Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice
作者机构：Department of Biomedical Science and EngineeringGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Korea Brain Research InstituteDaegu 41062Republic of Korea Department of Information and Communication EngineeringDaegu Gyeongbuk Institute of Science and TechnologyDaegu 42988Republic of Korea
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2021年第10卷第4期
页 面：630-642页
核心收录：
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
基 金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(Ministry of Science and ICT,2016M3C7A1905475 and 2018R1A2B6006797 to JGK,2017R1A5A1014708 and 2018 R1A2B6002804 to TK Ministry of Education,2015R1D1A1A01059119 to TK) 2021 Joint Research Project of Institutes of Science and Technology to TK KBRI basic research program through Korea Brain Research Institute funded by the Ministry of Science and ICT(21-BR-03-05)to JGK
主 题：Transcranial ultrasound stimulation Gamma band oscillation Amyloid-βplaques Alzheimer’s disease
摘 要：Background:Alzheimer s disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and *** Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological *** of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human ***,the therapeutic effect of gamma entrainment in AD mouse models has been *** that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse ***:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham *** and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent *** EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude ***:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the *** was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)*** addition,the length and number of microglial processes decreased in PIL and ***-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS ***:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by
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