A novel and efficient route for the preparation of atorvastatin
A novel and efficient route for the preparation of atorvastatin作者机构:Department of Biochemical Engineering Northeast Agricultural University Harbin 150030 China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou 318000 China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2011年第22卷第10期
页 面:1159-1162页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学]
基 金:the financial supports from the National Key Project for Basic Research(No.2010CB 11261 02) the Outstanding Youth Foundation of Heilongjiang Province(No.JC200706)
主 题:Atorvastatin Horner-Wadsworth-Emmons reaction Synthesis Intermediate
摘 要:A novel and efficient synthetic method of atorvastatin was *** key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/*** novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.