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Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim Hyun Jung lee Seung Woo lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong gwan Kim Kyung-Do Han Joo Sung Kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon lee gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung lee Seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Purifying behavior of photocatalytic TiO_2 anodized in nitrate ion containing solution

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中国有色金属学会会刊：英文版 2009年第4期19卷 1027-1030页

作者： Jin-Wook CHOI Seong-Eun lee Byung-gwan lee Yong-Soo JEONG Han-Jun OH Choong-Soo CHI School of Advanced Materials Engineering Kookmin University Korea Institute of Materials Science Department of Materials Science Han seo University

Mesoporous titanium dioxide films were fabricated on titanium plates by micro-arc oxidation *** increase the photocatalytic activity of the films,NH4NO3 was added to the H2SO4 solution,and anodizing was carried out at high voltages using a DC power *** crystal structure,chemical composition,surface morphology and the optical property of the films were investigated by XPS,XRD,UV-VIS spectroscopy and *** photocatalytic activity of the films was evaluated by the decomposition of aniline blue,and the activity of the films for the degradation turned out to be improved by the additives to the electrolyte *** enhanced photocatalytic activity might result from the increased porosity and nitrate ion incorporation into the anodic films by micro arcing,and thereby the TiO2 layer might exhibit an improved absorption property for the visible light.

关键词：二氧化钛硝酸溶液盐离子催化行为氧化钛薄膜光催化活性 H2SO4溶液净化

Formation behavior of anodic TiO_2 nanotubes in fluoride containing electrolytes

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中国有色金属学会会刊：英文版 2009年第4期19卷 842-845页

作者： Byung-gwan lee Jin-Wook CHOI Seong-Eun lee Yong-Soo JEONG Han-Jun OH Choong-Soo CHI School of Advanced Materials Engineering Kookmin University Korea Institute of Materials Science Department of Materials Science Han seo University

TiO2 nanotube layers can be formed with titanium in the electrolytes containing fluoride by electrochemical *** role of fluoride ion,the crystallinity of the anodic oxide,and the chemical state were *** results show the anodic film is composed of oxide and a little amount of *** presence of F- ions leads to chemical dissolution of Ti oxide layer and prevents hydroxide ***,chemical dissolution rate increases with increasing the fluoride content in the range of 0-2%(in mass fraction) because F- ions in electrolyte attack the interface and allow the ions of the electrolyte to easily penetrate into the *** as-anodized TiO2 nanotubes exhibit an amorphous *** treated nanotubes are composed of mixtures of the anatase and rutile phases.

关键词： TiO2纳米管阳极氧化处理氟离子电解质行为二氧化钛化学溶解电化学方法

Univector field method-based multi-agent navigation for pursuit problem in obstacle environments

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Journal of Central South University 2017年第4期24卷 1002-1012页

作者： Le Pham Tuyen Hoang Huu Viet Sang Hyeok An Seung gwan lee Dong-Han Kim Tae Choong Chung Department of Computer Science and Engineering Kyung Hee University Yongin Gyeonggi 446-701 Korea Department of Information Technology Vinh University 182-Le Duan Vinh City Nghe An 461056 Vietnam Humanitas College Kyung Hee University Yongin Gyeonggi 446-701 Korea Department of Electronics and Radio Engineering Kyung Hee University Yongin Gyeonggi 446-701 Korea

The pursuit problem is a well-known problem in computer science. In this problem, a group of predator agents attempt to capture a prey agent in an environment with various obstacle types, partial observation, and an infinite grid-world. Predator agents are applied algorithms that use the univector field method to reach the prey agent, strategies for avoiding obstacles and strategies for cooperation between predator agents. Obstacle avoidance strategies are generalized and presented through strategies called hitting and following boundary(HFB); trapped and following shortest path(TFSP); and predicted and following shortest path(PFSP). In terms of cooperation, cooperation strategies are employed to more quickly reach and capture the prey agent. Experimental results are shown to illustrate the efficiency of the method in the pursuit problem.

关键词： pursuit problem predator agent prey agent univector field method multi-agent systems

Publisher Correction to:Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第8期16卷 417-417页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon lee gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay JBandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Due to typesetting mistake,Hanul Min was missed to be denoted as a corresponding author in the *** type-setter apologizes for *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were *** images or other third party material in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the *** material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.

关键词： Creative Elastic Highly

Complete resection of large-cell neuroendocrine and hepatocellular carcinoma of the liver: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8277-8283页

作者： Byeong gwan Noh Hyung-Il Seo Young Mok Park Suk Kim Seung Baek Hong So Jeong lee Division of HBP Surgery and Transplantation Department of SurgeryPusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combined tumors comprising large-cell neuroendocrine carcinoma and hepatocellular carcinoma have been rarely reported in the *** SUMMARY We report a case of a 73-year-old woman with chronic hepatitis B suspected to have a malignant hepatic mass(segment 3;size,4.5 cm)and lymph node metastasis based on computed tomography and magnetic resonance *** being Child-Pugh class A,esophageal varices were *** underwent left lateral sectionectomy and lymph node *** examination revealed a collision tumor consisting of large-cell neuroendocrine(90%)and hepatocellular(10%)*** combined carcinoma had metastasized to one of the three lymph nodes *** patient recovered without any postoperative complications and was discharged in good condition on postoperative day *** chemotherapy was not *** recurrence occurred during a follow-up period of 24 *** To improve the therapeutic management of combined tumors in the liver,it is necessary to discuss each clinical experience and consider an appropriate method for the preoperative diagnosis and treatment.

关键词： Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis B Case report

Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice

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Translational Neurodegeneration 2021年第4期10卷 630-642页

作者： Mincheol Park Gia Minh Hoang Thien Nguyen Eunkyung lee Hyun Jin Jung Youngshik Choe Moon Hwan lee Jae Youn Hwang Jae gwan Kim Tae Kim Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Korea Brain Research Institute Daegu 41062Republic of Korea Department of Information and Communication Engineering Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988Republic of Korea

Background:Alzheimer's disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and *** Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological *** of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human ***,the therapeutic effect of gamma entrainment in AD mouse models has been *** that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse ***:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham *** and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent *** EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude ***:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the *** was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)*** addition,the length and number of microglial processes decreased in PIL and ***-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS ***:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by

关键词： Transcranial ultrasound stimulation Gamma band oscillation Amyloid-βplaques Alzheimer’s disease