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Injectable Fiber Electronics for Tumor Treatment

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Advanced Fiber Materials 2022年第2期4卷 246-255页

作者： Yang Zhao Chuanrui Chen Yangyang Qiu Tenglong Mei Lei Ye Huan Feng Ye Zhang Liyuan Wang Yue guo Xuemei sun Jiaxue Wu Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China The State Key Laboratory of Genetic Engineering School of Life ScienceZhongshan HospitalFudan UniversityShanghai 200438China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artifcial Functional Materialsand College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

Electrochemical therapy emerged as a low-cost and efective method for tumor ***,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft ***,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor *** design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through *** a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor *** fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 *** in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few *** tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy.

关键词： Flexible Biocompatible Implantable Fiber device Tumor therapy

Development and validation of a simple HPLC-UV method for the quantification of valproic acid in serum using protein precipitation combined with on-line solid phase extraction

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Development and validation of a simple HPLC-UV method for th...

Uniform Boundedness of Torsion Subgroups of Linear Groups

第四届全国治疗药物监测学术年会

作者： Ruan Can-Jun He jing guo Wei Rong Zhang sun Chuan Li Wen-Biao Laboratory of Clinical Psychopharmacology Beijing Key Lab of Mental DisordersBeijing Anding HospitalCapital Medical University

Objective:To develop and validate a simple HPLC-UV method for the quantification of valproic acid in serum used for ***:After protein precipitation of the serum sample,300μL supernatant was injected into the HPLC system which had two pumps and a six port switching *** analyte was automatically pre-concentrated and purified by the solid-phase extraction（SPE）column（C18,5μm,2.1×30mm）,then the fluent with the analyte was switched onto the analytical column（C18,3.5μm,150mm×2.1mm）for further separation and *** mobile phase was consisted of acetonitrile and 25 mM phosphate buffer（pH=6.8）（20:80,v/v）with an isocratic flow rate of 0.2 mL/min,and the ultra-violet detection wave length was ***:The assay was validated over the concentration range of 2.5-160μg/***-and inter-day precision for the analyte was＜2.5%.Method accuracy was between-11.4%and 1.1%.Additionally,the method had been compared with ARCHITECT i Valproic acid assay,and the results of Weighted Deming regression analysis showed that the on-line SPE HPLC-UV method had a good agreement with ARCHITECT i Valproic acid ***:A rapid,highly selective on-line SPE HPLC-UV method was developed and validated for the determination of VPA in human *** method has a good agreement with ARCHITECT i Valproic acid assay,and can be used for routine Therapeutic Drug Monitoring（TDM）for VPA.

关键词： valproic acid HPLC-UV on-line SPE protein precipitation

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Acta Mathematica Sinica,English Series 2008年第2期24卷 305-310页

作者： Bin Yong sun Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China

The torsion conjecture says： for any abelian variety A defined over a number field k, the order of the torsion subgroup of A（k） is bounded by a constant C（k,d） which depends only on the number field k and the dimension d of the abelian variety. The torsion conjecture remains open in general. However, in this paper, a short argument shows that the conjecture is true for more general fields if we consider linear groups instead of abelian varieties. If G is a connected linear algebraic group defined over a field k which is finitely generated over Q,Г is a torsion subgroup of G（k）. Then the order of Г is bounded by a constant C＇（k, d） which depends only on k and the dimension d of G.

关键词： linear algebraic group finite subgroup torsion conjecture torsion subgroup

钙调磷酸酶抑制剂在儿童难治性肾病综合征中的应用进展

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中国新药杂志 2018年第13期27卷 1515-1520页

作者：孙洁雨郭宏丽许静中国药科大学基础医学与临床药学学院南京211198 南京市儿童医院药学部南京210008

环孢素A和他克莫司是钙调磷酸酶抑制剂(calcineurin inhibitors,CNIs)家族主要成员,目前广泛应用于儿童难治性肾病综合征(refractory nephrotic syndrome,RNS)的治疗。环孢素A(cyclosporine A,Cs A)在RNS中应用较早,疗效显著,然而其停... 详细信息

环孢素A和他克莫司是钙调磷酸酶抑制剂(calcineurin inhibitors,CNIs)家族主要成员,目前广泛应用于儿童难治性肾病综合征(refractory nephrotic syndrome,RNS)的治疗。环孢素A(cyclosporine A,Cs A)在RNS中应用较早,疗效显著,然而其停药后复发率高,长期使用存在肾损伤风险。他克莫司(tacrolimus,FK506)免疫抑制作用强于Cs A,在儿童RNS中的应用越来越多,但临床对照研究多为小样本,依然存在远期复发率、肾毒性等问题。本文将根据多个临床试验结果对2种药物的疗效、不良反应、药物相互作用以及目前应用存在的问题等多方面进行对比综述,为临床合理用药提供依据。

关键词：钙调磷酸酶抑制剂环孢素A 他克莫司难治性肾病综合征儿童

基于Ollivier-Ricci曲率的图扩散节点分类算法

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计算机应用研究 2025年第1期42卷 165-170页

作者：孙宁李胤萱张帅汤璇魏宪辽宁工程技术大学软件学院辽宁葫芦岛125105 华东师范大学软件工程学院上海200241

为解决图扩散方法在处理复杂边关系时精度降低的局限性,提出了一种基于曲率的图扩散神经网络。首先,引入Ollivier-Ricci曲率量化图的边曲率,提供关于图结构的几何度量;其次,运用曲率调整随机转移矩阵的权重,根据几何关系进行相应的权重... 详细信息

为解决图扩散方法在处理复杂边关系时精度降低的局限性,提出了一种基于曲率的图扩散神经网络。首先,引入Ollivier-Ricci曲率量化图的边曲率,提供关于图结构的几何度量;其次,运用曲率调整随机转移矩阵的权重,根据几何关系进行相应的权重修改;最后,将处理后的曲率矩阵与图扩散矩阵结合,更新权重系数进行模型训练。实验结果表明,与传统的图扩散方法相比,改良后的方法保持了有效地平滑图信号和减少高频噪声的优点,并在不同边和节点数量的数据集上将精度提高0.3~2.0百分点。该方法通过优化图扩散的消息聚合,能够更有效地利用图结构中的节点信息和边权重,从而提升节点分类任务中的模型性能,为未来基于图方法的研究提供了更可靠的方法与实验。

关键词：图神经网络图扩散 Ollivier-Ricci曲率节点分类

User Decision-based Analysis of Urban Electric Vehicle Loads

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CSEE Journal of Power and Energy Systems 2021年第1期7卷 190-200页

作者： Lei Dong Chunfei Wang Mengting Li Ke sun Tianyi Chen Yingyun sun the State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources(North China Electric Power University) Changping DistrictBeijing 102206China the State Grid Economic and Technological Research Institute Co. Ltd.

The grid load attributable to electric vehicles (EVs)is affected by the choice behaviors of EV users. To analyze theeffects of factors such as travel demand and electricity priceson user behavior, a logit discrete choice model is introducedto simulate the users decisions to charge/travel. Based on aquasi-steady-state traffic network, a model for cluster electricvehicles considering the user’s behavior is designed to obtain theprobability distribution of the user’s behavior and the chargeand discharge curves of cluster EVs under various scenarios. Thevalidity of the proposed model is verified using an IEEE 9-nodetraffic network case and an urban traffic network case. Furthermore,the impact of the electricity price, traffic conditions, andother factors on the load curves of urban EVs is analyzed.

关键词： Cluster electric vehicles discrete choice model quasi-steady traffic network model vehicle-to-grid(V2G)

非厄米PT对称多通道光波导体系的调控及动力学

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原子与分子物理学报 2025年第1期42卷 108-117页

作者：孙武叶伏秋张光成吉首大学物理与机电工程学院吉首416000

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换... 详细信息

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换为重整化参数后的等效未调制系统后,发现可以通过额外引入单频周期调制的光波导去调控体系的PT对称性,并且讨论了周期调制的非厄米三通道波导体系的能谱特性.最后通过解析和数值的方法给出了光在非厄米三通道光学波导中的动力学演化.

关键词： PT对称非厄米三通道波导

Abdominal aortic aneurysm： Treatment options, image visualizations and follow-up procedures

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Journal of Geriatric Cardiology 2012年第1期9卷 49-60页

作者： Zhong-Hua sun Discipline of Medical Imaging Department of lmaging and Applied Physics Curtin University Perth Western Australia 6845 Australia

Abdominal aortic aneurysm is a common vascular disease that affects elderly *** surgical repair is regarded as the gold standard technique for treatment of abdominal aortic aneurysm,however,endovaseular aneurysm repair has rapidly expanded since its first introduction in *** a less invasive technique,endovascular aneurysm repair has been confirmed to be an effective alternative to open surgical repair,especially in patients with co-morbid *** tomography （CT） angiography is currently the preferred imaging modality for both preoperative planning and post-operative follow-up.2D CT images are complemented by a number of 3D reconstructions which enhance the diagnostic applications of CT angiography in both planning and follow-up of endovascular *** has the disadvantage of high cummulative radiation dose,of particular concern in younger patients,since patients require regular imaging follow-ups after endovascular repair,thus,exposing patients to repeated radiation exposure for *** is a trend to change from CT to ultrasound surveillance of endovascular aneurysm *** image visualizations demonstrate excellent morphological assessment of aneurysm and stent-grafts,but fail to provide hemodynamic changes caused by the complex stent-graft device that is implanted into the *** article reviews the treatment options of abdominal aortic aneurysm,various image visualization tools,and follow-up procedures with use of different modalities including both imaging and computational fluid dynamics *** directions to improve treatment outcomes in the follow-up of endovascular aneurysm repair are outlined.

关键词： Abdominal aortic aneurysm Computed tomography Follow-up Stent graft Treatment Visualization.

STABILITY OF A VON KARMAN EQUATION WITH INFINITE MEMORY

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Acta Mathematica Scientia 2017年第4期37卷 965-973页

作者： sun-Hye PARK Center for Education Accreditation Pusan National UniversityBusan 609-735South Korea

In this paper, we consider a von Karman equation with infinite memory. For yon Karman equations with finite memory, there is a lot of literature concerning on existence of the solutions, decay of the energy, and existence of the attractors. However, there are few results on existence and energy decay rate of the solutions for yon Karman equations with infinite memory. The main goal of the present paper is to generalize previous results by treating infinite history instead of finite history.

关键词： yon Karman equation general decay infinite memory