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人兽共患衣原体病原学特点和诊断方法的研究进展

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预防医学情报杂志 2024年第3期40卷 337-348页

作者：何琪富肖胜苟升东夏丽君郭紫晶成都市武侯区人民医院成都610041 成都市武侯区妇幼保健院成都610041 西南民族大学畜牧兽医学院成都610041

21世纪以来,人兽共患病已成为公共卫生关注的热点。衣原体是一类分布广泛、在细胞内寄生、有独特双相发育周期的原核细胞性病原体,部分衣原体种可以感染包括人类在内的多种哺乳动物以及鸟类,引起眼、关节、呼吸系统、神经系统、泌尿生... 详细信息

21世纪以来,人兽共患病已成为公共卫生关注的热点。衣原体是一类分布广泛、在细胞内寄生、有独特双相发育周期的原核细胞性病原体,部分衣原体种可以感染包括人类在内的多种哺乳动物以及鸟类,引起眼、关节、呼吸系统、神经系统、泌尿生殖系统疾病,治愈不及时甚至可引起死亡,对动物产品和人类健康等公共卫生安全领域产生严重威胁。本文从人兽共患衣原体的生物学特征、流行病学、临床特征以及实验室检测方法等方面进行综述,以期为人兽共患衣原体疫情监测工作及防控提供参考,为公共卫生安全和畜牧业健康发展提供保障。

关键词：人兽共患病衣原体病原学临床症状实验室检测

外源植物激素对小果野蕉和野蕉种子萌发率及胚活力的影响

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分子植物育种 2024年第8期22卷 2722-2731页

作者：孙长君程志号郭素霞曾学蔚谭再欢吴琼中国热带农业科学院热带生物技术研究所海南省香蕉遗传改良重点实验室海口571101 中国热带农业科学院热带生物技术研究所热带作物生物育种全国重点实验室三亚572024 中国热带农业科学院海口实验站海口571101

香蕉种子萌发率低是香蕉育种工作的重要“瓶颈”之一,香蕉种子萌发机制研究较少,严重制约了香蕉亲本组配、种质创新的进程。本研究以香蕉杂交常用可育亲本(香蕉栽培种的祖先种)小果野蕉(Musa acuminata Colla,AA)、野蕉(Musa balbisiana... 详细信息

香蕉种子萌发率低是香蕉育种工作的重要“瓶颈”之一,香蕉种子萌发机制研究较少,严重制约了香蕉亲本组配、种质创新的进程。本研究以香蕉杂交常用可育亲本(香蕉栽培种的祖先种)小果野蕉(Musa acuminata Colla,AA)、野蕉(Musa balbisiana Colla,BB)为材料,检测不同成熟度香蕉种子萌发率的差异,研究激素处理[赤霉素(GA3),2,4-二氯苯氧乙酸(2,4-D),激动素(KT),玉米素(ZT),6-苄氨基嘌呤(6-BA)]对不同成熟程度种子胚活力及萌发率的影响。结果表明:60%、80%和100%成熟度的小果野蕉种子胚活力随成熟度提高而降低,但萌发率为0,激素处理可以提高小果野蕉胚不同部位的活力,但种子萌发率没有提高。不同成熟度的野蕉胚活力为80%>100%>60%;种子萌发率为80%>100%>60%。激素能显著提高野蕉种子的萌发率,但不同激素种类、浓度的效果有较大的差异;低浓度(50 mg/L)的激素对60%成熟度的野蕉种子的萌发率和萌发速度有较好的提高;中浓度(100 mg/L)的激素对80%成熟度野蕉种子的萌发率和萌发速度有较好的提高效果;激素会降低100%成熟度野蕉种子种子萌发率和萌发速度。80%成熟度的野蕉种子经100 mg/L的ZT处理24 h为最优组合,70 d萌发率高达34.33%。GA3、ZT、6-BA均能提高野蕉种子的胚活力,但作用于胚的位点有差异。本研究通过对两种重要的野生香蕉萌发特征进行探讨,为香蕉杂交育种理论提供依据,为杂交父母本选配和后代遗传群体构建奠定基础。

关键词：香蕉种子外源植物激素成熟度萌发率胚活力

Electro-oxidation of Ascorbic Acid on PVP-stabilized Graphene Electrode

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Chemical Research in Chinese Universities 2010年第2期26卷 287-290页

作者： HAN Dong-fang SHAN Chang-sheng guo Li-ping NIU Li HAN Dong-xue State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Department of Chemistry Northeast Normal University Changchun 130024 P. R. China

Polyvinylpyrrolidone-stabilized graphene（PVP-graphene） was synthesized and investigated as a modifier for the determination of ascorbic acid（AA）. With PVP acting as stabilizer and dispersant, the resulting PVP-graphene material could disperse well into water. And the PVP-graphene modified glassy carbon electrode（PVP-graphene-GCE） showed an obvious electrocatalytical activity toward the oxidation of AA in a phosphate buffer solution（PBS, pH=7.0） with an oxidation potential of AA at 0.052 V vs. AglAgCl（sat. KCl）. The calibration curve for APt was linear in a concentration range from 1.0×10^-5 to 5.0×10^-4 mol/L with a correlation coefficient of 0.9998. And the detection limit was found to be 1 μtmol/L. During the oxidation of AA, the π-π interaction of graphene plane with conjugated hexenoic aeid-lactone in AA molecules might play a key role. As a result, an obvious decrease of overpotential was achieved at such a PVP-graphene electrode through a possible adsorption/enrichment process, which will probably trigger potential applications for the electroanalysis of some aromatic and heterocyclic compounds.

关键词： Graphene Polyvinylpyrrolidone Electro-oxidation Ascorbic acid

Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry(Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1846-1855页

作者： Sifan Luo Linbo guo Caimin sheng Yumei Zhao Ling Chen Chufang Li Zhengjin Jiang Haiyan Tian Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan UniversityGuangzhou 510632China Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou 510632China The State Key Laboratory of Respiratory Disease and the 1st Affiliated Hospital of Guangzhou Medical University Guangzhou 510663China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhou 510632China

Neuraminidase inhibitors(NAIs)are the mainstay antiviral drugs against influenza *** this study,a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads(NA-MB).After verifying the feasibility of NA-MB with an artificial mixture including NA inhibitors and non-inhibitors,the developed ligand fishing protocol was applied to screen NAIs from the crude extracts of Duchesnea indica ***-four NA binding compounds were identified from the normal butanol(n-BuOH)extract of *** as potential NAIs by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(HPLC-Q-TOF-MS)assisted with Compound Structure Identification(CSI):FingerID,including 12 ellagitannins,4 brevifolin derivatives,3 ellagic acid derivatives,and 4 *** them,9 compounds were isolated and tested for in vitro NA inhibitory activities against NA from Clostridium perfringens,and from oseltamivir sensitive and resistant influenza A virus *** results indicate that compound B23 has the NA inhibitory activities in both the oseltamivir sensitive and resistant viral NA,with half maximal inhibitory concentration(IC50)values of 197.9 and 125.4μmol/L,***,B23 can obviously reduce the replication of oseltamivir sensitive and resistant viruses in Madin-Darby canine kidney(MDCK)cells at the concentrations of 40 and 200μmol/L.

关键词： Neuraminidase inhibitors Duchesnea indica Andr. Ligand fishing Magnetic beads HPLCe Q-TOF-MS Influenza A Virus

A novel and efficient route for the preparation of atorvastatin

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Chinese Chemical Letters 2011年第10期22卷 1159-1162页

作者： Jian Gao Yang Hui guo Ya Ping Wang Xiang Jing Wang Wen sheng Xiang Department of Biochemical Engineering Northeast Agricultural University Harbin 150030 China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou 318000 China

A novel and efficient synthetic method of atorvastatin was *** key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/*** novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.

关键词： Atorvastatin Horner-Wadsworth-Emmons reaction Synthesis Intermediate

Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

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Chinese Journal of Polymer Science 2022年第9期40卷 1120-1128页

作者： Mei-Yu Jiang Jia-sheng wu Wei-Min Liu Hao-Hui Ren Xin Wang Peng-Fei Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer ***-targeted sonodynamic therapy(SDT)can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven ***,we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting,which constituted a nano sonosensitizer(T-cRGD NPs)for fluorescence imaging-guided sonodynamic therapy.A comparable sonosensitizer(T-PEG NPs)without the targeting unit was also prepared for illustration of therapeutic *** to the role of peptide targeting,T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in *** imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.

关键词： Sonodynamic therapy Glioma Cyclic peptide Target enrichment Deep penetration

TiO2/g-C3N4 heterojunctions： In situ fabrication mechanism and enhanced photocatalytic activity

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Frontiers of Materials Science 2016年第3期10卷 310-319页

作者： Li-Cheng wu Hang ZHAO Li-guo JIN Huan-Yan XU School of Materials Science and Engineering Harbin University of Science and Technology Harbin 150040 China

In situ fabrication of TiO21g-C3N4 （TCN） heterojunctions was achieved by a modified sol-gel method. TG analysis was employed to determine the content of Ti02 in TCN composites. XRD, FTIR, TEM and HRTEM were used to analyze the phase composition, functional groups, morphology and microstructure of as-obtained pro- ducts, respectively. Based on the measurement of surface Zeta potential of g-C3N4, a possible mechanism on in situ fabrication of TCN heterojunctions was concluded. The control experiments indicated that TCN heterojunctlons exhibited better photocatalytic performance than either Ti02 or g-C3N4, suggesting that the enchanced photocatalytic activity could be realized by TCN heterojunctionso Then, the evaluation of parameters affecting the photocatalytic performance of TCN heterojunctions was investigated. Even after five cycles, TCN heterojunctions still maintained high photocatalytic activity, exhibiting the good photocatalytic stability. UV-vis absorption spectra showed that almost all MB molecules were decomposed in the photocatalytic process. Finally, the possible mechanism on enhanced photocatalytic performance of TCN heterojunctions was discussed.

关键词： TiO2 g-C3N4 heterojuncUons photocatalytic mechanism

Internal collision double ionization of molecules driven by co-rotating two-color circularly polarized laser pulses

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Chinese Physics B 2024年第1期33卷 355-361页

作者：李雪峰乔月吴丹蔚瑞贤陈基根王俊郭福明杨玉军 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy Changchun 130012China School of Science Jilin Institute of Chemical TechnologyJilin 132022China Zhejiang Provincial Key Laboratory for Cutting Tools Taizhou UniversityJiaojiang 318000China

The double ionization process of molecules driven by co-rotating two-color circularly polarized fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that a considerable part of the sequential double ionization(DI) events of molecules occur through internal collision double ionization(ICD), and the ICD recollision mechanism is significantly different from that in non-sequential double ionization(NSDI). By analyzing the results of internuclear distances R = 5 a.u. and 2 a.u., these two recollision mechanisms are studied in depth. It is found that the dynamic behaviors of the recollision mechanisms of NSDI and ICD are similar. For NSDI, the motion range of electrons after the ionization is relatively large, and the electrons will return to the core after a period of time. In the ICD process,electrons will rotate around the parent ion before ionization, and the distance of the electron motion is relatively small. After a period of time, the electrons will come back to the core and collide with another electron. Furthermore, the molecular internuclear distance has a significant effect on the electron dynamic behavior of the two ionization mechanisms. This study will help to understand the multi-electron ionization process of complex systems.

关键词： non-sequential double ionization internuclear distance internal-collision circularly polarized laser field

Characterization of Obtuse Triangular Defects on 4H-SiC 4° off-Axis Epitaxial Wafers

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Chinese Physics Letters 2013年第9期30卷 109-111页

作者： DONG Lin SUN guo-sheng YU Jun ZHENG Liu LIU Xing-Fang ZHANG Feng YAN guo-guo LI Xi-Guang WANG Zhan-guo YANG Fei Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Dongguan Tianyu Semiconductor Inc.Dongguan 523000 State Grid Smart Grid Research Institute Beijing 100192

We investigate the triangular defects with different structural features on 4H-SiC epilayers by a Nomarski micro-scope,a Candela optical surface analyzer and ultraviolet photoluminescence(UV-PL)*** the foreign particles and the substrate scratches can cause the formation of the obtuse triangular *** central area of some obtuse triangular defects can have the spatially confined core,in which the in-grown stacking faults can be observed under the UV-PL *** contrast,the obtuse triangular defects induced by the scratches appear in the form of band-like defects,of which the width depends on the scratch direction and reaches the maximum when the scratch direction is parallel to the step flow *** formation mechanisms of these obtuse triangular defects are discussed.

关键词： triangular Epitaxial ultraviolet