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A novel and efficient route for the preparation of atorvastatin

A novel and efficient route for the preparation of atorvastatin

作     者:Jian Gao Yang Hui Guo Ya Ping Wang Xiang Jing Wang Wen Sheng Xiang 

作者机构:Department of Biochemical Engineering Northeast Agricultural University Harbin 150030 China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou 318000 China 

出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期:2011年第22卷第10期

页      面:1159-1162页

核心收录:

学科分类:1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基  金:the financial supports from the National Key Project for Basic Research(No.2010CB 11261 02) the Outstanding Youth Foundation of Heilongjiang Province(No.JC200706) 

主  题:Atorvastatin Horner-Wadsworth-Emmons reaction Synthesis Intermediate 

摘      要:A novel and efficient synthetic method of atorvastatin was *** key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/*** novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.

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