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抗生素复合纤维膜用于抗菌药物敏感性检测

分析化学 2024年第5期52卷 725-734页

作者：郭银利赵晨雨季栾玥鲁振坦武汉纺织大学纺织纤维及制品教育部重点实验室智能纺织材料与应用湖北省国际科技合作基地武汉纺织大学材料科学与工程学院

高效、快速的药物敏感性检测方法可以更精准地指导临床用药和提高新型抗菌药物的研发效率。传统的抗菌药物敏感性实验(Antimicrobial susceptibility testing, AST)操作简单、结果可靠、特异性强，但存在耗时长的缺点。CCK8法是基于2-(2... 详细信息

高效、快速的药物敏感性检测方法可以更精准地指导临床用药和提高新型抗菌药物的研发效率。传统的抗菌药物敏感性实验(Antimicrobial susceptibility testing, AST)操作简单、结果可靠、特异性强，但存在耗时长的缺点。CCK8法是基于2-(2-甲氧基-4-硝基苯基)-3-(4-硝基苯基)-5-(2, 4-二磺酸苯)-2H-四唑单钠盐可被细菌细胞的脱氢酶还原形成水溶性橙黄色甲臜，而活菌浓度与甲臜在450 nm处的吸光度成正比的原理实现活菌数量的检测。本研究以抗生素/培养基复合纤维膜为培养基质，采用CCK8法检测细菌在此基质上繁殖生长过程中活菌数量的差异，实现了简单、快速、高通量的抗菌药物敏感性检测，总检测时间在8 h之内。以创口模拟液中的金黄色葡萄球菌、铜绿假单胞菌和人工尿液中的大肠埃希菌为模拟实际样本，评估了本方法在临床应用上的可行性。结果表明，本方法对药物敏感性的评价结果与传统纸片扩散法具有良好的一致性。本方法为药物敏感性检测提供了新的思路，有助于指导临床用药和新型抗菌药物的研发。

关键词：抗生素复合纤维膜比色法抗菌药物敏感性检测快速检测

Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224-4234]

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Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

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徽学研究兴起往事

中国史研究动态 2024年第2期 32-38页

作者：栾成显中国社会科学院古代史研究所北京100101

1964年8月,我从北京师范大学历史系本科毕业,考取中国科学院哲学社会科学部历史研究所张政烺的研究生,来到历史研究所读研。不过,进所仅一个月,即随本所人员到山东搞“四清”,随后又进行劳动实习锻炼,至1965年底才回到北京。1966年初又... 详细信息

1964年8月,我从北京师范大学历史系本科毕业,考取中国科学院哲学社会科学部历史研究所张政烺的研究生,来到历史研究所读研。不过,进所仅一个月,即随本所人员到山东搞“四清”,随后又进行劳动实习锻炼,至1965年底才回到北京。1966年初又参加京郊门头沟“四清”两个月。而后遇到“文革”,学部成了重灾区,图书馆长期关闭,一直无法正规学习。“文革”结束以后,1964年进所的这批研究生遂转为正式研究人员。1977年,哲学社会科学部从中国科学院分离出来,中国社会科学院正式成立,研究业务逐渐恢复。改革开放之初,社会上掀起了一股科学热、学习潮,在社会科学界,多年积赞的研究热情也进发出来。

关键词：中国科学院中国社会科学院社会科学界研究生徽学研究哲学社会科学张政烺图书馆

Esophageal cancer screening,early detection and treatment:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-Tao Qu Qing Li Liang Hao Yan-Jing Ni Wen-Yu luan Zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

Efficacy of Online Learning and Influence on Skin and Eyes Among College Students

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International Journal of Plant Engineering and Management 2024年第1期29卷 14-27页

作者： luan Mei LI Luyao CHEN Jianan ZHAO Yixin HE qiannan Department of Dermatology the Frist Affiliated Hospital of Xi′an Jiaotong UniversityXi′an 710061China Department of Pathology the First Affiliated Hospital of Xi′an Jiaotong UniversityXi′an 710061China

To evaluate the efficacy of online learning and explore the impact of long-term use of electronic products on facial skin as well as eyes.A cross-sectional survey was conducted to 180 sophomores in Xi′an Jiaotong University by cluster random sampling from September to October *** questionnaire covering study condition,skin lesion and Ocular Surface Disease Index.χ_(2) test was used to compare the facial skin condition among different groups,and spearman correlation test was used to test the correlation of rank *** online education,students′learning pressure is reduced,their autonomy is improved,and the learning efficiency is *** were differences in the incidence of facial itching and papules among different *** of use of electronic products was positively correlated with the facial itching,with an r value of 0.231(P<0.05);the proportion of pigmentation in non-blue light protection groups(12.8%)was higher than that in blue light protection groups(1.7%),the difference was statistically significant(χ_(2)=8.384,P<0.05).The prevalence of dry eye among college students is 66.7%,and the proportion of moderate to severe dry eye is 34.5%.The study autonomy has been improved during online ***-term use of electronic products and no blue light protection have an impact on facial *** should enhance the knowledge of skin-care and eye-care and develop better habits.

关键词： online learning facial skin dry eye college students

“时代新人”精神状态的前提追问、主要内容及优化路径

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思想政治教育研究 2024年第4期40卷 133-140页

作者：栾青天津理工大学马克思主义学院天津300380

进入新时代,民族复兴伟业对担当大任的“时代新人”在各项能力和素质上都提出来更高的要求。据此,我们对“时代新人”进行了更加深入地探索,充分认识到其精神状态的重要性。要优化“时代新人”的精神状态就要从历史进程、现实发展以及... 详细信息

进入新时代,民族复兴伟业对担当大任的“时代新人”在各项能力和素质上都提出来更高的要求。据此,我们对“时代新人”进行了更加深入地探索,充分认识到其精神状态的重要性。要优化“时代新人”的精神状态就要从历史进程、现实发展以及理论渊源三个层面追问考察时代新人精神状态的依据,回答“为什么优化”的问题;全面分析其精神状态的主要内容,明确“优化什么”;进而通过深刻认识和发挥理论知识、文化资源、实践锻炼以及人的主观因素在优化人精神状态过程中的作用,帮助“时代新人”最终达成良好的精神状态,解决“如何优化”的问题。

关键词：时代新人精神状态优化路径

Recess-free enhancement-mode AlGaN/GaN RF HEMTs on Si substrate

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Journal of Semiconductors 2024年第6期45卷 81-86页

作者： Tiantian luan Sen Huang Guanjun Jing Jie Fan Haibo Yin Xinguo Gao Sheng Zhang Ke Wei Yankui Li Qimeng Jiang Xinhua Wang Bin Hou Ling Yang Xiaohua Ma Xinyu Liu High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of Chinese Academy of SciencesBe i-jing 100029China School of integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Faculty of integrated Circuits Xidian UniversityXi’an 710071China

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(<6 nm)/GaN heterostructure featuring a naturally depleted 2-D electron gas(2DEG)*** fabricated E-mode HEMTs exhibit a relatively high threshold voltage(VTH)of+1.1 V with good uniformity.A maxi-mum current/power gain cut-off frequency(fT/fMAX)of 31.3/99.6 GHz with a power added efficiency(PAE)of 52.47%and an out-put power density(Pout)of 1.0 W/mm at 3.5 GHz were achieved on the fabricated E-mode HEMTs with 1-μm gate and Au-free ohmic contact.

关键词： AlGaN/GaN heterostructure ultrathin-barrier enhancement-mode radio-frequency power added efficiency silicon substrate

Clinical and pathological characteristics and expression of related molecules in patients with airway disseminated lung adenocarcinoma

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Oncology and Translational Medicine 2024年第1期10卷 30-34页

作者： Wei luan Shuai Liu Kai Zhang Yin-Zai He Department of Oncology Inner Mongolia Autonomous Region People's HospitalHohhotInner MongoliaChina Thoracic Tumor Surgery Inner Mongolia Autonomous Region People's HospitalHohhotInner MongoliaChina

Objective:Lung adenocarcinoma exhibits diverse genetic and morphological backgrounds,in addition to considerable differences in clinical pathology and molecular biological *** these,the phenomenon of spread through air space(STAS),a distinct mode of lung cancer infiltration,has rarely been ***,this study aimed to explore the relationship between STAS tumor cells and the clinical and molecular characteristics of patients with lung adenocarcinoma,as well as their impact on ***:This study included 147 patients who were diagnosed with lung adenocarcinoma at the Inner Mongolia Autonomous Region Cancer Institute between January 2014 and December *** resection specimens were retrospectively *** univariate and multivariate Cox analyses,we assessed the association between STAS and the clinicopathological features and molecular characteristics of patients with lung ***,we investigated the effects on patient *** addition,we developed a column–line plot prediction model and performed internal ***:Patients with positive STAS had a significantly higher proportion of tumors with a diameter≥2 cm,with infiltration around the pleura,blood vessels,and nerves,and a pathological stage>IIB than in STAS-negative patients(P<0.05).Cox multivariate survival analysis revealed that clinical stage,STAS status,tumor size,and visceral pleural invasion were independent prognostic factors influencing the 5-year progression-free survival in patients with lung *** predictive values and P values from the Hosmer-Lemeshow test were 0.8 and 0.2,respectively,indicating no statistical *** operating characteristic curve analysis demonstrated areas under the curve of 0.884 and 0.872 for the training and validation groups,*** nomogram model exhibited the best fit with a value of ***:Clinical stage,pleural invasion,vascular invasion,periph

关键词： Airway dissemination of tumor cells Lung adenocarcinoma Clinicopathological characteristics Nomogram Prognosis prediction model

集束化预防策略联合改良浓度配比口腔护理液对重症脑卒中机械通气患者呼吸机相关性肺炎的预防作用

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临床医学研究与实践 2024年第9期9卷 157-160页

作者：郭明栾成艳来海欧安康市中心医院陕西安康725000 延安大学咸阳医院陕西咸阳712000

目的探讨集束化预防策略联合改良浓度配比口腔护理液对重症脑卒中机械通气患者呼吸机相关性肺炎(VAP)的预防作用。方法选取2020年1月至2022年1月收治的100例重症脑卒中机械通气患者为研究对象,根据随机数字表法将其分为对照组和观察组,... 详细信息

目的探讨集束化预防策略联合改良浓度配比口腔护理液对重症脑卒中机械通气患者呼吸机相关性肺炎(VAP)的预防作用。方法选取2020年1月至2022年1月收治的100例重症脑卒中机械通气患者为研究对象,根据随机数字表法将其分为对照组和观察组,各50例。对照组采用常规护理干预,观察组在对照组干预基础上采用集束化预防策略联合改良浓度配比口腔护理液护理。比较两组的干预效果。结果干预后,观察组的口腔清洁度优于对照组(P<0.05)。观察组的VAP发生率、撤机失败率低于对照组,机械通气时间、ICU住院时间短于对照组(P<0.05)。干预后,观察组的动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))高于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组(P<0.05)。结论集束化预防策略联合改良浓度配比口腔护理液有助于减少重症脑卒中机械通气患者VAP发生,缩短机械通气时间、ICU住院时间,改善血气指标,值得推广。

关键词：集束化预防策略改良浓度配比口腔护理液重症脑卒中机械通气呼吸机相关性肺炎