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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Regulating single-atom Mn sites by precisely axial pyridinic-nitrogen coordination to stabilize the oxygen reduction

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Journal of Energy Chemistry 2023年第5期80卷 542-552,I0012页

作者： Yuan Qin Chaozhong guo Zihao ou Chuanlan Xu Qi Lan rong Jin Yao Liu Yingchun Niu Quan Xu Yujun Si Honglin Li Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing University of Arts and SciencesChongqing 402160China School of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400054China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Biogas Upgrading UtilizationChina University of Petroleum-BeijingBeijing 102249China College of Chemistry and Environmental Engineering Sichuan University of Science and EngineeringZigong 643000SichuanChina School of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China

Designing single-atom catalysts for oxygen reduction reaction(ORR)are fashionable but challenging to boost the zinc-air battery *** enhanced ORR activity by manganese(Mn)singleatom catalysts can be achieved by accurately regulating the coordination number of isolated Mn *** calculations indicate that the single Mn-N5sites possess lower free energy barrier and higher oxygen adsorption performance than single Mn-N4sites to accelerate the ORR *** to it,here we synthesize an atomically dispersed Mn-N5catalyst by precisely axial coordination of pyridinic-N doped into two-dimensional(2D)porous nanocarbon sheets(~3.56 nm thickness),which reveals outstanding catalytic activity and ultrahigh stability for the ORR in zinc-air battery owing to the inhomogeneous charge distribution of Mn-N5sites compared to the conventional single-site Mn-N4catalyst and Pt/*** work gives a new strategy for in situ regulating the electronic structure of metal single-atoms and further promoting the overall ORR performance in energy systems.

关键词： Single-atom manganese catalyst Mn-N5 active moiety Oxygen reduction reaction,Coordination number Axial pyridinic-nitrogen coordination

Reconstruction of complex orbital fracture with titanium implants

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 488-492页

作者： Wen-Shu Yi, Xin-rong ou Department of Ophthalmology Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Neurologic Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Oral and Maxillofacial Xiangya Hospital Central South University Changsha 410008 Hunan Province China

AIM: To evaluate the effectiveness and safety of complex orbital fracture reconstruction with titanium implants. METHODS: A retrospective review of 46 patients treated with complex orbital fractures reconstruction using titanium implants from January 2005 to December 2008 was conducted. The following data were recorded: age, gender, mechanism of injury, preoperative and postoperative orbital CT, visual acuity, diplopia, ocular motility and Hertel exophthalmometer. RESULTS: The most common cause was motor vehicle accident (47.8%), followed by industrial injury (30.4%). All patients had improved appearance after operation and CT scan at one week after operation showed the fracture defects of orbit and neighboring areas had been reconstructed. Forty-six cases had various degrees of enophthalmos before operation. Among them, 32 cases were completely corrected, 11 cases improved obviously and 3 cases had no improvement after operation. Thirty-six patients with visual acuity =20/60 revealed diplopia of various degrees, including 26 patients had diplopia in right ahead and/or reading positions. At the sixth month after operation, diplopia disappeared in five patients, 7 patients still had diplopia in right ahead and/or reading positions, 14 patients had diplopia in positions rather than right ahead and reading positions (20 degrees). All patients had various degrees of ocular motility disorders before operation. At the sixth month after operation, eyeball movement disorder disappeared in 9 patients, 31 patients showed improvement and 6 patients had no improvement. Complications of implant infection, rejection and displacement were not reported after operation. CONCLUSION: The application of titanium implants in the repair of complex orbital fractures greatly improves the appearance and functional results, which is a favorable material for plastic surgery of complex orbital fracture.

关键词： complex orbital fractures titanium reconstruction

Corrosion risk analysis of tube-and-shell heat exchangers and design of outlet temperature control system

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Petroleum Science 2021年第4期18卷 1219-1229页

作者： Hao-Zhe Jin Yong Gu guo-Fu ou The Institute of Flow-Induced Corrosion Zhejiang Sci-tech UniversityHangzhou310000ZhejiangChina Institute of Flow Induced Corrosion and Intelligent Prevention and Control Changzhou UniversityChangzhou213000JiangsuChina

This study deals with the high-risk shell-and-tube heat exchangers in the effluent system of hydrogenation reaction of the petrochemical *** process of hydroprocessing reactor effluent system is simulated in Aspen Plus to study the distribution of corrosive medium in the three phases of oil,gas and *** least-squares method is utilized to calculate the ammonium salt crystallization ***,the heat exchanger with risk of ammonium salt crystal corrosion is *** mathematical modeling of the heat exchanger is established to determine the transfer function.A temperature control system with proportional integral derivative(PID)control of the heat exchanger outlet is designed,and fuzzy logic is used to implement self-tuning of PID *** MATLAB simulation,the results show the control system can achieve rapid control of the heat exchanger outlet temperature.

关键词： Shell-and-tube heat exchanger Corrosion risk Dynamic model Fuzzy logic control PID control

Semiconductor quantum computation

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National Science Review 2019年第1期6卷 32-54页

作者： Xin Zhang Hai-ou Li Gang Cao Ming Xiao Guang-Can guo guo-Ping guo Key Laboratory of Quantum Information CAS University of Science and Technology of China Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China

Semiconductors, a significant type of material in the information era, are becoming more and more powerful in the field of quantum information. In recent decades, semiconductor quantum computation was investigated thoroughly across the world and developed with a dramatically fast speed. The research varied from initialization, control and readout of qubits, to the architecture of fault-tolerant quantum ***, we first introduce the basic ideas for quantum computing, and then discuss the developments of single-and two-qubit gate control in semiconductors. Up to now, the qubit initialization, control and readout can be realized with relatively high fidelity and a programmable two-qubit quantum processor has even been demonstrated. However, to further improve the qubit quality and scale it up, there are still some challenges to resolve such as the improvement of the readout method, material development and scalable designs. We discuss these issues and introduce the forefronts of progress. Finally, considering the positive trend of the research on semiconductor quantum devices and recent theoretical work on the applications of quantum computation, we anticipate that semiconductor quantum computation may develop fast and will have a huge impact on our lives in the near future.

关键词： semiconductor quantum dot qubit quantum computation spin manipulation

Scavenging Microwave Wireless Power:A Unified Model,Rectenna Design Automation,and Cutting-Edge Techniques

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Engineering 2023年第11期30卷 32-48页

作者： Si-Ping Gao Jun-Hui ou Xiuyin Zhang Yongxin guo Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore School of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China School of Future Technology South China University of TechnologyGuangzhou 511442China

While sufficient review articles exist on inductive short-range wireless power transfer(WPT),long-haul microwave WPT(MWPT)for solar power satellites,and ambient microwave wireless energy harvesting(MWEH)in urban areas,few studies focus on the fundamental modeling and related design automation of receiver *** article reviews the development of MWPT and MWEH receivers,with a focus on rectenna design automation.A novel rectifier model capable of accurately modeling the rectification process under both high and low input power is *** model reveals the theoretical boundary of radio frequency-to-direct current(dc)power conversion efficiency and,most importantly,enables an automated system *** automated rectenna design flow is sequential,with the minimal engagement of iterative *** covers the design automation of every module(i.e.,rectifiers,matching circuits,antennae,and dc–dc converters).Scaling-up of the technique to large rectenna arrays is also possible,where the challenges in array partitioning and power combining are briefly *** addition,several cutting-edge rectenna techniques for MWPT and MWEH are reviewed,including the dynamic range extension technique,the harmonics-based retro-directive technique,and the simultaneous wireless information and power transfer technique,which can be good complements to the presented automated design methodology.

关键词： Microwave wireless power transfer Microwave wireless energy harvesting Unified Rectifier model Automated rectenna design Emerging rectenna techniques

光照不均匀条件下无人机航拍低照度图像增强方法

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现代电子技术 2025年第1期48卷 55-59页

作者：黄静欧余韬桂林电子科技大学计算机工程学院广西北海536000

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过... 详细信息

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过小波分解得到图像的高频参数和低频参数,分别通过双边滤波算法、软阈值方法和直方图对图像的低频参数和高频参数进行增强,采用小波重构对增强后的图像高频参数和低频参数进行重构,得到增强后的无人机航拍图像。通过实验验证,该方法能够实现一种效果较好的图像增强,在原始图像基础上,通过文中方法增强原始亮度8.14%、对比度提高了37.90%以及清晰度增加了31.01%,使得图像的整体质量得到了显著提升,为后续的图像分析、处理提供了更加准确、丰富的信息。

关键词：无人机航拍低照度图像增强高斯滤波小波分解与重构双边滤波算法软阈值方法

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Using multiple site-directed modification of epoxide hydrolase to significantly improve its enantioselectivity in hydrolysis of rac-glycidyl phenyl ether

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2181-2189页

作者： Yao Li Xiaoyang ou Zewang guo Minhua Zong Wenyong Lou Lab of Applied Biocatalysis School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

The epoxide hydrolase gene(SpEH) from Sphingomonas sp. HXN-200 was synthesized and expressed in robust Escherichia coli cells that had a dual protection system. The enantioselectivity(E-value) of the recombinant SpEH was 7.7 and the yield of the remaining(R)-PGE was 24.3% for the hydrolysis of racemic phenyl glycidyl ether(rac-PGE). To improve the catalytic properties of SpEH, the site-directed mutagenesis was carried out based on homology modeling, sequence alignment and molecular docking. Six residues(V195, V196, F218,N226, Q312, and M332) near the active site were mutated to hydrophobic amino acids and the positive mutations were selected for combinatorial mutation. The optimal mutant SpEH^(V196A/N226A/M332A) had an enhanced E-value of 21.2 and a specific activity of 4.57 U·mg^-1-wet cells, which were 2.8-, and 2.3-fold higher than those of wild-type SpEH. The optimal temperature and p H for purified Sp EHV196 A/N226 A/M332 Ato catalyze the hydrolysis of rac-PGE were 25 ℃ and 7.0 with 200 U·mg^-1. The enantioselectivity and yield of the remaining(R)-PGE of E. coliSpEH^(V196A/N226A/M332A)increased from 7.7 to 21.2 and 24.3% to 40.9%, respectively. The molecular docking and kinetic parameter analyses showed that SpEH^(V196A/N226A/M332A) has a greater affinity toward(S)-PGE than(R)-PGE, and that it was more difficult for the O-atom of ASP170 to achieve the nucleophilic attack on the Cα of(R)-PGE, resulting in its improved enantioselectivity.

关键词： Epoxide hydrolase Phenyl glycidyl ether Enantioselectivity Directed modification