A novel and efficient route for the preparation of atorvastatin

作     者：Jian Gao Yang Hui Guo Ya Ping Wang Xiang Jing Wang Wen Sheng Xiang 

作者机构：Department of Biochemical Engineering Northeast Agricultural University Harbin 150030 China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou 318000 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第10期

页      面：1159-1162页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基　　金：the financial supports from the National Key Project for Basic Research(No.2010CB 11261 02) the Outstanding Youth Foundation of Heilongjiang Province(No.JC200706) 

主　　题：Atorvastatin Horner-Wadsworth-Emmons reaction Synthesis Intermediate 

摘      要：A novel and efficient synthetic method of atorvastatin was *** key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/*** novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.