)含量消长的影响。0.07 μL/L及其以上浓度的1- MCP... 详细信息

研究了不同浓度(0、0.035、0.07和0.11 μL/L)的乙烯受体竞争性抑制剂1-甲基环丙烯(1- MCP)采后处理对绿熟期樱桃番茄的乙烯合成、果实软化、果实色素(叶绿素、茄红素、β-胡萝卜素)含量消长的影响。0.07 μL/L及其以上浓度的1- MCP降低了前期乙烯合成,同时推迟了乙烯释放高峰,但0.035μL/L浓度的1-MCP处理并不能抑制内源乙烯合成。1-MCP显著延迟了果实软化和叶绿素降解,但并不影响这两个过程的启动。茄红素合成的启动和积累均受到了1-MCP抑制,而 1-MCP并不推迟β-胡萝卜素合成的启动,只抑制其积累。这些结果提示了乙烯调节成熟生理过程的不同机制。对于绿熟期的樱桃番茄,0.07-0.11 μL／L的1-MCP是实用的有效处理浓度。1-MCP有效浓度可能用于了解果实的乙烯受体水平和乙烯敏感性。

关键词：樱桃番茄成熟 1-MCP

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0.5μm光刻采用大数值孔径i线步进机

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电子工业专用设备 1997年第3期 43-51页

作者：ＷＨＡｒｎｏｌｄ

采用几种实用ｉ线抗蚀剂，０４８ＮＡｉ线５×镜头具有０５μｍ线间对成像能力，焦深大于１μｍ。这种镜头与０４０ＮＡ的ｉ线镜头对比，０４０ＮＡ的ｉ线镜头对于≥０７μｍ的线间对图形具有较好的焦深，而０４８ＮＡｉ线... 详细信息

采用几种实用ｉ线抗蚀剂，０４８ＮＡｉ线５×镜头具有０５μｍ线间对成像能力，焦深大于１μｍ。这种镜头与０４０ＮＡ的ｉ线镜头对比，０４０ＮＡ的ｉ线镜头对于≥０７μｍ的线间对图形具有较好的焦深，而０４８ＮＡｉ线镜头对于＜０７μｍ的线间对图形具有较好的焦深，并且可将截止分辨率延伸到０３５μｍ。并探讨了这种镜头吸热效应的相对不灵敏性和这种镜头内Ｈｅ气体的过压作用。假设模拟制作０５μｍ线间对图形的最佳数值孔径在０５～０５５之间，进而提出对０４μｍ线间对图形具有足够焦深，使得ｉ线光刻成为ＤＵＶ光刻技术生产６４ＭＤＲＡＭ器件时代的竞争者。

关键词：焦深曝光范围镜头数值孔径边墙角光刻技术抗蚀剂线步

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Specific interaction of h.patitis C virus glycoproteins with.mannan binding lectin inh.bits virus entry

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Protein & Cell 2010年第7期1卷 664-674页

作者： Kristelle S.Brown Mich.el J.Keogh.Ania M.Owsianka Rich.rd Adair Arvind h.Patel James N.arnold Jonath.n K.Ball Robert B.Sim Alexander W.Tarr Timoth. P.h.ckling Institute of Infection Immunity and InflammationSchool of Molecular Medical SciencesThe University of NottinghamQueen’s Medical CentreNottinghamNG72UHUK Th. Medical Research.Council-University of Glasgow Centre for Virus Research University of GlasgowChurch StreetGlasgowG115JRUK MRC Immunoch.mistry Unit Department of BiochemistryUniversity of OxfordOX13QUUK Present address:Vitrology Biotech 5 South AvenueClydebank Business ParkGlasgowG812LGUK Present address:Pfizer Tech.ologies Ltd. Ramsgate RoadSandwichKentCT139NJUK

Mannan-binding lectin(MBL)is a soluble innate immune protein th.t binds to glycosylated *** acts as an opsonin and activates complement,contributing to th. destruction and clearance of infecting *** C virus(h.V)encodes two envelope glycoproteins E1 and E2,expressed as non-covalent E1/E2 h.terodimers in th. viral envelope.E1 and E2 are potential ligands for *** we describe an analysis of th. interaction between h.V and MBL using recombinant soluble E2 ectodomain fragment,th. full-length.E1/E2 h.terodimer,expressed in vitro,and assess th. effect of th.s interaction on virus entry.A binding assay using antibody capture of full length.E1/E2 h.terodimers was used to demonstrate calcium dependent,saturating binding of MBL to h.V *** with.various sacch.rides furth.r confirmed th.t th. interaction was via th. lectin domain of *** binds to E1/E2 representing a broad range of virus *** was sh.wn to neutralize th. entry into h.h.7 cells of h.V pseudoparticles(h.Vpp)bearing E1/E2 from a wide range of *** were neutralized to varying *** was also sh.wn to neutralize an auth.ntic cell culture infectious virus,strain JFh.1(h.Vcc).Furth.rmore,binding of MBL to E1/E2 was able to activate th. complement system via MBL-associated serine protease *** conclusion,MBL interacts directly with.h.V glycoproteins,wh.ch.are present on th. surface of th. virion,resulting in neutralization of h.V particles.

关键词： h.patitis C virus neutralization mannose binding lectin ch.onic viral infection

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高密度脂蛋白和载脂蛋白AⅠ促进单核细胞源性巨噬细胞产生前列腺素E_2

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华中科技大学学报（医学版） 2002年第3期31卷 284-286页

作者：周小琴 arnold von Eckardstein 华中科技大学同济医学院附属协和医院内科德国明斯特大学临床化学与实验医学研究所德国明斯特D-48149

前列腺素 E2 (PGE2 )是巨噬细胞产生的二十烷酸代谢的主要产物之一。为探讨高密度脂蛋白 (h.L )和载脂蛋白 A (apo A )抗动脉硬化的作用机制 ,观察了二者对单核细胞源性巨噬细胞产生 PGE2 的影响。培养的人外周血单核细胞源性巨噬细胞... 详细信息

前列腺素 E2 (PGE2 )是巨噬细胞产生的二十烷酸代谢的主要产物之一。为探讨高密度脂蛋白 (h.L )和载脂蛋白 A (apo A )抗动脉硬化的作用机制 ,观察了二者对单核细胞源性巨噬细胞产生 PGE2 的影响。培养的人外周血单核细胞源性巨噬细胞先经过脂质负载 ,再分别与 h.L3和 apo A 孵育 ;利用酶联免疫测定法检测细胞培养物上清液中的 PEG2 含量。结果显示 :孵育 2 4 h. h.L3组细胞合成与分泌的 PGE2 是对照组的 370 % ,apo A 也增加巨噬细胞 PGE2的产生。h.L3的作用明显大于 apo A ,且呈时间依赖性。表明 h.L3和无脂质 apo A 都可以促进巨噬细胞产生 PGE2 ,这可能参与 h.L和 apo A

关键词：动脉粥样硬化高密度脂蛋白载脂蛋白AⅠ 单核细胞源性巨噬细胞前列腺素E2

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Experimental investigation of th. uncertainty principle for radial degrees of freedom

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Ph.tonics Research 2022年第9期10卷 2223-2228页

作者： Zh.h. Zh.NG DONGKAI Zh.NG XIAODONG QIU YUANYUAN Ch.N SONJA FRANKE-arnold LIXIANG Ch.N Department of Ph.sics and Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Xiamen UniversityXiamen 361005China Sch.ol of Ph.sics and Astronomy SUPAUniversity of GlasgowGlasgow G128QQUK

Wh.le th. uncertainty principle for linear position and linear momentum,and more recently for angular position and angular momentum,is well establish.d,its radial equivalent h.s so far eluded *** we exploit th. logarith.ic radial position,ln r,and h.perbolic momentum,Ph.to formulate a rigorous uncertainty principle for th. radial degree of freedom of transverse ligh. *** sh.w th.t th. product of th.ir uncertainties is bounded by Planck’s constant,Δln r·ΔPh.h.2,and identify a set of radial intelligent states th.t satisfy th. *** illustrate th. radial uncertainty principle for a variety of intelligent states,by preparing transverse ligh. modes with.suitable radial *** use eigenmode projection to measure th. corresponding h.perbolic momenta,confirming th. minimum uncertainty *** systems are most naturally described in terms of cylindrical coordinates,and our radial uncertainty relation provides th. missing piece in ch.racterizing optical quantum measurements,providing a new platform for th. fundamental tests and applications of quantum optics.

关键词： radial momentum h.perbolic

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提高假编变形丝加工效率的新方法

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国际纺织导报 2006年第12期34卷 15-16页

作者： U. h.rrmann R. arnold M. Seeger h. Erth.h. Lucas 钱程（译）陈惠兰（校）萨克森纺织研究所（STFI）德国 h.rry Lucas纺织机械制造公司德国不详

探索了采用加工POY、MOY、LOY和PET长丝的新概念制成的假编变形丝的特性。将定型装置安装在编织区和卷绕区之间,这样确保生产的假编变形丝具有多种特性。研究表明牵伸连续性很好,假编变形丝特性的偏差很小。

关键词：假编变形纱纬编机工艺

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